Polymethyl Methacrylate Thickness Research Articles

Estimation of the absorbed dose in simultaneous digital breast tomosynthesis and mechanical imaging.

Use of mechanical imaging (MI) as complementary to digital mammography (DM), or in simultaneous digital breast tomosynthesis (DBT) and MI - DBTMI, has demonstrated the potential to increase the specificity of breast cancer screening and reduce unnecessary biopsies compared with DM. The aim of this study is to investigate the increase in the radiation dose due to the presence of an MI sensor during simultaneous image acquisition when automatic exposure control is used. A radiation dose study was conducted on clinically available breast imaging systems with and without an MI sensor present. Our estimations were based on three approaches. In the first approach, exposure values were compared in paired clinical DBT and DBTMI acquisitions in 97 women. In the second approach polymethyl methacrylate (PMMA) phantoms of various thicknesses were used, and the average glandular dose (AGD) values were compared. Finally, a rectangular PMMA phantom with a 45mm thickness was used, and the AGD values were estimated based on air kerma measurements with an electronic dosemeter. The relative increase in exposure estimated from digital imaging and communications in medicine headers when using an MI sensor in clinical DBTMI was . For the phantom measurements of various thicknesses of PMMA, the relative increases in the AGD for DM and DBT measurements were, on average, and , respectively. The relative increase in the AGD using the electronic dosemeter was in DM and in DBT. The average difference in dose between the methods was . Our measurements suggest that the use of simultaneous breast radiography and MI increases the AGD by an average of . The increase in dose is within the acceptable values for mammography screening recommended by European guidelines.

Physical Image Quality Metrics for the Characterization of X-ray Systems Used in Fluoroscopy-Guided Pediatric Cardiac Interventional Procedures: A Systematic Review.

Pediatric interventional cardiology procedures are essential in diagnosing and treating congenital heart disease in children; however, they raise concerns about potential radiation exposure. Managing radiation doses and assessing image quality in angiographs becomes imperative for safe and effective interventions. This systematic review aims to comprehensively analyze the current understanding of physical image quality metrics relevant for characterizing X-ray systems used in fluoroscopy-guided pediatric cardiac interventional procedures, considering the main factors reported in the literature that influence this outcome. A search in Scopus and Web of Science, using relevant keywords and inclusion/exclusion criteria, yielded 14 relevant articles published between 2000 and 2022. The physical image quality metrics reported were noise, signal-to-noise ratio, contrast, contrast-to-noise ratio, and high-contrast spatial resolution. Various factors influencing image quality were investigated, such as polymethyl methacrylate thickness (often used to simulate water equivalent tissue thickness), operation mode, anti-scatter grid presence, and tube voltage. Objective evaluations using these metrics ensured impartial assessments for main factors affecting image quality, improving the characterization of fluoroscopic X-ray systems, and aiding informed decision making to safeguard pediatric patients during procedures.

Highly Sensitive Thin‐Film Sensing with a Toroidal Dipole Resonance in the Midinfrared Supported by an E‐Shaped Germanium Metasurface

Optical sensing applications based on resonant structures always demand on novel optical resonances with large quality factors to achieve high sensitivities. Herein, it is experimentally demonstrated that a toroidal dipole (TD) response working in the midinfrared, supported by a metasurface structure composed of E‐shaped germanium elements on a CaF2 substrate, can be harnessed to achieve high‐performance optical sensors. By elaborately designing the geometrical parameters of the E‐shaped element, a TD resonance can be supported, which is verified by multipole decomposition of the scattering spectrum. Thin films of polymethyl methacrylate (PMMA) with different thicknesses coated on top of the metasurface structures are used as an example to demonstrate the sensing characteristics of the TD resonance. Both numerical and experimental results show that the TD spectral position is highly dependent on the PMMA thickness and a minimum measurable thickness below 10 nm can be steadily achieved. The results demonstrate that the use of TD resonances provides an effective and viable approach for thin‐film sensing, which may find broad applications in biological and medical diagnosis.

Development of an algorithm to convert mammographic images to appear as if acquired with different technique factors.

