Population-specific Normative Data Research Articles

Normative data for the squat, bench press and deadlift exercises in powerlifting: Data from 809,986 competition entries

ObjectivesStrength assessment and comparison to normative values are an important benchmarking tool in human health and performance. However, population specific normative data are several decades old, lack information about adolescent and adult strength levels and are not representative of the strength levels of strength trained individuals. The purpose of this study was to develop contemporary strength norms for the squat, bench press, and deadlift using powerlifters competing in un-equipped, drug-tested competitions. DesignRetrospective cross-sectional analysis. MethodsRetrospective data from global drug-tested, unequipped powerlifting competitions were collated with 809,986 samples (571,650 males, 238,336 females) included. Strength was assessed according to sex, United Nations age classifications, and competitive powerlifting weight class. Strength was expressed relatively (ratio of weight lifted/bodyweight) and computed for the 10th–90th percentile for each of the above categories. ResultsRelative strength was greatest for young adults (18–35 years; 90th percentile for squat [male: 2.83 × bodyweight, female: 2.26], bench press [male: 1.95, female: 1.35], deadlift [male: 3.25, female: 2.66]) before declining thereafter for all three exercises. Although lower than their younger counterparts, very old adults (>80 years) had 90th percentile data for the squat of male: 1.72 and female: 1.01, bench press: male: 1.31 and female: 0.92, and deadlift: male: 2.30 and female: 1.68. ConclusionsThese findings provide a comprehensive, accurate and precise representation of strength for drug-tested, unequipped powerlifters in each category and serve as a point of reference for other trained population groups. To facilitate uptake and ease of comparison, we have developed a freely available online tool (www.thestrengthinitiative.com).

Stretched Penile Length in Boys - A Cross-sectional Single Centre Study

Introduction: Stretched penile length is the most relevant measurement to define the size of the penis, which varies in various ages, geographical regions and ethnicities. Thus, a population specific normative data on stretched penile length helps in early diagnosis of penile abnormalities and endocrine disorders in children.
 Methods: A cross sectional study was done in 501 healthy boys from neonatal period till 12 years of age. Boys with abnormalities of external genitalia, suspected endocrine disorders, suspected syndromes, chronic diseases were excluded from the study. Stretched penile length was measured with a transparent ruler from the pubic ramus till the tip of the glans penis excluding the foreskin. Height and weight of the boys were also recorded. Spearman’s rank correlation coefficient test was used to find the correlation of stretched penile length vs height and weight of the boys. P < 0.05 was considered significant.
 Results: The median, 5th, 95th percentiles of stretched penile length were calculated. The median stretched penile length of the boys ranged from 3.01 (2.32, 3.06) cm in infancy to 6.33 (6.04, 6.62) cm by 12 years. The correlation of stretched penile length vs height and weight showed a statistically significant positive correlation. (rs = 0.979, p < 0.001; rs = 0.971, P < 0.001 respectively).
 Conclusions: Our study provides normative data on stretched penile length from neonatal period till 12 years of age. There was a significant positive correlation between stretched penile length and height and weight of the boys.

Sex and population-specific cutoff values of muscle quality index: Results from NHANES 2011–2014

Muscle quality index (MQI) is used to measure the quality of the muscles. It is defined as the ratio of muscle strength per unit of muscle mass, but since this might vary by rage and ethnicity, we aimed to develop sex, and population-specific normative data and cutoff values for MQI (extremally low and low) using the arm or appendicular skeletal muscle mass (ASM) obtained from a population-representative sample. This cross-sectional analysis included data from 4849 volunteers (aged 20-59 years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Measures of handgrip strength (HGS) were performed using a hand dynamometer. ASM was assessed by dual-energy X-ray absorptiometry (DXA). Arm ASM mass was used to calculate MQIArm [dominant HGS/dominant arm ASM (kg/kg)]; ASM was used to calculate MQIApp [dominant HGS/ASM (kg/kg)]; and the sum of the non-dominant hand and dominant hand were used to calculate MQItotal [HGS sum/ASM (kg/kg)]. Cutoff values were derived from a young reference subgroup (n=1625 aged, 20-39 years), with low and extremely low MQI defined as 1 and 2 sex-specific standard deviations below the mean, respectively. MQIArm, MQIApp, and MQITotal differed by sex and population studied. Overall, using the proposed cutoffs, men showed lower values of MQIArm than women, and higher MQIApp, and MQITotal values. Compared to non-Hispanic Whites, non-Hispanic Asians had higher values of MQI while non-Hispanic Black people had lower values. MQIs cutoffs were established for both sexes and different populations studied. MQIArm, MQIApp, and MQITotal values were lower after the fifth-decade in men, but not in women.

Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography.

PurposeTo establish normative data on the size, shape and vascular profile of the foveal avascular zone (FAZ) in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Certain diseases may alter FAZ appearance. Normative databases provide normal baseline values for comparison, thus improving diagnostic ability.MethodsOne hundred and fifty-four subjects aged 18–35 years old were recruited. Superficial FAZ area, diameter, circularity, ganglion cell layer, central macular thickness (CMT), vascular perfusion and density were measured using the Cirrus 5000. Axial length was measured with the IOL Master and blood pressure was measured using the Omron sphygmomanometer.ResultsMean FAZ area was 0.22 ± 0.07 mm2, mean CMT was 263.08 ± 18.73μm. Both were larger in females than males (p = 0.022, p = 0.000). Mean vessel density and perfusion central were 14.11 ± 2.77 mm/mm2 and 24.70 ± 4.96% respectively. Both were lower in females (p = 0.010, p = 0.019). Vessel density and perfusion inner correlated positively with minimum ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness (p = 0.001, p = 0.019). CMT correlated positively with vessel density and perfusion central (p = 0.000 for both) and negatively with FAZ area (p = 0.000).ConclusionsThis study provides normative data for FAZ appearance and vascularity for the first time in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Establishing machine and population specific normative data, particularly in relation to vessel density and perfusion is paramount to the early identification of ocular disease using Optical Coherence Tomography Angiography.

Developmental changes of the facial skeleton from birth to 18 years within a South African cohort (A computed tomography study)

Skeletal remains are often found on a crime scene in which a forensic anthropologist is then consulted to create a biological profile, which includes the estimation of age, sex, ancestry and stature. The viscerocranium plays an important role in the formation of a biological profile. However, to utilise the viscerocranium for age estimation, population specific normative data and knowledge of the development of the viscerocranium is required. Therefore, this study aimed to investigate the developmental changes from birth to 18 years of age of the facial skeleton of individuals from a South African cohort. This study comprised of 239 computed tomography (CT) scans (128 males; 111 females). The viscerocranium was subdivided into five regions viz.: orbital, nasal, midfacial, maxillary and mandibular. The linear parameters in each region were correlated to age to identify the developmental growth patterns of the viscerocranial regions according to male and female. The measurements which displayed the highest correlations with age were used to develop formulas which could be used for age estimation. The results of this study showed that the measurements in the orbital, midfacial, maxillary and mandibular regions experienced rapid growth between 0 and 5 years of age, with the nasal region increasing steadily over time. It was noted that males displayed overall larger measurements than females except for the anterior interorbital distance and both right and left zygomatic arch lengths (ZAL). Although only the left orbital height, nasal aperture height and mandible width displayed statistically significant size differences according to sex (p ≤ 0.05). The measurements which showed the highest correlations to age were the zygomatic arch distance (r = 0.8842, p < 0.001), ZAL (right: r = 0.8929, p < 0.001; left: r = 0.8656, p < 0.001) and the mandible width (r = 0.8444, p < 0.001). Formulas were derived for the measurements that could be used to forensically estimate age within a subadult cohort.

