Poor Interpersonal Functioning Research Articles

Paranoia: From Passive Social-Threat Perception to Misattunement in Social Interaction

Paranoia, defined as the unfounded belief that others intend to cause harm, negatively affects individuals across the continuum from healthy to pathological. Despite a definition that is explicitly social, paranoia is often studied as an isolated characteristic of the person who is experiencing it. In the current review, we propose that the study of paranoia could be advanced by adopting a perspective focused on its interactional nature. Specifically, we hypothesize that aberrant dynamic interaction and/or misattunement between social partners may be a critical component in the formation and maintenance of paranoia. We also speculate that the relationship between paranoia and social functioning is bidirectional in which poor interpersonal functioning is both a result of and a contributor to paranoia. This approach may identify novel mechanisms and potential treatment targets.

Study of mentalizing ability in borderline personality disorder: relationship with impulsivity

IntroductionBorderline personality disorder (BPD) is a severe mental disorder characterized by affective, behavioral and relational instability, along with interpersonal hypersensitivity and unstable affective relationships (APA 2013). Poor interpersonal functioning could be associated with critical deficits in the ability to mentalize in these patients, together with high levels of impulsivity. Although most studies have described hypermentalization deficits among BPD patients (Bora Psychol Med 2021;51 2541-2551), existing literature is still scarce on this aspect, as well as its relationship with the impulsive behavior.Objectives1) to assess specific mentalizing deficits in BPD compared to healthy controls in a complex ecological mentalization task; 2) evaluate the relationship between mentalization and impulsivity in BPD.Methods63 patients diagnosed with borderline personality disorder and 31 control subjects were studied using the Movie for the Assessment of Social Cognition -MASC- (Dziobeck et al. J Autism Dev Disord 2006; 36 623-636) and the Barratt Impulsivity Scale -BIS-11- (Patton et al. J Clin Psychol 1995; 51 768-774), as well as other sociodemographic and clinical factors. The clinical research study was approved by the Clinical Research Ethics Committee of the Hospital Clínico San Carlos (Madrid, Spain).ResultsThe results showed significant differences in the scores related to correct mentalization, hypomentalization, and non-mentalizing responses between patients and controls, with BPD patients showing worse performance. A significant negative relationship was also observed between impulsivity scores and correct mentalizing responses in BPD patients.ConclusionsThe results showed a deficit in the ability to mentalize in BPD patients, compared to control subjects, characterized by a hypomentalization and an absence of mentalization. Likewise, this deficit in mentalization ability was related to greater impulsive behavior in patients. These results would be consistent with the hyperarousal hypothesis in BPD, which would reduce inhibitory control, causing mentalization deficits (Euler et al. J Pers Disord. 2021; 35 177-193). Future studies will try to associate specific impulsive behaviors associated with the characteristics of hypomentalization and absence of mentalization observed in our results.Disclosure of InterestNone Declared

The prevalence of borderline personality features and borderline personality disorder during the perinatal period: a systematic review and meta-analysis.

Borderline personality disorder (BPD) is a psychiatric disorder marked by severe affective instability and poor interpersonal functioning. Existing literature has highlighted that individuals with BPD are at greater risk for a wide range of adverse physiological and psychosocial outcomes in the perinatal period compared to perinatal individuals without BPD. However, to date, no systematic review has addressed the prevalence of BPD and borderline personality features (BPF) in pregnant and postpartum individuals. A systematic review and meta-analysis was conducted by searching three databases (PubMed, PsycINFO, and Embase) on April 6th, 2021. Research articles and conference abstracts that evaluated BPF or BPD in pregnant, postpartum, or mixed perinatal populations were included. Sixteen publications were included in the systematic review (n = 14 research articles, n = 2 conference abstracts), seven of which were included in the meta-analysis. Among non-clinical samples, prevalence rates of BPF during pregnancy ranged from 6.9 to 26.7%, while rates of BPD across the perinatal period ranged from 0.7 to 1.7%. Among clinical samples, rates of BPF and BPD across the perinatal period spanned 9.7-34% and 2.0-35.2%, respectively. Results from the meta-analysis revealed that the pooled prevalence rate of BPD in clinical samples during the perinatal period is 14.0% (95% CI [7.0, 22.0]). Among clinical perinatal samples, there is a high prevalence of borderline personality pathology. This review highlights the need for appropriate validated screening methods to identify and treat BPD in the perinatal population.

