Poor Rate Research Articles

EXTH-28. DEVELOPING A NOVEL INJECTABLE IMMUNOTHERAPEUTIC GEL FOR ENCAPSULATION OF NATURAL KILLER CELLS FOR POST-SURGICAL GLIOBLASTOMA TREATMENT

Abstract Malignant brain tumors are one of the leading causes of death among all cancers. Approximately 40,000 people are diagnosed with malignant brain tumors every year. Among these patients, 15,000 cases are glioblastoma (GBM) with a very poor prognosis; even after aggressive surgical resection and adjuvant chemo/radiotherapy, the median survival is only 14.6 months. The major reason for poor prognosis is the blood-brain barrier, which prevents therapeutic agents from reaching the target area. Therefore, there are only a few choices of drugs available for brain tumor treatment. To date, temozolomide (TMZ) and the Gliadel wafer have been clinically used as standard chemotherapy agents after brain tumor resection. However, drug resistance to TMZ and the poor drug diffusion rate of the Gliadel wafer still result in ineffective suppression of residual cancer cells. To overcome the above-mentioned difficulties in clinical brain tumor treatment, in situ self-crosslinking multifunctional hydrogels was developed to carry natural killer cells (NK cells) and radiosensitizers as a novel brain tumor treatment system. Unlike traditional hydrogels catalyzed by pH value or temperature, this new system is stable and consistent as an immune cell carrier. We used fibrinogen, thrombin, and alginic acid as the backbone of the in situ self-crosslinking hydrogel, tested the properties of the synthesized hydrogel, and analyzed the gel-formation time and swelling rate. The release rate of NK cells was also examined. In a brain tumor animal model, the use of hydrogel-NK cells significantly inhibited tumor proliferation and prolonged animal survival time. In conclusion, this therapeutic hydrogel carrying NK cells can serve as a novel post-operation adjuvant therapeutic tool for malignant brain tumors.

Redox Mediator as Highly Efficient Charge Storage Electrode Additive for All‐Solid‐State Lithium Metal Batteries

AbstractAll‐solid‐state lithium metal batteries (ASSLBs) have the potential to provide a significant increase in energy density and safety. However, most ASSLBs are still suffering from low cathode loading, poor rate capability, and low attainable energy/power densities, which seriously limit their practical application. Besides developing solid electrolytes with high conductivity, constructing a highly loaded cathode with rapid reaction kinetics is also essential for achieving high‐performance ASSLBs. Herein, the methylamine hydroiodide (CH6NI) is investigated as a functional electrode additive to enable rapid Li+ transport and charge transfer in LiFePO4 (LFP) cathode, whereby the CH6NI serves as a charge storage carrier that facilitates the reaction kinetics during the delithiation and lithiation process of LFP. As a result, the ASSLB assembled with LFP@CH6NI cathode shows excellent cycling stability over 700 cycles at 2 C with a high capacity retention of 87.6%, while the cell with bare LFP cathode shows no capacity at high current rates (≥0.5 C). Moreover, the ASSLB pared with a high active loading cathode (5.6 mg cm−2) still exhibits a high specific capacity of 144.9 mAh g−1 at 0.5 C. This work provides a facile strategy that opens new possibilities for designing high‐loading electrodes for high‐performance ASSLBs.

Greece: Political Developments and Data in 2023

AbstractThe year 2023 was marked by two national elections during the summer months, as well as regional and municipal elections in October. New Democracy dominated electorally in both. Another key political change was the resignation of the head of the Coalition of the Radical Left, Alexis Tsipras, following his party's devastating defeats in national elections. He was replaced in internal elections later that year by Stefanos Kasselakis—a political newcomer with no prior experience. The deadly Tempi train crash, wildfires across the country, hooligan violence, and the devastating floods caused by Storm Daniel in Thessaly raised issues about the effectiveness of the government and added to the general mistrust of politics and politicians. In October, Greece regained investment grade in its credit rating from Standard & Poor's Global Ratings. Inflation, at 3.5 per cent in December, continued to be top of mind for most citizens. The devastating consequences of gender‐based violence persisted this year, with a staggering 15 femicides recorded in total.