Promoting psychological adaptation among navy sailors

The mandate of the Institute for Maritime Medicine (IMM) is to support and enhancethe operational performance of sailors of the South African Navy during maritimeoperations, while also ensuring positive long-term mental health outcomes of sailorswho serve their country at sea. To achieve this, the IMM proposes to re-orientate themobilisation and demobilisation programmes used for ship-based maritime operationstowards a predict-and-promote (P&amp;P) approach, to enhance the psychological adaptationof sailors to the emotional demands of deployment as well as to support more adaptiveforms of mental health resilience, both before and after sea-going operations.First, this article aims to present the proposed P&amp;P approach for enhancingpsychological adaptation during and after seaward deployments, with a specific focuson assessing personal emotional regulation (ER). For effective implementation, thisapproach is contingent on several clinical assumptions about ER in the operationalenvironment, namely: the absence of significant psychopathology; the stability ofthe ER measure; the role of dispositional factors in operational adaptation; and theavailability of population-specific normative data, which act as an interpretative guideof ER profiles for sailors. The second aim is to consider support for these assumptions,using previous experience during the mobilisation and/or demobilisation of shipsinvolved in maritime operations. Support was found for all four assumptions, indicatingthe clinical and operational utility of the P&amp;P approach at the IMM broadly, and theassessment of ER for sailors in particular.

Native Spanish-speaker’s test performance and the effects of Spanish-English bilingualism: results from the neuropsychological norms for the U.S.-Mexico Border Region in Spanish (NP-NUMBRS) project

Objective: We aimed to investigate whether or not demographically-corrected test scores derived from the Neuropsychological Norms for the U.S.-Mexico Border Region in Spanish (NP-NUMBRS) would be less accurate if applied to Spanish-speakers with various degrees of English fluency. Spanish-English Method: One hundred and seventy primarily Spanish-speaking adults from the NP-NUMBRS project completed a comprehensive neuropsychological test battery. T-scores adjusted for age, education, and sex (but not degree of bilingualism), were derived for each test utilizing population-specific normative data. English fluency was assessed via the Controlled Oral Word Association Test in English (F-A-S), and Spanish fluency with “P-M-R,” and degree of relative English fluency was calculated as the ratio of English language words over total words produced in both languages. Effects of degree of bilingualism on the NUMBRS battery test scores (raw scores and T-scores) were examined via Pearson’s product moment correlation coefficients, and language groups (Spanish dominant vs. relative bilingual) were compared on demographically adjusted T-scores via independent samples t-tests. Results: Higher Spanish-English bilingualism was associated with higher education and SES, and was significantly associated with higher raw scores on all tests, but only associated with higher T-scores on a limited number of tests (i.e., WAIS-III Digit Symbol, Symbol Search, Letter-Number Sequencing and Trails B). Conclusion: Degree of Spanish-English bilingualism generally did not account for significant variance in the normed tests beyond the standard demographic adjustments on most tests. Overall, the normative adjustments provided by the NP-NUMBRS project appear applicable to native Spanish speakers from the U.S.-Mexico border region with various degrees of Spanish-English bilingualism.

Cardiac Structure and Function in Elite Female and Male Soccer Players

Population-specific normative data are essential for the evaluation of competitive athletes. At present, there are limited data defining normal electrocardiographic (ECG) and echocardiographic values among elite US soccer players. To describe ECG and echocardiographic findings in healthy elite US soccer players. This cross-sectional study analyzed Fédération Internationale de Football Association-mandated screening sessions performed at US Soccer National Team training locations from January 2015 to December 2019. US women's and men's national team soccer players undergoing mandated cardiovascular screening were included. Normal training-related and abnormal ECG findings were reported using the International Recommendations for Electrocardiographic Interpretation in Athletes. Echocardiographic measurements of structural and functional parameters relevant to cardiovascular remodeling were assessed relative to American Society of Echocardiography guideline-defined normal ranges. A total of 238 athletes (122 [51%] female; mean [SD] age, 20 [4] years; age range, 15-40 years) were included. Male athletes demonstrated a higher prevalence of normal training-related ECG findings, while female athletes were more likely to have abnormal ECG patterns (14 [11%] vs 0 in male cohort), largely accounted for by abnormal T-wave inversions. Echocardiography revealed no pathologic findings meeting criteria for sport restriction, but athletes frequently exceeded normal ranges for structural cardiac parameters responsive to exercise-induced remodeling including body surface area-indexed left ventricular (LV) mass (58 of 113 female athletes [51%] and 67 of 114 male athletes [59%]), indexed LV volume (89 of 115 female athletes [77%] and 76 of 111 male athletes [68%]), and LV wall thickness (37 of 122 female athletes [30%] and 47 of 116 male athletes [41%]). Age-stratified analysis revealed age-dependent increases in LV wall thickness, mass, and volumes among female athletes and LV wall thickness and mass among male athletes. These data represent the first set of comprehensive normative values for elite US soccer players and one of the largest sport-specific echocardiographic remodeling studies in female athletes. Abnormal ECG findings were more common in female athletes, while both female and male athletes frequently exceeded clinical normality cut points for remodeling-associated echocardiographic parameters.

