Preferred Position Research Articles

New mid‐Cretaceous macrothelids showing a similar living mode to extant Macrothelidae (Araneae: Mygalomorphae)

AbstractFive new spider fossils of the family Macrothelidae (Araneae: Mygalomorphae) are described from mid‐Cretaceous Kachin amber, Myanmar. A new genus Acanthomacrothele gen. nov. is established for three new species: Acanthomacrothele pauciverrucae sp. nov., Acanthomacrothele geminata sp. nov., and Acanthomacrothele longicaudata sp. nov. Both male and female specimens of A. pauciverrucae sp. nov. are described, representing a rare case of a fossil spider with both sexes known. We also describe an unidentified juvenile of Macrothelidae to document different developmental stages of Cretaceous species. To test the phylogenetic position of the new fossils, we undertook phylogenetic analyses using both topology‐unconstrained and topology‐constrained methods. Our analyses supported the placement of Acanthomacrothele gen. nov. in Macrothelidae, although its phylogenetic relationship to other genera of Macrothelidae differed among different analytical methods. The fossils documented here have elongated, widely spaced posterior lateral spinnerets, compact rectangular group of eyes on a tubercle, and more spines on male tibia of anterior legs than female, similar to extant macrothelids, suggesting that they probably have similar retreat construction behavior, habitat preference, and mating position to their living relatives.

Insights into pupal development of Bactrocera dorsalis: factors influencing eclosion.

In the life cycle of the oriental fruit fly where larvae reside within fruits and adults exhibit high activity, the pupal stage occurs in the soil, closely tied to agricultural soil management. This study investigates the impact of four variables (body orientation, burial depth, soil particle size, and pH) on Bactrocera dorsalis' physiological preferences, eclosion rates, and pupal stage duration. Notably, body orientation, burial depth, soil texture (particle size), and pH affect eclosion rates. The fruit fly demonstrates a preference for a supine position during eclosion, with average eclosion rates of 97.33%, contrasting with decreases to 78.00% in a head-down position. Soil with mixed particle sizes is detrimental to pupal eclosion, reducing the eclosion rate to 56.67%. And at a pH of 9.98, eclosion rates decrease to 16.67%. These factors significantly influence eclosion rates However, these factors do not significantly alter the duration of the pupal stage, with mean changes not exceeding one day when experimental conditions are modified. These findings suggests that soil manipulations affecting these variables could reduce eclosion rates without compromising the uniformity of adult emergence. This study provides a foundation for environmentally friendly pest control practices and addresses gaps in the pupal stage research of the oriental fruit fly.

CUPID: Improving Battle Fairness and Position Satisfaction in Online MOBA Games with a Re-matchmaking System

The multiplayer online battle arena (MOBA) genre has gained significant popularity and economic success, attracting considerable research interest within the Human-Computer Interaction community. Enhancing the gaming experience requires a deep understanding of player behavior, and a crucial aspect of MOBA games is matchmaking, which aims to assemble teams of comparable skill levels. However, existing matchmaking systems often neglect important factors such as players' position preferences and team assignment, resulting in imbalanced matches and reduced player satisfaction. To address these limitations, this paper proposes a novel framework called CUPID, which introduces a novel process called ''re-matchmaking'' to optimize team and position assignments to improve both fairness and player satisfaction. CUPID incorporates a pre-filtering step to ensure a minimum level of matchmaking quality, followed by a pre-match win-rate prediction model that evaluates the fairness of potential assignments. By simultaneously considering players' position satisfaction and game fairness, CUPID aims to provide an enhanced matchmaking experience. Extensive experiments were conducted on two large-scale, real-world MOBA datasets to validate the effectiveness of CUPID. The results surpass all existing state-of-the-art baselines, with an average relative improvement of 7.18% in terms of win prediction accuracy. Furthermore, CUPID has been successfully deployed in a popular online MOBA game. The deployment resulted in significant improvements in match fairness and player satisfaction, as evidenced by critical Human-Computer Interaction (HCI) metrics covering usability, accessibility, and engagement, observed through A/B testing. To the best of our knowledge, Cupid is the first re-matchmaking system designed specifically for large-scale MOBA games.

