Polyvinyl Pyrollidone Research Articles

Engineering of clarithromycin loaded stimulus responsive dissolving microneedle patches for the treatment of biofilms

This study aimed to fabricate clarithromycin laden Eudragit S-100-based microfibers (MF), microfibers coated film (MB), clarithromycin loaded polyvinyl pyrollidone, hyaluronic acid and sorbitol-based dissolving microneedle patches (CP) and microfibers coated microneedle patches (MP). Morphological and phase analysis of formulations were carried out by scanning electron microscopy and differential scanning calorimetry, X-ray diffraction, respectively. Substrate liquefaction test, in vitro drug release, antimicrobial assay and in vivo antibiofilm studies were performed. MF exhibited a uniform surface and interconnected network. Morphological analysis of CP revealed sharp-tipped and uniform-surfaced microstructures. Clarithromycin was incorporated within MF and CP as amorphous solid. Liquefaction test indicated hyaluronate lyase enzyme responsiveness of hyaluronic acid. Fibers-based formulations (MF, MB and MP) provided an alkaline pH (7.4) responsive drug release; ∼79 %, ∼78 % and ∼81 %, respectively within 2 h. CP showed a drug release of ∼82 % within 2 h. MP showed ∼13 % larger inhibitory zone against Staphylococcus aureus (S. aureus) as compared to MB and CP. A relatively rapid eradication of S. aureus in infected wounds and subsequent skin regeneration was observed following MP application as compared to MB and CP indicating its usefulness for the management of microbial biofilms.

Antimicrobial potential of polyvinyl pyrollidone stabilized silver nanoparticles synthesized by Sphingobacterium multivorum

Antimicrobial potential of polyvinyl pyrollidone stabilized silver nanoparticles synthesized by Sphingobacterium multivorum

Cellulose nanofibrils reinforced chitosan-gelatin based hydrogel loaded with nanoemulsion of oregano essential oil for diabetic wound healing assisted by low level laser therapy

Diabetic foot ulcers are imperfections in the process of wound healing due to hyperglycemic conditions. Here, a nanoemulgel fabricated with oregano essential oil nanoemulsion, assisted by low-level laser therapy, was investigated for its efficacy in diabetic wound healing. A hydrogel- based healing patch, fabricated using biological polymers namely chitosan and gelatin and, polyvinyl pyrollidone. The hydrogel was reinforced with cellulose nanofibrils for enhanced stability and barrier properties. Nanoemulsion of oregano essential oil, with an average particle size of 293.7 ± 8.3 nm, was prepared via homogenization with chitosan as the coating agent. Nanoemulsion impregnated hydrogel, termed as the nanoemulgel, was assessed for its physio-mechanical properties and healing efficiency. The strong linkages in nanoemulgel demonstrated its large swelling capacity, high mechanical strength, and maximum thermal stability. The optimized conditions for low-level laser therapy using 808 nm were 1 W. cm−2 and 5 min. The optimized drug concentration of 128 μg. mL−1 exhibited viability of NIH/3 T3 fibroblasts as 75.5 ± 1.2 % after 24 h. Cell migration assay demonstrated that dual therapy facilitated wound healing, with a maximum closure rate of 100 % at 48 h. In vivo results revealed the rapid healing effects of the dual therapy in diabetic rat models with foot ulcers: a maximum healing rate of 97.5 %, minimum scar formation, increased granulation, enhanced reepithelialization, and a drastic decrease in inflammation and neutrophil infiltration within the treatment period compared to monotherapy and control. In summary, the combinatorial therapy of nanoemulgel and low-level laser therapy is a promising regimen for managing diabetic foot ulcers with a rapid healing effect.