A-06 Current Norms May Overestimate Rates of Neurocognitive Impairment among American Indian and Alaskan Native Adults.

Abstract Objective Currently available normative data subsume American Indian and Alaskan Native (AI/AN) populations within the non-Latinx white (NLW) ethnoracial group. The classification accuracy of such norms among AI/AN remains unknown. This cross-sectional study aims to identify whether disparities exist in the rates of neurocognitive impairment (NCI) between AI/AN and NLW adults. &amp;lt; br&amp;gt;&amp;lt;br &amp;gt; Method Two hundred community-dwelling adults (50&amp;#37; NLW; 50&amp;#37; Male; M Age = 42 ± 14 years; M Education = 13 ± 3 years) completed comprehensive neurocognitive, quality of education (Wide Range Achievement Test- 4 [WRAT-4]), neuromedical, urine toxicology, and psychiatric/substance use evaluations. Average T-scores were calculated using widely used demographically corrected (age, gender, education) NLW norms to identify NCI (&amp;gt; 1 SD; e.g., Heaton et al., 2004; Heaton &amp; Marcotte, 2000). A comorbid condition propensity score (CCPS) identified the probability to which comorbid conditions (e.g., Heaton et al., 2010) informed ethnoracial identity. &amp;lt;br&amp;gt;&amp;lt;br &amp;gt; Results After adjusting for WRAT-4 and CCPS, the results of a logistic regression analysis demonstrated a significant ethnoracial disparity in risk for NCI (X2(3) = 13.88, p&amp;lt;.01, R2 = .07), such that the AI/AN group was at 2.52 times higher odds (32.3&amp;#37; vs. 16.0, CI: 1.15–5.46, p = .01, Cohen’s d = .51) for NCI in comparison to the NLW group. &amp;lt;br&amp;gt;&amp;lt;br &amp;gt; Conclusions Published norms for NLW adults may overestimate impairment in AI/AN adults. Thus, population-specific normative data are needed to clarify the classification accuracy of neurocognitive impairment and possible disparities in neurocognitive disorders (e.g., HIV-associated neurocognitive disorders) among AI/AN adults. Future work should replicate these findings among other diverse populations (e.g., Caribbean, Middle Eastern) lacking population-specific normative data.876199.

Demographically-adjusted norms for the processing speed subtests of the WAIS-III in a Spanish-speaking adult population: Results from the Neuropsychological Norms for the U.S.-Mexico Border Region in Spanish (NP-NUMBRS) project