Motif mapping during chickpea germination reveals a complex sequential activation of different proteolytic activities.

Despite the importance of grains and legumes in the human diet, little is known regarding peptide release and the temporal changes of protease activities during seed germination. LC/MS-MS peptidomic analysis of two cultivars of germinating chickpea followed by computational analyses indicated cleavage dominated by proteases with a single position preference (mainly before (P1) or after cleavage (P1'): L at P2 (cysEP-like); R or K at P1 (vignain-like), N or Q at P1 (legumain-like); and previously unidentified K, R, A and S at P1'; A at P2'). While P1 N cleavages were relatively constant, P1' K/R preferences were high in soaked garbanzo (kabuli) seeds, declined by four days, and returned at six days, but were much rarer in the brown (desi) cultivar. Late Embryogenesis Associated (LEA) peptides were markedly released during early germination. Vicilin peptides rich in glutamic acid near their N-termini markedly increased with germination, consistent with strong proteolytic resistance, even to human digestion, as indicated by analyses of separate datasets. Thus, this first peptidomics study of seed germination proteolytic profiles unveils a complex cultivar-specific programme of sequential activation and inactivation of a series of proteases, associated with the differential release of peptides from different protein groups.

Trophic Position Stability of Benthic Organisms in a Changing Food Web of an Arctic Fjord Under the Pressure of an Invasive Predatory Snow Crab, Chionoecetes opilio

The introduction of a large predatory snow crab, Chionoecetes opilio, into the Kara Sea is a unique situation where the impact of an invasive species affecting an otherwise undisturbed ecosystem can be observed unhindered by other ecosystem stressors. Trophic interactions are one of the principal relationships between animals and can help assess an ecosystem’s stability. The trophic positions and sources of organic material for the most common benthic species of Blagopoluchiya Bay sampled at different stages of the invasion were calculated using stable isotope analysis. The most pronounced changes in the trophic web occurred amongst the megabenthic species, where previously most abundant deposit-feeding ophiuroids have disappeared. However, the benthic species’ trophic position and primary production source preference did not change. A sea star, Urasterias lincki, remained the highest carnivore in the bay, and the invasive crab remained at a lower trophic level, showing higher omnivory in its diet. Any changes in the consumers’ prey items were within the same trophic level. Overall, active predators became one of the most abundant feeding mode groups. The average weighted trophic position of all megabenthic species increased to the third trophic level, where mostly secondary consumers remained.

Kinetic and Mechanistic Analysis of Phenol Adsorption on Activated Carbons from Kenaf

Activated carbons were prepared from kenaf (Hibiscus cannabinus L.). Carbonization was carried out at 600 °C for 2 h, and activation was performed using air at 600 °C and using CO2 at 750 °C. The activated carbons obtained were treated with HNO3 and H2SO4. The samples were characterized by their chemical and physical structure. The activated carbons obtained were mainly macroporous, and their structure underwent major changes with the activation method and acid treatment. Activated carbons were alkaline and acid-treated carbons were neutral. They were used for phenol adsorption and a kinetic and mechanistic study of adsorption was carried out. The fit to the pseudo-second order and Elovich models was predominant. The rate-limiting step of the process was determined to be diffusion within the pores, as the experimental data fit the Bangham model. DFT simulation showed that the preferred adsorption position involves π-π stacking and that oxidation enhances this interaction. Furthermore, the simulation showed that the interaction of phenol with oxygenated functional groups depends on the type of functional group.