Purpose: We set out a fully developed algorithm for adapting mammography images to appear as if acquired using different technique factors by changing the signal and noise within the images. The algorithm accounts for difference between the absorption by the object being imaged and the imaging system. Approach: Images were acquired using a Hologic Selenia Dimensions x-ray unit for the validation, of three thicknesses of polymethyl methacrylate (PMMA) blocks with or without different thicknesses of PMMA contrast objects acquired for a range of technique factors. One set of images was then adapted to appear the same as a target image acquired with a higher or lower tube voltage and/or a different anode/filter combination. The average linearized pixel value, normalized noise power spectra (NNPS), and standard deviation of the flat field images and the contrast-to-noise ratio (CNR) of the contrast object images were calculated for the simulated and target images. A simulation study tested the algorithm on images created using a voxel breast phantom at different technique factors and the images compared using local signal level, variance, and power spectra. Results: The average pixel value, NNPS, and standard deviation for the simulated and target images were found to be within 9%. The CNRs of the simulated and target images were found to be within 5% of each other. The differences between the target and simulated images of the voxel phantom were similar to those of the natural variability. Conclusions: We demonstrated that images can be successfully adapted to appear as if acquired using different technique factors. Using this conversion algorithm, it may be possible to examine the effect of tube voltage and anode/filter combination on cancer detection using clinical images.

Evaluation of the Accuracy of the Displayed Average Glandular Dose in Mammography

We aimed to clarify the error of displayed value against the measured value of the average glandular dose (AGD) in two-dimensional (2D) mammography and digital breast tomosynthesis (DBT) and evaluate the accuracy of the displayed AGD as an index to estimate AGD. Polymethyl methacrylate (PMMA) phantoms with thicknesses varying from 20 to 80 mm were imaged, and the values displayed on the mammography system were used as the displayed AGD. The incident air kerma and the half-valued layer were measured, and the measured AGD in 2D mammography was calculated using the equation by Dance et al. On the other hand, the measured AGD in DBT was calculated by correcting for different projection angles. The relative error to the PMMA thickness was evaluated by assessing the relative error of the displayed AGD against the measured AGD. The maximum relative error of the displayed AGD against the measured AGD was 17.3% in 2D mammography, 19.1% in the standard (ST) mode, and 19.8% in the high-resolution (HR) mode. The relative error of the displayed AGD against the measured AGD tended to increase with increase in PMMA thickness. This tendency was especially noticeable for PMMA with thicknesses of 70 and 80 mm in DBT.

Controllable refractive index sensing and multi-functional detecting based on the spin Hall effect of light.

In this work, based on the spin Hall effect of light (SHEL), by considering the surface plasmon resonance (SPR) effect, a multi-functional detecting and controllable refractive index (RI) sensing structure containing sodium is theoretically established. The results reveal that the sodium layer has great influence on transverse shift (TS) of SHEL, while the polymethyl methacrylate (PMMA) layer has a large impact on the resonance angle. In the symmetrical distribution of TS, sodium has obvious advantages over gold and silver in the TS and sensitivity. The quantitative relationship between the TS and the RI of the sensing medium is established. Fermi energy, thicknesses of PMMA and sodium can be adjusted to measure the RI of three different orders. Remarkably, the sensitivity can be controlled by changing the thickness of sodium. The structure can also be used to measure the resonance angle and Fermi energy. Therefore, besides the advantages of sodium, this work realizes controllable sensing of RI and the functions of resonance angle and Fermi energy detecting. These studies may open avenues for the application of optical RI sensors and the precision measurement of other physical quantities.

Comparison of spectra and mean glandular dose (MGD) with tube voltage used in digital mammography for simulated, metrological and clinical cases

