Pooling Of Contrast Material Research Articles

Management of vascular lake phenomenon on angiography during chemoembolization with superabsorbent polymer microspheres.

Contrast material pooling on angiography within a tumor bed during embolization for hepatocellular carcinoma (HCC) presents as the vascular lake (VL) phenomenon. This retrospective study aimed to evaluate the frequency and management of VLs during chemoembolization with drug-eluting beads (DEBs) and the relationship between the VL and local response. A total of 123 HCC patients without vascular invasion or intrahepatic metastases who underwent chemoembolization with DEBs (50-100 µm superabsorbent polymer microspheres loaded with epirubicin) were enrolled. Gelatin sponge particles (GS) were injected for additional embolization in limited patients with steadily increasing size of VLs during DEB injection. Overall, 338 nodules were divided into three groups: lesions without a VL (non-VL; n = 250); lesions with a VL but without additional GS embolization [VL-GS (-), n = 58]; and lesions with both VL and additional GS embolization [VL-GS (+); n = 30]. The local responses were statistically compared by Fisher's exact test with the Bonferroni correction. The frequency of VLs was 26.0% (88/338). The response rate in the non-VL group (54.0%) was significantly lower than those in the VL-GS (-) (91.4%; P < 0.0001) and VL-GS (+) (96.7%; P < 0.0001) groups. VL is a common angiographic finding and might be associated with the local response.

Western Trauma Association Critical Decisions in Trauma: Nonoperative Management of Adult Blunt Hepatic Trauma

Western Trauma Association Critical Decisions in Trauma: Nonoperative Management of Adult Blunt Hepatic Trauma

Bleeding From Posterior Superior Alveolar Artery in Le Fort I Fracture

This article describes a patient in whom significant oronasal bleeding developed after an injury to posterior superior alveolar artery of the maxillary artery in Le Fort I fracture.A 34-year-old man had a facial injury after an explosion of a furnace. Computed tomography demonstrated Le Fort I fracture, right open zygomatic tripod fracture, and open nasal bone fracture. Blood pressure, hemoglobin, and hematocrit levels had fallen to 110/60 mm Hg, 5.7 mg/dL, and 16.1%, respectively, 10 hours after injury despite continuous blood transfusion. Selective digital angiography confirmed an injury to the posterior superior alveolar artery, with extravasated pooling of contrast material in the maxillary sinus. The distal internal maxillary artery was embolized with n-butyl cyanoacrylate and lipiodol. Postembolization angiogram showed resolution of the contrast leak, and the patient's oronasal bleeding resolved.We suggest that if the oronasal bleeding continues in Le Fort fracture, bleeding from the posterior superior alveolar artery should be suspected. In case the vital sign is not stable, selective angiography should be performed before surgery.

Hemostatic Agents Injected Directly Into Hepatic Injury Sites for Liver Trauma Hemorrhage Under the Guidance of Contrast-Enhanced Ultrasound: An Animal Experiment

Abstract We investigated whether direct injection of hemostatic agents into injury sites under the guidance of contrast-enhanced ultrasound (CEUS) can decrease blood loss from liver trauma. Twelve adult healthy dogs underwent laparotomy, and a hepatic wound (6.0 × 4.5 cm) was created in each dog. All animals were divided randomly into two groups: the treatment group and the control group. In the treatment group, hemocoagulase Atrox (Solco Basle Ltd., Birsfelden, Switzerland) and absorbable cyanoacrylate were injected directly into the liver injury sites, and 0.9% normal saline was injected into the injury sites in the control group. Resuscitation volume in the treatment group was less than that in the control group (55 ± 12 mL vs. 105 ± 23 mL, p < 0.001). The control group presented bleeding from liver injury sites. Times of bleeding at the injury site in the treatment groups were 6 ± 1 s. Both groups presented an-echo and/or hypo-echo contrast regions, with contrast material pooling in the injury sites before the therapy. After the injection, the contrast material pooling disappeared in the treatment group observed by CEUS. Gross examination of liver tissue revealed that the injury site that had been treated was covered by clot and glue membrane. Histopathologic examination showed that there was hemostitic glue embolizing the microvessels and inflammatory cell infiltration among hepatocytes. Direct injection of hemocoagulase Atrox and cyanoacrylate into the liver injury sites guided by CEUS can effectively reduce blood loss from liver trauma within a short time. This experimental study may suggest a possible treatment for liver trauma hemorrhage and provide an experimental evidence for treating blunt abdominal parenchyma organs trauma under the guidance of CEUS. (E-mail: lvjin8912@163.com)

