Central Population Register Research Articles

Twenty-four hour urinary sodium and potassium excretion in adult population of Slovenia: results of the Manjsoli.si/2022 study.

The objective of study was to assess 24-h urinary Na and K excretion and estimate the average salt and K intakes in a nationally representative sample of the adult population of Slovenia. A nationally representative cross-sectional study was conducted in four stages between September and November 2022: study questionnaire, physical measurements, 24-h urine collection and laboratory analysis. Slovenia. We invited 2000 adult, non-institutionalised inhabitants of Slovenia, aged between 25 and 64 years. A stratified two-staged sample was selected from this population by the Statistical Office of Slovenia, using sampling from the Central Population Register. According to the WHO methodology, additional eligibility criteria were screened before participating. A total of 518 individuals participated in all four stages of the study, resulting in a response rate of 30 %. The mean 24-h urinary Na excretion was 168 mmol/d (95 % CI 156, 180), which corresponds to a mean estimated intake of 10·3 g salt/d (95 % CI 9·6, 11·1). Mean 24-h urinary K excretion was 65·4 mmol/d (95 % CI 63·2, 67·5), and the estimated mean K intake was 2·93 g/d (95 % CI 2·84, 3·03). There were statistically significant differences in mean intakes between males and females. The mean sodium-to-potassium ratio was 2·7 (95 % CI 2·5, 2·8). The study results highlighted that the salt intake in the adult population of Slovenia remains much higher than recommended by the WHO, and K intakes are insufficient, as most participants did not meet the recommendations.

Pregnancies in patients with systemic lupus erythematosus during 2000–2018 in Finland: a case–control study

ObjectivesThe aim was to investigate, how pregnancies proceed in patients with systemic lupus erythematosus (SLE) compared to their individually matched population controls.Material and methodsAdult incident SLE patients were identified from the register of new special reimbursement decisions for SLE drugs in 2000–2014. For each patient, 1–3 randomly selected controls from the Population Register Centre were matched. Data regarding pregnancies were obtained from the Finnish Medical Birth Register, Care Register and Register of Congenital Malformations until 2018. The study utilized data from the Drug Purchase Register and educational information from Statistic Finland.ResultsA total of 163 deliveries for 103 mothers with SLE and 580 deliveries for 371 population controls were identified. The duration of pregnancies in SLE women was significantly shorter compared to controls (38.9 versus 39.6 weeks). There were more urgent Caesarean Sections. (15% versus 9%) and need for care at neonatal intensive care unit (NICU) (21% versus 11%) among deliveries in SLE mothers. No statistical difference was observed between SLE and control groups in the occurrence of preeclampsia or major congenital malformations. Gestational age was 2.5 weeks shorter when the mother experienced pre-eclampsia. Hydroxychloroquine was purchased by 30% of SLE mothers during pregnancy.ConclusionThe course of pregnancies in Finnish SLE patients seems to be quite moderate compared to controls, and no new safety issues were detected. The low utilization of hydroxychloroquine indicates that the benefits of the drug to pregnancy and disease course are not optimally recognized by specialists treating SLE mothers.

(056) The Association Between Disgust Sensitivity, Sexual Desire, Relationship Satisfaction in Finland

Abstract Introduction Disgust is a basic emotion directed towards certain objects to avoid harm (Angyal, 1941), mainly pathogens. Research, however, has proposed a heterogeneity of disgust beyond pathogen avoidance to generate the functional model, which proposed the functionally distinct domains of disgust: moral, pathogen, and sexual. This model proposes that sexual disgust is an avoidance of sexual contact with unfit partners that may yield unfit offspring (Tybur & de Vries, 2013), this may be due to other anxiety related disorders (Davey, 2011 and Troop et al., 2002) Objective This study focuses on the association between disgust sensitivity with sexual desire, and relationships satisfaction. Hypothesis: elevated levels of disgust sensitivity are negatively associated with sexual desire and relationship satisfaction. Methods Invitation letters were sent out to the registered Finnish population in the Finnish Central Population Registry to participate in a(n) (online) survey, 9,319 individuals responded to the invitation and completed the survey and agreed to participate in the research. The tools used in this study were Perceived Relationship Quality Component (PRQC), Sexual Desire Inventory (SDI), and the Three-Disgust Domain Scale (TDDS). Results The results indicate that the sexual desire and sexual disgust sensitivity, are negatively correlated, the relationship satisfaction correlations are positive except the men pathogen disgust which is a negative correlation between pathogen disgust sensitivity and relationship satisfaction. The correlation between the study variables indicated that among men and women sexual disgust is negatively correlated with sexual desire, and the correlation of relationship satisfaction and sexual disgust was positively correlated. Conclusions The results show the negative association of sexual disgust with sexual desire, but there is a positive relationship between sexual disgust and relationship satisfaction. Disclosure No.

Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark

BackgroundAutoimmune diseases have been linked to an increased risk of pregnancy-related complications. A family history of autoimmune diseases may be related to the risk of childhood cancer based on similar histocompatibility antigens. We utilized data from national registries in Denmark to examine associations between maternal autoimmune disease and cancer in their offspring. MethodsWe linked data from several national registries in Denmark to identify childhood cancer cases in children <20 years diagnosed between 1977 to 2016. Controls were selected from the Central Population Register and matched to cases by birth year and sex (25:1). Mothers with autoimmune disease diagnosed in pregnancy or prior were identified from the National Patient Register. Multivariable conditional logistic regression analyses were used to estimate associations between maternal autoimmune diseases and childhood cancer in offspring. ResultsAutoimmune diseases (all types) were positively associated with all childhood cancers combined (Odds Ratio (OR) = 1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52, 95% CI 1.09, 2.13), Burkitt lymphoma (OR = 2.69, 95% CI 1.04, 6.97), and central nervous system tumors (OR = 1.45, 95% CI 1.06, 1.99), especially astrocytoma (OR = 2.27, 95% CI 1.36, 3.77) and glioma (OR = 1.75, 95% CI 1.13, 2.73). When we examined mothers with rheumatoid arthritis, we observed an increased association for all cancers (OR = 2.15, 95% CI 1.40, 3.30), acute lymphoblastic leukemia (OR = 3.55, 95% CI 1.69, 7.47), and central nervous system tumors (OR = 2.91, 95% CI 1.46, 5.82), especially glioma (OR = 3.58, 95% CI 1.40, 9.18) in offspring. ConclusionThere is a positive association between maternal autoimmune disease and childhood cancer. This association is especially prominent in the offspring of women with rheumatoid arthritis.

Is the degree of religiosity related to community belonging and trust in society? A cross-sectional study among Muslims in Norway

IntroductionIt is unclear if the degree of religiosity within Muslim minority groups causes health inequality because of poor community belonging and lack of trust in society. We aimed to investigate the association of the degree of Muslim religiosity with community belonging and trust in society, including general trust and trust in political authorities, political power, media and monarchy. MethodsThis study had a cross-sectional design, including a random sample of 1129 men and women aged 18–85 years, originating from Muslim countries and currently living in Norway. Data were retrieved from the Norwegian Central Population Register. ResultsIn logistic regression analyses, adjusted for confounders, the degree of Muslim religiosity was not associated with general trust (crude odds ratio [OR] = 1.00, 95% confidence interval [CI]: 0.91–1.10; p = 0.90) or trust in political authorities (OR = 0.96, 95% CI: 0.87–1.06; p = 0.40) and monarchy (OR = 0.92, 95% CI: 0.84–1.00; p = 0.08). However, the degree of Muslim religiosity showed a negative association with trust in political power (OR = 0.91, 95% CI 0.83–1.00; p = 0.04) and media (OR = 0.80, 95% CI: 0.73–0.87; p < 0.01), whereas there was a positive association with community belonging (OR = 1.11, 95% CI: 1.01–1.21; p = 0.03). ConclusionA higher degree of Muslim religiosity, compared with lower, was not a barrier to trust in society or community belonging among Muslims in Norway. Hence, these findings support the use of culturally sensitive health interventions involving Muslim religiosity in reaching out to Muslim communities. Considering the negative association of the degree of Muslim religiosity with trust in political power and media, the involvement of politicians and political symbols or the use of traditional media in public health communication with this minority group should be pursued with caution.

