Cadmium (Cd) contamination of soil is a global environmental issue. Traditional remediation techniques such as immobilization, leaching and phytoextraction have numerous shortcomings, which has led to growing interest in the development of low cost, high-efficiency, and environmentally friendly agents for removing Cd from soil. In this study, Fe3O4/polyaniline (Fe3O4/PANI) was developed as a remediation agent with magnetic separation and regeneration capabilities. Its Cd adsorption isotherms showed a better fit to Langmuir model, exhibiting a high Cd adsorption capacity of 47.62 mg·g-1 at 25°C. In bench-scale experiments, Fe3O4/PANI was first attempted to remediating four typical Chinese soils with Cd concentration of 180 mg·kg-1: black, brown, cinnamon, and red. Results showed that the total Cd removal efficiency was satisfactory at 25.25%–38.91% and that the exchangeable Cd removal efficiency was 36.03% on average. In addition, the soil basic properties did not show major changes after remediation. Regarding the regeneration performance, after the first regeneration cycle, a better total Cd removal efficiency was achieved, i.e., 27.89%–44.96%. After two regeneration cycles, it decreased but still remained above 95% of the initial performance. Fe3O4/PANI has a simple and cost-effective synthetic process, and it combines high Cd removal efficiency with easy recovery and recyclability. It is a promising solution for the sustainable and efficient remediation of Cd-contaminated soils, especially for the reclamation of highly contaminated development land.