Poly Vinyl Alcohol Networks Research Articles

Highly selective CO2 permeable double-network ionogel membrane containing 1-ethyl-3-methylimidazolium dicyanamide

A double-network (DN) ionogel membrane containing 1-ethyl-3-methylimidazolium dicyanamide ([C2mim][DCA]) was developed and evaluated for its mechanical robustness and its CO2 permeation properties. Polyvinyl alcohol (PVA) was used as the initial network for the DN ionogel membrane. It forms a partially-crystalline physical crosslinking within [C2mim][DCA] and acts as a sacrificial bond to toughen the ionogel. A loosely crosslinked poly(N,N-dimethylacrylamide) (PDMAAm) network was formed by free-radical polymerization to interpenetrate with the physically crosslinked PVA network. The more the gel was elongated, the more the physical crosslinking in the PVA network were broken and the more energy was dissipated. As a result, the ion gel toughened. Owing to its excellent toughness, the developed DN ionogel membrane retained 93 wt% of [C2mim][DCA] and exhibited the CO2 permeability and the CO2 perm-selectivity over N2 of 2920 barrer and 61, respectively, the highest level of CO2 separation performance among the latest CO2 separation membranes. The DN ionogel membrane kept the CO2 separation performance required for CO2 capture from flue gases from coal-fired power plants even at 80 °C and 80 % relative humidity.

Synthesis of Water-Soluble Polyethylene Glycol Fumarates for Biomedical Applications

Polyethylene glycol fumarate (PEGF) with controlled structural composition has been obtained for further synthesis of double network crosslinked hydrogels for biomedical applications. The copolymer has been synthesized by polycondensation reaction of fumaric acid and polyethylene glycol (PEG-600). Molecular weight of PEGF has been determined by gel permeation chromatography to be approximately 6000 Da with gel permeation chromatography. The polycondensation of fumaric acid and PEG-600 was studied throughout the reaction process. The structure of the reaction product has been evidenced using FTIR- and 1H NMR-spectroscopy. The quantitative ratios of the amount of –C=C– bonds and –COO groups to –C=O groups in the obtained PEGF have been estimated from IR-spectra for different synthesis time. The time-dependence of molar ratio of double bonds to methyl groups in PEGF has been obtained from corresponding 1H NMR-spectra. FTIR and 1H NMR-spectroscopy, both, demonstrate that after the end of reaction the unsaturated –C=C– double bonds remain in the structure of the macromonomer, that is essential for further preparation of cross-linked hydrogels. The addition of the tightly cross-linked network of polyvinyl alcohol leads to formation of highly tough biocompatible material for preparation of the artificial meniscus which can further be used as a solution n the treatment of diseases such as osteoarthritis.

Hydrogel network of polyvinyl alcohol (PVA), pyrogallol (PG) and Fe(III) for building superhydrophilic PVDF membrane

High hydrophobicity of polyvinylidene fluoride (PVDF) membrane surface results in adsorption of oil droplets and membrane fouling. A hydrogel coating with crosslinking network of polyvinyl alcohol (PVA), pyrogallol (PG) and Fe(III) based on PVDF membrane was proposed. Hydrogen bonds between PVA and PG in water were regulated by ethanol to form a uniform hydrophilic hydrogel coating on PVDF membrane. Chelation between PG and Fe3+ significantly enhanced hydrogel adhesion. The surface energy of the developed PVDF-PVA/PG-Fe3+ membrane was 39.96 mJ·m−2, 2.71 times that of the pristine PVDF membrane, while its adhesion to oil is close to 0 μN. The permeate flux reached 1341 L·m−2· h−1 at 0.1 bar for separating isooctane-in-water emulsions with good separation efficiency (>99 %) and cycling stability. The developed membrane could also effectively separate petroleum ether-in-water and dodecane-in-water emulsions.