Mammography has a crucial role in breast cancer detection. The National Cancer Institute (INCA) estimates that 29.7% of the cancer cases in Brazil are related specifically to the breast. It is necessary to evaluate the mean glandular dose with a new solid-state detector in a digital radiography system, utilizing PMMA phantoms and spacers for different thicknesses. The Selenia Dimensions (Hologic, Bedford) direct radiography (DR) system can perform full-field digital mammographies through digital detectors. This system uses new technologies, such as the digital breast tomosynthesis system (DBT), and employs a sequence of projections acquired over the breast, resulting in images with low contrast. The estimation of breast dose is an important part of mammographic quality control for x-ray mammography. Nevertheless, there are currently no standard protocols for the dosimetry of breast imaging in 3D. Additionally, a x-ray spectra function is crucial to measure a considerable output in x-ray spectrometry. The purpose of this work was to assess the mean glandular dose (MGD) and the spectra in slabs of polymethyl methacrylate (PMMA) and breast equivalent thickness through digital mammography using four experiments: a Hologic Selenia Dimensions mammograph with a solid-state detector; a spectrometer (only for the spectra, in this case); a clinical COMET x-ray tube with a solid-state detector; and the MCNPX code. References recommend that the real environments that work well with digital mammography are in the following tube voltages: 25 kVp; 26 kVp; 28 kVp; 31 kVp and 33 kVp. Taking into account several thicknesses of PMMA, the results of both the MGD in metrological, clinical and simulated cases were in accordance with the references, from 30 mm of PMMA. All the spectra for all cases have indicated good agreement with the references.

Enhanced detectivity of PbS quantum dots infrared photodetector by introducing the tunneling effect of PMMA

With extremely high optical absorption coefficient in infrared regime, lead sulfide (PbS) quantum dots (QDs)-based photodetectors are promising for diverse applications. In recent years, synthesis of materials has made great progress, but the problem of low sensitivity of quantum dots photodetector still unresolved. In this work, the introduction of a tunneling organic layer effectively address this problem. The dark current is decreased by the appropriate thickness of polymethyl methacrylate (PMMA) barrier layer by suppressing the spontaneous migration of ions, and the photogenerated carriers are little effected, thereby the responsivity of the device is improved. As a result, the device exhibits a high responsivity of 3.73 × 105 mA W−1 and a giant specific detectivity of 4.01 × 1013 Jones at a low voltage of −1 V under 1064 nm illumination. In the self-powered mode, the responsivity reaches a value of 157.6 mA W−1, and the detectivity up to 5.9 × 1011 Jones. The performance of the photodetectors is obviously better than most of the reported QDs photodetectors. The design of this device structure provides a new solution to the problem of low sensitivity and high leakage current of quantum dots based infrared photodetectors.

COMPARISON OF SPECTRA AND MEAN GLANDULAR DOSE WITH TUBE VOLTAGES USED IN DIGITAL BREAST TOMOSYNTHESIS FROM SIMULATED, METROLOGICAL AND CLINICAL CASES.

Digital breast tomosynthesis (DBT) is a screening and diagnostic modality that acquires images of a breast at multiple angles during a short scan. The Selenia Dimensions (Hologic, Bedford, Mass) DBT system can perform both full-field digital mammography and DBT. The system acquires 25 projections over a 15° angular range (from -7.5° to +7.5°). X-ray spectroscopy is generally linked with a high-resolution semiconductor detector through a correction to its energy response function. The energy spectrum describes the radiation field, in which several quality parameters can be extracted, such as the effective energy, half-value layer and exposure. X-ray spectroscopy is usually performed with solid-state semiconductor detectors. Radiation dose is a concern in mammography, as the current protocols recommend that medical physicians evaluate mean glandular dose (MGD) as a part of service quality control. Studies are needed for radiation dose optimization from tomosynthesis patients. The COMET metrological X-ray tube, considered as with a constant potential and cooled, has proved to be a crucial tool in order to obtain the high energy resolution for low-energy radiographs in mammography. The Monte Carlo method, through Monte Carlo N-Particle eXtended (MCNPX), was proven to be an essential tool for image formation and posterior analysis of the deposited dose from breast simulators and radiographic contrast evaluation, for several anode/filter combinations. The purpose of this work was to assess the MGD and spectra in slabs of polymethyl methacrylate (PMMA) and breast equivalent thicknesses using four experiments with a Hologic Selenia Dimensions mammography X-ray tube with multimeter, a spectrometer (only for spectra, in this case), a metrological X-ray tube with a multimeter, and the MCNPX code. References indicate that the real conditions for a mammography X-ray tube that conducts tomosynthesis include tube voltages of 26, 29, 30 and 33kVp. Taking into account several thicknesses of PMMA, both the MGD and spectral results were in accordance with the references. Most of the spectra were in accordance with the references, showing that the resources used in the experiments can evaluate the energy level received by a patient. The MGD values were lower than those in the references from 30 to 50mm PMMA, and the data can be used for improvements in the detectors used in the Laboratory of Metrology in the State of Rio de Janeiro University, Brazil. Additionally, in the future, optimization of image quality can be performed for both semiconductors and mammography X-ray equipment.