Mechanical Thrombectomy for Treatment of Acute Cerebral Infarction due to Distal Medium Vessel Occlusions: A Retrospective Cohort Study

ABSTRACTBackgroundMechanical thrombectomy (MT) is standard of care for acute cerebral infarction (ACI) due to large vessel occlusions. However, its clinical efficacy in patients with ACI due to distal medium vessel occlusions (DMVOs) remains unclear. This study evaluates the efficacy and safety of MT in patients with ACI due to DMVOs.MethodsTotally, 306 patients with ACI at a very early stage were assigned into DMVOs‐MT, M1‐MT, and DMVOs‐intravenous thrombolysis (IVT) groups. These groups were compared regarding baseline data, recanalization rate, location of vessel occlusions, number of thrombectomy, first‐pass recanalization, mRS scores, NIHSS scores, 90‐day mRS scores, incidence of adverse events, and mortality. Risk factors for poor prognosis of patients with DMVOs following MT were analyzed.ResultsDMVOs‐MT and M1‐MT groups showed comparable first‐pass recanalization rates, recanalization rates, and NIHSS score reduction ratios, with marked differences in location of vessel occlusions. Versus DMVOs‐IVT, DMVOs‐MT had increased differences between pre‐ and post‐treatment NIHSS scores and between pre‐treatment NIHSS scores and NIHSS scores at discharge and elevated NIHSS reduction ratios. The poor prognosis rate of DMVOs‐MT group was insignificantly different from that of M1‐MT group but lower than that of DMVOs‐IVT group. Adverse events and mortality incidences were comparable among the three groups. Diabetes, first‐pass recanalization, and pre‐treatment NIHSS scores were independent risk factors for poor prognosis in DMVO patients after MT.ConclusionMT is as effective and safe in patients with DMVOs as in patients with M1 occlusions. In patients with DMVOs, MT has higher efficacy and safety than IVT.

NiCo2S4 nanoparticles encapsulated within hollow mesoporous carbon spheres enabling rapid and stable sodium storage

Poor rate capability and cycling performance significantly impair the utilization of NiCo2S4 as an anode material in sodium-ion batteries. Herein, hollow mesoporous carbon spheres (HMCSs) are synthesized using a hard-template method. NiCo2S4 nanoparticles with sizes ranging from 15 to 43 nm are grown in-situ within HMCSs (NiCo2S4@HMCS) by melt adsorption, solution impregnation, and gas-phase sulfurization. Specifically, NiCo2S4 nanoparticles are uniformly distributed on the inner walls of HMCSs and within the mesoporous channels of spherical shells. In half-cells, NiCo2S4@HMCS exhibits reversible capacities of 482 mAh g−1 after 340 cycles at 1.0 A g−1, 340 mAh g−1 after 600 cycles at 5.0 A g−1, and 271 mAh g−1 after 700 cycles at 10.0 A g−1. In NiCo2S4@HMCS//Na3V2(PO4)3 full-cells, NiCo2S4@HMCS maintain reversible capacities of 203 mAh g−1 after 1200 cycles at 1.0 A g−1 and 122 mAh g−1 after 2000 cycles at 5.0 A g−1. The unique nano-encapsulated structure prevents the detachment of NiCo2S4 from HMCSs, maintaining electrochemical activity and stability of NiCo2S4. Additionally, the nano-encapsulated structure also facilitates electrolyte penetration and enhances the electronic conductivity of NiCo2S4. These effects synergistically result in rapid and stable sodium storage performance.