EHDA engineering of Piroxicam-PVP components for pharmaceutical dosages

This study aimed to prepare piroxicam loaded polyvinyl pyrollidone (PVP) particulate mat, fabricated mat incorporated tablets and coated polyvinyl alcohol (PVA) films. The mat, engineered by using electrohydrodynamic atomisation (EHDA) technique, was evaluated for morphological features and particle size using scanning electron microscopy. In vitro drug release, ex vivo skin permeation and in vivo anti-inflammatory studies of oral (i.e., tablets) and topical (i.e., films) dosage forms were conducted to assess the efficiency of prepared formulations. The EHDA processed piroxicam-PVP components exhibited spherical shape, uniform surface and particle size of 3.67 ± 0.70 μm. The piroxicam mat incorporated oral and coated topical formulations exhibited release percentage of 73.79 ± 1.9% and 80.11 ± 2.3% respectively over a time period of 180 min. During ex vivo permeation study, treatment of rat skin using 500 μm microneedles led to a higher permeation of piroxicam (from coated films i.e., 75.54 ± 2.2% as compared to unpierced skin i.e., 58.23 ± 2.7% with a gradient of 0.28 and 0.21 respectively within 240 min. During in vivo anti-inflammatory study, a 52.58 ± 3.2% decrease in paw inflammation was observed in mat incorporated tablets administered group within 360 min. In comparison, topical application of coated films led to a 67.28 ± 2.9% decrease in inflammation. Microneedle treatment followed by topical application of coated films resulted in an 81.43 ± 3.1% reduction in paw inflammation over 360 min. Micropiercing of the skin resulted in breaching of uppermost skin barrier layer stratum corneum leading to an increased piroxicam permeation and rapid therapeutic response. It was concluded that EHDA processed mat incorporated tablets and coated topical films can serve as a promising choice for improving the solubility of poorly soluble piroxicam and oral/topical anti-inflammatory therapy.

Economical Voltammetric Sensor for Sensitive Rapid Determination of Ondansetron in the Presence of Opioid Antagonist Naltrexone

The electrochemical actions of ondansetron (OND) were investigated on the modified electrode with Polyvinyl Pyrollidone (PVP) and multi-walled carbon nanotube (MWCNTs). The oxidation peak current was enhanced to be doubled when compared to the bare electrode as a result of the synergistic effect of nanomaterial and cation-exchange polymer on the electron transfer rate. Following optimization of the experimental conditions, the Square Wave Voltammograms (SWV) method was employed to determine ondansetron in pharmaceutical formulations. Moreover, the modified electrode MWCNTs/PVP/CPE displayed high selectivity in the voltammetric measurements of ondansetron and co-administrated opioid antagonist drug naltrexone (NAL) with strong potential separation (422 mV). The response peak currents had a linear relationship with drug concentration in the range of (2.00–200.0 nmolL−1) with detection limits 430 pmolL−1 and 456 pmolL−1 for ondansetron and naltrexone, respectively. The electrode was successfully used to detect both medications electrochemically in human plasma samples.Graphical abstract

In-vitro biocompatibility studies of nanochitosan/ polyvinylpyrrolidone blends on MC3T3-E1 cells showing beneficial effect in bone tissue engineering

Chitosan is a naturally occurring polymer with numerous biological properties that can be used in the biomedical field. Chitosan was modified to nanochitosan in this study. The polycationic nature of chitosan interacts with polyanions (TPP) to form nanoparticles. The prepared nanochitosan was mixed with polyvinyl pyrollidone to create binary blends with ratios of 1:1, 1:2, and 2:1. The polymeric blends were interpreted by using the analytical tools FTIR, XRD and SEM. The results of the FTIR and XRD confirm the formation of binary blends with strong electrostatic interaction. The study aims to investigate the compatibility of the prepared blend as tissue regenerative material. The blends were evaluated in-vitro using fluorscent spectroscopy, MTT assay, NRR assay and ALP assay to study its biocompatibility and cell viability. The results revealed that the quick multiplication followed by a moderate increment in cell number of MC3T3-E1 as cells reacted to the prepared material and hence the materials can be used in the regenerative medicine.

Tailoring Release Profiles of BCS Class II Drugs Using Controlled Release Amorphous Solid Dispersion Beads with Membrane-Reservoir Design: Effect of Pore Former and Coating Levels.