Objective The Wechsler Adult Intelligence Scale (WAIS) processing speed subtests are among the most ubiquitous indices of processing speed in the field. The aim of this study was to develop and examine demographically-adjusted normative data for Spanish language versions of the WAIS-III Digit Symbol Coding (DSC) and Symbol Search (SS) subtests for US-dwelling Spanish-speakers living in the US/Mexico border region. Methods The sample included 203 healthy participants who were part of the larger Neuropsychological Norms for the US-Mexico Border Region in Spanish (NP-NUMBRS) project (DSC: n = 201; SS: n = 200). Results Older age and higher education were both related to lower scores on the DSC and SS subtests (all ps < .0001). There were no significant effects for gender (all ps > .05). Raw-to-scaled score conversions were calculated for both subtests, and fractional polynomial equations were derived to compute demographically-adjusted T-scores accounting for age, education, and gender for each subtest and the Processing Speed Index. Published norms for English-speaking non-Hispanic white adults slightly overestimated impairment rates (T-scores <40) on both the DSC and SS subtests, while the norms for English-speaking non-Hispanic Black/African Americans and the new NP-NUMBRS norms Spanish-speakers both yielded impairment rates that fell within expected limits for healthy controls (i.e. 13%–14%). Conclusions This study suggests that population-specific normative data can improve the diagnostic validity of these measures for U.S.-dwelling Spanish-speakers living in the US/Mexico border region. Future research is needed to investigate the utility of these norms for other U.S.-dwelling Spanish-speaking subpopulations (e.g. Caribbean, Central American, South American).

Demographically-adjusted norms for the Grooved Pegboard and Finger Tapping tests in Spanish-speaking adults: Results from the Neuropsychological Norms for the U.S.-Mexico Border Region in Spanish (NP-NUMBRS) Project

Objective We developed demographically-corrected norms for Spanish-speakers from the U.S.-Mexico border regions of California and Arizona on two tests of motor skills - the Grooved Pegboard Test (Pegboard) and Finger Tapping Test (Tapping) - as part of a larger normative effort. Method Participants were native Spanish-speakers from the Neuropsychological Norms for the U.S.-Mexico Border Region in Spanish (NP-NUMBRS) Project (Pegboard: N = 254; Tapping: N = 183; age: 19–60 years; education: 0–20 years; 59% women). We examined the association of demographics (age, education and gender) with raw scores. Raw test scores were then converted to demographically-corrected T-scores via fractional polynomial equations. We also examined rates of impairment (T-score < 40) based on the current norms and on previously published norms for English-speaking non-Hispanic Whites and Blacks. Results Having more years of education was associated with better raw test score performance on both tests (p < .001), and increased age was associated with worse performance on Pegboard (p < .001). Men outperformed women on Tapping, and older age was associated with lower raw scores in men only on the Tapping non-dominant hand trial (p = .02). The normed T-scores were confirmed to be normally distributed and free from demographic influences, and resulted in expected rates of impairment. Applying existing norms for English-speaking non-Hispanic Whites and Blacks to the raw scores of Spanish-speakers generally yielded lower than expected impairment rates (2–13%), with one exception: non-dominant Pegboard, for which non-Hispanic White norms overestimated impairment (23%). Conclusions Present findings underscore the importance of appropriate, population-specific normative data, even for tests of motor ability.

Demographically-adjusted norms for the paced auditory serial addition test and letter number sequencing test in Spanish-speaking adults: Results from the neuropsychological norms for the U.S.-Mexico border region in Spanish (NP-NUMBRS) Project

Objective The Paced Auditory Serial Addition Test (PASAT) and Wechsler Adult Intelligence Scale Letter Number Sequencing subtest (LNS) are two commonly used measures of working memory. Demographic variables (age, education, ethnicity, etc.) can impact performance on these measures, underscoring the need for demographically adjusted norms. We aimed to develop normative data for the PASAT and LNS for Spanish-speaking adults living in the U.S.-Mexico border region as part of a larger normative effort. Method Participants were native Spanish-speakers from the Neuropsychological Norms for the U.S. Mexico Border Region in Spanish (NP-NUMBRS) project. Two hundred and forty-nine participants completed the PASAT and 202 participants completed LNS. Ages ranged from 19 to 60 and education from 0 to 20 years. Results Older age was associated with lower scores on LNS (p < .01) but not PASAT. Lower education was associated with lower scores on both tests (ps < .001). Women obtained lower raw scores than men on PASAT (ps < .003), and there were no significant main effects of gender on LNS raw scores. Raw-to-scaled score conversions were calculated, and fractional polynomial equations were developed to calculate demographically-adjusted T-scores accounting for age, education, and gender. Published norms for English-speaking non-Hispanic Whites substantially overestimated rates of impairment (defined as T-score < 40) on both the PASAT and LNS. Conclusions The use of the population-specific normative data may improve detection of working memory dysfunction in U.S. Spanish-speaking adults and contribute to improved diagnostic accuracy and treatment planning in this population. Whether the norms generalize to U.S. Spanish-speakers from other countries remains to be determined.