Soft-templating of biomass derivatives into edge-N doped 3D-interconnected hierarchical porous carbon for multi-scenario supercapacitive energy storage

Rational design of the pore structure for carbon materials is of great significance for solving the low specific capacitance and poor rate capability of supercapacitors. A novel soft-templating strategy is proposed by using biomass-derived sodium lignosulphonate as a carbon precursor and sublimable hexamethylenetetramine as a soft template. The hexamethylenetetramine nanoparticles are formed in the confined spaces of the precursor, and then these templates sublime to leave mesopores after the lignosulfonate transformed from linear structure to bulk structure by thermostabilization treatment. A high nitrogen content of 40 wt% in hexamethylenetetramine is also beneficial for the subsequent in-situ N-doping. The as-obtained nitrogen-doped hierarchical porous carbon microspheres possess a high specific surface area of 1416 m2 g−1 with an N-doping content of 4.32 % (86.26 % edge-N). In a two-electrode system, the soft-templating carbon exhibits a decent specific capacitance of 234 F g−1 at 0.1 A g−1, an excellent rate capability of 62.4 % at 50 A g−1, and a high energy density of 8.1 Wh kg−1 at 15.0 kW kg−1 in 6 M KOH aqueous electrolyte. Moreover, advanced additive manufacturing technology of direct ink writing was applied to construct a quasi-solid-state in-plane interdigital microsupercapacitor by using the soft-templating carbon, and it presents a superior areal/volumetric capacitance, rate performance, mechanical stability, and flexibility with PVA/H2SO4 gel electrolyte. This work broadens the pore structure engineering methodology by novel soft-templating biocarbon for multi-functional and multi-scenario energy storage systems.

A donor-acceptor conjugated bipolar polymer with multielectron redox sites for long-cycle-life and high-rate aqueous zinc dual-ion batteries

Aqueous zinc-ion batteries (AZIBs) have hugely latent advantages in large-scale energy storage due to its innate safety, reasonable price, and sustainability. However, most AZIB cathode materials suffer from short cycling life and poor rate performance. Herein, a bipolar donor-acceptor (D-A) conjugated microporous polymer (PTZ-BDTB), consisting of electron-withdrawing benzo[1,2-b:4,5-b’]dithiophene-4,8-dione (BDTB) units and electron-donating phenothiazine (PTZ) units, is developed as the cathode material of aqueous zinc dual-ion batteries (AZDIBs). The D-A type structure design could reduce the band gap, thus promoting electron transfer in the polymer framework. Therefore, the PTZ-BDTB cathode in a 30 mol/kg (m) ZnCl2 water-in-salt electrolyte exhibits a high reversible capacity of 202 mA h g−1 at 0.05 A g−1 with excellent rate performance (109 mA h g−1 at 15 A g−1), which is far superior to its counterpart polymers PPTZ and PB-BDTB. Impressively, PTZ-BDTB shows ultra-stable cycle performance with capacity retention ratios of 76.2% after 460 cycles at 0.05 A g−1 and 96% after 27000 cycles at 5 A g−1. PTZ-BDTB also exhibits a low self-discharge ability with capacity retention about 76.4% after resting the battery for 28 days. These results demonstrate that D-A type structural design is a promising strategy for constructing high performance cathode materials for AZDIBs.

Assess of students’ Knowledge Concerning Effect of Lifestyle on Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS), also known as Stein-Leventhal syndrome, is an endocrine disorder that affects 15% to 20% of women of reproductive age and involves the presence of multiple follicular cysts on one or both ovaries. This study was conducted to assess the knowledge about PCOS, effects of lifestyle habits on PCOS and knowledge of diverse treatment methods to reduce the risks of the syndrome.180 female students from three colleges were participate a questionnaire include demographic information of students and scientific questions concerning PCOS, Among the 180 female students whose knowledge was evaluated about the effect of lifestyle on polycystic ovary syndrome, (32%) of the participants had a good knowledge rate, (53%) of them had a moderate knowledge rate, and (15%) had a poor knowledge rate.