Pseudoaneurysm of the Cystic Artery Secondary to Cholecystitis as a Cause of Hemobilia: Report of a Case

Spontaneous intracholecystic bleeding is very rare. We report herein a very rare case of a pseudoaneurysm of the cystic artery due to acute cholecystitis. A 58-year-old man presented at the emergency department complaining of colicky pain in the right upper quadrant. Dynamic magnetic resonance imaging demonstrated an early-enhanced pooling of contrast material (suggestive of a pseudoaneurysm of the cystic artery) inside the neck of the gallbladder. After the proximal control of the hepatic artery, the patient underwent a cholecystectomy and a ligation of the cystic artery. The resected specimen of the gallbladder showed evidence of a massive intracholecystic hematoma. Proximal to the impacted gallstone in the neck, a 2-cm diameter saccular-type pseudoaneurysm was identified. Although a pseudoaneurysm of the cystic artery is very rare, it should be included in the differential diagnosis of hemobilia. Once the pseudoaneurysm is confirmed, its embolization before a cholecystectomy (which can be attempted laparoscopically) may be useful to ensure the safety of the patient.

Nontraumatic abdominal hemorrhage: MDCTA

Multidetector row computed tomographic angiography (MDCTA) plays a crucial role in the evaluation of patients with suspected abdominal hemorrhage in the emergency setting. It offers several advantages over single-detector CT in the assessment of patients with emergent conditions [1]. The shorter scanning time with multidetector row CT allows better visualization of blood vessels and more consistent contrast enhancement of the adjacent organ parenchyma. Further, faster data acquisition makes it possible to obtain multiple consecutive phases in a short time. The development of multidetector CT in combination with advances in computer hardware, software, and display technology has facilitated three-dimensional (3D) image reconstruction [1]. Shaded surface display, volume rendering (VR), and maximum intensity projection (MIP) are the three most commonly used 3D reconstruction techniques. In patients with suspected abdominal hemorrhage, MIP and VR of image data from MDCTA can enable vascular visualization that is equal or superior to that obtained with catheter angiography. In our experience, MDCTA allows the detection of not only organ injuries but also vascular anomalies such as rupture of arterial aneurysms and, in some cases, the active bleeding (AB) sign. The AB sign (also called the ‘‘contrast blush’’ or ‘‘blush sign’’) is an active pooling of contrast material caused by vascular or visceral organ injuries [2, 3]. In the absence of a previous traumatic event, detection of the AB sign is of paramount importance because this finding may indicate a life-threatening condition. The AB sign is considered a rare finding on conventional CT images of patients with abdominal trauma. The prevalence of this sign was only 0.2% in a study conducted by Taylor et al. [4]. Therefore, the prevalence of the AB sign in patients without trauma should be even lower than in patients who had sustained abdominal trauma. This assumption is supported by the fact that, to our knowledge, no data are available to assess the prevalence of the AB sign in patients without trauma by using MDCTA. This article describes our experience in the evaluation of patients without trauma but with suspected abdominal hemorrhage by using MDCTA.