Exploring screening for borderline personality disorder in pediatric inpatients with psychiatric Illness

Borderline Personality Disorder (BPD) is a severe psychiatric illness associated with poor personal and interpersonal functioning. Screening for BPD in adolescents and provision of specialized treatment may improve life circumstances in vocations and relationships. The purpose of this study was to determine the number of pediatric inpatients who would screen positive for BPD with a self-rating measure, and to compare their personal and interpersonal characteristics with youth who did not screen positive. A survey with self-report measures was administered to patients to screen for BPD. The mean age of the sample was 15 years and 71% identified as female gender. Of 109 patients 72 (66%) screened positive for BPD while only eight (7%) patients were diagnosed by psychiatrists with BPD or features of BPD. There were no statistically significant differences between those who scored positive versus negative for BPD in age, gender, or avoidant anxiety. There were statistically significant differences in anxious attachment, distress, clinical symptoms, problematic use of electronic devices, considered suicide, past trauma and prior suspensions from school. This exploration in pediatric inpatients suggests that many of these patients may be at risk for a diagnosis of BPD later in life and may benefit from early identification and specialized intervention.

Elucidating posttraumatic stress symptom dimensions and health correlates among postpartum women

BackgroundPosttraumatic stress disorder (PTSD) is associated with interpersonal dysfunction and adverse maternal health during the perinatal period (extending from conception through one year postpartum). However, PTSD is a heterogeneous disorder, and little is known about which aspects of this disorder may be particularly deleterious to the health of new mothers. Such data may inform more personalized approaches to PTSD prevention and treatment among postpartum women. MethodsUsing confirmatory factor analysis, we compared three models of PTSD symptom structure—the four-factor dysphoria model, four-factor emotional numbing model, and five-factor dysphoric arousal model—in 1,663 postpartum women from the Community and Child Health Network (CCHN). We examined associations between PTSD symptom dimensions of the best-fitting model with four correlates relevant to maternal health and functioning—parenting stress, partner relationship stress, relationship satisfaction, and contraceptive use. ResultsThough all models fit well, the five-factor dysphoric arousal model provided optimal fit. Symptom dimensions from this model—re-experiencing, avoidance, numbing, dysphoric arousal, and anxious arousal—evidenced differential associations with the maternal health indicators. Numbing symptoms were most strongly associated with indicators of poor interpersonal functioning, whereas dysphoric arousal symptoms were most strongly related to low-efficacy contraceptive use. LimitationsOur cross-sectional study assessed DSM-IV PTSD symptoms. ConclusionsPTSD symptoms among postpartum women are best-represented by five factors. Numbing symptoms (e.g., restricted affect, detachment) are most strongly associated with interpersonal difficulties, whereas dysphoric arousal symptoms (e.g., agitation, irritability) are linked with low-efficacy contraceptive use. Screening for these symptoms may help promote the health of new mothers.

Latent Class Analysis of Adolescent Psychosocial Functioning and Course of Major Depression.

There are few studies on the predictors of long-term course of major depressive disorder (MDD) with an onset in childhood and adolescence. Studies have relied on variable-centered methods, utilizing psychosocial and clinical characteristics to predict depression outcomes. However, fewer studies have used person-centered approaches that rely on profiles of functioning to predict course and outcomes of depression. This study examined the long-term course and outcome of early onset depression as a function of profiles of psychosocial and clinical characteristics in adolescence. Participants from the Oregon Adolescent Depression Project with a history of MDD by study entry (Mage = 16.29years) and who had follow-up assessments at age 30 were included (n = 215). Psychosocial and clinical constructs, including domains of internalizing problems, externalizing problems, correlates of internalizing problems, adolescent stress, and social support, were assessed in adolescence. Latent profile analyses found a 3-class solution with Low Negative Cognitive Style (LNCS; 27.9%); Internalizing and High Negative Cognitive Style (INT/HNCS; 53.9%); and Internalizing and High Negative Cognitive Style plus Poor Interpersonal Functioning and High Stress (INT/HNCS+ ; 18.1%). Overall, classes differed in depression morbidity, such that the INT/HNCS+ class had the greatest depression morbidity across follow-up assessments. Social adjustment differed between all classes, with the INT/HNCS+ class showing the worst functioning, the LNCS class showing the best functioning, and the INT/HNCS class falling in the middle. Patterns of clinical and psychosocial functioning were differentially associated with long-term depression and social adjustment among youth with depression.

Investigating associations between hoarding symptoms and affective and cognitive empathy.