Comparing Sciatic Nerve Block in Novel Convenient Supine Position Via Medial Approach Versus Lateral Position Via Lateral Approach

Introduction: Popliteal sciatic nerve block performed in lateral position usually requires a change in position for the patient. This is time consuming and may cause discomfort to the patient. Methods: This prospective study compared patients' preference and peri-operative outcomes in supine position via medial approach to the sciatic nerve and lateral position via lateral approach to the nerve. Prospective registration of this study with NHG Human Research Protection Programme was on 9 Sept 2021. Institutional review board approval was obtained for this study on 20 May 2022. All research participants provided written informed consent with the first patient enrolled on 05 June 2022. 50 patients from Ng Teng Fong General hospital (NTFGH) who were undergoing popliteal sciatic nerve block with or without sedation were recruited for the study and randomised to either receive the block in supine or lateral position. Results: This study showed that there were significantly more patients in the supine group preferring to be in supine position during the block with p-valve <0.001. 45.8% of patients who had the block performed in lateral position preferred supine position instead. There was no significant difference in the peri-operative outcomes or duration taken for block completion. Most patients preferred to be in the supine position for popliteal sciatic nerve block as it was more comfortable. Conclusion: Performing the block in supine position increased patient’s comfort significantly and is non-inferior to performing it in lateral position in terms of safety, efficacy and efficiency profile.

A preserved neural code for temporal order between memory formation and recall in the human medial temporal lobe.

Temporal memory enables us to remember the temporal order of events happening in our life. The human medial temporal lobe (MTL) appears to contain neural representations supporting temporal memory formation, but the cellular mechanisms that preserve temporal order information for recall are largely unknown. Here, we examined whether human MTL neuronal activity represents the temporal position of events during memory formation and recall, using invasive single and multi-unit recordings in human epilepsy patients (n = 19). Participants freely navigated a virtual environment in order to explore and remember locations and temporal positions of objects. During each exploration period, they sequentially encountered two or three different objects, placed in different locations. This allowed us to examine single- and multi-unit neuronal firing rates (FR) as a function of the temporal position the objects were presented in. We found that a significant number of multi-units and single-units in various MTL regions including the hippocampus showed selectivity to the temporal position of objects during the exploration period. During recall, patients were asked to indicate which one of two objects from the same trial was found latter. Neural firing rates during recall showed a selectivity supporting recall of temporal positions. Interestingly, most of the selective single-units that stayed selective during encoding and recall preserved their temporal position preference. Our results thus suggest that neuronal activity in the human MTL contains a preserved neural code for temporal order in memory formation and recall.

Behavior of Trapped Molecules in Lantern-Like Carcerand Superphanes.

Superphanes are a group of organic molecules from the cyclophane family. They are characterized by the presence of two parallel benzene rings joined together by six bridges. If these bridges are sufficiently long, the superphane cavity can be large enough to trap small molecules or ions. Using ab initio (time scale of 80 ps) and classical (up to 200 ns) molecular dynamics (MD) methods, we study the behavior of five fundamental molecules (M = H2O, NH3, HF, HCN, MeOH) encapsulated inside the experimentally reported lantern-like superphane and its two derivatives featuring slightly modified side bridges. The main focus is studying the dynamics of hydrogen bonds between the trapped M molecule and the imino nitrogen atoms of the side chains of the host superphane. The length of the N···H hydrogen bond increases in the following order: HF < HCN < H2O < MeOH < NH3. The mobility of the trapped molecule and its preferred position inside the superphane cage depend not only on the type of this molecule but also largely on the in/out conformational arrangement of the imino nitrogens in the side chains of the superphane. Their inward-pointing positions allow the formation of strong N···H hydrogen bonds. For this reason, these nitrogens are the preferred sites of interaction. The mobility of the molecules and their residence times on each side of the superphane have been explained by referring to the symmetry and conformation of the given superphane cage. All force field MD simulations have shown that the encapsulated molecule remained inside the superphane cage for 200 ns without any escape event to the outside. Moreover, our simulations based on some endohedral complexes in the water box also showed no exchange event. Thus, the superphanes we study are true carcerand molecules. We attribute this property to the hydrophobic side chains and their pinwheel arrangement, which makes the side walls of the studied superphanes fairly impenetrable to small molecules.

