Retinal prosthetics are one of the leading therapeutic strategies to restore lost vision in patients with Retinitis Pigmentosa and age-related macular degeneration. Much work has described patterns of spiking in retinal ganglion cells (RGCs) in response to electrical stimulation, but less work has examined the underlying retinal circuitry that is activated by electrical stimulation to drive these responses. Surprisingly, little is known about the role of inhibition in generating electrical responses, or how inhibition might be altered during degeneration. Using whole-cell voltage clamp recordings during subretinal electrical stimulation in rd10 and wt retina, we found electrically evoked synaptic inputs differed between ON and OFF RGC populations, with ON cells receiving mostly excitation and OFF cells receiving mostly inhibition and very little excitation. We found that inhibition of OFF bipolar cells limits excitation in OFF RGCs, and a majority of both pre and post synaptic inhibition in the OFF pathway arises from glycinergic amacrine cells, and stimulation of the ON pathway contributes to inhibitory inputs to the RGC. We also show that this presynaptic inhibition in the OFF pathway is greater in rd10 retina, compared to wild-type (wt) retina.Significance Statement Changes in circuit processing may have deleterious effects on vision restoration for patients with retinitis pigmentosa. Prior research has focused on feedforward excitatory drive and not the interactions between excitation and inhibition that comprise normal retinal function. This study demonstrates that retinal ganglion cells respond to electrical stimulation in three broad functional groups that correspond to their anatomical structure. We show that while both degenerated and wt retina display the same three groups, degenerated retina has an increased amount of OFF pathway presynaptic inhibition limiting their excitatory output to OFF ganglion cells.