Hoarding is associated with poor interpersonal functioning, such as social isolation and difficulties in forming relationships, but the reasons for these social problems are not well understood. Previous studies have identified empathy as an important precursor to social functioning, particularly for clinical disorders characterized by social deficits. The aim of the current study was therefore to investigate associations between measures of cognitive and emotional empathy and hoarding symptoms. A total of 278 participants recruited via MTurk completed online self-report questionnaires on hoarding, empathy (including cognitive and affective components), and depression. All participants subsequently completed The Awareness of Social Inference Test-Short version (TASIT-S), a behavioural measure of theory of mind, a concept used interchangeably with cognitive empathy. Hoarding symptoms were associated with greater self-reported emotional empathy, specifically emotional contagion, and less self-reported cognitive empathy. Emotional empathy predicted hoarding even after controlling for depression symptoms. Hoarding symptoms were also associated with poorer performance on the TASIT-S with respect to both emotion recognition and theory of mind, with theory of mind remaining a unique predictor of hoarding symptoms after controlling for depression. Participants who reported clinically significant hoarding symptoms were impaired in emotion recognition and theory of mind according to TASIT-S norms. Hoarding symptoms are associated with increased emotional contagion and decreased cognitive empathy. Empathy may be an avenue for understanding and treating interpersonal difficulties in hoarding disorder. As hoarding increased, self-reported emotional contagion increased As hoarding increased, self-reported and behavioural cognitive empathy decreased Self-reported emotional empathy and behavioural cognitive empathy predicted hoarding even after controlling for depression Empathy may be an avenue for understanding social difficulties in hoarding disorder.

Examining Personality, Interpersonal, and Symptom Correlates of Social Anhedonia in Early Adolescent Males and Females

Social anhedonia, a tendency toward experiencing social stimuli as less positive or pleasurable, is associated with maladaptive personality traits, poor interpersonal functioning, and psychopathology, and is typically elevated in males compared with females. However, the correlates of social anhedonia in youth have not been well defined. In this study, 275 young adolescents from a community sample completed measures of social anhedonia, personality, interpersonal functioning, and symptoms; mothers also completed personality and symptom measures. Social anhedonia was associated with low positive emotionality and, to a lesser extent, high disinhibition and negative emotionality. Social anhedonia was also correlated with several markers of poor interpersonal functioning and a wide range of internalizing and externalizing symptoms. Interactions between sex variables indicated that associations were particularly strong in males. Overall, findings suggest that social anhedonia is an important construct to explore in early adolescence, with meaningful associations with psychosocial functioning, especially among males.

How spontaneous brain activity and narcissistic features shape social interaction

There is an increasing interest in how ongoing spontaneous brain activity and personality provide a predisposition for the processing of environmental demands. It further has been suggested that the brain has an inherent sensitivity to the social environment. Here we tested in healthy volunteers if spontaneous brain activity contributes to a predisposition for social behavior and how this is modulated by narcissistic personality features associated with poor interpersonal functioning. Functional magnetic resonance imaging included a resting state and an experimental paradigm focusing on the anticipation of actively touching an animate (human hand) versus an inanimate target (mannequin hand). The experimental task induced a significant modulation of neural activity in left postcentral gyrus (PostCG), right culmen and, co-varying with narcissistic features, in right anterior insula (AI). Neural activity in anticipation of the animate target significantly correlated with spontaneous activity during the resting state indexed by the Power Law Exponent (PLE) in PostCG and AI. Finally, the correlation between spontaneous and task-induced activity in AI was mediated by narcissistic features. These findings provide novel evidence for a relationship between intrinsic brain activity and social behavior and show how personality could contribute to individual differences in our predisposition to approach the animate world.

Construct Validity of the MMPI–2–RF Triarchic Psychopathy Scales in Correctional and Collegiate Samples

