Polymethacrylate Polymers Research Articles

BJS 2 - Tumour targeted oxygen-generating nanoparticles for enhanced radiotherapy in the treatment of pancreatic cancer

Abstract Aim To determine if novel oxygen-generating nanoparticles, encased in a pH-sensitive polymethacrylate polymer (SOG-01), can enhance radiotherapy-based treatment in a preclinical pancreatic cancer model. SOG-01 nanoparticles are stable in circulation and, at the lower pH in hypoxic tumours, the polymer coating dissolves to expose a solid peroxide core, capable of generating oxygen in the tumour microenvironment. Since hypoxia reduces the efficacy of radiotherapy, this particle could potentially be employed to enhance radiotherapy-based approaches for the treatment of pancreatic cancer. Methods A human xenograft pancreatic cancer model (BxPC-3) in mice was employed as a target. SOG-01 was administered systemically and animals (n=6 per experimental group) were subsequently treated with radiation (a single dose of 6 Gy) using a Gulmay (160kV) AGO HS-MP1 X-Ray generator. Control animals were either untreated, treated with SOG-01 alone, or radiation alone. Tumour size and survival were employed as a measure of therapeutic efficacy. Results When the mean tumour size of groups treated with SOG-01 or radiation alone was compared with that of the untreated group at day 23 no statistically significant decrease was observed. However, a dramatic 89% and statistically significant decrease (p = 0.001; α = 0.05) was observed for tumours treated with combination of SOG-01 and radiation. Additionally, Kaplan Meier analysis demonstrated enhanced survival to 65 days when compared with 38 day survival for the group treated with radiation alone. Conclusions The data suggest that SOG-01 may play a role in enhancing radiotherapy-based approaches for the treatment of pancreatic cancer.

Urinary Extracellular Vesicles as a Readily Available Biomarker Source: A Simplified Stratification Method.

Urine, a common source of biological markers in biomedical research and clinical diagnosis, has recently generated a new wave of interest. It has recently become a focus of study due to the presence of its content of extracellular vesicles (EVs). These uEVs have been found to reflect physiological and pathological conditions in kidney, urothelial, and prostate tissue and can illustrate further molecular processes, leading to a rapid expansion of research in this field In this work, we present the advantages of an immunoaffinity-based method for uEVs' isolation with respect to the gold standard purification approach performed by differential ultracentrifugation [in terms of purity and antigen presence. The immunoaffinity method was made feasible by combining specific antibodies with a functionalized polymethacrylate polymer. Flow cytometry indicated a significant fluorescence shift, validating the presence of the markers (CD9, CD63, CD81) and confirming the effectiveness of the isolation method. Microscopy evaluations have shown that the morphology of the vesicles remained intact and corresponded to the expected shapes and dimensions of uEVs. The described protocol is inexpensive, fast, easy to process, has good reproducibility, and can be applied to further biological samples.

Designing functionalized polymers through post-polymerization modification of side chain leucine-based polymer

The opportunity to modify the chemical functionality of the incorporated amino acid moiety in side chain amino acid-based polymers provides access to tailor their optical, mechanical, and biological properties. Methacrylate monomers from C-terminus modified amino acids and their subsequent polymerization leads to the formation of polymethacrylate polymers with pendant amine (-NH2) groups. To this end, the post-polymerization reactions on the amine groups offer a facile route to prepare functionalized side chain amino acid-based polymeric materials. Herein, we synthesized side chain L-leucine pendant homopolymer using reversible addition-fragmentation chain transfer (RAFT) polymerization of Boc-L-leucine methacryloyloxyethyl ester (Boc-leu-HEMA) and subsequently the Boc group is deprotected to prepare P(H3N+-leu-HEMA). Post-polymerization modifications on the pendant amine groups were performed to incorporate fluorescent probe, propargyl group, methacrylic moiety, hydrophobic fatty acid, anionic pendant, and hydrophilic polyethylene glycol (PEG) units; which demonstrates an efficient platform to build a library of functionalized polymers from a single polymeric backbone. We have studied the solvatochromic behavior of fluorescence probe bearing polymers using fluorescence spectroscopy. The ability of the pendent methacrylic unit containing polymers to undergo crosslinking and the mechanical properties of the synthesized gel are investigated by the rheological study.