Bio‐Inspired Magnetic‐Responsive Supramolecular‐Covalent Semi‐Convertible Hydrogel

Bio-inspired magnetic-responsive hydrogel is confined in exceedingly narrow spaces for soft robots and biomedicine in either gel state or magnetofluidic sol state. However, the motion of the gel state magnetic hydrogel will be inhibited in various irregular spaces due to the fixed shape and size and the sol-state magnetofluid gel may bring unpredictable residues in the confined narrow space. Inspired by the dynamic liquid lubricating mechanism of biological systems, novel magnetic-responsive semi-convertible hydrogel (MSCH) is developed through imbedding magnetic-responsive gelatin and amino-modified Fe3O4 nanoparticles network into the covalent network of polyvinyl alcohol, which can be switched between gel state and gel-sol state in response to magnetic stimuli. It can be attributed the disassembly of triple-helix structures of the gelatin under the action of the magnetic field, driven by force from the magnetic particles conjugated on the gelatin chain through electrostatic interactions, while the covalent network retains the hydrogel structural integrity. This leads to a sol layer on the MSCH surface enabling the MSCH to pass effectively through the confined channel or obstacle under magnetic field. The present MSCH will provide an alternative mode for magnetic field-related soft robots or actuators.

Vanillin/fungal-derived carboxy methyl chitosan/polyvinyl alcohol hydrogels prepared by freeze-thawing for wound dressing applications

In this study, we developed hydrogels using polyvinyl alcohol (PVA), vanillin (V), and a fungus-derived carboxymethyl chitosan (FC) using a freeze-thaw-based method. These hydrogels were strengthened by bonding, including Schiff's base bonding between V and FC and hydrogen bonding between PVA, FC, and V. The physiological properties of these PFCV hydrogels were characterized by FTIR, TGA, compressive mechanical testing, and rheology and water contact angle measurements. FTIR spectra confirmed the effective integration of FC and V into the PVA network. TGA results showed that FC and V enhanced the thermal stability of PFCV hydrogels. Mechanical tests showed increasing the amount of V reduced mechanical properties but did not alter the elastic character of hydrogels. SEM images displayed a well-interconnected porous structure with excellent swelling capacity. In addition, we examined biological properties using cell-based in vitro studies and performed antibacterial assessments to assess suitability for potential wound dressing applications. Prestoblue™ and live/dead cell analysis strongly supported skin fibroblast attachment and viability, DPPH assays indicated substantial antioxidant activity, and PFCV hydrogels showed enhanced antibacterial effects against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). In summary, incorporating V and FC into PVA hydrogels appears to be attractive for wound dressing applications.

Bovine Serum Albumin/Polyvinyl Alcohol Double‐Network Hydrogel Containing ϵ‐Polylysine for Antibacterial Performance

AbstractWith the discovery and abuse of antibiotics, bacterial resistance has become a key problem in the field of antibacterial materials. Therefore, antibacterial materials that can effectively inhibit bacterial infection are considered to be important biological materials. In this study, a double‐network hydrogel system was designed using bovine serum albumin (BSA) and polyvinyl alcohol (PVA) as the main body. The first network was formed by reducing the disulfide bond on BSA to sulfhydryl group by tris (2‐carboxyethyl) phosphine (TCEP). The second network of PVA was used as the hydrogel to prepare a double‐network hydrogel with good mechanical strength. The introduction of ϵ‐polylysine gives the hydrogel antibacterial activity, which enables it to destroy the cell structure and kill bacteria through electrostatic interaction, and can effectively solve the problem of drug resistance in the field of antibacterial medicine.

One-step Fabrication of Physical Eutectogel with Recyclability: Crystalline Domain Regulation Induced by Microgels

HypothesisDespite their non-volatility, low cost, and recyclability, physical eutectogels’ appeal is hindered by the intricate fabrication process and the involvement of hazardous chemicals. The network of polyvinyl alcohol (PVA) in deep eutectic solvent (choline chloride and glycerol) might be developed by the addition of microgels of polyacrylic acid (Carbopol). ExperimentsHydrogen-bond interactions between Carbopol and PVA are revealed through Fourier-transform infrared spectroscopy. The impact of microgels on crystalline domains and the polymer network can be observed using X-ray diffraction and scanning electron microscopy. The physical properties of the eutectogel, including mechanical strength and ionic conductivity, are investigated as well. Finally, the strain-sensing ability and remarkable recyclability of the eutectogel are demonstrated. FindingsThe physical eutectogel can be obtained through a one-step fabrication process using only green and low-cost materials. It demonstrates robust strength (1.02 MPa) and remarkable stretchability (1000 % strain). This is attributed to the uniform dispersion of PVA crystalline domains within the deep eutectic solvent, facilitated by the hydrogen bonds and space restriction effects between PVA and Carbopol. Furthermore, the physical eutectogel with recyclability can consistently generate electrical resistance signals, highlighting its potential as a reliable strain sensor.

