The Zaylik-Sarilar epithermal deposit is located 35 km southeast of Ahar in the Ahar-Arasbaran Zone in the Alborz-Azerbaijan Magmatic Belt, NW Iran. Exposed rocks in the Zaylik-Sarilar deposit are mainly composed of Eocene volcanic rocks and Miocene dacite-rhyodacite that are intruded by younger intrusions. The deposit occurs within a sequence of Eocene porphyritic andesite and andesitic lithic tuff. Mineralization occurs as open space filling, taking place as irregular veins, veinlets, and hydrothermal breccias. The mineralization zones can be categorized into two main groups according to sulfides and sulfosalts mineralogy, alteration assemblages, ore textures, and fluid inclusion data. The first group consists of gold-bearing quartz-sulfide ± breccia veins, silicified-phyllic ± argillic zones, and a few quartz-calcite veins. The second group is composed of barren milky (or white) quartz veins, silicified lithocaps, and argillic-kaolinite ± silicic zones. Pyrite, chalcopyrite, bornite, galena, sphalerite, and Au-Ag sulfosalts were identified in ore paragenesis of the gold-bearing veins. Pyrite is the main sulfide mineral in the barren quartz veins and silicified lithocaps. Gold and silver were enriched during oxidation and supergene alteration of the gold-bearing veins. Textural evidences from the gold-bearing veins, such as mosaic breccia monomicts, floating clast breccias, hydrothermal breccias, colloform-crustiform textures, ginguro bands, dendrite textures, and rarely lattice- and parallel-bladed calcite replacement textures, suggest that boiling occurred in the veins. Comb, cockade, reed molds, zonal, and feathery textures are common in the barren veins and silicified lithocaps. Fluid inclusion data show a decreasing trend in salinity and homogenization temperature (Th) from the gold-bearing quartz veins to the barren ones. The average salinity and homogenization temperature (Th) of fluid inclusions from the gold-bearing veins are 1.05 wt% NaCl equiv. and 297 °C, respectively; higher than the average salinity (0.68 wt% NaCl equiv.) and homogenization temperature (192 °C) of fluid inclusions from the barren quartz veins. Th versus salinity diagram suggests that boiling was the main mechanism of ore deposition in the gold-bearing quartz veins and silicified zones. These data propose that the barren quartz veins and silicified lithocaps were formed by cooling. A combination of the geologic, mineralogic, alteration, and fluid inclusion data from the Zaylik-Sarilar deposit represents an epithermal system of low-sulfidation type. Structurally, mineralization has been controlled through the NW-trending strike-slip principal displacement zone and it’s subsidiary Riedel fractures in response to a N-trending compression in the Arabia-Eurasia collision zone.