Total and Regional Body Composition of NCAA Division I Collegiate Basketball Athletes.

This study aimed to examine body composition using dual X-ray absorptiometry (DXA) in male and female NCAA Division I collegiate basketball athletes. Two-hundred ten (male [M]/female [F]=88/122) basketball athletes' total and regional fat mass, lean mass, bone mineral density, and visceral adipose tissue were measured. Athletes were classified as: point guards (M/F=27/34), shooting guards (M/F=18/27), small forwards (M/F=13/18), power forwards (M/F=21/27), and centers (M/F=9/16). ANOVA and Tukey's HSD assessed positional differences by sex. In males, centers and power forwards had greater total fat mass (p<0.025), lean mass (p≤0.001), and visceral adipose tissue (p<0.001) than other positions. Male centers had greater arm and leg fat mass and lean mass than point guards, shooting guards, and small forwards (p≤0.049), and greater arm bone mineral density than point guards (p=0.015). In females, centers had greater total fat mass (p<0.001) vs. other positions and greater total lean mass, arm fat and lean masses, arm and leg bone mineral density, and visceral adipose tissue vs. point guards and shooting guards (p≤0.005). Female point guards had lower total bone mineral density than power forwards (p=0.008). In conclusion, these sex- and position-specific total and regional body composition measurements in collegiate basketball players provide population-specific normative data.

Demographically-Corrected Norms for the Grooved Pegboard Test and Finger Tapping Test in monolingual Spanish speakers from the U.S.-Mexico Border Region

Abstract Objective We developed demographically-corrected norms for US-dwelling, Spanish-speaking Hispanics on two widely used tests of motor skills - the Grooved Pegboard Test (Pegs) and Finger Tapping Test (Tapping). We then examined the effects of applying established norms for non-Hispanic Caucasians (NH Whites) and non-Hispanic African Americans (NH Blacks) on motor test results from our Hispanic population. Participants and Method 254 participants living in the US-Mexico border region of San Diego, CA and Tucson, AZ completed Pegs, and a subset (n = 183) completed Tapping. Age ranged from 19-60 and education from 0-20 years, with 59% women. Raw test scores were converted to demographically-corrected T-scores with a fractional polynomial procedure and compared to a fitted curve for the original data. Results Findings included significant main effects of education on both tests (p &amp;lt; .001), and of age for Pegs (p &amp;lt; .001). There was a significant interaction of sex and age on Tapping, such that older age was associated with lower scores in men only (p = .02). The resulting normative T-scores were confirmed to be free from demographic influences. Using a T &amp;lt; 40 cut point, rates of impairment in the Spanish speaking normative sample for dominant (D) and nondominant (ND) hands, respectively, were 17% and 14% for Pegs, and 12% and 10% for Tapping. Applying existing norms for NH Whites and NH Blacks to the raw scores of Spanish speakers generally yielded lower impairment rates on all measures, with one exception, Pegs ND, for which NH White norms overestimated impairment (23%). Conclusions Normative standards from other groups are not a good fit for interpreting motor test performance in this Hispanic population, which in the current instance would have generally underdiagnosed fine motor impairment. These findings underscore the importance of appropriate, population-specific normative data- even for tests of motor ability.

