Porokeratosis Ptychotropica Research Articles

Malignant Transformation in Porokeratosis Ptychotropica: A Systematic Review.

Porokeratosis ptychotropica (PP) is a rare and unusual variant of porokeratosis. There is a dearth of information on the natural history, epidemiology, and optimal treatment options. This study aimed to characterize the worldwide distribution, epidemiology, clinical features, and treatments attempted for all reported cases of porokeratosis ptychotropica. A total of 59 cases of porokeratosis ptychotropica have been reported, with most cases originating from the United States. The median age of patients affected with porokeratosis ptychotropica was 49 years. The most involved body locations are the buttocks and gluteal cleft. The risk of malignant transformation in porokeratosis ptychotropica is approximately 1.7% but there is significant bias in estimating rare occurrences in rare diseases. In conclusion, PP is an important but under-recognized variant of porokeratosis, with a likely low risk of malignant transformation. The best available treatment modality remains uncertain; however, the use of topical lovastatin/cholesterol cream appears promising. Long-term surveillance appears prudent for porokeratosis ptychotropica due to a risk of cancerization.

Penile and Scrotal Porokeratosis: A Single-Institution Experience.

There is a paucity of data regarding porokeratosis confined to the penis and scrotum. We evaluated our single-institutional experience regarding this entity. We interrogated our pathology archive for all specimens from the penis or scrotum, signed out as porokeratosis between 2000 and 2022. Clinical and histopathological features were reviewed, including the number of cornoid lamella(e) per tissue profile and squamous dysplasia. Nine patients were included in the study. The median age at the time of diagnosis was 51 years. Multiple lesions were present in 3 patients. Six patients had exclusively penile involvement, whereas 2 patients had exclusively scrotal involvement. One patient had multiple lesions consistent with porokeratosis ptychotropica, extending from the scrotum to the buttocks and perineum. Clinically, a collarette of scale was noted in 3 patients and diagnosis of porokeratosis was considered in 1 patient before biopsy. Histopathologically, 2 patients exhibited multiple cornoid lamellae in the same profile and 1 patient had follicular cornoid lamellae. Focal squamous dysplasia was only present in 1 patient. Follow-up was available for 5 patients (median duration: 35 months). In 4 patients, the lesions were removed completely during the shave biopsy procedure. At the past follow-up, there were no signs of recurrence or malignant transformation to squamous cell carcinoma in any patient. Porokeratosis involving the penis and/or scrotum may be elusive to diagnosis based on clinical features alone, emphasizing the role of histopathological examination. Increased awareness of this entity may help better delineate its clinicopathological presentation and appropriate classification.

Porokeratosis Ptychotropica With Scalp Involvement: A Case Report

Porokeratosis Ptychotropica With Scalp Involvement: A Case Report

Ptychotropic porokeratosis (porokeratosis ptychotropica): features of clinical and histological manifestations

Ptychotropic porokeratosis (porokeratosis ptychotropica): features of clinical and histological manifestations

Clinicopathological retrospective analysis of porokeratosis ptychotropica and genitogluteal porokeratosis: confusion-prone but essentially different twins.

Clinicopathological retrospective analysis of porokeratosis ptychotropica and genitogluteal porokeratosis: confusion-prone but essentially different twins.

P06 Porokeratosis ptychotropica: a rare and recalcitrant genitogluteal eruption

Abstract A 45-year-old man with a history of psoriasis presented to our male genital dermatology clinic with a several-year history of pruritic, painful, hyperkeratotic red–brown plaques on both buttocks. He had previously been treated unsuccessfully with cryotherapy and topical imiquimod and podophyllotoxin for suspected condyloma acuminata. A 4-mm punch biopsy from the left buttock showed hyperkeratosis, hypergranulosis, papillomatosis and multiple columns of parakeratin with underlying agranulosis and dyskeratosis, consistent with cornoid lamella formation. A diagnosis of porokeratosis ptychotropica was made. He was treated with Dovobet® ointment and Trimovate® cream, with little improvement. He underwent four cycles of topical photodynamic therapy to his right buttock and two cycles to his left buttock, with minimal improvement. Oral isotretinoin was also trialled, but this led to lipid derangement prior to any observed benefit, so it was stopped. Porokeratosis ptychotropica is a rare and under-recognized variant of porokeratosis, characterized by epidermal keratinization that manifests as keratotic papules in the genitogluteal region. It is often misdiagnosed as psoriasis, tinea cruris or condyloma acuminata, as in our case. Typically, multiple cornoid lamellae are seen on histology (Lucker GP, Happle R, Steijlen PM. An unusual case of porokeratosis involving the natal cleft: porokeratosis ptychotropica? Br J Dermatol 1995; 132:150–1). The aetiology of porokeratosis ptychotropica is unknown, but there is potential for malignant transformation (Mazori DR, Shvartsbeyn M, Meehan SA et al. Transformation of porokeratosis ptychotropica into invasive squamous cell carcinoma. Int J Dermatol 2017; 56:679–80). It is commonly recalcitrant to treatment, with varying reports of success with topical retinoids, keratolytics, tacrolimus, calcipotriol, topical 5-fluorouracil, imiquimod, systemic retinoids, psoralen ultraviolet A, intralesional bleomycin, cryotherapy, photodynamic therapy, excision, dermabrasion and CO2 laser.