A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds

Wound management is an important issue that places enormous pressure on the physical and mental health of patients, especially in cases of infection, where the increased inflammatory response could lead to severe hypertrophic scars (HSs). In this study, a hydrogel dressing was developed by combining the high strength and toughness, swelling resistance, antibacterial and antioxidant capabilities. The hydrogel matrix was composed of a double network of polyvinyl alcohol (PVA) and agarose with excellent mechanical properties. Hyperbranched polylysine (HBPL), a highly effective antibacterial cationic polymer, and tannic acid (TA), a strong antioxidant molecule, were added to the hydrogel as functional components. Examination of antibacterial and antioxidant properties of the hydrogel confirmed the full play of the efficacy of HBPL and TA. In the in vivo studies of methicillin-resistant Staphylococcus aureus (MRSA) infection, the hydrogel had shown obvious promotion of wound healing, and more profoundly, significant suppression of scar formation. Due to the common raw materials and simple preparation methods, this hydrogel can be mass produced and used for accelerating wound healing while preventing HSs in infected wounds.

The spectral properties and dispersion parameters of electrospun nanofibers Poly(vinyl alcohol/ Poly(acrylamide)

Electrospun nanofibers based on polyvinyl alcohol (PVA), polyacrylamide (PAAm), and a PVA-PAAm blend (50/50 wt.%) were effectively made a room temperature(RT) and a voltage of (12kV). The products were studied using Field Emission Scanning Electron Microscope (FESEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy(FT-IR) and Ultraviolet-visible (UV–Vis) spectroscopy. The result of FESEM analysis showed that the polymer PVA, PAAm, and blend samples produced a random distribution of fine fibres at an average diameter of (214.12, 317.1, 157.65) nm with a smooth surface. In addition, the FESEM images demonstrate the fibres' suitability for use in gas sensing applications due to their branching fibres and porosity surface. XRD showed that the film polymeric of PVA, PAAm polymeric blend PVA-PAAm was seen to have a semicrystalline nature. According to the FTIR analysis, the PVA and PAAm networks in the PVA-PAAm polymer nanofibers were entangled due to the powerful hydrogen bond contact between the PAAm and PVA chains. Observed around (3473.79 and 3414) cm-1 were attributed to the N–H vibration and overlapped to O–H stretching. The spectra of the prepared films exhibit prominent absorption peaks, which are at the wavelength range (200-320) nm. PVA-PAAm polymer nanofibers decrease the energy gap from 3.70eV to 3.40eV. The Wemple-DiDomenico model was used to derive dispersion parameters such as dispersion energy, single oscillator energy, Urbach energy, the static refractive index and the moments of optical spectra the result of calculating by this model was compatible with that value calculated by the Tauc relation. While increased which qualifies them to be used in the electronic devices.

Wearable multifunctional organohydrogel-based electronic skin for sign language recognition under complex environments

Language barrier is the main cause of disagreement. Sign language, which is a common language in all the worldwide language families, is difficult to be entirely popularized due to the high cost of learning as well as the technical barrier in real-time translation. To solve these problems, here, we constructed a wearable organohydrogel-based electronic skin (e-skin) with fast self-healing, strong adhesion, extraordinary anti-freezing and moisturizing properties for sign language recognition under complex environments. The e-skin was obtained by using an acrylic network as the main body, aluminum (III) and bayberry tannin as the crosslinking agent, water/ethylene glycol as the solvent system, and a polyvinyl alcohol network to optimize the network performance. Using this e-skin, a smart glove was further built, which could carry out the large-scale data collection of common gestures and sign languages. With the help of the deep learning method, specific recognition and translation for various gestures and sign languages could be achieved. The accuracy was 93.5%, showing the ultra-high classification accuracy of a sign language interpreter. In short, by integrating multiple characteristics and combining deep learning technology with hydrogel materials, the e-skin achieved an important breakthrough in human-computer interaction and artificial intelligence, and provided a feasible strategy for solving the dilemma of mutual exclusion between flexible electronic devices and human bodies.