Entacapone microsponges in the treatment of acute Parkinson’s disease

Objective: The current study was based on the many different dose frequencies of entacapone, an anti-Parkinson's drug that was loaded with microsponges to change the dose frequency of the drug administration. Methods: Microsponges were made utilizing polymethacrylate polymers such as eudragit L100, eudragit S 100, and eudragit RS 100 in various ratios using a quasi-emulsion solvent diffusion, ratios such as (1:0.5, 1:1, 1:1.5 and 1:2). These polymers release the drug in a controlled manner. The polymer used for the preparation of microsponges was useful in forming sponges in which the drug was entrapped. By using the 3 polymers,12 formulations were prepared. Results: FT-IR and DSC tests were carried out and it was clear from the FT-IR and DSC spectra that there were no interactions between the entacapone and the polymer. out of 12 formulations 3 formulations were selected as optimized formulations based on the production yield (%), encapsulating efficiency, drug loading (%), and SEM analysis says that the produced microsponges formulation was extremely porous, indicating their potential for increased drug loading.

Preparation and characterization of colon-targeted pH/Time-dependent nanoparticles using anionic and cationic polymethacrylate polymers

Inflammatory bowel disease (IBD), which is a chronic inflammatory disease of the gastrointestinal system, has two subtypes: Ulcerative Colitis (UC) and Crohn's Disease (CD). Only pH-sensitive drug delivery systems are commonly utilized for the treatment of IBD, but their effectiveness is frequently obstructed by the change in intestinal pH. To overcome the inadequacy of only pH-dependent delivery systems, we developed in vitro evaluated both pH- and time-dependent nanoparticles loaded budesonide (BUD) for the treatment of IBD in this study. Anionic polymethacrylate was utilized as a pH-dependent polymer whereas cationic polymethacrylate was utilized as a time-dependent sustained release polymer. Nanoparticles were prepared through a single oil-in-water emulsion/solvent evaporation method. The encapsulation efficiency, mean particle size, zeta potential, polydispersity index (PDI), drug release profiles, drug release kinetics, and stability of these nanoparticles were investigated. In all formulations, mean particle sizes were below 250 nm and PDI values were between 0.1 and 0.3. Nanoparticles containing 90% anionic-10% cationic polymethacrylate polymers inhibited burst BUD release under acidic conditions and exhibited sustained drug release at neutral pH. Consequently, in the medication of IBD, BUD-loaded pH and time-dependent nanoparticles may be a promising choice as a drug delivery system.

P-P11 A tumour responsive, oxygen-generating nanoparticle to combat hypoxia in pancreatic tumours

Abstract Background Pancreatic cancer remains a significant therapeutic challenge and its poor prognosis has remained relatively unchanged for the past 40 years. Pancreatic tumours are highly desmoplastic and impenetrable lesions in which both gas and mass transfer is severely compromised. This leads to the development of hypoxia within the tumour and this compromises therapeutic approaches that rely on cytotoxic reactive oxygen species, e.g. photodynamic therapy, sonodynamic therapy and radiotherapy. Hypoxia also results in a relatively low pH within the tumour microenvironment. Here we describe a pH sensitive nanoparticle that can generate oxygen in the tumour and enhance ROS generating therapeutic approaches. Methods CaO2 NPs were generated by exposing to low frequency ultrasound and subsequently coated using a polymethacrylate polymer that becomes soluble at pH 6.4. For some studies, the sonosensitiser, Rose Bengal was attached to the particles. Oxygen generation in tumours (BxPC3) was demonstrated by inserting a dissolved oxygen probe into tumours following IV administration of particles. Particles were also employed together with photodynamic therapy (PDT) and sonodynamic therapy (SDT) using human xenograft and syngeneic pancreatic tumour models. In some cases, tumour tissues were recovered and analysed for tumour infiltrating immune cells using flow cytometry. Results Conclusions Coating CaO2 nanoparticles with a pH sensitive polymer provides in situ oxygen generation in tumours. Transient provision of oxygen enhances therapies that depend on the generation of cytotoxic reactive oxygen species. When used with SDT, and using a bilateral syngeneic pancreatic tumour model, a powerful abscopal effect was observed and this was shown to be immune-mediated. The above data suggest that the particles may be exploited to enhance other therapies that depend on the generation of ROS, e.g. radiotherapy, and further suggest that the approach can be used to treat either local or disseminated forms of pancreatic cancer.

