Abstract Rising affluence and a warming climate mean that the demand for air conditioning (AC) is rising rapidly, as society adapts to climate extremes. Here we present findings from a new methodological framework to flexibly couple and emulate these growing demands into a global integrated assessment model (IAM), subsequently representing the positive feedbacks between rising temperatures, growth in cooling demand, and carbon emissions. In assessing global and regional climate change impacts on cooling energy demand, the emulator incorporates climate model uncertainties and can explore behavioural and adaptation-related assumptions on setpoint temperature and access to cooling. It is also agnostic to the emissions and climate warming trajectory, enabling the IAM to run new policy-relevant scenarios (Current Policies, 2 °C and 1.5 °C) with climate impacts that do not follow Representative Concentration Pathways. We find that climate model uncertainty has a significant effect, more than doubling the increase in electricity demand, when comparing the 95th percentile cases to the median of the climate model ensemble. Residential AC cooling energy demands are expected to increase by 150% by 2050 whilst providing universal access to AC would result in the order of a 400% increase. Depending on the region, under current policies and limited mitigation, climate change could bring in the order of 10%–20% higher cooling-related electricity demands by 2050, and approximately 50% by 2100. Set point temperature has an important moderating role—increasing internal set-point from 23 °C to 26 °C, approximately halves the growth in electricity demand, for the majority of scenarios and regions. This effect is so strong that the change in set point temperature to both residential and commercial sectors outweighs the growth in demand that would occur by providing universal access to AC by 2050 to the 40% of the global population who would otherwise not afford it.