Blunt Hepatic Trauma: Evaluation With Contrast-Enhanced Sonography

The purpose of this study was to report our initial experience in the assessment of liver trauma with real-time contrast-enhanced sonography (CES). From January 2000 to December 2003, there were 431 hemodynamically stable patients evaluated with sonography for blunt abdominal trauma. Among these patients, 87 were selected to undergo second-level imaging, consisting of CES and computed tomographic (CT) evaluation. Indications for further assessment were baseline sonographic findings positive for liver injury, baseline sonographic findings positive for injury to other abdominal parenchyma, baseline sonographic findings positive for free fluid only, baseline sonographic findings indeterminate, and baseline sonographic findings negative with persistent clinical or laboratory suspicion. There were 23 hepatic lesions shown by CT in 21 patients. Peritoneal or retroperitoneal fluid was identified in 19 of 21 positive cases by all 3 imaging modalities. Liver injury was found in 15 patients on sonography and in 19 on CES. Contrast-enhanced sonography compared better than unenhanced sonography with the criterion standard for related injury conspicuity, injury size, completeness of injury extension, and involvement of the liver capsule. Both CES and CT showed intrahepatic contrast material pooling in 2 cases. All patients with false-negative sonographic or CES findings recovered uneventfully. Contrast-enhanced sonography is an effective tool in the evaluation of blunt hepatic trauma, being more sensitive than baseline sonography and correlating better than baseline sonography with CT findings. In institutions where sonography is regarded as the initial procedure to screen patients with trauma, this technique may increase its effectiveness. In addition, CES may be valuable in the follow-up of patients with conservatively treated liver trauma.

The significance of contrast blush on computed tomography in children with splenic injuries

Purpose Most children and adults with blunt splenic injuries are treated nonoperatively by well-established management protocols. The “blush sign” is an active pooling of contrast material within or around the spleen seen during intravenous enhanced computed tomography (CT) scan. Adult treatment algorithms often include the “blush sign” as an indication for embolization or surgical intervention. This study was designed to evaluate the implications of the “blush sign” in children with blunt splenic injuries. Methods A review was performed of all children with blunt splenic injuries treated between January 1996 and December 2001 at a level I pediatric trauma center using an established solid organ injury protocol. The demographic, CT imaging, and outcome data were recorded. Treatment was categorized as operative or nonoperative. A single pediatric radiologist retrospectively reviewed all available CT scans to confirm injury grade and the presence or absence of a “blush sign.” Results There were 133 eligible children admitted with blunt splenic trauma, with a mean age of 9.1 years (range, 1 to 15), including 86 children with an abdominal CT available for review. A “blush sign” on initial CT scan was noted in 6 children, all with grade 3 or above splenic injuries, 5 of who were treated nonoperatively. In this series, the single child with a “blush sign” who did not respond to nonoperative treatment had a severe polytrauma requiring urgent splenectomy and left nephrectomy. None of the children died of their splenic injury. Conclusions Although associated with higher grades of injury, the blush sign did not mandate embolization or surgical intervention in children with blunt splenic trauma in this series. Severe splenic injuries with a blush sign on the initial CT scan may be successfully treated nonoperatively when using an established treatment protocol. Management should be based primarily on physiological response to injury rather than the radiologic features of the injury.

Classification and treatment of pooling of contrast material on computed tomographic scan of blunt hepatic trauma.

Pooling of contrast material on computed tomographic (CT) scan represents free extravasation of blood as a result of active bleeding. For patients with blunt hepatic injury, aggressive management such as angiography or celiotomy is usually indicated if this sign is detected. The purposes of this study were to further categorize this CT scan finding and to correlate its characteristics with clinical outcomes. This CT scan classification might be helpful for the selection of appropriate management. During a 42-month period, 276 patients with blunt hepatic injury were treated. Two hundred twelve of them were hemodynamically stable after initial resuscitation and underwent abdominal CT scan examination. Pooling of contrast material was detected on the CT scans of 15 patients. The CT scans and medical records were reviewed. Special attention was paid to the presence, location, and character of the extravasated contrast material. The finding of pooling of contrast material on CT scan was categorized into three types according to its location and character. Type I showed extravasation and pooling of contrast material in the peritoneal cavity (six patients). All patients with type I CT scan findings became hemodynamically unstable soon after CT scan examination and required emergent laparotomy. Type II findings showed simultaneous presence of hemoperitoneum and intraparenchymal contrast material pooling (six patients). Four patients with type II CT scan findings required laparotomy for hemostasis. Type III findings showed intraparenchymal contrast material pooling without hemoperitoneum (three patients). All patients with type III CT scan signs remained hemodynamically stable. With the use of a high-speed spiral CT scanner, it is possible to predict the necessity of operative management or angiography for patients with blunt hepatic injury before deterioration of hemodynamic status. The presence of pooling of contrast material within the peritoneal cavity indicates active and massive bleeding. Patients with this CT scan finding show rapid deterioration of hemodynamic status. Most of these patients might require emergent surgery. Pooling of contrast material in a ruptured hepatic parenchyma indicates active bleeding. Close monitoring and emergent angiography should be performed. Deterioration of hemodynamic status in these patients usually requires prompt surgical intervention. Intraparenchymal pooling of contrast material with unruptured liver capsule often indicates a self-limited hemorrhage. Patients with this CT scan finding have a high possibility of successful nonoperative treatment.