A Comprehensive Study on the Effects of Microfinance Institutions’ Activities on Economic Growth of India

India has supported social banking for a long time. Policy directions to rapidly expand rural branches, mandate credit allocations for priority sectors (including agriculture), deliver large subsidy oriented credit programmes to serve marginal communities and poor households and control interest rates have been tried for over 35 years. For these purposes, microfinance industry is set to reach new heights. With superlative growth numbers in a period of economic downturn, the sector has come to attention of a wider range of investors. The rapid growth of the microfinance sector in the last few years has completely changed its complexion and nature. The growth has transformed microfinance: from being a sub-set of the development sector it has become a sub-set of the financial services industry. In the last two years competition amongst microfinance institutions (MFIs) as well as with the Self Help Group (SHG) movement has emerged India. This paper discusses the role of microfinance industry in country‟s economic growth in terms of its GDP. It also discusses the changed scenario in the competitive environment and the issues in microfinance institutions. Karl Pearson‟s coefficient of correlation is used to determine the role of microfinance in country‟s growth, which state a very high correlation between these two.

Attack efficiency in first league men’s volleyball for playing positions, according to the value level of the teams

Background and Study Purpose. The attack is a crucial technical element in scoring points in volleyball. This research aims to identify differences in attack efficiency and errors based on the value level of teams in the competitive system, considering different playing positions. Material and Methods. The analysis included 86 attacking players from the rosters of 12 teams in the men’s domestic first league. The distribution by positions was as follows: 37 outside hitters, 19 opposites, and 30 middle blockers. Statisticians from each team recorded the data using Data Volley software during three championship matches. For each player, the following parameters were interpreted: Attack Efficiency (E%), Error% (=), Blocked Attack% (/), Poor% (-), Blocked but Recovered% (!), Positive% (+), and Winning% (#). Attack efficiency was analyzed for each playing position across top teams (positions 1-4 in the final ranking), mid-level teams (positions 5-8), and lower-level teams (positions 9-12). Results. Across all three playing positions, top teams demonstrate higher percentages in attack efficiency, winning executions, and positive outcomes compared to average and lower-level teams. Top and average teams also have lower percentages of errors in attack executions. For the outside hitter position, no statistically significant superiority is observed between top and middle teams for any attack variable, indicating a balance in player performance. In the opposite hitter position, top and middle-level players show higher attack efficiency and direct point scores (Winning). They also have lower poor execution rates, despite the lack of statistical confirmation for superiority in many attack variables. Among all positions, top middle blockers exhibit a clear superiority over low-level teams across all attack variables. Conclusions. The findings of the study highlight the critical role of team value level in influencing attack efficiency and execution quality across different playing positions in volleyball. The results underscore the importance of strategic differentiation in training and game planning. This is especially crucial for teams aiming to optimize their performance. Coaches and trainers should focus on tailored approaches that address the specific strengths and weaknesses of each playing position. They should also consider the overall team value level in their strategies. This approach could lead to improved competitive outcomes and a more effective utilization of player potential across all levels of competition.

Diagnosis of Respiratory Sarcopenia for Stratifying Postoperative Risk in Non–Small Cell Lung Cancer