Single-Source Thermal Evaporation Growth and the Tuning Surface Passivation Layer Thickness Effect in Enhanced Amplified Spontaneous Emission Properties of CsPb(Br0.5Cl0.5)3 Perovskite Films.

High-quality inorganic cesium lead halide perovskite CsPb(Br0.5Cl0.5)3 thin films were successfully achieved through evaporation of the precursors and deposition sequentially by a single-source thermal evaporation system. The different melting points of the precursors were enabled us to evaporate precursors one by one in one trip. The resulting films through its fabrication were smooth and pinhole-free. Furthermore, this technique enabled complete surface coverage by high-quality perovskite crystallization and more moisture stability oppositely of that produce by solution-processed. Then the perovskite films were encapsulated by evaporated a polymethyl methacrylate (PMMA) polymer as a specialized surface passivation approach with various thicknesses. The blue emission, high photoluminescence quantum yield (PLQY), stable, and low threshold of amplified spontaneous emission (ASE) properties of CsPb(Br0.5Cl0.5)3 films in the bulk structure at room temperature were achieved. The effects of the surface-passivation layer and its thickness on the optical response were examined. Detailed analysis of the dependence of ASE properties on the surface passivation layer thickness was performed, and it was determined this achieves performance optimization. The ASE characteristics of bare perovskite thin film were influenced by the incorporation of the PMMA with various thicknesses. The improvement to the surface layer of perovskite thin films compared to that of the bare perovskite thin film was attributed to the combination of thermal evaporation deposition and surface encapsulation. The best results were achieved when using a low PMMA thickness up to 100 nm and reducing the ASE threshold by ~11 μJ/cm2 when compared with free-encapsulation and by ~13 μJ/cm2 when encapsulation occurs at 200 nm or thicker. Compared to the bare CsPb(Br0.5Cl0.5)3, ASE reduced 1.1 times when the PMMA thickness was 100 nm.

Towards National Diagnostic Reference Levels for Mammography in Serbia.

The objective of this work is to investigate the possibility to set a national diagnostic reference levels (nDRLs) for diagnostic and screening mammography in Serbia based on local practice and available resources. This study included all types of mammography systems that are currently used in Serbia, namely screen-film mammography (SFM), computed radiography (CR) and full-field digital mammography (FFDM). The nDRLs are provided in terms of mean glandular dose (MGD) for different breast thicknesses simulated by polymethyl methacrylate (PMMA) phantom. For each breast thickness, MGD was calculated for the X-ray tube output, using clinically used exposure parameters. DRLs were chosen as the 75th percentile of MGD distribution for 20-, 40-, 45-, 60- and 70-mm phantom thicknesses. For SFM units proposed nDRL values are 0.7, 2.1, 2.7, 4.6 and 6.8mGy; for CR units proposed nDRL values are 0.7, 1.8, 2.4, 4.5 and 5.6mGy; and corresponding values for FFDM units are 0.8, 1.7, 2, 2. and 3.2mGy for 20-, 40-, 45-, 60- and 70-mm PMMA thickness, respectively.

Plasmon-phonon coupling between mid-infrared chiral metasurfaces and molecular vibrations.

Plasmon-phonon coupling between metamaterials and molecular vibrations provides a new path for studying mid-infrared light-matter interactions and molecular detection. So far, the coupling between the plasmonic resonances of metamaterials and the phonon vibrational modes of molecules has been realized under linearly polarized light. Here, mid-infrared chiral plasmonic metasurfaces with high circular dichroism (CD) in absorption over 0.65 in the frequency range of 50 to 60 THz are demonstrated to strongly interact with the phonon vibrational resonance of polymethyl methacrylate (PMMA) molecules at 52 THz, under both left-handed and right-handed circularly polarized (LCP and RCP) light. The mode splitting features in the absorption spectra of the coupled metasurface-PMMA systems under both circular polarizations are studied in PMMA layers with different thicknesses. The relation between the mode splitting gap and the PMMA thickness is also revealed. The demonstrated results can be applied in areas of chiral molecular sensing, thermal emission, and thermal energy harvesting.