ABSTRACTThis study examined the MMPI–2–RF (Ben-Porath & Tellegen, 2008/2011) Triarchic Psychopathy scales recently developed by Sellbom et al. (2016) in 3 separate groups of male correctional inmates and 2 college samples. Participants were administered a diverse battery of psychopathy specific measures (e.g., Psychopathy Checklist–Revised [Hare, 2003], Psychopathic Personality Inventory–Revised [Lilienfeld & Widows, 2005], Triarchic Psychopathy Measure [Patrick, 2010]), omnibus personality and psychopathology measures such as the Personality Assessment Inventory (Morey, 2007) and Personality Inventory for DSM–5 (Krueger, Derringer, Markon, Watson, & Skodol, 2012), and narrow-band measures that capture conceptually relevant constructs. Our results generally evidenced strong support for the convergent and discriminant validity for the MMPI–2–RF Triarchic scales. Boldness was largely associated with measures of fearless dominance, social potency, and stress immunity. Meanness showed strong relationships with measures of callousness, aggression, externalizing tendencies, and poor interpersonal functioning. Disinhibition exhibited strong associations with poor impulse control, stimulus seeking, and general externalizing proclivities. Our results provide additional construct validation to both the triarchic model and MMPI–2–RF Triarchic scales. Given the widespread use of the MMPI–2–RF in correctional and forensic settings, our results have important implications for clinical assessment in these 2 areas, where psychopathy is a highly relevant construct.

Attentional processing of emotional faces in schizophrenia: Evidence from eye tracking.

Severe emotional disturbances such as anxiety and depression have been closely related to aberrant attentional processing of emotional stimuli. However, this has been little studied in schizophrenia, which is also characterized by marked emotional impairments such as heightened negative affect and anhedonia. In the current study, we investigated temporal dynamics of motivated attention to emotional stimuli in schizophrenia. For this purpose, we tracked eye movements of 22 individuals with schizophrenia or schizoaffective disorder (ISZs) and 19 healthy controls (HCs) to emotional (i.e., happy, sad, angry) and neutral face pairs presented either for 500 ms or 1,500 ms. Initial fixation direction and viewing time at 3 successive intervals (0-500, 500-1,000, 1,000-1,500 ms) were calculated. The results showed that both ISZs and HCs were more likely to orient initial fixations and exhibited longer viewing times to emotional than neutral faces. However, compared with HCs, ISZs allocated less attention to overall faces during the late stage (1,000-1,500 ms) when one of the paired faces displayed negative emotions. Furthermore, positive symptoms were highly associated with initial fixation avoidance to angry faces while depressive symptoms were related to later avoidance of angry faces. Both social amotivation and poor interpersonal functioning were closely related to diminished sustained attention to happy faces. This suggests that early attentional capture of emotional salience may be relatively preserved in schizophrenia, but the people with this disorder display an atypical late attentional process characterized by generalized attentional avoidance of negative stimuli. Of note, aberrant attentional processes of social threat and reward were closely associated with major symptoms and functioning in this disorder. (PsycINFO Database Record

Sensitivity to criticism differentially mediates the relationship between interpersonal problems and state and trait depression.

Both state- and trait-like manifestations of depression have been associated with poor interpersonal functioning. One mechanism by which this could occur is through individuals' sensitivity to criticism. In the present study, 414 undergraduates were assessed with the Beck Depression Inventory-II (Beck et al. 1996) and Depressive Personality Disorder Inventory (Huprich et al. 1996) as representative measures of state and trait depression respectively. They also were assessed with self-report measures of sensitivity to criticism and interpersonal problems. Sensitivity to criticism significantly mediated the relationship between state and trait depression within five dimensions of interpersonal problems. However, sensitivity to criticism was more strongly related to the trait depression-interpersonal problems relationship than the state depression-interpersonal problems relationship, when controlling for state depression and trait depression respectively. Copyright © 2016 John Wiley & Sons, Ltd.

Parental criticism, self-criticism and their relation to depressive mood: an exploratory study among a non-clinical population

Internalized self-criticism (ISC) has been identified as one dimension of depression and has been related to poor interpersonal functioning, severity of depressive symptoms among patients with a diagnosis of major depressive disorder, and suicidal behaviors. Finally, it has been indicated as a maintaining factor in depression, able to impair the efficacy of psychological treatment. The present study aimed to investigate the role of perceived parental criticism, perfectionistic concern over mistakes and ruminative brooding in predicting internalized self-criticism; in addition, we explored the predictive value of all the considered variables for depressive mood in a nonclinical population. The final model showed a complete mediation for concern over mistakes and ruminative brooding in the relationship between perceived parental criticism and ISC, with the final model explaining 32% of the variance. Moreover, ISC predicted the level of depressive symptoms over and above the contribution of the other variables considered. The findings suggest that a thinking style characterized by ruminative brooding and the tendency to be concerned with mistakes can facilitate the development of a self-critical person, more than a parental style perceived as critical. Moreover, the tendency to be self-critical may be more predictive of depressive symptoms than the other variables considered.