Exploring the impact of sexual positions on ejaculation: Insights from a survey study by the Andrology Working Group of the Society of Urological Surgery in Turkey.

Sexual position is one of the several aspects that affects ejaculation control, which is essential for sexual pleasure. Still little is known, nevertheless, about the connection between sexual positions and ejaculation duration. To investigate the impact of various sexual positions on the duration of ejaculation and gain a deeper understanding of the elements that influence the ability to control ejaculation. An online survey was carried out on a sample of 1904 heterosexual men between the ages of 18-65 years. Premature ejaculation (PE) diagnostic tool was used to define PE. Demographic, behavioral, and physiological traits that are linked to PE and non-PE groups were collected. The participants listed their preferred sexual positions and the ones they changed to during ejaculating. Also, analyses were performed between male/female active or deep/shallow thrust positions and PE status. Although there were no appreciable variations in age or circumcision between PE and non-PE groups, the age of first sexual experience was associated with PE status. Groups also varied in the number of weekly ejaculations, the duration of the favored ejaculations, and the characteristics of the erection. The most preferred sexual posture was the doggy style regardless of the group. When the non-PE group felt to ejaculate, they preferred to change the position significantly more than the PE group (74%vs 67.2%; p<0.05). However, when participants felt ejaculate, non-PE participants tended to switch to shallow thrusting positions significantly more than PE participants, who preferred deeper positions (27.1%vs. 18%; p<0.05). This study underlines the relevance of considering sexual positions in controlling PE. Modifying positions during sexual intercourse may offer a non-pharmacological therapeutic alternative for improving ejaculation control. Future studies in this field might help to create tailored PE treatment strategies.

Ammonothermal Synthesis of Luminescent Imidonitridophosphate Ba4P4N8(NH)2:Eu2.

The structural variability of a compound class is an important criterion for the research into phosphor host lattices for phosphor-converted light-emitting diodes (pc-LEDs). Especially, nitridophosphates and the related class of imidonitridophosphates are promising candidates. Recently, the ammonothermal approach has opened a systematic access to this substance class with larger sample quantities. We present the successful ammonothermal synthesis of the imidonitridophosphate Ba4P4N8(NH)2:Eu2+. Its crystal structure is solved by X-ray diffraction and it crystallizes in space group Cc (no.9) with lattice parameters a=12.5250(3), b=12.5566(4), c=7.3882(2)Å and β=102.9793(10)°. For the first time, adamantane-type (imido)nitridophosphate anions [P4N8(NH)2]8- are observed next to metal ions other than alkali metals in a compound. The presence of imide groups in the structure and the identification of preferred positions for the hydrogen atoms are performed using a combination of quantum chemical calculations, Fourier-transform infrared, and solid-state NMR spectroscopy. Eu2+ doped samples exhibit cyan emission (λmax=498nm, fwhm=50nm/1981cm-1) when excited with ultraviolet light with an impressive internal quantum efficiency (IQE) of 41%, which represents the first benchmark for imidonitridophosphates and is promising for potential industrial application of this compound class.

Effects of seatback angles on passenger kinematics among the longitudinal braking scenario

With the development of autonomous vehicles and zero gravity seats, the passengers are more likely to sit in their preferred postures, such as the high reclined positions. This study aims to analyse the passenger kinematics under different seatback angles by volunteer experiments, which is beneficial for future smart restraint system development. For this study, four volunteers were selected to participate in the longitudinal braking experiments from 80 km/h to 0 km/h, and each volunteer repeated 3 times. Among the tests, three seatback angles (25°, 45°, and 60° from the vertical) were introduced, while the seat pan angles were the same. The seatbelt forces, as well as the volunteers’ motions were recorded among the experiments. The experimental results indicated that both head displacement and the first thoracic vertebrae (T1) displacement increased gradually with the increase of the seatback angle. The average T1 displacements for four volunteers under 25° seatback angle were between 180.2 mm to 245.5 mm, while the T1 displacements for 45° seatback angle and 60° seatback angle were between 291.4 mm to 374.3 and 366.2 mm to 444.5 mm respectively. Both shoulder belt force and lap belt force increased with the increase of seatback angle, except for the 60° case of No.1 volunteer, which might due to the muscle activation level difference. In this study, there was no significant correlation between the seatback inclination angle and the amount of seat belt outlet amount. The study is beneficial for active human model validation and future smart restraint system development.