Experimental Study on the Effect of Flow around Solid Combustibles and Thermal Thickness on Heat Release Rate Characteristics

In this study, an ISO 5660-1 cone calorimeter experiment was conducted to examine the effects of changes in flow and thermal thickness around solid combustibles on heat release rate characteristics. Polymethyl methacrylate (PMMA) is a solid combustible material that does not generate char during the combustion reaction. Hence, it was selected for the experiment, and the thermal penetration depth was calculated to distinguish the thermal thickness of PMMA. Furthermore, the thermal decomposition characteristics were analyzed by measuring the heat release rate measured during the combustion of PMMA. This was performed after generating the forced flow around the combustibles by setting the duct flow of the cone calorimeter to 12, 24, and 40 L/s. The results confirmed that the thermal release rate of the thermally thin combustible material was not significantly affected by the change in the surrounding flow. Hence, the thermally thick combustible material was significantly affected by the change in the flow rate.

Characterization of materials embedded in thick objects using spectral small-angle x-ray scattering

Small-angle x-ray scattering (SAXS) can identify a material based on its scattering features. However, SAXS techniques have been limited to the study of thin samples in the mm scale. We investigated the use of spectral SAXS (sSAXS) in the 30–45 keV energy range to identify embedded materials in up to 5 cm thick objects. A prototype sSAXS system was built by integrating a polychromatic x-ray source and a 2D spectroscopic detector in a two-pinhole collimation setup. The elastically scattered x-rays at deflection angles smaller than 10° were measured without collimating the scattered rays or filtering the energy spectrum. Using caffeine as a target material in 1 to 5 cm polymethyl methacrylate (PMMA) slabs, we demonstrate the capability of sSAXS technique to identify caffeine targets in all cases with 600 s acquisition times. The distinct Bragg peaks of caffeine at 8.44 and 18.64 nm−1 were recovered with a q-resolution of 0.6 nm−1 after attenuation and background corrections. Furthermore, we show the effect of PMMA thickness and target location to estimate the caffeine amount from the recovered signal using area-under-the-peak (AUP) analysis. We found that AUPs were slightly overestimated due to signal contamination by PMMA when the scattered photons from the caffeine target traverse through 1 to 3 cm PMMA slabs. This effect was more significant in the 5 cm thick PMMA with an average transmission factor of 24%, where the AUP was overestimated approximately by 34%.

Reduction of Radiation Exposure to Operator with Radiation Protective Device in ERCP Procedure Using Over-coach X-ray TV System

It is important to reduce the dose received by medical staffs. The purpose of this study was to evaluate the effect of protective curtain and the property of small optically stimulated luminescence (OSL) dosimeters used for ambient dose measurement in fluoroscopy. The property of small OSL dosimeters was investigated in terms of uniformity, changing fluoroscopy time and polymethyl methacrylate (PMMA) thickness, and angular dependence. Paper pipes were assembled in glid shape and ambient dose was investigated by using small OSL dosimeters that were put on them with and without protective curtain. Air kerma was investigated by small OSL dosimeters that were put on a head phantom at the position of eyes. Dose response of small OSL dosimeters was independent of fluoroscopy time and PMMA thickness, so it is appropriate to measure ambient dose by small OSL dosimeters. In relation to ambient dose, there was significant difference with and without protective curtain (p<0.001, paired-t-test). These air kerma on the head phantom were reduced to approximately 20% by attaching protective curtain. In order to reduce the dose received by operators, it is desirable to use protective curtain.