Perceptions of social dominance through facial emotion expressions in euthymic patients with bipolar I disorder

The ability to accurately perceive dominance in the social hierarchy is important for successful social interactions. However, little is known about dominance perception of emotional stimuli in bipolar disorder. The aim of this study was to investigate the perception of social dominance in patients with bipolar I disorder in response to six facial emotional expressions. Participants included 35 euthymic patients and 45 healthy controls. Bipolar patients showed a lower perception of social dominance based on anger, disgust, fear, and neutral facial emotional expressions compared to healthy controls. A negative correlation was observed between motivation to pursue goals or residual manic symptoms and perceived dominance of negative facial emotions such as anger, disgust, and fear in bipolar patients. These results suggest that bipolar patients have an altered perception of social dominance that might result in poor interpersonal functioning. Training of appropriate dominance perception using various emotional stimuli may be helpful in improving social relationships for individuals with bipolar disorder.

Adolescent emotionality and effortful control: Core latent constructs and links to psychopathology and functioning.

Temperament is associated with important outcomes in adolescence, including academic and interpersonal functioning and psychopathology. Rothbart's temperament model is among the most well-studied and supported approaches to adolescent temperament, and contains 3 main components: positive emotionality (PE), negative emotionality (NE), and effortful control (EC). However, the latent factor structure of Rothbart's temperament measure for adolescents, the Early Adolescent Temperament Questionnaire Revised (EATQ-R; Ellis & Rothbart, 2001) has not been definitively established. To address this problem and investigate links between adolescent temperament and functioning, we used confirmatory factor analysis to examine the latent constructs of the EATQ-R in a large combined sample. For EC and NE, bifactor models consisting of a common factor plus specific factors for some subfacets of each component fit best, providing a more nuanced understanding of these temperament dimensions. The nature of the PE construct in the EATQ-R is less clear. Models replicated in a hold-out dataset. The common components of high NE and low EC where broadly associated with increased psychopathology symptoms, and poor interpersonal and school functioning, while specific components of NE were further associated with corresponding specific components of psychopathology. Further questioning the construct validity of PE as measured by the EATQ-R, PE factors did not correlate with construct validity measures in a way consistent with theories of PE. Bringing consistency to the way the EATQ-R is modeled and using purer latent variables has the potential to advance the field in understanding links between dimensions of temperament and important outcomes of adolescent development.

Investigating the role of alexithymia on the empathic deficits found in schizotypy and autism spectrum traits

Alexithymia, the inability to identify and describe one’s emotional experience, is elevated in many clinical populations, and related to poor interpersonal functioning. Alexithymia is also associated with empathic deficits in individuals with autism spectrum disorders. Accordingly, a better understanding of alexithymia could elucidate the nature of social-cognitive deficits transdiagnostically. We investigated alexithymia and components of empathy in relation to schizotypal and autism spectrum traits in healthy college students. Specifically, we examined higher-order components of empathic processing that involve perspective taking and other-oriented concern, which are reduced in alexithymia.Higher-order empathic processing was inversely correlated with both schizotypal and autism spectrum traits. Bootstrapping techniques revealed that alexithymia had a significant indirect effect on the relationship between higher-order empathy and these personality traits; thus, alexithymia contributes uniquely to their relationship. These findings suggest alexithymia represents one possible mechanism for the development of empathic deficits in these populations.These results are consistent with the perspective that awareness of one’s own emotional state may predicate a successful empathic response to another’s. This work highlights the importance of a consideration of alexithymia in elucidating the nature of empathic deficits in various clinical populations, and points to a potential point of social intervention.

Bipolar and borderline patients display differential patterns of functional connectivity among resting state networks

Bipolar disorder (BD) and borderline personality (BPD) disorder share clinical features such as emotional lability and poor interpersonal functioning but the course of illness and treatment differs in these groups, which suggests that the underlying neurobiology of BD and BPD is likely to be different. Understanding the neural mechanisms behind the pathophysiology of BD and BPD will facilitate accurate diagnosis and inform the administration of targeted treatment.Since deficits in social cognition or emotion regulation or in the self-referential processing system can give rise to these clinical features, and impairment in these domains have been observed in both patient groups, functional connectivity within and between networks subserving these processes during resting was investigated using functional magnetic resonance imaging. Data were acquired from 16 patients with BD, 14 patients with BPD, and 13 healthy controls (HC) and functional connectivity strength was correlated with scores using the Difficulties in Emotion Regulation Scale.Functional network connectivity (FNC) patterns differentiated BD and BPD patients from HC. In BD, FNC was increased while in BPD it was decreased. In BD impaired FNC was evident primarily among networks involved in self-referential processing while in BPD it also involved the emotion regulatory network. Impaired FNC displayed an association with impulsivity in BPD and emotional clarity and emotional awareness in BD.This study shows that BD and BPD can perhaps be differentiated using resting state FNC approach and that the neural mechanisms underpinning overlapping symptoms discernibly differ between the groups. These findings provide a potential platform for elucidating the targeted effects of psychological interventions in both disorders.