To count or to estimate: A note on compiling population estimates from administrative data

Like many countries, Ireland has been researching new systems of population estimates compiled using administrative data. Ireland does not have a Central Population Register from which the estimates can be compiled. The primary step in compiling population estimates from administrative data is to first build a Statistical Population Dataset (SPD). Ideally an SPD will have one record for each person in the population containing the relevant attributes. The ideal SPD then allows compilation of statistics by simply counting over records. In practice, the compilation of SPDs is prone to error. These errors can be classified into 4 types of error; overcoverage, undercoverage, domain misclassification and linkage error. Ireland, to date, has investigated 2 different approaches to the compilation of population estimates from administrative data. The first, labeled in this paper as the simple count method, is based on building an SPD which minimises the overall number of individual record errors such that simple counts from the SPD will provide population estimates. The second, labeled in this paper as the estimation method, is based on building an SPD which aims to eliminate all error types bar that of undercoverage and then adjusts counts for undercoverage using Dual System Estimation (DSE) methods to obtain population estimates. This paper explores the advantages and disadvantages of both methods before considering how they could be integrated to eliminate the disadvantages. Many NSIs will be considering similar challenges when compiling annual Census like population estimates and this paper aims to contribute to that discussion.

First live birth before surgical verification of endometriosis-a nationwide register study of 18324 women.

First live birth before surgical verification of endometriosis-a nationwide register study of 18324 women.

The Development of Microhistorical Databases in Norway. A Historiography

Norwegian work on microdata started out with the full count 1801 census and census and vital records from around the capital. Today, most census and ministerial records from 1801 until the mid-20th century have been scanned, transcriptions are being completed, much is encoded and made available via the websites of the Digital National Archives and UiT The Arctic University of Norway. This article complements a previous publication on empirical results from historical microdata. It is primarily organized by technical issues: digitization of source materials, encoding and standardization, building of the Historical Population Register for the period since 1800, record linkage and source criticism as well as GIS. Presently, partner institutions are building the Historical Population Register with prolonged support from the Norwegian Research Council. This will contain longitudinal records of the nine million persons who lived in Norway since 1800. The register increasingly makes it possible to follow the entire population. Unique personal IDs with corresponding URLs to the person page providing links to many sources introduce a new level of historical documentation. Cross-sectional and vital records are being interlinked with automatic and manual record linkage software. Longitudinal data is available for searching as timelines and in Intermediate Data Structure format from UiT The Arctic University and for searching at Histreg.no, which also caters for manual editing. We are well on the way to creating a database that can fill the void in the two centuries before the Central Population Register starts in 1964.

Maternal migraine and risk of pediatric cancers.

Maternal migraine has been linked to adverse birth outcomes including low birth weight and preterm birth, as well as congenital anomalies in offspring. It has been speculated that this may be due to the use of medications in pregnancy, but lifestyle, genetic, hormonal, and neurochemical factors could also play a role. There is evidence for varying cancer incidences among adults with migraine. Here, we utilized data from national registries in Denmark to examine associations between maternal diagnoses of migraine and risk for cancer in offspring. We linked several national registries in Denmark to identify cases from the Cancer Registry among children less than 20years (diagnoses 1996-2016) and controls from the Central Population Register, matched to cases by birth year and sex (25:1 matching rate). Migraine diagnoses were identified from the National Patient Register using International Classification of Diseases, versions 8 and 10 codes and migraine-specific acute or prophylactic treatment recorded in the National Pharmaceutical Register. We used logistic regression to estimate the risk of childhood cancers associated with maternal migraine. Maternal migraine was positively associated with risk for non-Hodgkin lymphoma (odds ratio [OR]=1.70, 95% confidence interval [CI]: 1.01-2.86), central nervous system tumors ([OR=1.31, 95% CI: 1.02-1.68], particularly glioma [OR=1.64, 95% CI: 1.12-2.40]), neuroblastoma (OR=1.75, 95% CI: 1.00-3.08), and osteosarcoma (OR=2.60, 95% CI: 1.18-5.76). Associations with maternal migraine were observed for several childhood cancers, including neuronal tumors. Our findings raise questions about the role of lifestyle factors, sex hormones, genetic, and neurochemical factors in the relationship between migraine and childhood cancers.