Fabrication and characterization of budesonide loaded colon-specific nanofiber drug delivery systems using anionic and cationic polymethacrylate polymers

Inflammatory bowel disease (IBD) is a chronic disease characterized by the inflammation of the gastrointestinal system (GIS). Electrospun nanofibers are commonly used in pharmaceutical technology due to many advantages such as high porosity, loading efficiency, large surface area, and stability. Budesonide is the first choice drug in the treatment of IBD and is used as a model drug. In this study, it was aimed to obtain controlled release nanofibers for colon targeting by using anionic, pH-sensitive Eudragit S100 (ES100) and cationic, time-dependent Eudragit RL100 (ERL100) polymers. The conductivity, surface tension, and viscosity of the polymer solutions were analysed before electrospinning process. After production, the surface morphology, drug release kinetics, water contact angle, swelling index, and mucoadhesion studies of nanofibers were evaluated. Drug release studies were carried out at pH 1.2, 6.8, and 7.4. The formulation containing ES100:ERL100 (95:5) showed the most suitable drug release as a colon-specific drug delivery system with a minor release at pH 1.2, 6.8, and major release at pH 7.4. As a result, electrospun nanofibers obtained by mixing anionic and cationic polymethacrylate polymers may be a promising alternative as a drug delivery system in the treatment of IBD and other intestinal diseases.

Influence of polar groups on the depressive effects of polymethacrylate polymers as cold flow improvers for diesel fuel

In this study, a series of polymethacrylate polymers of tetradecyl methacrylate-N-benzylmaleimide copolymers (C14MC-BMI), tetradecyl methacrylate-4-acryloylmorpholine copolymers (C14MC-ACM), and tetradecyl methacrylate-N-benzylmaleimide-4-acryloylmorpholine terpolymers (C14MC-BMI-ACM) were synthesized and characterized by 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The influences of benzene rings and morpholine groups on the depressive effects of the polymers as cold flow improvers for diesel fuel were investigated. Results indicated that C14MC-BMI-ACM with benzene rings and morpholine groups leads to better cold flow properties in diesel in contrast to that of C14MC-BMI with benzene rings groups and C14MC-ACM with morpholine groups. Moreover, C14MC-BMI-ACM (9:0.25:0.75) at 1000 ppm showed the best depressing effect and decreased the solid point and cold filter plugging point of diesel by 22 °C and 12 °C, respectively. In addition, the depressive mechanism was studied using viscosity-temperature curves, differential scanning calorimeter, macrocrystal images, and polarizing optical microscope. The results revealed that compared with copolymers with only benzene rings or morpholine groups, terpolymers with benzene rings and morpholine groups delayed crystal precipitation, changed the number of crystals and liquid state, and modified crystal morphology, thereby significantly reducing the low-temperature viscosity and improving the cold flow properties of diesel fuel.

Detergent-free solubilisation & purification of a G protein coupled receptor using a polymethacrylate polymer

G protein coupled receptors (GPCRs) function as guanine nucleotide exchange factors (GEFs) at heterotrimeric G proteins, and conduct this role embedded in a lipid bilayer. Detergents are widely used to solubilise GPCRs for structural and biophysical analysis, but are poor mimics of the lipid bilayer and may be deleterious to protein function. Amphipathic polymers have emerged as promising alternatives to detergents, which maintain a lipid environment around a membrane protein during purification. Of these polymers, the polymethacrylate (PMA) polymers have potential advantages over the most popular styrene maleic acid (SMA) polymer, but to date have not been applied to purification of membrane proteins. Here we use a class A GPCR, neurotensin receptor 1 (NTSR1), to explore detergent-free purification using PMA. By using an NTSR1-eGFP fusion protein expressed in Sf9 cells, a range of solubilisation conditions were screened, demonstrating the importance of solubilisation temperature, pH, NaCl concentration and the relative amounts of polymer and membrane sample. PMA-solubilised NTSR1 displayed compatibility with standard purification protocols and millimolar divalent cation concentrations. Moreover, the receptor in PMA discs showed stimulation of both Gq and Gi1 heterotrimers to an extent that was greater than that for the detergent-solubilised receptor. PMA therefore represents a viable alternative to SMA for membrane protein purification and has a potentially broad utility in studying GPCRs and other membrane proteins.