Transcatheter Arterial Embolization in Blunt Hepatic Trauma

Patients with blunt hepatic injury can safely be managed nonoperatively if they show hemodynamic stability. Transcatheter arterial embolization (TAE) is a useful adjunct in the treatment of patients who show evidence of continued hemorrhage or who have pooling of contrast material on computed tomography (CT). In these patients, TAE may reduce transfusion requirements and allow healing of the injury without operation. Complications are uncommon and are usually managed nonoperatively.

Pooling of contrast material on computed tomography mandates aggressive management of blunt hepatic injury

Background: Nonoperative management of blunt hepatic injury is currently a widely accepted treatment modality. Computed tomography (CT) is an important imaging study both for diagnosis and follow-up of these patients. There is, however, no reliable predictor of failure of nonoperative treatment other than the ultimate development of hemodynamic instability. Previous reports mostly were based on the data obtained from low-speed dynamic incremental scanners. The purpose of this study is to evaluate the value of a high-speed helical scanner in predicting the outcome of patients managed nonoperatively. Methods: During a 30-month period, 194 patients with blunt hepatic injury were treated, 150 of them were hemodynamically stable after initial resuscitation and underwent abdominal CT examination. All CT scans were performed with the High Speed Advantage Scanner. The CT scans and medical records were reviewed. Results: Nonoperative management was successfully applied to all patients with grade I and II, 93% of grade III, 87% of grade IV, and 67% of grade V liver injuries. Twelve patients required liver-related celiotomy. Pooling of contrast material was detected on the CT scans of 8 patients. Six (75%) of these patients developed hemodynamic instability and required liver-related celiotomy later. Pooling of contrast material can be detected in 50% of the patients receiving liver-related celiotomy. Conclusion: The presence of pooling of contrast material within the hepatic parenchyma indicates free extravasation of blood as a result of active bleeding. In patients with blunt hepatic injury, if this sign is detected, nonoperative treatment should be terminated and angiography or celiotomy undertaken promptly. With the increasing use of high-speed spiral CT scanner and improvement in scanning technique, pooling of contrast material may become a sensitive sign for active bleeding and may be used as a guide for the selection of treatment modality.

TWO CASES OF PRIMARY SMALL BOWEL CANCER SHOWING EXTRALUMINAL GROWTH

Two cases of primary small bowel cancer showing extraluminal growth are repoted. Case 1 was a 61-year-old woman, who presented with abdominal pain. X-ray examination of the small bowel showed a diverticular like pooling of contrast material in the jejunum. CT showed air within the tumor. Angiography revealed encasement of the jejunal artry. Case 2 was a 72-year-old man, who presented with general fatigue. X-ray examination of the small bowel showed irregular pooling of barium with ileal stenosis. The CT and angiographic findings were similar to those in case 1. Surgical treatment consisted of resection of the tumor with the invaded adjacent organs in both cases. Histologically, both tumors showed moderately-differentiated adenocarcinoma. Carcinoma with extraluminal growth should be kept in mind when an extraluminally-growing malignant tumor of the small bowel is differentially diagnosed.

Swallowing Disorders in Patients with Prolonged Orotracheal Intubation or Tracheostomy Tubes

Eleven patients were tested for swallowing dysfunction after prolonged orotracheal intubation. Ten had a tracheostomy tube. Mean duration of orotracheal intubation was 19.9 days, mean age 65 yr, and no patient had a concomitant neurologic deficit. All patients had a modified barium swallow with videofluoroscopy. All patients had at least one defect of 11 defects characterized. There was a mean of six defects/patient. The most common defects were delayed triggering of the swallow response (present in all patients) and pharyngeal pooling of contrast material (n = 9). Follow-up videofluoroscopy was performed in five patients (all had improved) with mean defects decreasing from 6.1 to 2.8/patient. With one exception, no patient had any defect that was worse than mild in severity. We concluded that prolonged orotracheal intubation with or without tracheostomy may cause prolonged and severe swallowing dysfunction. The deficits improve with time. The presence of a gag reflex does not confer protection against aspiration of pharyngeal contrast.