A system of population estimates compiled from administrative data only

Abstract This paper presents a novel system of annual Population Estimates Compiled from Administrative Data Only (PECADO) for Ireland in the absence of a Central Population Register. The system is entirely based on data originated from administrative sources, so that population estimates can be produced even without purposely designed coverage surveys or a periodic census to recalibrate estimates. It requires several extensions to the traditional Dual System Estimation (DSE) methodology, including a restatement of the underlying assumptions, a trimmed DSE method for dealing with erroneous enumerations in the administrative register, and a test for heterogeneous capture probabilities to facilitate the choice of blocking in applications. The PECADO estimates for years 2011–2016 are compared to the Census counts in 2011 and 2016. We demonstrate how the system can be used to investigate the Census 2016 under-count in Ireland, in place of the traditional approach of deploying additional population coverage surveys.

Juvenile idiopathic arthritis in children and adolescents with atopic dermatitis: A Finnish nationwide registry study

Juvenile idiopathic arthritis in children and adolescents with atopic dermatitis: A Finnish nationwide registry study

Long‐term mortality in pediatric solid organ recipients—A nationwide study

The present study aimed at investigating long-term mortality of patients who underwent solid organ transplantation during childhood and at identifying their causes of death. A cohort of 233 pediatric solid organ transplant recipients who had a kidney, liver, or heart transplantation between 1982 and 2015 in Finland were studied. Year of birth-, sex-, and hometown-matched controls (n=1157) were identified using the Population Register Center registry. The Causes of Death Registry was utilized to identify the causes of death. Among the transplant recipients, there were 60 (25.8%) deaths (median follow-up 18.0 years, interquartile range of 11.0-23.0 years). Transplant recipients' risk of death was nearly 130-fold higher than that of the controls (95% CI 51.9-1784.6). The 20-year survival rates for kidney, liver, and heart recipients were 86.1% (95% CI 79.9%-92.3%), 58.5% (95% CI 46.2%-74.1%), and 61.4% (95% CI 48.1%-78.4%), respectively. The most common causes of death were cardiovascular diseases (23%), infections (22%), and malignancies (17%). There were no significant differences in survival based on sex or transplantation era. The late mortality is still significantly higher among pediatric solid organ recipients in comparison with controls. Cardiovascular complications, infections, and cancers are the main causes of late mortality for all studied transplant groups. These findings emphasize the cruciality of careful monitoring of pediatric transplant recipients in order to reduce long-term mortality.

Selective migration and mortality by economic status in Lolland-Falster, Denmark, 1992–2018

During the past 30 years, a mortality gap developed between Lolland-Falster (the rural-provincial southeastern part) and the rest of Denmark. A main driver was selective in-migration of Danes with a high risk of death, especially of working-ages. In the present study, we determined the role of economic status in this selective in-migration. We used individual-level data from the Central Population Register and data on income source; self- or publicly supported. The study population included people aged 30–64 and living in Denmark at any time between 1992 and 2018. Mortality rate ratios (MRR) were calculated using Poisson regression for three time-periods: 1992–1999, 2000–2009 and 2010–2018. Two in five in-migrants to Lolland-Falster were people on public support. In 2010–2018, they had an MRR of 8.71 (95% confidence interval (CI): 8.05–9.42) compared with self-supported people, and an MRR of 1.49 (95% CI: 1.38–1.61) compared with publicly supported people elsewhere in Denmark. In-migration of working-aged people on public support was a main contributor to the excess mortality in Lolland-Falster as compared with the rest of Denmark. To understand urban–rural differences in health, population movements and national income patterns are important to take into account.

Impact of child disability on parental employment and labour income: a quasi-experimental study of parents of children with disabilities in Norway