Physical biomarkers for stratifying patients with lung cancer into subtypes suggestive of outcomes are underexplored. To investigate the clinical utility of respiratory sarcopenia for optimizing postoperative risk stratification in patients with non-small cell lung cancer (NSCLC). This retrospective cohort study reviewed consecutive patients undergoing lobectomy and mediastinal lymph node dissection for NSCLC at 2 institutions in Tokyo, Japan, between 2009 and 2018. Eligible patients underwent electronic computed tomography image analysis. Follow-up began at the date of surgery and continued until death, the last contact, or March 2022. Data analysis was performed from April 2022 to March 2023. Respiratory sarcopenia was identified by poor respiratory strength (peak expiratory flow rate) and was confirmed by a low pectoralis muscle index (PMI; pectoralis muscle area/body mass index). Patients with poor peak expiratory flow rate but normal PMI received a diagnosis of pre-respiratory sarcopenia. Short-term and long-term postoperative outcomes were compared among patients with a normal status, pre-respiratory sarcopenia, and respiratory sarcopenia. Group differences were analyzed using the Kruskal-Wallis test and Pearson χ2 test for continuous and categorical data, respectively. Survival differences were compared using the log-rank test. Univariable and multivariable analyses were conducted using the Cox proportional hazards model. Of a total of 1016 patients, 806 (497 men [61.7%]; median [IQR] age, 69 [64-76] years) were eligible for electronic computed tomography image analysis. The median (IQR) duration of follow-up for survival was 5.2 (3.6-6.4) years. Respiratory strength was more closely correlated with PMI than pectoralis muscle radiodensity (Pearson r2, 0.58 vs 0.29). Respiratory strength and PMI declined with aging simultaneously (both P for trend < .001). Pre-respiratory sarcopenia was present in 177 patients (22.0%), and respiratory sarcopenia was present in 130 patients (16.1%). The risk of postoperative complications escalated from 82 patients (16.4%) with normal status to 39 patients (22.0%) with pre-respiratory sarcopenia to 39 patients (30.0%) with respiratory sarcopenia (P for trend < .001), as did the risk of delayed recovery after surgery (P for trend < .001). Compared with patients with normal status or pre-respiratory sarcopenia, patients with respiratory sarcopenia exhibited worse 5-year overall survival (438 patients [87.2%] vs 133 patients [72.9%] vs 85 patients [62.5%]; P for trend < .001). Multivariable analysis identified respiratory sarcopenia as a factor independently associated with increased risk of mortality (hazard ratio, 1.83; 95% CI, 1.15-2.89; P = .01) after adjustment for sex, age, smoking status, performance status, chronic heart disease, forced expiratory volume in 1 second, diffusing capacity for carbon monoxide, C-reactive protein, albumin, carcinoembryonic antigen, histology, and pathologic stage. This study identified individuals at higher risk of poor outcomes by screening and staging respiratory sarcopenia. The early diagnosis of respiratory sarcopenia could optimize management strategies and facilitate longitudinal care in patients with NSCLC.

Efficacy of Panchakarma therapy and lifestyle modification in essential hypertensive patients to reduce anti-hypertensive dependency

Background: Anti-hypertensive drugs are associated with a plethora of adverse reactions which can lead to poor treatment adherence, increased morbidity and mortality rates, and significant economic burden. The blood pressure management program (BPMP) is an Ayurvedic treatment strategy that combines Panchakarma with diet management. Thus, the current study sought to assess the efficacy of the BPMP in essential hypertensive patients to reduce anti-hypertension dependency. Methods: A retrospective, observational, single-centre study was conducted between December 2018 and September 2023 in Maharashtra, India. Patients aged 30-75 years diagnosed with primary/essential hypertension regardless of gender participated in the BPMP and were included in the study. Follow-up was conducted after 90 days. Day 1 and day 90 data were compared. Results: A total of 59 patients were assessed. Daytime ambulatory blood pressure monitoring (ABPM) systolic blood pressure decreased (day 1: 123.71±11.83 mmHg and day 90: 123.12±12.36 mmHg), night-time ABPM systolic blood pressure decreased (day 1: 114.76±13.41 mmHg and day 90: 114.31±14.40 mmHg), daytime ABPM diastolic blood pressure decreased (day 1: 77.03±8.28 mmHg and day 90: 76.31±9.45 mmHg, and night-time ABPM diastolic blood pressure decreased (day 1: 69.53±8.32 mmHg and day 90: 68.42±8.85 mmHg). Nocturnal dipping decreased (day 1: 7.08±8.19 and day 90: 6.08±8.99). Dependency on allopathic medication also decreased. Conclusions: The Ayurveda-based BPMP effectively reduces blood pressure and dependency of allopathic medication. It also improves quality of life of patients diagnosed with primary/essential hypertension.