Fabrication of Hard-Soft Microfluidic Devices Using Hybrid 3D Printing.

Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed part is accurately mated and adhered to a second, soft, flexible component (thermoplastic polyurethane elastomer) printed by an FDM printer. The prescribed mounting and alignment of the first-printed SLA-printed hard component, and its pre-treatment and heating during the second FDM step, can produce leak-free bonds at material interfaces. To demonstrate the utility of such hybrid 3D-printing, we prototype and test three components: i) finger-actuated pump, ii) quick-connect fluid coupler, and iii) nucleic acid amplification test device with screw-type twist sealing for sample introduction.

Influence of compression at elevated temperature on the compactibility of thermo-mechanically processed polymers

Hot-melt extrusion (HME) is increasingly applied in the pharmaceutical industry for the formulation of solid dispersions of drugs with improved solubility and release. However, tableting of milled extrudates may present problems due to adverse thermo-mechanical effects on elasto-plasticity. In this work compression of hot-melt extruded polyvinyl based and polymethacrylate polymers with glass transition temperatures (Tg) up to 80 °C was performed at ambient (20 °C) and elevated (40 °C, ‘hot’ compression) temperature aiming for compactibility improvement. Polymers were characterized for morphology, particulate properties, thermal properties, microhardness and compaction behavior (‘in-die’ force-displacement data). Hot-melt extruded polymers showed lower Tg and work of compaction but higher elastic recovery and yield pressure (Kuenz-Leuenberger and Kawakita models) resulting in weak tablets. ‘In all cases, ‘hot’ compression decreased considerably the yield pressure for both unprocessed and extruded polymers indicating greater plasticity. For Eudragit® RSPO, Eudragit® L100-55 and Soluplus® with microhardness between 2.20 and 2.69 MPa it also increased consolidation due to softening of edges, thus facilitating interparticle slippage, which explained their tablet strength enhancement. Conversely, it did not affect the consolidation of Kollidon® SR with lower microhardness 0.31 and the large strength increase was attributed to the yield pressure reduction and the closeness of its Tg (42 °C) with the compression temperature increasing molecular mobility and operation of intermolecular forces. Compared to ambient compression, greater plastic deformation due to ‘hot’ compression was visible in the SEM images of tablet surfaces by the extensive formation of interparticle boundaries and by the elimination of pores. Relationships were found between yield pressure, elastic recovery, tensile strength and friability of tablets with homologous compression temperature which may be useful during formulation.

Easy Processing of Metal–Organic Frameworks into Pellets and Membranes

Herein, we present a simple and inexpensive method for the immobilization of Metal–Organic Framework (MOF) particles in the form of pellets and membranes. This processing procedure is possible using polymethacrylate polymer (PMMA) as a binding or coating agent, improving stability and significantly increasing the water repellency. HKUST and MMOF-74 (M = Mg2+, Zn2+, Co2+ or Ni2+) are stable with the processing and high loadings of MOF materials into the processed pellet or membranes. These methods can provide the know-how for the immobilization of MOFs for, for example, application in air purification and the removal of toxic compounds and are well-suited for deployment in air purification devices.

Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin

Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers (Eudragit®) as carriers. Liquid SV-loaded self-microemulsifying drug delivery systems (SMEDDS), composed of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, or propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (PEG-15 hydroxystearate), were characterized in terms of emulsification time, robustness to dilution, and droplet size. To enable targeted SV release at desired pH, the liquid SMEDDS were mixed with solid carriers, Eudragit® L100 and/or Eudragit® S100. The resulting gel-like lipid-based drug delivery systems were transparent and ductile, and exhibited viscoelastic rheological properties. In vitro dissolution data indicated sustained SV release in pH medium corresponding to distal ileum. The simulation results revealed that sustained SV release from the designed systems is expected to increase SV bioavailability. Overall, our results demonstrate that sustained-release drug delivery systems, composed of liquid SMEDDS and polymethacrylate carriers (Eudragit® polymers), have the potential to enhance oral bioavailability of drugs with preferred absorption site in the pH medium corresponding to distal ileum.