Integration of inorganic ionic oligomers and nanocellulose within PVA networks: A degradable and green nanocomposite with self-healable property and high mechanical strength in a wet state

Preparation of green expandable biodegradable polymer materials with high strength and toughness has always been the goal of researchers. Although the research of biodegradable polymer materials has made some progress in recent years, it is still a huge challenge to prepare biodegradable polymer materials with green expandable technology. In this study, biodegradable polyvinyl alcohol (PVA), inorganic calcium phosphate oligomers (CPO ∼ 1 nm), and TEMPO oxide cellulose nanofibers (TOCN) were used to prepare composite materials through simple and green process. The obtained materials, due to the high density of hydrogen bonds and coordination interaction, are conducive to the preparation of PVA-based plastics with fracture strength ≈176.0 MPa. The breaking strength of PVA-based plastics after soaking in water for 7 days at room temperature is ≈ 16.1 MPa, similar to polyethylene in the dry state. In addition, PVA/TOCN/CPO composites can be processed into products with the required shape.

2D MXenes Embedded Perovskite Hydrogels for Efficient and Stable Solar Evaporation.

Solar evaporation is a facile and promising technology to efficiently utilize renewable energy for freshwater production and seawater desalination. Here, the fabrication of self-regenerating hydrogel composed of 2D-MXenes nanosheets embedded in perovskite La 0.6Sr 0.4Co 0.2Fe 0.8O3- δ (LSCF)/polyvinyl alcohol hydrogels for efficient solar-driven evaporation and seawater desalination is reported. The mixed dimensional LSCF/Ti3C2 composite features a localized surface plasmonic resonance effect in the polymeric network of polyvinyl alcohol endows excellent evaporation rates (1.98kg m-2 h-1) under 1k Wm-2 or one sun solar irradiation ascribed by hydrophilicity and broadband solar absorption (96%). Furthermore, the long-term performance reveals smooth mass change (13.33kg m-2) during 8 h under one sun. The composite hydrogel prompts the dilution of concentrated brines and redissolves it back to water (1.2g NaCl/270 min) without impeding the evaporation rate without any salt-accumulation. The present research offers a substantial opportunity for solar-driven evaporation without any salt accumulation in real-life applications.

Construction of organic–inorganic hybrid heterostructure towards solvent responsive hydrogel with high stiffness

Solvent responsive hydrogel is a kind of intelligent soft material, which can be used in soft robots. Currently, most of the solvent responsive hydrogels are based on pure organic materials which has limited stiffness for actuations. Herein, a novel organic–inorganic composite hydrogel is designed and prepared. Calcium phosphate oligomers nanoclusters are incorporated in polymer solution containing polyvinyl alcohol (PVA) and sodium alginate to form organic–inorganic hybrid copolymer suspensions. The solvent responsive hydrogel is simply prepared using co-evaporation method by optimizing the components in the colloid system. The inorganic nanoparticles work as the scaffold in the porous PVA network and the evaporation caused nonuniformity distribution further induces the formation of heterostructure, which has different shrinkage ratios along the thickness direction. The prepared hydrogel demonstrates excellent shape memory property by changing the environmental solvents between water and ethanol and its repeatability is also verified. The stiffness of hydrogel is enhanced and it has large deformation after incorporation of calcium phosphate nanoparticles. The bending angle of hydrogel can be well controlled by different water to ethanol ratios, allowing for underwater actuation. The functionality of an artificial gripper based on responsive hydrogel with high stiffness is demonstrated to transfer objects in ethanol. The design of organic–inorganic composite hydrogel with high stiffness may provide new insights for preparation of intelligent soft materials for underwater applications.

Fabrication of electrospun nanofibrous thermoresponsive semi-interpenetrating poly(N-isopropylacrylamide)/polyvinyl alcohol networks containing ZnO nanoparticle mats: characterization and antibacterial and cytocompatibility evaluation.