Abstract Strengths and difficulties Lithuania

Abstract Background Most mental health disorders begin before the age of 18, peaking at 14.5 years (Solmi, 2022) and manifest as emotional and behavioural difficulties that are more frequent in institutional social care (ISC): former foster care recipients have higher rates of depression and PTSD than the general population (Pecora, 2009). The rate of children living in residential care facilities in Europe and Central Asia is double the global average (UNICEF, 2024). This study aims to assess and compare the mental health of children in ISC centers and regular high schools. Methods A cross-sectional study was conducted in ISC centres and high schools in 2022-2023. The sample size consisted of children aged 11-17 living in ISC (n = 49) or in families (n = 193). Online anonymous survey was applied to assess the prevalence of endured violence, substance use and measure mental health outcomes using the Strengths and Difficulties Questionnaire (SDQ-25). Results A total of 242 respondents (age mean 14.6, SD = 2.12) in ISC and families showed similar poor mental health rates (42% and 44%, respectively). Prosocial behaviour problems were exhibited more by boys (p &amp;lt; 0.05), whereas emotional symptoms were more common in families (p &amp;lt; 0.001): 90% normal SDQ-25 scores in ISC vs 60% in families. Enduring psychological (38% vs 60.2%) violence was more prevalent among children in families (p &amp;lt; 0.05); smoking - in ISC, alcohol use - in families (p &amp;lt; 0.05). In both groups enduring physical violence was associated with smoking and alcohol use (p &amp;lt; 0.05), and overall poor SDQ-25 results strongly correlated (p &amp;lt; 0.001, r = 0.815, r = 0.610, respectively) with hyperactivity. Conclusions A significant part of study participants reported poor mental health outcomes with most problems in relationships with peers. Mental health risk factors such as violence or substance abuse are associated with poor emotional wellbeing while being more common among children living with families. Key messages • Children living in ISC and in families demonstrate similar level of mental health problems. • Varying prevalence of substance abuse among children living in different settings highlights the importance of environmental factors when addressing the issue.

Improving the Cycle Stability of LiNiO2 through Al3+ Doping and LiAlO2 Coating.

In this study, we addressed the poor cycling and rate performance of LiNiO2, a material with ultrahigh nickel content considered a strong contender for high-energy-density lithium-ion battery cathodes. We introduced nano-Al2O3 during the lithiation process to achieve dual modified material through bulk phase element doping and in situ LiAlO2 coating. Comparison revealed notable improvements in the modified materials. In particular, LiNi0.99Al0.01O2 maintained a capacity retention rate of 73.1% after 300 cycles in a long-cycle test at 0.5C current density, outperforming the undoped material. In rate performance tests, the doped samples consistently exhibited higher discharge-specific capacities than that of the undoped counterpart. Notably, at a high current density of 5C, LiNi0.99Al0.01O2 exhibited a discharge-specific capacity of 101.75 mAh g-1. The results indicate that an appropriate amount of Al doping can effectively stabilize the layered structure of the cathode material and delay the irreversible phase transition from H2 to H3. Further, Al doping facilitates the formation of a LiAlO2 coating on the surface of the particles. This coating acts as a fast-ion conductor, enhancing the transport of lithium ions and reducing the erosion of the active material by the electrolyte.