BackgroundCaring for children with disabilities has both immediate and long-term economic costs that affect the well-being of children, parents, and society. The purpose of this study was to investigate the impact of child disability on parental employment and labour income by examining differences by parental gender, disability severity, and child age.MethodsThe study included children with disabilities born between 2004 to 2011 and their mothers (n = 139,189) and fathers (n = 134,457). Longitudinal data on employment, working hours and labour income was obtained from Statistics Norway, specifically the National Education Database, the Central Population Register and the Event History Database. A quasi-experimental difference-in-differences model was used to examine differences in employment, working hours and labour income.ResultsThe results showed that caring for children with disabilities has a negative effect on mothers’ labour market participation, working hours and labour income. The more severe a child’s condition is, the more likely the mother was to work and earn less, or to stop working entirely. Additionally, the differences in labour market participation and income between mothers of children with and without disabilities increased as their children reached school age. Labour market participation, working hours, and labour income for fathers of children with less severe disabilities is comparable to those of fathers of children without disabilities. Caring for children with more severe disabilities reduces fathers’ labour income but has no effect on their working hours or labour market participation.ConclusionPolicymakers and child welfare stakeholders should evaluate policy options and provide the necessary welfare support particularly to mothers caring for children with a more severe disability.

Study of Parental Occupational Exposures to Solvents and Risk of Autism Spectrum Disorder in Offspring

BACKGROUND AND AIM: Solvents can accumulate in fat and later metabolize during pregnancy. Additionally, these toxicants could lead to germline mutations. We investigated associations between multiple parental occupational solvent exposures and odds of autism spectrum disorder (ASD) diagnosis in offspring. METHODS: Using population-based data from the Danish National Patient Registry, we identified a subset of ASD cases from 1982 to 2016 and 1:100 sex and birth-year matched controls obtained from the Central Population Register. We determined parental occupation history from age 16 years through 6 months post-childbirth from the Danish Pension Fund and estimated cumulative benzene, methylcyclohexane, toluene, trichloroethylene, perchloroethylene, and 1,1,1-trichloroethane exposure for mothers and fathers based on job exposure matrices (JEMs). Conditional logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for exposures one year prior to conception and during pregnancy. RESULTS: In analysis of data from 1898 people with ASD and 141,702 without ASD, there were no observed associations between maternal solvent exposures during pregnancy and risk of ASD in offspring. However, analysis for maternal benzene exposure one year prior to conception revealed higher adjusted odds for those with any exposure (aOR=1.55; 95% CI 1.02, 2.37). Additionally, although there were no significant associations between paternal solvent exposures during pregnancy and ASD risk, there were significantly increased odds of ASD in offspring whose fathers were exposed to benzene (aOR=3.07; 95% CI 1.72, 5.46) and toluene (aOR=1.66; 95% CI 1.05, 2.62) one year before conception. CONCLUSIONS: Although previous studies have suggested parental solvent exposure during pregnancy can contribute to pathogenesis of ASD, our findings suggest that risk may be increased through exposures prior to conception. However, unavoidable non-differential misclassification from the use of JEMs may have masked truly increased risk during pregnancy.

Residential road traffic and railway noise and risk of childhood cancer: A nationwide register-based case-control study in Denmark

BackgroundThe aetiology of most childhood cancers remains poorly understood. We conducted a nationwide register-based case-control study to assess the association between residential road traffic and railway noise exposure and risk of childhood cancers. MethodsWe identified all cases of first cancers diagnosed in children aged 0–19 years in 1985–2013 from the Danish Cancer Registry (N = 3962) and sampled four individually matched (by sex and date of birth) controls per case (N = 14,790) using the Central Population Register. We estimated time-weighted exposure averages of residential road traffic and railway noise at the most (Lden max) and least (Lden min) exposed façades from birth to index-date (for additional analysis: in utero period) based on the individual address history for the respective time windows. We fitted conditional logistic regression models to estimate odds ratios (OR) and their 95% confidence intervals (CI). ResultsORs varied by noise estimate and cancer type, with generally wide CIs mostly including 1.00. We found a tendency of higher ORs with increasing railway and road traffic noise for Hodgkin lymphoma (ORs for railway and road Lden min were 1.63 (95% CI 1.00; 2.66) and 1.14 (95% CI 0.87; 1.48) per 10 dB), as well as a tendency of higher ORs with increasing railway noise for non-Hodgkin lymphoma. For embryonal CNS tumours and astrocytoma and other glioma we observed also some weak suggestions of a positive association. Analysing exposure to traffic noise in utero revealed similar patterns to those of the main analyses. ConclusionsThis nationwide study with minimal risk of bias suggests no strong associations between traffic noise and risk of most childhood cancers. We found however some suggestive evidence for a positive association with Hodgkin lymphoma, non-Hodgkin lymphoma and some CNS tumours. Further research is warranted to confirm these associations in other populations and elucidate the underlying biological mechanisms.