Swallowing disorders in patients with prolonged orotracheal intubation or tracheostomy tubes

Eleven patients were tested for swallowing dysfunction after prolonged orotracheal intubation. Ten had a tracheostomy tube. Mean duration of orotracheal intubation was 19.9 days, mean age 65 yr, and no patient had a concomitant neurologic deficit. All patients had a modified barium swallow with videofluoroscopy. All patients had at least one defect of 11 defects characterized. There was a mean of six defects/patient. The most common defects were delayed triggering of the swallow response (present in all patients) and pharyngeal pooling of contrast material (n = 9). Follow-up videofluoroscopy was performed in five patients (all had improved) with mean defects decreasing from 6.1 to 2.8/patient. With one exception, no patient had any defect that was worse than mild in severity. We concluded that prolonged orotracheal intubation with or without tracheostomy may cause prolonged and severe swallowing dysfunction. The deficits improve with time. The presence of a gag reflex does not confer protection against aspiration of pharyngeal contrast.

Identifying types of female incontinence with retrograde urethrocystography

The most specific radiographic findings characterizing stress incontinence (SI) onupright retrograde urethrocystography include replacement of a flat or rounded bladder base with a concave funnelled base; patency of the bladder neck with contrast material pooling in the proximal urethra; the descent of the intravesical Foley balloon beyond the internal meatus and into the proximal urethra. e found that neither a cystocele nor the dependent position of the urethra at the bottom of the bladder were diagnostic of SI if the above stigmata were absent. On the other hand the defect of urgency incontinence (UI) is functional. The bladder can usually be filled by retrograde urethral infusion (though in severe UI this may not be the case). An alert technician can frequently obtain a film when the patient is, experiencing uninhibited voiding. The finding of contrast material throughout the urethra, in the distal urethra alone, or in the parameatal area is strongly suspicious for UI, especially when trabeculation is also seen. These findings in association with the stigmata of SI give warning of combined SI and UI.

Studies of oesophageal function

SUMMARYLesions of the sympathetic nervous system have been associated with grass sickness for many years (Obel, 1955). Dysphagia is also an accepted clinical feature of subacute or chronic cases. Megaoesophagus has been reported in horses with grass sickness, but it was uncertain whether oesophageal dilation was a primary condition, or a sequel to gastric distension (Greet, 1982). Robertson and others, (1948) suggested that dysphagia was alleviated in affected horses after drainage of gastric contents. It is interesting to note that dysphagia was present in less than half the cases in this study although radiological abnormalities of the oesophagus were similar in all cases.Consistent radiological abnormalities of the oesophagus occurred in 12 out of the 14 horses examined (this consisted of incoordination or atony of the thoracic oesophagus). In the two suspected cases of grass sickness which made a clinical recovery, the radiological abnormalities were slightly different. Contrast material was transferred slowly through the cervical oesophagus and pooled at the thoracic inlet as well as at several sites in the cervical oesophagus. Eventually the contrast material passed through the distal oesophagus into the stomach.Although gastric distension was present in many of the cases examined it was not possible to identify this by radiographic means. It is unlikely that the signs of oesophageal incoordination and dilation were related only to gastric distension, as in most of the cases, contrast material pooled in the oesophagus at the thoracic inlet rather than just cranial to the diaphragm. It seems reasonable to suggest that these radiological abnormalities resulted from neurological impairment of the oesophagus. It would be of particular value to examine horses with obstructive lesions of the stomach or duodenum to evaluate the effect of upper gastro‐intestinal obstruction on oesophageal motility.A number of horses with other conditions of the upper alimentary tract have been examined radiographically at these clinics. Two horses suspected of suffering from grass sickness were found to have primary oesophageal abnormalities. One had a diverticulum and the other a localized area of dilation; both showed regurgitation of food and weight loss. Barium swallows in both horses defined the sites of their localized lesions but there was no evidence of either Type I or Type II oesophageal malfunction, and at post‐mortem examination the ganglionic changes associated with grass sickness were absent. Examination of one horse with ileocaecal intussusception did not show radiological features of the oesophagus typical of those shown by cases of grass sickness. However, contrast material passed slowly through the upper oesophagus of a foal with congenital megaoesophagus in a manner similar to the Type II oesophageal malfunction described above. It also demonstrated dilation and gross inco‐ordination of the thoracic oesophagus with pooling of contrast material at the thoracic inlet and oscillation between the thoracic inlet and diaphragm as seen in Type I malfunction in proven grass sickness.It is recognized that the radiological findings of oesophageal dilation and inco‐ordination merely demonstrate the presence of neuromuscular impairment of oesophageal movement. Until more cases of upper gastro‐intestinal disease can be examined, the specificity of these functional abnormalities for grass sickness cannot be accurately assessed. However the results assume considerable diagnostic significance when demonstrated in an adult horse which is exhibiting signs of grass sickness, particularly those of colonic impaction.The need for sophisticated equipment and thus the necessity of transport to centres so equipped, is clearly a drawback to the technique but this is often outweighed by the advantage of being able to avoid unnecessary laparotomy. As there is at present no cure for grass sickness, the improved diagnostic capability will allow severely ill horses to be destroyed without delay. It may also identify horses which on rare occasions appear to be making a slow recovery.