Integrated geophysical and geospatial techniques for surface and groundwater modeling

An integrated approach using geophysical and geospatial techniques was employed to model the surface and subsurface water-bearing strata and assess aquifer vulnerability in the Sehnsa town, Kotli district, State of Azad Kashmir, Pakistan. The inadequate scientific studies in the hilly terrain with such complex geological conditions has led to the failure of the boreholes for groundwater extraction. For the evaluation of groundwater potential and subsurface lithology, 30 vertical electrical soundings (VES) stations utilizing the Schlumberger electrode configuration were completed, modeled and analyzed spatially. Numerous geoelectrical parameters like true resistivity, thickness of subsurface layers and Dar-Zarrouk parameters were evaluated. The subsurface lithology delineated comprised topsoil, clayey sand, sandstone, and boulder clays which closely resemble to the borehole lithologs available in the study area. The inversion model confirms the presence of patches of high-resistivity sandstone in the southwestern part of the study area with the maximum thickness of the aquifer up to 140 m. Most aquifers were classified as unconfined with Q–type resistivity curves. The protective overburden capacity of the aquifers is rated as poor at VES 1, 3–5, 8, 10–16, 18, 19, 22–25, 27 and 30 whereas the moderate category was found at VES 2, 9 and 20 and excellent at VES 7 and 28, respectively. Therefore, the VES stations with poor and moderate ratings of overburden protective capacity are vulnerable for surface contaminants. The aquifer recharge was associated with rainfall and partly from the Poonch River. The effective integration of geophysical and geospatial techniques in this study provides sufficient information about the regional water resources and gives a preliminary model that can facilitate efficient water resource management in the area. These approaches can be successfully applied to diverse geographical and hydrogeological sites due to their versatility and reliability.

Mitigating the Kinetic Hysteresis of Co-Free Ni-Rich Cathodes via Gradient Penetration of Nonmagnetic Silicon.

Co-free Ni-rich layered oxides are considered a promising cathode material for next-generation Li-ion batteries due to their cost-effectiveness and high capacity. However, they still suffer from the practical challenges of low discharge capacity and poor rate capability due to the hysteresis of Li-ion diffusion kinetics. Herein, based on the regulation of the lattice magnetic frustration, the Li/Ni intermixing defects as the primary origin of kinetic hysteresis are radically addressed via the doping of the nonmagnetic Si element. Meanwhile, by adopting gradient penetration doping, a robust Si-O surface structure with reversible lattice oxygen evolution and low lattice strain is constructed on Co-free Ni-rich cathodes to suppress the formation of surface dense barrier layer. With the remarkably enhanced Li-ion diffusion kinetics in atomic and electrode particle scales, the as-obtained cathodes (LiNixMn1-xSi0.01O2, 0.6≤x≤0.9) achieve superior performance in discharge capacity, rate capability, and durability. This work highlights the coupling effect of magnetic structure and interfacial chemicals on Li-ion transport properties, and the concept will inspire more researchers to conduct an intensive study.

Mitigating the Kinetic Hysteresis of Co‐Free Ni‐Rich Cathodes via Gradient Penetration of Nonmagnetic Silicon

AbstractCo‐free Ni‐rich layered oxides are considered a promising cathode material for next‐generation Li‐ion batteries due to their cost‐effectiveness and high capacity. However, they still suffer from the practical challenges of low discharge capacity and poor rate capability due to the hysteresis of Li‐ion diffusion kinetics. Herein, based on the regulation of the lattice magnetic frustration, the Li/Ni intermixing defects as the primary origin of kinetic hysteresis are radically addressed via the doping of the nonmagnetic Si element. Meanwhile, by adopting gradient penetration doping, a robust Si−O surface structure with reversible lattice oxygen evolution and low lattice strain is constructed on Co‐free Ni‐rich cathodes to suppress the formation of surface dense barrier layer. With the remarkably enhanced Li‐ion diffusion kinetics in atomic and electrode particle scales, the as‐obtained cathodes (LiNixMn1−xSi0.01O2, 0.6≤x≤0.9) achieve superior performance in discharge capacity, rate capability, and durability. This work highlights the coupling effect of magnetic structure and interfacial chemicals on Li‐ion transport properties, and the concept will inspire more researchers to conduct an intensive study.