Impaired Theory of Mind and psychosocial functioning among pediatric patients with Type I versus Type II bipolar disorder

Deficits in Theory of Mind (ToM) have been documented among pediatric patients with Bipolar Disorder (BD). However, fewer studies have directly examined differences between type I and type II patients and whether or not ToM deficits are related to psychosocial difficulties. Therefore, the aim of this study was to compare type I versus type II pediatric bipolar patients and matched Healthy Controls (HC) on ToM and interpersonal functioning tasks. All participants completed the Revised Mind in the Eyes Task (MET), the Cognitive and Emotional Perspective Taking Task (CEPTT), and the Index of Peer Relations (IPR). Type I BD patients reported greater peer difficulties on the IPR compared to HC, and also performed more poorly on the MET and the cognitive condition of the CEPTT, but did not differ significantly on the emotional condition. There were no significant group differences between type II BD patients and HC. More impaired ToM performance was associated with poorer interpersonal functioning. Type I BD patients show deficits in the ability to understand another's mental state, irrespective of emotional valence. Deficits in understanding others' mental states could be an important treatment target for type I pediatric patients with BD.

Interpersonal functioning deficits in association with DSM-IV personality disorder dimensions

According to DSM, interpersonal functioning deficits are a main criterion for the general definition of personality disorders (PDs), but some PD diagnoses do not appear to be related to impaired interpersonal functioning. Social deficits have rarely been studied in all PD dimensions to date. We analyzed 511 adults aged 20-41 years from the general population of the canton of Zurich, Switzerland, using data from the Epidemiology Survey of the Zurich Programme for Sustainable Development of Mental Health Services (ZInEP). PD dimensions were measured with a questionnaire and indicators of interpersonal functioning with a semi-structured interview. Associations were analyzed with generalized linear models. All PD dimensions were significantly associated with various indicators of interpersonal functioning deficits, such as distress and conflicts in friendships and partnership, feeling lonely, few close friends, and reduced social support. Schizotypal and borderline PD were relatively strongly associated with distress in friendships when compared with other PD dimensions. Furthermore, both dimensions were significantly related to all indicators of interpersonal functioning deficits. Subjects scoring high on any PD dimension reported considerable deficits in interpersonal functioning as characterized by a solitary lifestyle, conflictual and distressful social relations, and lack of social support. All DSM-IV PDs are associated with poor interpersonal functioning, but there is some evidence that schizotypal and borderline symptomatology affects deficits in social interactions even more profoundly and pervasively than other PD dimensions.

Heterogeneous trajectories of depressive symptoms: Adolescent predictors and adult outcomes

BackgroundDepressive symptoms display heterogeneous trajectories across adolescence and early adulthood. Identifying risk and protective factors for distinct trajectory groups, and their respective outcomes, may provide insight into the etiological underpinnings of different symptom courses and inform the targets and timing of intervention. MethodsA school-based sample of 719 adolescents completed four diagnostic evaluations and up to 7 annually mailed questionnaires assessing psychiatric symptoms and psychosocial risk and protective factors. Parental history of psychiatric disorder was assessed. Growth mixture modeling (GMM) was used to identify latent depressive symptom trajectories from mid-adolescence through age 30, as well as their predictors in mid-adolescence and adult outcomes. ResultsA three class model consisting of high stable (32%), moderate decreasing (44%), and low decreasing (24%) depressive symptom trajectories emerged as the preferred solution. Demographic, psychosocial, and psychiatric characteristics differentiated the low and high symptom classes, and provided support for interpersonal models of depression chronicity. Members of the moderate and high symptom classes evidenced the worst psychosocial and psychiatric outcomes by age 30, with members of the high symptom class showing the greatest levels of impairment. LimitationsCross-sectional measurement and floor effects of several predictor variables may have obscured the relations between those predictors and trajectory class membership. ConclusionThese findings suggest that prevention and intervention strategies may specifically target young women and those who experience poor interpersonal functioning in an effort to alter the course of depressive symptoms through early adulthood.