Universal strategy for rapid design and analysis of gas detection peptide chips with positional preference

The design and analysis of gas detection chips directly affect their detection efficiency and applicability. Detection devices are currently restricted by detection principles, facing drawbacks like intricate structural design, limited applicability, and low detection efficiency. We have designed a complete set of design and analysis scheme for a peptide gas detection chip. First, we selected specific and high-affinity peptide combinations from existing peptide-gas affinity datasets. Then, the peptide chip's arrangement was grouped according to the variations in peptides' affinity towards different gases. Peptides were arranged based on their affinity levels within each group, striking a balance between discrimination and flexibility in the design of the chip. Finally, we evaluated the analysis methods by generating simulated data based on a reference affinity matrix constructed from actual data. Due to the preprocessing role of chip design on affinity data, all methods can effectively accomplish gas classification. In gas concentration prediction tasks, our method reduced mean square error to 0.41, significantly outperforming other methods. This gas detection scheme shortens the development cycle of chip design and analysis methods, fully utilizing the specificity of peptides, enhancing gas analysis effectiveness, and demonstrating the agile development of gas detection chips.

Engineering bacteriophages through deep mining of metagenomic motifs.

Bacteriophages can adapt to new hosts by altering sequence motifs through recombination or convergent evolution. Where such motifs exist and what fitness advantage they confer remains largely unknown. We report a new method, Metagenomic Sequence Informed Functional Scoring (Meta-SIFT), to discover sequence motifs in metagenomic datasets that can be used to engineer phage activity. Meta-SIFT uses experimental deep mutational scanning data to create sequence profiles to enable deep mining of metagenomes for functional motifs which are otherwise invisible to searches. We experimentally tested over 17,000 Meta-SIFT derived sequence motifs in the receptor-binding protein of the T7 phage. The screen revealed thousands of T7 variants with novel host specificity with functional motifs sourced from distant families. Position, substitution and location preferences dictated specificity across a panel of 20 hosts and conditions. To demonstrate therapeutic utility, we engineered active T7 variants against foodborne pathogen E. coli O121. Meta-SIFT is a powerful tool to unlock the functional potential encoded in phage metagenomes to engineer bacteriophages.

Dissection of core promoter syntax through single nucleotide resolution modeling of transcription initiation.

How the DNA sequence of cis-regulatory elements encode transcription initiation patterns remains poorly understood. Here we introduce CLIPNET, a deep learning model trained on population-scale PRO-cap data that predicts the position and quantity of transcription initiation with single nucleotide resolution from DNA sequence more accurately than existing approaches. Interpretation of CLIPNET revealed a complex regulatory syntax consisting of DNA-protein interactions in five major positions between -200 and +50 bp relative to the transcription start site, as well as more subtle positional preferences among transcriptional activators. Transcriptional activator and core promoter motifs work non-additively to encode distinct aspects of initiation, with the former driving initiation quantity and the latter initiation position. We identified core promoter motifs that explain initiation patterns in the majority of promoters and enhancers, including DPR motifs and AT-rich TBP binding sequences in TATA-less promoters. Our results provide insights into the sequence architecture governing transcription initiation.

Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues.