Polymethacrylates as Polymeric Film Formation in Patches Containing α-Mangostin and Resveratrol

Polymethacrylates polymeric film formation in patches containing α-mangostin and resveratrol were developed using solvent casting method. Eudragit® E100 (E) and Eudragit® L100 (L) were dissolved in ethanol and the plasticizer (propylene glycol (PG) and polyethylene glycol (PEG) 400) was individual added and followed with the drying process. The dried films were evaluated for the morphology and flexibility. After the stable film was achieved, the α-mangostin and resveratrol were incorporated into the film. The variation of weight and thickness, swelling property, pH surface, mechanical properties and drug content of patches was evaluated. Fourier transform infrared spectrophotometry (FT-IR) was also conducted to confirm that drugs were qualitatively loaded into the patches. The results indicated that patch of L and PG was found to be stable. PG enhanced the flexibility of patch. The patches were less variation in weight and thickness. This patch did not effect to the physiological pH in the human body. In addition, patch had a tensile strength high enough to withstand tearing during handing. The qualitative and quantitative analysis indicated the α-mangostin and resveratrol was well incorporated in this patch. These results suggest that polymethacrylate polymer could be a promising polymeric film formation in patches for drug delivery.

EXPLORING THE POTENTIAL OF EUDRAGIT FOR DEVELOPMENT OF MICROPARTICLES OF WATER SOLUBLE DRUG USING QUALITY BY DESIGN APPROACH

Objective: In the present protocol, employability of polymethacrylate polymer Eudragit RS100 for development of microparticles of water soluble drug with desired values of response variables was investigated by central composite optimization design through application of Design Expert® software (Series DX10).
 Methods: The microparticles were developed by emulsion solvent evaporation process employing Eudragit RS100. Two effective independent variables drug: polymer ratio and stirring speed were selected to assess performance prospective of Eudragit on mean particle size, entrapment efficiency, percent yield and drug release in 12 h of microparticles. Thirteen batches generated by software were prepared and subjected to different characterization test parameters obligatory for the evaluation of formulation. Validation of optimization model and Statistical interpretation of results was done using Analysis of Variance (ANOVA)
 Results: ANOVA indicated that the independent variables had significant effect on response variables. Optimized formulation demonstrated close agreement amongst experimental and predicted responses with high desirability factor. In vitro drug liberation study for optimized formulation proposed a sustained release of drug from microparticles.
 Conclusion: In conclusion, optimization technique was imperative in indicating the efficient applicability of Eudragit RS100 polymer in controlling the drug release of hydrophilic drugs.

Improvement an Expansive Soil using Polymethacrylate Polymer

One of the worldwide problematic soil is expansive clay accompanied by large volume change response when it subjected to a change in the water content. A chemical method for enhancing the swelling of expansive clayey soil is provided using Polymethacrylate (PMA) polymer material. An expansive soil is prepared in the laboratory by adding bentonite. Then experimental program is conducted to estimate the effects of adding the (PMA) polymer on the properties of the prepared expansive soil. Modified clay specimens are characterized based on sieve analysis, hydrometer, Atterberg limits, standard compaction, swelling potential, swelling pressure, unconfined compression strength and California Bearing Ratio (CBR) tests and 10 groups of soil samples are prepared at three various percentages of PMA (i.e. 3%, 5% and 7% by weight of dry soil).The tests results indicated that the induced of PMA polymers within expansive soil caused a decrease in the liquid limit (LL), plasticity index (PI), free swell%, rebound index (Cr) and optimum moisture content (OMC) and increase in plastic limit (PL), Unconfined Compression Strength (UCS) taken into consideration the influence of increasing curing time, compression index (Cc) and California Bearing Ratio (CBR). Also adding PMA polymers increase maximum dry density (MDD).The swelling potential decreased up to 71.7% with increasing PMA content to 7% respectively. The results of the tests indicated that the polymers significantly overcome the problems of expansive soils. In addition, higher UCS by 52.8% are observed by adding PMA with a percentages of 7%. Also adding same percentages of PMA polymer caused increasing in CBR value by 72.8%.

