Problem Statement and Purpose. The article highlights the issue of the demographic situation and demographic potential of the Odesa region as a leading component of its development and the development of relevant regional strategies and programs. Regional features have been established and an intra-regional analysis of the demographic potential in the conditions of administrative-territorial reform has been carried out. The prerequisites of geodemographic processes in the region were clarified and their assessment was carried out taking into account the geographical basis and subregional specificity of the multicultural and polyethnic environment. The results of the study call for a revision of the demographic policy in the region within the framework of decentralization reforms, the successful completion of which is complicated by the state of war. The purpose of the study is to analyze the demographic potential of the Odesa region in the conditions of decentralization and martial law. The object of the study is demographic processes in the Odesa region. The subject of the study is the analysis of the demographic situation and demographic potential in the Odesa region in conditions of uncertainty caused by the decentralization reform and changes in the administrative-territorial system, complicated by the state of war. Data & Methods. When writing the article, traditional general scientific research methods were used. Statistical materials of the demographic situation at the national and regional levels were used for data analysis, and statistical and specific demographic methods were used for their subject processing. Public management methods were used to analyze the demographic potential in order to make appropriate management decisions. When processing data for the obtained results, software tools of office packages (in particular, Word, Excel) were used. When analyzing and writing the proposed publication, official statistical reporting data was used. Results. Undoubtedly, after the end of the war, in order to restore Ukraine and the region in particular, in order to improve the demographic potential of the Odesa region, it is necessary to adopt the necessary regional programs aimed at increasing the birth rate, creating new jobs, improving the quality of life, reducing the mortality rate, and supporting young families. The implementation of these programs requires a systematic approach and balanced decisions on the part of regional and central authorities.