Sound localization is critical for real-world hearing, such as segregating overlapping sound streams. For optimal flexibility, central representations of auditory space must adapt to peripheral changes in binaural cue availability, such as following asymmetric hearing loss in adulthood. However, whether the mature auditory system can reliably encode spatial auditory representations upon abrupt changes in binaural input is unclear. Here we use 2-photon Ca2+ imaging in awake head-fixed mice to determine how the higher-order "shell" layers of the inferior colliculus (IC) encode sound source location in the frontal azimuth, under binaural conditions and after acute monaural hearing loss induced by an ear plug ipsilateral to the imaged hemisphere. Spatial receptive fields were typically broad and not exclusively contralateral: Neurons responded reliably to multiple positions in the contra- and ipsi-lateral hemifields, with preferred positions tiling the entire frontal azimuth. Ear plugging broadened receptive fields and reduced spatial selectivity in a subset of neurons, in agreement with an inhibitory influence of ipsilateral sounds. However ear plugging also enhanced spatial tuning and/or unmasked receptive fields in other neurons, shifting the distribution of preferred angles ipsilaterally with minimal impact on the neuronal population's overall spatial resolution; these effects occurred within 2 hours of ear plugging. Consequently, linear classifiers trained on fluorescence data from control and ear-plugged conditions had similar classification accuracy when tested on held out data from within, but not across hearing conditions. Spatially informative neuronal population codes therefore arise rapidly following monaural hearing loss, in absence of overt experience.

240 Feed preference of weanling pigs fed diets containing extruded corn ground to different particle sizes

Abstract The objective was to test the null hypothesis that there were no effects of reducing particle size of extruded corn on feed preference by weanling pigs. Three corn-based diets containing extruded corn ground to 700, 500, or 300 μm were prepared. An 8-d feed preference test was conducted with all possible combinations of the three diets. Each pair of diets constituted a treatment group (i.e., 700 vs. 500 μm; 700 vs. 300 μm; 500 vs. 300 μm). A total of 48 growing pigs [initial body weight (BW) = 12.1 ± 1.34 kg] were allotted to the three preference test combinations using a randomized complete block design with initial BW group as the blocking factor, resulting in eight replicate pens per treatment group. Two pigs were housed in each pen. Pigs had ad libitum access to feed and water. For each preference test, each pen contained two feeders with two of the three diets. Feeder positions within each pen were switched daily to minimize positional preference. Feed allotments and feed disappearances were recorded daily. Feed preference (%) was calculated by dividing the amount of feed disappeared for each diet by the total amount of two diets consumed by pigs. Three statistical models for each preference test included particle size of corn as fixed effect and block as random effect. Results indicated that pigs had greater (P &amp;lt; 0.05) daily feed disappearance and preference for corn with 700 µm on d 1, 4, 5, 7, and 8 when pigs had a choice between 700 µm vs. 500 µm (Table 1). For the other two preference tests, which were 700 µm vs. 300 µm and 500 µm vs. 300 µm, pigs had a greater (P &amp;lt; 0.05) preference for the larger particle size corn (700 and 500 µm, respectively) for d 3 to 8. In conclusion, it was demonstrated that pigs have a preference for larger particle sizes of extruded corn when given the choice. This may be a result of better texture of feed, a satisfying chewing experience, and the perception of greater bulkiness provided by greater particle sizes. However, further research with longer-term feeding trials is needed because pigs may have already adapted to consuming diets with 700 µm particle size prior to the experiment, which is similar to commercial diets.

Manual therapy plus sexual advice compared with manual therapy or exercise therapy alone for lumbar radiculopathy: a randomized controlled trial.