Normative Data for Two Working Memory Tasks in Spanish-Speaking US-Dwelling Adults

Abstract Objective Working memory assessment is an important component of a neuropsychological evaluation. The Paced Auditory Serial Addition Task (PASAT) and the Wechsler Adult Intelligence Scale – Third Edition Letter Number Sequencing subtest (LNS) are two commonly used measures of working memory. Demographic variables (age, education, ethnicity, and country of origin) can impact performance on these measures, underscoring the need for demographically adjusted norms when utilizing these tests. We aimed to develop normative data for the PASAT and LNS for Spanish-speaking adults living in the US. Participants and Method The PASAT and LNS were administered to Spanish-speaking adults living in the US-Mexico border regions of California and Arizona as part of a larger normative effort in this population. Two hundred and forty-nine participants completed the PASAT and a subset (n = 202) also completed LNS. Ages ranged from 19-60 and education from 0-20 years. Results Older age was associated with lower scores on LNS (p &amp;lt; .01), but not the PASAT. Lower education was associated with lower scores on both tests (ps &amp;lt; .001). Females obtained lower raw scores than males on the PASAT (ps &amp;lt; .003), and there were no significant main effects of gender on LNS raw scores. Raw-to-scaled score conversions were calculated for the PASAT-50 item, PASAT-200 item, and LNS, and fractional polynomial equations were developed to calculate demographically-adjusted T-scores accounting for age, education, and gender. Published norms for English-speaking non-Hispanic Whites drastically overestimated rates of impairment (defined as T-score &amp;lt; 40) on both the PASAT and LNS. Conclusions The use of the population-specific normative data may improve detection of working memory dysfunction in Spanish-speaking adults living in the US and contribute to improved diagnostic accuracy and treatment planning in this population.

Determining Filipino Normative Data for a Battery of Neuropsychological Tests: The Filipino Norming Project (FNP)

Background: Filipino normative data for neuropsychological tests are lacking. Objectives: This study aimed to determine the Filipino normative data for the Filipino Norming Project (FNP) Neuropsychological Battery, combining the Alzheimer’s Disease Assessment Scale – Cognitive (ADAS-Cog) and the Neuropsychological Test Battery from the Uniform Dataset of Alzheimer’s Disease Center (UDS-ADC). Methods: We recruited participants 60 years and older with normal cognition (MMSE score of 25 and above and did not fulfill criteria for dementia according to DSM-IV criteria). Psychologists administered the tests to the study participants. We conducted multivariate analyses to study the effect of age, gender, and education on test performance. Results: A total of 191 participants underwent the FNP Neuropsychological Test Battery. The mean age was 68.8 years (SD 5.4). The majority were female (84.1%). The mean score of ADAS-Cog was 9.98 (SD 4.74). The effect of education was prominent throughout the cognitive domains tested while the effect of age was limited to a few cognitive domains. The mean ADAS-Cog scores were 11.80 ± 4.40 for primary education, 9.93 ± 5.08 for secondary, and 8.15 ± 3.95 for tertiary. On average, women scored 2.75 points lower than men and performed better on the verbal components. Men performed better on the constructional praxis component. The same effect of education and gender was observed for the UDS-ADC. Conclusion: For the first time, normative data are available for the ADAS-Cog and UDS-ADC for a Filipino older population. This study stresses the importance of establishing population-specific normative data, taking into account the specific sociocultural and linguistic context of that population.

Assessment of fitness for duty of underperforming physicians: The importance of using appropriate norms.

ObjectiveTo determine whether population-specific normative data should be employed when screening neurocognitive functioning as part of physician fitness for duty evaluations. If so, to provide such norms based on the evidence currently available.MethodsA comparison of published data from four sources was analyzed. Data from the two physician samples were then entered into a meta-analysis to obtain full information estimates and generate provisional norms for physicians.ResultsTwo-way analysis of variance (Study x Index) revealed a significant main effect and an interaction. Results indicate differences in mean levels of performance and standard deviation for physicians.ConclusionsReliance on general population normative data results in under-identification of potential neuropsychological difficulties. Population specific normative data are needed to effectively evaluate practicing physicians.

Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study.