Thermoresponsive nanofiber composites comprising biopolymers and ZnO nanoparticles with controlled release and antibacterial activity are fascinating scientific research areas. Herein, poly(N-isopropylacrylamide) (PNIPAm) was prepared and mixed with poly(vinyl alcohol) (PVA) in 75/25 and 50/50 weight ratios together with ZnO (0, 1, and 2 phr) to construct nanofiber composites. The morphology of the crosslinked nanofiber composites, ZnO content, and their mechanical behavior were assessed by SEM, EDX, and tensile analyses. The wettability results show an increment in nanofiber surface hydrophobicity by increasing the temperature above the LCST of PNIPAm. The in vitro ZnO release exhibits a faster release profile for the sample with 50 wt% PNIPAm (lower crosslinking density) compared to the one with 25 wt%. Besides, a strong interaction between PVA hydroxyl groups and ZnO can restrict the release content. However, by increasing the temperature from 28 to 32 °C, the relative ZnO release becomes half for both compositions. All crosslinked nanofiber composites demonstrated reliable biocompatibility against L929 fibroblast cells. Agar disc-diffusion and optical density methods showed thermo-controllable antibacterial activity against Staphylococcus aureus upon temperature variation between 28 and 32 °C. Furthermore, in vivo and histological results indicate the potentiality of the prepared multidisciplinary wound dressing for robust wound healing and skin tissue engineering.

Unlimited recyclable wearable sensors based on a homogeneous ionic liquid and polyvinyl alcohol network

Smart wearable electronics are now of great significance in the fields of biomedical applications and environmental sensors.

Infrared-light-driven self-healing MoS2/polyvinyl alcohol hydrogel with simultaneous enhancement of strength and ductility

Self-healing hydrogels exhibit special self-healing or self-recovery function like human skin after injuring, thereafter, draw lots of attention in biomedical applications. However, self-healing hydrogels with strong mechanical and rapid self-healing properties are not fully realized. MoS 2 /polyvinyl alcohol (PVA) hydrogels are developed to achieve rapid self-healing function by utilizing the excellent photothermal conversion effect of MoS 2 under near-infrared (NIR) light. Effects of microstructure and content of MoS 2 on self-healing and mechanical properties of MoS 2 /PVA hydrogels are investigated, including flower-like MoS 2 spheres by bottom-up hydrothermal reaction and MoS 2 sheets by liquid-phase stripping method. The MoS 2 /PVA hydrogels embodied with the two types of MoS 2 were produced by simple freezing/thawing method, and exhibited rapid self-healing function, together with simultaneous enhancement of strength and ductility. The MoS 2 /PVA hydrogel modified by flower-like MoS 2 spheres with a content of 0.5 wt% presents a significant self-healing function with a healing efficiency up to 90.0% within 5 min, and an enhancement of tensile strength of 9.1 MPa (190% to blank PVA) and a ductility of 162.5% (290% to blank PVA). Furthermore, the MoS 2 /PVA gel with flower-like MoS 2 spheres into the PVA networks produces a significant enhancement of fracture strength (58.4 MPa) after fully curing, characterized by an increases of 612% compared with the pure PVA. The photo-induced self-healing and strengthening effects of the MoS 2 /PVA hydrogels are discussed. • A rapid self-healing MoS 2 /PVA hydrogels is developed under near-infrared light. • Photo-thermal conversion effect of MoS 2 produces the self-healing property. • Flower-like MoS 2 spheres exhibit better healing efficiency than MoS 2 sheets. • MoS 2 /PVA hydrogels present a simultaneous increase of strength and plasticity. • 2D and 3D strengthening effects of the MoS 2 /PVA composites are discussed.

Construction of double-network hydrogel based on low methoxy pectin/polyvinyl alcohol and its structure and properties

In this study, an interpenetrating double-network hydrogel (LMP/AA/PVAH) was prepared based on low methoxy pectin (LMP), acrylic acid (AA) and polyvinyl alcohol (PVA). The first rigid network of chemical crosslinking was constructed via free radical polymerization of LMP and AA, and the second of ductile physical crosslinking network was constructed via cyclic freeze-thaw of PVA. The first cycle hardness and elasticity of the LMP/AA/PVAH significantly increased from 13.08 N and 0 to 24.28 N and 0.79, respectively, when the second network structure was constructed in the hydrogel by PVA. Besides, the PVA network might enhance the ductile and limit the swelling of hydrogel. In addition, the adsorption properties of LMP/AA/PVAH were evaluated by adsorption of methylene blue (MB). The adsorption behavior of MB by LMP/AA/PVAH conformed to the pseudo-second-order kinetic model. Besides, after 4 cycles of adsorption, there was no significant difference in adsorption capacity of LMP/AA/PVAH. The results showed that LMP/AA/PVAH had good reusability.