The biopsychosocial approach to managing low back pain (LBP) has the potential to improve the quality of care for patients. However, LBP trials that have utilized the biopsychosocial approach to treatment have largely neglected sexual activity, which is an important social component of individuals with LBP. The objectives of the study are to determine the effects of manual therapy plus sexual advice (MT+SA) compared with manual therapy (MT) or exercise therapy (ET) alone in the management of individuals with lumbar disc herniation with radiculopathy (DHR) and to determine the best sexual positions for these individuals. This was a single-blind randomized controlled trial. Fifty-four participants diagnosed as having chronic DHR (>3 months) were randomly allocated into three groups with 18 participants each in the MT+SA, MT and ET groups. The participants in the MT+SA group received manual therapy (including Dowling's progressive inhibition of neuromuscular structures and Mulligan's spinal mobilization with leg movement) plus sexual advice, those in the MT group received manual therapy only and those in the ET group received exercise therapy only. Each group received treatment for 12 weeks and then followed up for additional 40 weeks. The primary outcomes were pain, activity limitation, sexual disability and kinesiophobia at 12 weeks post-randomization. The MT+SA group improved significantly better than the MT or ET group in all outcomes (except for nerve function), and at all timelines (6, 12, 26, and 52 weeks post-randomization). These improvements were also clinically meaningful for back pain, leg pain, medication intake, and functional mobility at 6 and 12 weeks post-randomization and for sexual disability, activity limitation, pain catastrophizing, and kinesiophobia at 6, 12, 26, and 52 weeks post-randomization (p<0.05). On the other hand, many preferred sexual positions for individuals with DHR emerged, with "side-lying" being the most practiced sexual position and "standing" being the least practiced sexual position by females. While "lying supine" was the most practiced sexual position and "sitting on a chair" was the least practiced sexual position by males. This study found that individuals with DHR demonstrated better improvements in all outcomes when treated with MT+SA than when treated with MT or ET alone. These improvements were also clinically meaningful for sexual disability, activity limitation, pain catastrophizing, and kinesiophobia at long-term follow-up. There is also no one-size-fits-all to sexual positioning for individuals with DHR.

Integration and competition between space and time in the hippocampus

Episodic memory is organized in both spatial and temporal contexts. The hippocampus is crucial for episodic memory and has been demonstrated to encode spatial and temporal information. However, how the representations of space and time interact in the hippocampal memory system is still unclear. Here, we recorded the activity of hippocampal CA1 neurons in mice in a variety of one-dimensional navigation tasks while systematically varying the speed of the animals. For all tasks, we found neurons simultaneously represented space and elapsed time. There was a negative correlation between the preferred space and lap duration, e.g., the preferred spatial position shifted more toward the origin when the lap duration became longer. A similar relationship between the preferred time and traveled distance was also observed. The results strongly suggest a competitive and integrated representation of space-time by single hippocampal neurons, which may provide the neural basis for spatiotemporal contexts.

Impact of fetal spine alignment according to maternal lateralization during early labor on maternal comfort and birth outcomes: A prospective cohort study in Kelantan, Malaysia.

Maternal positioning during labor significantly influences maternal comfort. This study aims to identify the preferred maternal lateral position during the latent phase and examine the impact of alignment between maternal lateralization and fetal spine positioning during the active phase of the first stage of labor on maternal comfort. Pregnant women in the first stage of labor beyond 37 weeks of gestation were recruited over six months from March to August 2020 for this prospective cohort study at Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia. Eligible individuals were randomly allocated to align with the fetal spine (n=180) or oppose it (n=180). Fetal spine positions were confirmed via transabdominal ultrasound. Maternal mean comfort scores were assessed using the established Maternal Comfort Assessment Tool. Statistical analysis was performed using IBM SPSS version 27, with a p<0.05 considered significant. There was a significant association between the preferred maternal position during the latent phase and concordance with the same maternal lateralization-fetal spine alignment (p<0.001). Higher mean comfort scores were observed when the maternal lateral position matched the fetal spine alignment during the active phase of labor. There was a significant association of normal CTG tracings when the maternal position was aligned with the fetal spine (p<0.001). Parturients preferred lying in alignment with the fetal spine lateralization during the latent phase. This position also offers increased comfort during the active phase of labor. It highlights the importance of considering maternal-fetal alignment as a critical factor in intrapartum care.