Poor aqueous solubility is a major limiting factor during the development of BCS Class II drug candidates in a solid oral dosage form. Conventional amorphous solid dispersion (ASD) systems focus on maximizing the rate and extent of release by employing water-soluble polymeric crystallization inhibitors; however, they often encounter rapid supersaturation and solution-mediated phase transformation (SMPT). Therefore, in this work, a controlled release membrane was introduced onto ASD beads to mitigate the SMPT problem. A membrane-reservoir controlled release amorphous solid dispersion (CRASD) bead system was designed, and the effects of the coating thickness and pore former content on drug release profiles were investigated. CRASD beads were manufactured by spray-coating polyvinyl acetate with polyvinylpyrollidone (PVP) as a pore former onto sugar bead substrates layered with the ASD reservoir of celecoxib and PVP. Raising the pore former content and/or lowering the coating level imparted higher release rates and supersaturation levels. The extent of release, measured by the area under the curve, was greatest when an optimal balance between the release rate and peak concentration could be established, corresponding to a high pore former/high coating level combination. Attributed to a thicker membrane structure with a higher pore former, rapid initial release could be achieved, yet controlled gradually for several hours, avoiding the critical threshold where the onset of SMPT predominates. The greater membrane capacity to transiently immobilize drug molecules (i.e., preserve amorphicity) and gradually release drug over a prolonged duration may be key to balancing supersaturation on both sides of the membrane; hence coating variables should be tactfully selected to exploit this benefit.

Evaluation of the effect of carrier material on modification of release characteristics of poor water soluble drug from liquisolid compacts.

Liquisolid compact is a novel dosage form in which a liquid medication (liquid drug, drug solution/dispersion in non-volatile solvent/solvent system) is converted to a dry, free flowing powder and compressed. Objective of the study was to elucidate the effect of carrier material on release characteristics of clopidogrel from liquisolid compacts. Different formulations of liquisolid compacts were developed using microcrystalline cellulose, starch maize, polyvinyl pyrollidone and hydroxypropyl methylcellulose as carrier material in three concentrations (40, 30 and 20%, w/w). Liquid vehicle was selected on the basis of solubility of clopidogrel. Colloidal silicondioxide was used as coating material and ratio of carrier to coating material was kept 10. A control formulation comprised of microcrystalline cellulose (diluents), tabletose-80 (diluents), primojel (disintegrant) and magnesium stearate (lubricant) was prepared by direct compression technique and was used for comparison. All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and water (2:1, v/v) was selected as liquid vehicle. Drug content was in the range of 99–101% of the claimed quantity. All the formulations showed better mechanical strength and their friability was within the official limits (<1%). Microcrystalline cellulose and starch maize resulted in faster drug release while polyvinyl pyrollidone and HPMC resulted in sustaining drug release by gel formation. It is concluded from results that both fast release and sustained release of clopidogrel can be achieved by proper selection of carrier material.

Antibiofilm Effects of Macrolide Loaded Microneedle Patches: Prospects in Healing Infected Wounds.

The aim of this study was to fabricate polymeric microneedles, loaded with macrolides (erythromycin, azithromycin), using hyaluronic acid and polyvinyl pyrollidone. These microneedles were fabricated using a vacuum micromolding technique. The integrity of the microneedle patches was studied by recording their morphologic features, folding endurance, swelling and micro-piercing. Physicochemical characteristics were studied by differential scanning calorimetry, thermogravimetric analysis and fourier transform infrared spectroscopy. In-vitro drug release, antibiofilm and effect of microneedle patch on wound healing were also studied to confirm the efficacy of the formulations. Formulated patches displayed acceptable folding endurance (>100) and uniform distribution of microneedles (10 × 10) that can penetrate parafilm. Differential scanning calorimetry results depict a decrease in the crystallinity of macrolides following their incorporation in to a polymer matrix. Percentage release of azithromycin and erythromycin from the polymeric patch formulations (over 30min) was 90% and 63% respectively. Broadly, the zone of bacterial growth inhibition follows the same order for Staphylococcus aureus, Escherichia coli and Salmonella enterica. After 5days of treatment with azithromycin patches, the wound healing was complete and skin structure (e.g. hair follicles and dermis) was regenerated. It was concluded that azithromycin loaded microneedle patches can be used to treat biofilms in the infected wounds.

Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres

The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin sodium microspheres were prepared using polyvinyl pyrollidone K-30 and Poloxamer 407 through solvent evaporation via freeze drying. We adopted a central composite design to examine the influence of independent variables viz. drug:polymer (X1) and surfactant (X2) on the t50 % (Y1), Q90 (Y2) and percentage drug content (Y3) along with determination of an optimized composition for production of an optimal Fluvastatin sodium microspheres. Design expert software illustrated that an optimized Fluvastatin sodium microspherescould be achieved using 1:3.496 drug:polymer and 3.102 % poloxamer 407 which would illustrates t50 % (36.33 min), Q90 (79.99 %) and percentage drug content (81.589 %). The mean diameter and polydispersity index of Fluvastatin sodium microspheres using dynamic light scattering was found 0.78 μm and 0.287, respectively. Sustained release tablet of optimized Fluvastatin sodium microspheres (Fluvastatin sodium microspheres-sustained release tablet) was manufactured using Eudragit RS 100 and Eudragit RL 100 based granules by wet granulation technique. In vitro drug release kinetics studies were executed to assess the drug release mechanism from optimized Fluvastatin sodium microspheres and Fluvastatin sodium microspheres-sustained release tablet. The dissolution level of Fluvastatin sodium was 3.58-fold improved wthin 2 h through the freeze dried microspheres. Fluvastatin sodium microspheres-sustained release tablet showed sustained drug release over 24 h and was matched properly to Korsmeyer-Peppas model with release exponent of 0.5318, which indicated drug release through diffusion and erosion mechanism. Conclusively, it has been demonstrated that novel combination of freeze dried microspheres and their Eudragit polymers-based matrix tablet techniques could find great potential for improving drug dissolution and sustained release of water insoluble drugs along with reduced dosage frequency.

Solubility Enhancement of Methotrexate by Solid Nanodispersion Approach for the Improved Treatment of Small Cell Lung Carcinoma.

The present work aimed to develop MT loaded solid Nano dispersion by improving its solubility, half-life and bioavailability in biological system thereby this formulation may be afforded economically. Small cell lung carcinoma is a type of malignant tumor characterized by uncontrolled cell growth at lung tissues. The potent anti-cancer drug methotrexate (MT) chosen for the present work is poorly soluble in water (BCS type IV class) with short half-life and hepatotoxic effect. With the concept of polymeric surfactant to improve the solubility along with wettability of drugs, the present work has been hypothesized to improve its solubility using polyvinyl pyrollidone (PVP K30) polymer and α- tocopheryl polyethylene glycol 1000 succinate (TPGS) surfactant, thereby the bioavailability is expected to get enhanced. By varying the PVP K30 and TPGS ratios different formulations were developed using emulsification process. The developed MT loaded solid nanodispersion was further characterized for its particle size, charge, morphology, encapsulation efficiency and in-vitro release behavior etc. Results: The results of FT-IR spectrometric analysis indicated the compatibility nature of MTX, PVPK30 and TPGS. The developed formulations showed spherical morphology, particle size ranging from 59.28±24.2 nm to 169.33±10.85 nm with a surface charge ranging from -10.33 ± 2.81mV to -9.57 ± 1.2 mV. The in vitro release studies as performed by dialysis bag method showed a sustained release pattern as checked by UV Spectrophotometer. Residual solvent analysis for MTXNDs performed by HPLC indicates there is no residual DMSO in the formulation. Transmission electron microscopic image of MTXNDs revealed that the particles are spherical shaped with a solid core structure. Haemolytic assay indicates that the developed formulation is safe for intravenous administration. Cell culture studies in A549 cells indicates the enhanced cytotoxic effect for the developed formulation. This proof of study indicates that the developed formulation may have anticancer potential for SCLC treatment.

Graft copolymerization of polyvinylpyrollidone onto Azadirachta indica gum polysaccharide in the presence of crosslinker to develop hydrogels for drug delivery applications

In this work, graft-copolymerization of poly vinylpyrollidone onto Azadirachta indica gum polysaccharide in the presence of crosslinker has been carried out to prepare the hydrogel for use in drug delivery. The polymers were characterized by cryo-SEM, AFM, FTIR, and 13C NMR. The gel strength, cross-link density, mesh size, thrombogenicity, antioxidant and mucoadhesion properties of the gum-PVP hydrogels were determined along with the evaluation of drug release profile of methyl prednisolone, a colonic anti-inflammatory agent, from the drug loaded hydrogels. Cryo SEM images showed the porous crosslinked structure of the polymer network. The drug release from the polymer followed non-Fickian diffusion mechanism. The polymers showed 71.47 ± 4.63% haemo-compatibility and 05.52 ± 0.59 Nmm gel strength. The value of DPPH radical scavenging assay (73.16 ± 04.85%) indicated that the gum-PVP polymers are antioxidant. The results of biocompatibility, antioxidant activity, mucoadhesion and drug release properties of the polymers inferred the use of this drug carrier for colonic drug delivery.

