Introduction: Popliteal sciatic nerve block performed in lateral position usually requires a change in position for the patient. This is time consuming and may cause discomfort to the patient. Methods: This prospective study compared patients' preference and peri-operative outcomes in supine position via medial approach to the sciatic nerve and lateral position via lateral approach to the nerve. Prospective registration of this study with NHG Human Research Protection Programme was on 9 Sept 2021. Institutional review board approval was obtained for this study on 20 May 2022. All research participants provided written informed consent with the first patient enrolled on 05 June 2022. 50 patients from Ng Teng Fong General hospital (NTFGH) who were undergoing popliteal sciatic nerve block with or without sedation were recruited for the study and randomised to either receive the block in supine or lateral position. Results: This study showed that there were significantly more patients in the supine group preferring to be in supine position during the block with p-valve <0.001. 45.8% of patients who had the block performed in lateral position preferred supine position instead. There was no significant difference in the peri-operative outcomes or duration taken for block completion. Most patients preferred to be in the supine position for popliteal sciatic nerve block as it was more comfortable. Conclusion: Performing the block in supine position increased patient’s comfort significantly and is non-inferior to performing it in lateral position in terms of safety, efficacy and efficiency profile.