Low molecular weight polymethacrylates as multi-functional lubricant additives

Low molecular weight, moderately polar polymethacrylate polymers are explored as potential multi-functional lubricant additives. The performance of these novel additives in base oil is evaluated in terms of their viscosity index, shear stability, and friction and wear. The new compounds are compared to two benchmarks, a typical polymeric viscosity modifier and a fully-formulated oil. Results show that the best performing of the new polymers exhibit viscosity index and friction comparable to that of both benchmarks, far superior shear stability to either benchmark (as much as 15× lower shear loss), and wear reduction significantly better than a typical viscosity modifier (lower wear volume by a factor of 2–3). The findings also suggest that the polarity and molecular weight of the polymers affect their performance which suggests future synthetic strategies may enable this new class of additives to replace multiple additives in typical lubricant formulations.

Tribological properties of trimellitates containing polymethacrylates viscosity modifiers

In the present work, physical property, film-forming property, and tribological performance of three trimellitates and their blends with polymethacrylates viscosity modifiers were investigated. The results showed that the addition of polymethacrylate can significantly improve the viscosity and low temperature fluidity of the base fluids, while exerting slight influence on the viscosity-temperature properties and film forming performance. Tribological tests showed that under boundary lubrication conditions, polymethacrylate modified lubricants exhibit better friction reducing properties over a wide range of temperature and load. However, under high temperature or high load, the performance is weakened. This phenomenon should be due to the formation and destruction of the physically absorbed layer of the polymethacrylate polymer molecular on the metal surface. Under moderate boundary lubrication conditions, the physically absorbed layer can effectively prevent the direct contact of rubbing surface, resulting in a reduction of friction coefficient, while under more severe boundary lubrication conditions, the adsorbed layer is destroyed and the friction coefficient increases again.

Highly fluorinated polymers with sulfonate, sulfamide and N,N-diethylamino groups for the capillary electromigration separation of proteins and steroid hormones.

Highly fluorinated polymers are promising materials in separation methods due to their combination of high chemical and thermally stability, hydro- and oleophobicity, and weak intermolecular forces. However, application of these polymers in chromatography is limited because of their low solubility in aqueous-organic solvents. In our research, the highly fluorinated water soluble polymers with -SO3- N(Et)4+ , -SO2 NH2 , and -N(Et)2 terminal groups were synthesized and applied as additives to the background electrolyte for the separation of steroid hormones and proteins by capillary electromigration methods. It is shown that highly fluorinated polymers can be used both as pseudo-stationary phases in electrokinetic chromatography for high separation efficiency (N∼200×103 ) and selectivity (α∼1.1) of uncharged analytes (e.g., steroid hormones), and as dynamic modifiers of fused silica capillary walls. The highest separation efficiency (N∼1×106 ) and selectivity (α∼1.3) of steroid hormones was achieved by combination of sodium dodecyl sulfate and fluoropolymer with sulfonate groups in background electrolyte with pH 2. Dynamic wall coatings based on fluoropolymer with -SO2 NH2 (which are easier and faster to create and wash off) exhibit significantly higher separation efficiency and selectivity compared to capillary electrochromatography on capillary columns based on polymethacrylate polymers.

Novel Salted Anionic-Cationic Polymethacrylate Polymer Blends for Sustained Release of Acidic and Basic Drugs.

Since a unique matrix tablet formulation that independently controls the release of various drug types is in a great demand, the objective of this research was to develop a sustained release matrix tablet as a universal dosage form using a binary mixture of the salt forms of Eudragit polymers rather than their interpolyelectrolyte complexes. Tablets were prepared by wet granulation and compressed at different compression forces, depending on drug type. Dissolution tests were conducted using USP XXII rotating paddle apparatus at 50 rpm at 37°C in consecutive pH stages. Tablets containing Ibuprofen (IB) as a model acidic drug and Metronidazole (MD) as a model basic drug showed controlled/sustained release behavior. For IB tablets containing 80% Ibuprofen and 5% (w/w) polymeric combination; the time for 50% of the drug release was about 24 hours compared to 8.5 hours for plain tablets containing 80% IB. In case of MD, the drug release extended to about 7 hours for tablets containing 80% MD and 5% (w/w) polymeric combination, compared to about 1 hour for plain tablets containing 80% MD. In terms of extending the release of medications, the dissolution profiles of the tablets containing polymeric salts forms were found to be statistically superior to tablets prepared by direct compression of the polymers in their powdered base forms, and superior to tablets containing the same polymers granulated using isopropyl alcohol. The findings indicated the significance of combining the polymers in their salt forms in controlling the release of various drug types from matrices.