A CASE OF ACUTE HEMORRHAGIC RECTAL ULCER COMPLICATING CEREBRAL INFARCTION

A case of acute hemorrhagic rectal ulcer complicating cerebral infarction is reported. the patient was a 75-year-old male, transferred from another hospital, with massive rectal homorrhage complicating cerebral infarction. Acute selective angiography revealed a pooling of contrast material in the left branch of the superior rectal artery. Colonofiberscopy demonstrated pulsating fibrinoid coagula at 3 O'clock direction in the rectal wall 3.5cm proximal to the anal verge. With ligation of the superior rectal artery together with resection of the ulcer, acitve bleeding discontinued. Microscopical findings showed a UL-II-type ulcer with inflammatory cell infiltration and thickening of the arterial wall. Rectal ulcers with acute massive hemorrhage compllcaing brain diseases or severe illnesses have been reported. Kawano called this lesion acute hemorrhagic rectal ulcer in 1980. There are 45 cases (including ours) of rectal ulcers like this lesion reported in the literature. With reference to these reports we discuss particularly the clinical picture.

Fixed transverse folds in the esophagus: a sign of reflux esophagitis.

Scarring from reflux esophagitis is usually manifested by circumferential stricture formation. This article reports 17 cases in which double-contrast esophagography demonstrated fixed transverse folds in the esophagus, presumably secondary to longitudinal scarring from reflux esophagitis. In all cases, pooling of contrast material between the folds produced a series of horizontal, relatively parallel collections of barium in a "stepladder" arrangement. This appearance should be distinguished from linear ulcerations, tertiary esophageal contractions, and the delicate transverse striations that are occasionally observed as a transient phenomenon on the double-contrast examination.

Clinical and arthrographic findings in meniscal cysts.

Fifty meniscal cysts (36 lateral and 14 medial) were found in a review of 2,522 knee arthrograms. Thirty-eight cysts presented as a palpable bulge. In all cases characteristic horizontal tears extended into the periphery, with pooling of contrast material and club-shaped terminations. The differential diagnosis of a bulge around the knee joint is discussed. Arthrographic evaluation is valuable in determining appropriate treatment.

Sarcoma of the kidney: angiographic features

Sarcomas of the kidney are highly malignant neoplasms. Abnormal vascularity can be detected in almost all types of sarcomas, but arteriovenous shunting, pooling of contrast material, and tumor staining are seldom present. Extension to renal vein and inferior vena cava may occur. While angiographic findings in our seven cases of renal sarcomas were nonspecific, this diagnosis should be considered in a relatively hypovascular neoplasm especially when the capsular arteries contribute considerably to the vascular supply. Nevertheless, statistically the most likely diagnosis of a hypovascular mass is renal cell carcinoma. Angiographic studies do not alter the management of the patient but merely suggest the diagnostic possibility of sarcoma. Angiographic diagnosis of different histologic types of sarcomas is not possible.