Influence of polymer washing on thermal conductivity enhancement of Cu nanofluids

AbstractThis work aims at enhancing the thermal conductivity of base fluids (water and methanol) through successive washing of polymers from the surface of polyvinylpyrollidone (PVP)‐stabilized copper (Cu) nanoparticles. Cu nanofluids were successfully synthesized and characterized using transmission electron microscope and UV–vis spectrophotometer. Thermal conductivity of freshly prepared Cu nanofluid shows ~10% enhancements. The poor enhancement in thermal conductivity is due to the presence of thick polymer coating on the surface of nanoparticles. A new technique has been developed to erode the polymers from the nanoparticle surface by repeated washing and redispersion. After one‐time washing and redispersion, the thermal conductivity of nanofluid has been increased to 0.732 W/mK (~22% enhancements). Greater enhancement (~30.34%) has been achieved after three times continuous washing and redispersion. Finally, the experimental values of thermal conductivity were compared and validated against the existing Maxwell effective model.

Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique.

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7±1.12μg/ml) was amplified 20-fold in FSS-SD (179±4.16μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

Gene expression programming for process parameter optimization during ultrafiltration of surfactant wastewater using hydrophilic polyethersulfone membrane

Surfactants are the emerging contaminant and cause a detrimental effect on the ecosystem. In this study, an attempt is made to removal anionic surfactant Sodium dodecyl sulfate (SDS) containing wastewater using hydrophilic polyvinylpyrollidone (PVP) (5–15 wt%) modified polyethersulfone (PES) ultrafiltration membrane. The influence of operating variables on membrane performance was also sequentially analyzed using tests and three numerical modeling methods such as multiple linear regression (MLR), multiple Ln-equation regression (MLnER), and gene expression programming (GEP). Contact angle value of 10 wt% PVP modified PES membrane decreased up to 23.8°, whereas the neat PES membrane is 70.7°. This study indicates that the required hydrophilic property was improved in the modified membrane. The water flux and porosity also enhanced in PVP modified PES membranes. In performance evaluation, the optimum operating variable condition of transmembrane pressure (TMP), feed concentration, and the temperature is found to be 3 bar, 100 ppm, and 25 °C, respectively. Among the models, GEP has a good correlation with experimental anionic surfactant SDS filtration data. GEP performs better than other model with respect to statistical parameter and error terms. This study provides an insight into an adaptation of novel numerical modeling methods for the prediction of membrane performance to the treatment of surfactant wastewater.

Fully Reversible Electrically Induced Photochromic-Like Behaviour of Ag:TiO2 Thin Films

A TiO2 thin film, prepared on fluorine-doped indium tin oxide (FTO)-coated glass substrate, from commercial off-the-shelf terpinol-based paste, was used to directly adsorb Ag plasmonic nanoparticles capped with polyvinylpyrollidone (PVP) coating. The TiO2 film was sintered before the surface entrapment of Ag nanoparticles. The composite was evaluated in terms of spectroelectrochemical measurements, cyclic voltammetry as well as structural methods such as scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). It was found that the Ag nanoparticles are effectively adsorbed on the TiO2 film, while application of controlled voltages leads to a fully reversible shift of the plasmon peak from 413 nm at oxidation inducing voltages to 440 nm at reducing voltages. This phenomenon allows for the fabrication of a simple photonic switch at either or both wavelengths. The phenomenon of the plasmon shift is due to a combination of plasmon shift related to the form and dielectric environment of the nanoparticles.

Central composite designed ezetimibe solid dispersion for dissolution enhancement: synthesis and in vitro evaluation.