The Phase Transition of Covariant Lyapunov Vector Precisely Locates a Stability Reversal of Quasi-Periodic Response

Abstract Assessing the stability of quasi-periodic (QP) response is crucial, as the bifurcation of QP response is usually accompanied by a stability reversal. The largest Lyapunov exponent (LLE), as an important indicator for chaotic motion, can also be used for the stability analysis of QP response. The precise location of a stability reversal, however, is tough to achieve as a poor convergence rate would be usually encountered when solving the LLE. Herein a straightforward and precise approach is suggested to identify the critical point when a stability reversal happens. Our approach is based on an explicit differential equation that provides the LLE straightforwardly via numerical integration, and the corresponding covariant Lyapunov vector is simultaneously obtained. The major finding consists in the phase transition of the covariant Lyapunov vector, which can happen much early before the LLE reaches a relatively convergent value. More importantly, the phase transition can serve as a strong indicator to locate a stability reversal of the QP response qualitatively. Numerical examples are provided to verify of the effectiveness and wide applicability the presented approach.

Lightweight Advanced Deep Neural Network (DNN) Model for Early-Stage Lung Cancer Detection

Background: Lung cancer, also known as lung carcinoma, has a high mortality rate; however, an early prediction helps to reduce the risk. In the current literature, various approaches have been developed for the prediction of lung carcinoma (at an early stage), but these still have various issues, such as low accuracy, high noise, low contrast, poor recognition rates, and a high false-positive rate, etc. Thus, in this research effort, we have proposed an advanced algorithm and combined two different types of deep neural networks to make it easier to spot lung melanoma in the early phases. Methods: We have used WDSI (weakly supervised dense instance-level lung segmentation) for laborious pixel-level annotations. In addition, we suggested an SS-CL (deep continuous learning-based deep neural network) that can be applied to the labeled and unlabeled data to improve efficiency. This work intends to evaluate potential lightweight, low-memory deep neural net (DNN) designs for image processing. Results: Our experimental results show that, by combining WDSI and LSO segmentation, we can achieve super-sensitive, specific, and accurate early detection of lung cancer. For experiments, we used the lung nodule (LUNA16) dataset, which consists of the patients’ 3D CT scan images. We confirmed that our proposed model is lightweight because it uses less memory. We have compared them with state-of-the-art models named PSNR and SSIM. The efficiency is 32.8% and 0.97, respectively. The proposed lightweight deep neural network (DNN) model archives a high accuracy of 98.2% and also removes noise more effectively. Conclusions: Our proposed approach has a lot of potential to help medical image analysis to help improve the accuracy of test results, and it may also prove helpful in saving patients’ lives.

What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study

BackgroundPost-stroke stress can trigger instant survival but its influence on long-term ischemic stroke outcomes remains controversial. Thus, we sought to explore the associations of acute post-stroke stress evidenced by endocrine and metabolic changes, with long-term ischemic stroke outcomes.MethodsAdmissions for acute ischemic stroke within seven days of onset were prospectively recruited to determine acute endocrine and metabolic variations measured by thyroid parameters and the stress hyperglycemia ratio (SHR). Long-term ischemic stroke prognoses were followed up for one year, with the primary outcome being a modified Rankin Scale score of 3 to 6.ResultsA total of 887 patients were enrolled, of which 535 reached the final one-year followed up at a poor prognosis rate of 29.3%. Patients with poor outcomes were observed to have lower levels of free triiodothyronine (fT3) and higher levels of SHR on admission. Medium values (fT3, 4.4 mmol/L; SHR, 8 nmol/L) were used to divide patients into four gradient stress degrees. Larger acute endocrine and metabolic variations (fT3 < 4.4 mmol/L and SHR ≥ 8 nmol/L) were independently associated with a poor one-year prognosis (adjusted OR = 4.231, P = 0.001).ConclusionsHigh degrees of acute post-stroke stress may aggravate long-term ischemic stroke prognosis and timely stress-reduced interventions may help promote post-stroke living quality is equally important as survival.