We consider shift-invariant multiresolution spaces generated by q-elliptic splines in $${\mathbb {R}^{d}},d\ge 2,$$ which are tempered distributions characterized by a complex-valued elliptic homogeneous polynomial q of degree $$m>d$$ . To construct Riesz bases of $$L^{2} ({\mathbb {R}^{d}}),$$ a family of non-separable basic smooth functions are obtained by localizing a fundamental solution of the operator q(D), properly. The construction provides a generalization of some known elliptic scaling functions, the most famous being polyharmonic B-splines. Here, we prove that real-valued q leads to r-regular multiresolution analysis, with $$r=m-d-1.$$ In addition, we prove that there exist r-regular non-separable prewavelet systems associated with not necessarily regular multiresolution analyses. These prewavelets have $$m-1$$ vanishing moments and the approximation order of the prewavelet decomposition can be established.