621 Topical simvastatin for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial

621 Topical simvastatin for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial

Anorectal Syphilis Presenting at Crohn’s Disease: A Case Report

Abstract This article reports on a case of anorectal syphilis in a 54-year-old man with a history of Crohn’s disease. The patient began experiencing a new onset perianal rash approximately when his medication regimen for Crohn’s disease was switched from sulfasalazine to mesalamine. There was no reported history of new sexual partners or sexually transmitted infection exposures. Chief differential at this time included Cutaneous Crohn’s disease, Lichen Planus, Extramammary Paget’s Disease, and Porokeratosis Ptychotropica; however, shave biopsy results revealed unexpected syphilis. There is only one other reported case of syphilis presenting as Crohn’s disease, but the incidence of syphilis has been rapidly increasing within the last decade. A high index of clinical suspicion is needed to properly diagnose syphilis, even with a lack of sexual history, for new onset genital lesions.

Porokeratosis ptychotropica: a 30-year wait for the correct diagnosis and a challenging therapeutic endeavour

Porokeratosis ptychotropica: a 30-year wait for the correct diagnosis and a challenging therapeutic endeavour

A 58‐year‐old man with porokeratosis ptychotropica: A successful treatment with alone cryotherapy and literature review

A 58‐year‐old man with porokeratosis ptychotropica: A successful treatment with alone cryotherapy and literature review

Porokeratosis ptychotropica: a rare variant that is commonly misdiagnosed

Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis characterized by pruritic, scaly papules and plaques localized to the perianal and gluteal cleft regions. Clinically, PP resembles other common disorders, resulting in frequent misdiagnosis. The diagnosis of PP often takes several years to make, therefore many reported cases in the literature described the late stages of PP. We report a case of PP diagnosed at an early stage. By presenting our patient, we aim to raise further awareness of PP to avoid a delay in diagnosis, thus preventing long term complications of this rare entity.

Bilateral Porokeratosis Ptychotropica on the Gluteal Cleft: A Case Report and Review of the Literature

Porokeratosis ptychotropica (PP) is a rare variant of porokoretosis that is distinctive based on its clinical presentation of pruritic, verrucous papules and plaques that often form a “butterfly” shape, commonly located on the perinatal cleft with extension to the buttocks. Similar to other variants of porokeratosis, it is histologically distinguished by the presence of cornoid lamellae. Proper diagnosis is necessary as some studies suggest that PP may predispose to squamous cell carcinoma. Furthermore, there are limited evidence-based treatment options.We report the case of a47 year-old-male who presented with a rash on the buttocks and legs for 3 years. Physical exam revealed erythematous, annular, and verrucous plaques on the bilateral periglueteal area and bilateral distal lower extremities. The patient felt that lesions on the legs were disfiguring but otherwise asymptomatic. Biopsy results demonstrated hyperkeratosis and parakeratosis suggestive of cornoid lamellae. Clinical and histologic findings were suggestive of PP. Lesions on the legs were treated with cryotherapy, which resulted in resolution at a 3-month follow-up.PP remains a diagnostic and therapeutic challenge due to its rarity. No standard of care has been established, though topical calcipotriol, topical imiquimod, topical tretonoin, and cryotherapy have been used with success in the literature. This case highlights unique characteristics of PP in order to aid in early detection and cancer prevention while also describing various treatment modalities.

Bilateral porokeratosis ptychotropica on the gluteal cleft: A case report and review of the literature

Bilateral porokeratosis ptychotropica on the gluteal cleft: A case report and review of the literature

368 Novel mevalonate kinase mutation in a patient with porokeratosis ptychotropica

368 Novel mevalonate kinase mutation in a patient with porokeratosis ptychotropica

Pink verrucous plaque in a man with systemic mastocytosis

Porokeratosis ptychotropica is a rare and commonly misdiagnosed subtype of porokeratosis involving the body folds. We present a 53-year-old man with systemic mastocytosis who presented with a pruritic, verrucous plaque in the gluteal fold that showed multiple cornoid lamellae on histopathologic evaluation, diagnostic of porokeratosis ptychotropica. Various treatments have been reported, including topical corticosteroids, retinoids, vitamin D analogs, calcineurin inhibitors, imiquimod, phototherapy, cryotherapy, or ablative laser therapy, but recurrences are common.

Disseminated verrucous porokeratosis successfully treated with 5-FU followed by oral isotretinoin- a case report

Introduction Multiple clinical variants of porokeratosis are known The verrucous variant is usually confined to the buttocks porokeratosis ptychotropica and is one of the less commonly reported entities Case description We report a case of disseminated verrucous porokeratosis involving almost any area of the body mostly the upper trunk successfully treated with oral retinoids following topical FU Discussion Histological examination is crucial for the diagnosis The observation of multiple cornoid lamellae and the absence of other characteristic findings establish the diagnosis Several therapeutic modalities have been described therefore the approach to treatment must be individualized Our case adds to the growing list of porokeratosis rsquo variants and suggests that oral retinoids following topical FU is a good therapeutic alternative in the treatment of the disease nbsp

Porokeratosis ptychotropica: A differential diagnosis for “psoriasis” of the gluteal region

Porokeratosis ptychotropica: A differential diagnosis for “psoriasis” of the gluteal region

Porokeratosis ptychotropica: A common misdiagnosis

Porokeratosis ptychotropica: A common misdiagnosis

Porokeratosis Ptychotropica Coexisting with Tinea Corporis.

Porokeratosis Ptychotropica Coexisting with Tinea Corporis.

Coexistence of porokeratosis ptychotropica with porokeratosis of Mibelli in a Chinese man.

Coexistence of porokeratosis ptychotropica with porokeratosis of Mibelli in a Chinese man.