Dual Energy CBCT Methods to Produce RED, Zeff and Proton RSP Images Using the On-Board Imager of a Linear Accelerator

To present a feasibility study for using dual-energy (DE) cone beam computed tomography (CBCT) to produce relative electron density (RED), effective atomic number (Zeff) and proton relative stopping power (RSP) images, using the on-board imager (OCI) of a commercial linear accelerator. Low- and high-energy (80 kVp and 130 kVp, respectively) CBCT scans of the Catphan 604 phantom were acquired sequentially using the OBI of a commercial Linac. Each acquired projection pair was subsequently decomposed into basis material equivalent thicknesses using a calibration obtained from an aluminum (Al) and polymethyl methacrylate (PMMA) wedge phantom. The Al and PMMA thicknesses projections where then recombined using the linear attenuation coefficient (μ) for each basis material at the desired energy and reconstructed to produce virtual monoenergetic (VM) CBCT images. RED values for each insert of the phantom were obtained by converting the measured μ values for 150 keV VM-CBCT images directly to RED values based on a theoretical μ-RED linear correlation at that energy. The Zeff numbers for each insert were generated using the correlation between the ratio of 40 and 150 keV μ values and the reference Zeff. After obtaining RED and Zeff images, RSP images were obtained using the parametric method proposed by Hunemohr et al. Our theoretical analysis showed good linear correlation (0.9937) between 150 keV μ-values with the reference RED for elements with Z from 6 to 20, with a mean prediction error of 0.000 ± 0.073.The mean RED percentage error for phantom inserts was -0.24% ± 0.75%. The 50% bone insert had the largest percentage error (-1.49%). A logarithmic fit that transforms the ratio of 150/40 keV μ theoretical values to Zeff values from 6 to 20 was also defined. This fit resulted in a correlation coefficient of 0.9979, with a mean prediction error of 0.000 ± 0.021. Applying this data to the phantom inserts, the mean percentage error found for Zeff was 0.08% ± 2.09%. The Teflon insert had the largest percentage error for Zeff estimation (3.44%). The mean percentage RSP error value was -0.19% ± 1.78% with the 50% bone insert having the highest percentage error (-3.74.%). The presented method successfully obtained RED, Zeff and RSP images from VM-CBCT images produced using a sequential DE approach by scanning the phantom directly with the OBI of a commercial linear accelerator. Such an approach may allow for direct verification of RSP values at the time of treatment for proton systems that are equipped with an OBI.

Mammography Dose Survey Using International Quality Standards

Digital mammography is the current standard for breast cancer screening. The absence of any dosimetric data, the quality standards, and the fear of radiation detriment, sometimes, hampers the smooth introduction of this technology and the launch of breast cancer screening programmes. As the breast cancer screening programmes are in development in Morocco, quality standards have been set in this study, so that any new breast cancer screening service could get started with their first analysis. The purpose of this study was to report the first Moroccan breast dose and to test quality standards compared with European guidelines. A dosimetric study is conducted by calculating mean glandular dose (MGD) for patients' breasts and polymethyl methacrylate (PMMA) for each thickness from recorded radiographic factors and X-ray tube (output and half-value layer) measurements using Dance's model for a digital mammography system. This is carried out to determine the correlation between phantom and patient measurements.The mean MGD for patient data was 1.02 ± 0.5 mGy and the compressed breast thickness was 55 ± 14 mm. For compressed breast thickness range of 50–60 mm, the MGD was 0.94 ± 0.3 mGy and the dose calculated with PMMA phantom for the same range thickness was 1.33 mGy. The results of MGD as a function of PMMA thickness is lower than the achievable limit curve proposed in the European guidelines. The average doses, which depend on the technical parameters of the mammography equipment, are in line with values obtained in European guidelines. In addition, an investigation is needed throughout the Moroccan territory, in the sense of optimization of radiological practices and techniques in mammographic centres aligning with the international recommendations.