Fabrication of Thermo-Responsive Controllable Shape-Changing Hydrogel.

Temperature response double network (DN) hydrogels comprising a network formed by polymerization of methacrylic acid (MA) modified PVA, N,N’-methylene bis(acrylamide), N-isopropylacryl amide (NIPAM), and one formed from crystalline polyvinyl alcohol (PVA) are prepared in a 3D printed tailor-made mold. The (PVA-MA)-g-PNIPAAm thermoset intermediate is formed in water by a radical, photo-initiated process, and in the presence of dissolved PVA polymers. A subsequent freezing-thawing sequence induces the crystallization of the PVA network, which forms a second network inside the thermoset NIPAM polymer. The prepared hydrogel is thermoresponsive by the phase transition of PNIPAAm segments (T ≈ 32 °C) and has good mechanical properties (tensile strength 1.23 MPa, compressive strength 1.47 MPa). Thermal cycling between room temperature at 40 or 50 °C shows the product converses from a virgin-state to a steady-state, which most likely involves the reorganization of PVA crystals. The swelling-deswelling cycles remain clear at a length change of about 13%.

Casein micelles embedded composite organohydrogel as potential wound dressing

Excellent mechanical and tissue adhesive properties, long-lasting environmental suitability and reliable biocompatibility are essential factors for the hydrogels to be applied as wound dressing in the clinical fields. Based on the self-assembly micelle structures, a new type of casein micelles (CEs)/polyvinyl alcohol (PVA) GW (glycerol-water) organohydrogel was designed and synthesized by a simple one-pot method. Through a unique “load sharing” effect, the CEs which own suitable adhesion abilities and drug loading capacities simultaneously were embedded into the PVA networks by rich hydrogen bonds, so that to obtain the composite organ hydrogel with not only excellent adhesive abilities, but also enhanced mechanical properties. Benefited from the unique GW binary solvent system, the organohydrogel showed long-lasting moisture lock-in capacity and extreme temperature tolerance (in the range of ‐−20 °C ~ 60 °C). Particularly, after loading the model antibacterial drugs (allicin) within the CEs, the as-developed CEs/PVA GW gel exhibited a prominent long-lasting (>100 h) antibacterial properties (>90%). Furthermore, the organohydrogel was confirmed with prominent biocompatibility to support fibroblast cell proliferation and migration. This work proposed a new strategy to build CEs-based gel system, which have a great potential application in terms of prevent bacterial infection, accelerate tissue proliferation and wound healing.

Ionic liquid-based non-releasing antibacterial, anti-inflammatory, high-transparency hydrogel coupled with electrical stimulation for infected diabetic wound healing

Bacterial colonization , prolonged inflammatory phase , angiogenesis difficulties, collagen deposition deficiency, and other serious complications can impede the infected wound repair process, particularly for infected wounds of diabetic patients. Electrical stimulation (ES), as an attractive emerging therapy, has been widely carried out for promoting skin regeneration. Herein, we constructed a conductive antibacterial multifunctional hydrogel combined with exogenous ES as a strategy for Staphylococcus aureus -infected wound healing. The hydrogel is composed of an ionic liquid (1-Vinyl-3-butylimidazolium bromide, [VBIM]Br) polymer network and a polyvinyl alcohol (PVA)-borax dynamic borate network. The [VBIM]Br conferred the hydrogel with excellent electrical conductivity to favor the introduction of ES therapy for wound healing. Moreover, the ionic liquid polymer network endowed the hydrogel with anti-bacterial abilities to kill bacteria, anti-inflammatory capacities to shorten the inflammation period, high transparency to observe the healing process, and excellent protein absorption ability. The dynamic borate bonds in the PVA network provided the hydrogel with self-healing and tissue adhesion properties. Furthermore, the [VBIM]Br composite hydrogel coupled with exogenous ES promoted cell proliferation , migration, angiogenesis, and collagen deposition, which demonstrated great potential in chronic diabetic infected wound repair. • Dual-network triple-crosslinked hydrogel with multifunction is prepared and characterized. • Hydrogel exhibits excellent conductivity, antibacterial, anti-inflammatory, and high-transparency properties. • Hydrogel combined with ES promotes infected wound healing in the diabetic rat model. • This study provides a promising and effective strategy for infected diabetic wound management.