Background: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease. Executive dysfunction is common in patients with ALS, with up to 50% of patients performing within an impaired range. There is evidence that social cognitive deficits associated with ALS are a function of deficits in executive function. The ‘Reading the Mind in the Eyes’ Test is a recognized test of social cognitive function, although the reliability of this instrument remains to be established. Methodology: Patients with ALS (n = 106), and age and IQ matched controls (n = 50) were recruited and asked to perform the Reading the Mind in the Eyes Test as part of an on-going population-based study of cognitive function. ALS patients were sub-stratified based on the presence, and/or extent of executive dysfunction. Results: Cronbach’s Alpha of .73 was observed, indicating good reliability on this measure. Split-half reliability analysis further confirms these findings (p = 0.826). The Reading the Mind in the Eyes test had excellent psychometric properties when discriminating between ALS patients who are cognitively intact, and those who have executive impairment, with an overall medium difficulty. There was a large magnitude significant difference between patients and controls (p< 0.001; η2 = .19). Post-hoc analysis revealed that controls performed significantly higher than patients with executive impairment (p< 0.001), and patients with single executive deficits (p = 0.002). Conclusion: Executive dysfunction impacts on social cognitive performance. This study contributes not only to the psychometric knowledge of this measure, but also to the usability, efficacy, and reliability of social cognitive assessment in ALS. Using population-specific normative data, we confirm the Reading the Mind in the Eyes Test is a reliable measure of social cognitive processes in ALS.

Evaluation of interpupillary distance in the Turkish population.

PurposeThe aim of this study was to report normative values and ranges of interpupillary distance (IPD) in different age groups of a Turkish population.MethodsA total of 756 healthy subjects were included in this prospective study. After a complete ophthalmic evaluation, subjects were divided into four age groups to assess differences between age groups in relation to IPD. The age groups were 20–30, 31–50, 51–70, and 71–89 years. Far IPD measurements were performed using an autorefractometer (Topcon RM-8800).ResultsThe mean age was 48.42±20.55 years, ranging from 19 to 89 years. The mean IPD was calculated as 62.5±4.1 mm (range 49–76). The mean IPD value was observed to be significantly higher among males compared to females (P<0.001). The difference among groups in terms of mean IPD was statistically significant (P<0.001). IPD increased by 4.19 mm in males and 3.11 mm in females from the young adults (20–30 years) to older adults (51–70 years), and then a decrease (2.6 and 0.19 mm for males and females, respectively) occurred between 70 and 89 years of age.ConclusionThe current study offers the population-specific normative data on far IPD in different age groups. Our study showed that sex and age had a significant effect on IPD. Knowledge of normal values in this population subgroup may be useful in studying orbito-cranial growth patterns, syndrome diagnosis, surgical management of cranio-facial deformities and trauma, and manufactures of optical frames and lenses.

Evaluation of panoramic radiomorphometric indices in Indian population

800x600 Objecitves: Radiomorphometric indices on dental radiographs can be used for screening of osteoporosis. However population-specific normative data is sparse. Aim was to establish radiomorphometric indices in Indian population and to determine role of age, gender and dentition on these indices. Materials and Methods: Cross sectional study was undertaken from January 2010 to December 2010. OPGs of 80 samples were divided into four age groups. Mental index, panoramic mandibular index, mandibular cortical index, antegonial index were measured. Relationships with age and dentition were analysed using Statistical Package for the Social Sciences SPSS12.0. Student t -test, one way analysis of variance, Chi square test was used to find the statistical significance. P value < 0.05 was considered to be significant. Results: In most of the study population endosteal margins of the mandibular cortex were even and sharp on both sides i.e.C1 appearance except in 60-69 years females who showed increased tendency of lacunar cortical defects i.e. C2 appearance. No correlation between dentition and mandibular cortical index (MCI), mental index (MI), panoramic mandibular index ( PMI) & Antegonial index (AI) ( p value 0.583, 0.059, 0.491 respectively) . Population’s mean of AI, MI, and PMI among males were 3.33, 3.97, 0.33 respectively and among females were 3.06, 3.64, and 0.32 respectively. ( p value for AI, MI, PMI were 0.048, 0.028,0.037 respectively). Conclusions: All indices negatively correlated with age. There was a general downward trend with age until sixth decade, when values declined sharply. No statistical significance was found between AI, MI, and PMI and dentition. Normal 0 21 false false false TR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:Normal Tablo; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Calibri,sans-serif;}