Evaluation of Radiation Dose and Image Quality for Angiographic System with Spectral Shaping Filter

Complex procedures for interventional radiology can result in high radiation doses to patients and physicians. A spectral shaping filter (SSF) has recently been developed and equipped with angiographic systems to modulate the X-ray beam spectrum. In our feasibility study, the radiation doses to patients and physicians, air kerma rate at image receptor, and image quality were evaluated when SSF was applied in fluoroscopy. Polymethyl methacrylate (PMMA) phantom, a catheter attached on the bottom was placed on the examination table. The entrance air kerma rate at patient entrance reference point, H* (10) rate at a distance of 100 cm from the center of PMMA, air kerma rate at image receptor and the fluoroscopic catheter images were recorded as a function of PMMA thickness. Contrast-to-noise ratio (CNR) was used for the objective image quality. As a subjective image quality evaluation, three physicians (cardiologist, neurologist, and radiologist) rated the catheter images by a Likert scale. With SSF, the entrance air kerma rate and H* (10) rate reduced by about 34 and 21%, respectively. The air kerma rate at image receptor in conventional filter mode increased when the PMMA was up to 10 cm and then CNR was also improved. However, no significant differences were found in the subjective image qualities. In conclusion, SSF was contributed to the reduction of the radiation doses to patients and physicians while the subjective image quality was not affected.

Surface-enhanced Raman scattering effect of composite structure with gold nano-cubes and gold film separated by polymethylmethacrylate film

The composite structure of metal nanoparticle and metal film can be used as a surface-enhanced Raman scattering (SERS) substrate to significantly enhance the Raman signal of adsorbed molecules due to the strong coupling between local surface plasmons and propagating surface plasmons. An SERS substrate of the composite structure with gold nano-cubes and gold film separated by polymethylmethacrylate (PMMA) film is proposed. The optimum thickness of PMMA is 15 nm obtained by numerical simulation through using finite element method. The composite structure of PMMA spacer with a thickness of 14 nm is prepared experimentally. Using R6G as the Raman probe molecules and He-Ne laser with a wavelength of 633 nm as an excitation source, the SERS effect of the composite structure and single gold nano-cubes are studied. It is found that the composite structure can make the probe molecules produce a stronger Raman signal than the single structure. Furthermore, the SERS spectra of R6G molecules on the composite structure under the condition of aqueous solution of gold nano-cubes with different concentrations are studied. The results show that when the concentration of gold nano-cubes’ aqueous solution is 5.625 &lt;inline-formula&gt;&lt;tex-math id="M2"&gt;\begin{document}${\text{μ}}{\rm g/mL}$\end{document}&lt;/tex-math&gt;&lt;alternatives&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="3-20190054-ue-wan-revised_M2.jpg"/&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="3-20190054-ue-wan-revised_M2.png"/&gt;&lt;/alternatives&gt;&lt;/inline-formula&gt;, the SERS signal of the R6G molecules on the composite structure is strongest. The lowest concentration of R6G molecules which can be detected is about 10&lt;sup&gt;–11&lt;/sup&gt; mol/L.

Applicability and repeatability in angiography systems of statistical method for the low contrast detectability

Purpose The aim of this study is to evaluate the applicability and repeatability of the Low Contrast Detectability (LCD) statistical method in angiography systems [1] , [2] . Methods A phantom consisting of a square aluminum target and a 5-step-wedge (0.2–1 mmAl) was built according to Radice et al. [2] . Different acquisition protocols were used (low, normal and high dose fluoroscopy; abdomen and cerebtal fluorography), and measurements were repeated for several thicknesses of PolyMethylMethAcrylate (PMMA). A Matlab software automatically calculates LCD values in terms of Pixel Value (PV) and contrast threshold (Ct); it also converts PV in mmAl (Fig. 1), providing the LCD(mmAl) [2] . The short- and long-term repeatability were evaluated by repeating acquisitions five times for every session and monthly (for six months) respectively. Results The Coefficients of Variation CV(%) reported in Table 1 are always higher for LCD(mmAl) than for LCD(PV) and LCD(Ct), especially in case of long-term measurements which consequently are not repeatable. This difference is related to unstable conversion from PV to mmAl; indeed, the image noise makes difficult to select the steps of the wedge. To overcome the problem, it would be possible to extend the step-wedge up to 2 mmAl, to introduce the point (0,0) in the conversion curve and to use only the curves with R2 > 0.8. Conclusions The LCD statistical method is easy to implement and provides consistent results for LCD(PV) and LCD(Ct). However, the LCD(mmAl) values seem to be not repeatable because of the instability of PV-mmAl conversion; the suggested solutions can improve the conversion, leading to more robust LCD (mmAl) values.