Risk of poor mental health and experience of violence among a young adult population with same-sex sexuality: a cross-sectional study in southern Sweden

ObjectivesTo assess prevalence and correlates of same-sex sexuality and its relationship to poor mental health and experiences of violence among youth and young adults in Sweden. A secondary aim was...

Prevalence of and Risk Factors for Back Pain Among Young Male Conscripts During Compulsory Finnish Military Service.

Back pain is a major reason for sick leaves and disability pension in primary health care. The prevalence of back pain among adolescents and young adults is believed to be increasing, and back pain during military service predicts unspecified back pain during later life. The aim of this study was to investigate the prevalence and risk factors of back pain among conscripts in compulsory Finnish military service during the period 1987-2005. The Finnish Defence Forces recruit all men aged 18 years for compulsory military service, and new conscripts enter the service twice a year. Before entering the service, all conscripts must pass a medical examination and conscripts entering the service are generally healthy.Health care in Finnish military service is organized by the public Garrison Health Center, and all medical records are stored as part of the Finnish health care operation plan. For this study, we randomly selected 5,000 men from the Finnish Population Register Centre, according to their year of birth from five different age categories (1969, 1974, 1979, 1984, and 1989). We gathered 4,029 documents for the analysis. The incidence of back pain varied between 18% and 21% and remained unchanged during the examination period. The risk factors for back pain were smoking (risk ratio 1.35, P-value <.001), elementary school only as education (risk ratio 1.55, P-value <.001), and back problems reported before military service (risk ratio 2.03, P-value .002). Half of the back pain incidences occurred during the first months of service. The prevalence of back pain among male Finnish military service conscripts has not changed in the last 25 years. Twenty percent of conscripts suffer from back-related problems during their military service. The majority of the visits to health centers occurred in the first service months. The risk factors for back pain include smoking, low education level, and musculoskeletal disorders in general. Educating the young people about harms of tobacco and supporting education is a way to influence the back pain prevalence. Strength of this study is a good generalized population sample of young Finnish adult males because of the fact that the Finnish military service is compulsory for all men. All medical records of all visits to the Garrison Health Care Centre were available, and all the conscripts filled the same pre-service questionnaire, minimizing the possibility of selection bias. The sample size was also large. Weakness of this study is that the service time changed during the study period and in the latest conscript group born in 1989, data collection and the data available for this cohort was limited, because nearly half of the conscripts had not yet started their service. The Finnish military service is compulsory only for men and because of the low number of female conscripts, they were excluded from this study. Diagnoses were also missing from 70% of the back-related visits, and these visits were recorded as back pain-related visits according to the reason for seeking care.

Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

ObjectivesNasopharyngeal malignancies are reported having decreasing incidence and reduced mortality. This study provides a nationwide update of the incidence and survival in Denmark. Materials and methodsThe Danish Cancer Registry (DCR) and Central Population Register (CPR) were used to identify all patients registered with nasopharyngeal malignancies between 1980 and 2014 in Denmark. We evaluated the age-adjusted incidence rate (AAIR), average annual percent change (AAPC) and relative survival (RS) and also constructed age-population-cohort (APC) models. Results911 patients were identified with a male:female ratio of 2.2:1, a median age of 57.7 years (range 2.8–98.3 years) and an overall median follow-up time of 2.7 years (range 0–37 years). The AAIR was 0.39 cases per 100 000 in 1980 and 0.28 cases per 100 000 in 2014 with an AAPC of −3.2 (95% CI: −7.5; 1.2, p = 0.1). The overall 1-year and 5-year RS rates were 76.3% and 42.1%, respectively. We found a significant age effect in the APC model for the incidence of nasopharyngeal malignancies, but no significant cohort or period effects. ConclusionThe incidence of nasopharyngeal carcinomas has slightly decreased over the last four decades, however insignificantly. Meanwhile, the relative survival has increased significantly in Denmark since 1980. The cause of improved relative survival might be attributed to altered treatment practices.

Atopic dermatitis and the risk of eating disorders: A population-based cohort study

Atopic dermatitis and the risk of eating disorders: A population-based cohort study