Street canyons are fundamental units of urban spaces where individuals engage in social activities. The air quality within street canyons directly impacts the health and behavior of residents. Therefore, it is crucial to comprehensively assess and depict the actual distribution of multiple air pollutants (SO2, CO, NO2, O3, PM2.5, and PM10) in street canyons, for both investigation and validation purposes. However, an efficient and accurate method for doing so is rarely available. To address this issue, indoor and field measurements were conducted to determine the response times of these pollutants in various polluted environments, identify the optimal stay duration at individual sampling points, and optimize the sampling layout. A method based on Unmanned Aerial Vehicle (UAV) was developed to efficiently measure the spatial pattern of pollutants in street canyons and verified through field application. The results showed that the actual response times of pollutants in heavily and slightly polluted environments were less than 30 s. The recommended stay duration at an individual sampling point in an outdoor environment was determined to be 2 min, with uncertainty of 2 %. For the sampling layout, it is recommended to take 12 samples to obtain a spatial pattern of a street canyon. These samplings should be arranged at the air inlet, middle, and air outlet along the middle of the street canyon, as well as at their bottom, 20 %–30 %, 50 %–60 %, and top in the vertical direction, respectively. The UAV-based method can efficiently complete the sampling process in just 24 min.
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