Aim: The current research is focused on increasing aqueous solubility and dissolution of BCS class II drug by using modified solvent evaporation technique to produce solid dispersions of ezetimibe (EZSD) using gelucire 50/13 and polyvinyl pyrollidone K30. Methodology & results: Central composite design analyzed the effect of gelucire 50/13 and polyvinyl pyrollidone K30 on the percentage of drug released in 5 and 30min. Ezetimibe (EZ) aqueous saturation solubility (4.56±0.94μg/ml) was increased 25-fold in EZSD (115±3.41μg/ml). Cumulative drug release from EZ and optimized EZSD were observed 24.67 and 87.54% within 1h, respectively. Conclusion: Manufacturing EZSD using modified solvent evaporation technique using rotary evaporator holds great promise for enhancing EZ's solubility and dissolution.

Effect of graphene oxide (GO) and polyvinylpyrollidone (PVP) additives on the hydrophilicity of composite polyethersulfone (PES) membrane

Membrane based separation system is considered as a promising technology to purify water, owing to its simplicity and efficiency in operation. However, the application is limited by membrane fouling, which can lead to the declination of water flux and premature failure of membrane. The fouling can be controlled through membrane surface modification by blending hydrophilic materials during the casting solution preparation. Polyethersulfone (PES) membrane is naturally hydrophobic due to lack of oxygen functional group, which limits its application in the filtration of water. Therefore, modification of PES-based membranes is required. In this work, modification of the PES membrane was carried out by incorporating carbon-based nanomaterials (graphene oxide (GO)) and a well-known organic polymer (polyvinylpyrrolidone (PVP)). The effect of each additive toward the hydrophilicity of composite PES membrane was then investigated. GO was synthesized using modified Hummers method due to its simpler and shorter process. Each additive was added during the casting solution preparation and the amount added was varied from 0.5 to 1.0 wt%. The resultant composite PES membranes were characterized using XRD, FTIR and TGA prior to hydrophilicity and pure water flux (PWF) measurement. It was observed that the additives (PVP and GO) have significantly affected the membranes hydrophilicity, resulting in lower contact angle and higher pure water flux. The highest value of PWF (230 L/m2.h) with lowest contact angle (42 °) were observed for PES-1.0GOPVP membrane due to high amount of GO and PVP. Improved PWF performance of composite PES-1.0GOPVP membrane was attributed to the better dispersibility of the PVP and GO and increased surface hydrophilicity of the modified composite membranes. This study indicated that PVP and GO are effective modifiers to enhance the performance of PES membrane

Tobramycin Collagen Fast Dissolving Ocular Films for Corneal Tissue Engineering of Keratoconus

Fast dissolving films are a one of novel dosage form in pharmaceutical research. They have convenience and ease of use over other dosage forms such as orally disintegrating tablets and immediate release tablets. In the present research, rapidly dissolving films of Tobramycin were developed using Polyvinyl acetate (PVA) and polyvinyl pyrollidone (PVP) as film forming polymers by solvent casting method. The prepared films were evaluated for drug content, weight variation, thickness and in vitro in vivo disintegration time. The in vitroand in vivodissolving time of the optimized formulation was found to be below 15–40 seconds respectively. The prepared films exhibited good integrity and thickness. In vitro dissolution studies were performed as per the FDA dissolution guidelines for about 3 minutes, the optimum formulation released complete drug within 3 minutes. Statistical analysis showed no drug polymer interaction.

A review on Nanocomposite Drug Delivery

Low aqueous solubility is the major problem come across the formulation development of new chemical entities as well as for the generic development. Supplementary than 40% New Chemical Entities developed in pharmaceutical industry are practically insoluble in water. Hence, there is a need for boosting the solubility and dissolution of such drugs. Enhancement of the solubility and dissolution of the practically insoluble drug was achieved by forming nanocomposites. Nanocomposities are formed by using synthetic polymers such as gelatin, chitosan, polyvinyl pyrollidone, carboxymethyl cellulose, etc. Selection of polymers was based on their surfactant and wetting properties. To check the solubility enhancement of drugs solubility studies is carried out. Nanocomposites are characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. As the concentration of polymer in the composite increased the solubility and dissolution of poorly water soluble drug were enhanced. In end, new technology require substances showing novel properties and/or progressed performance in comparison to conventionally processed additives. In this context, nanocomposites are appropriate materials to meet the emerging needs bobbing up from medical and technologic advances. Keywords: nanocomposites, polymers, synthesis.