Carbon dioxide (CO2), whose atmospheric volume has been increasing, is the principal greenhouse gas (GHG) that causes global warming and climate change. Climate change from increasing greenhouse gases (GHGs) has broad health and environmental influences. Human-emitted GHGs constitute a significant cause of global warming. The main objective of this article is to assess the influence of technological innovation, economic growth, fossil energy use, renewable energy consumption, and globalisation on CO2 emissions (CO2Es) in South Africa over the observation period 1990–2020. The Dynamic Ordinary Least Squares (DOLS) estimator was implemented to examine the relationship between the constituents. The study results indicate that economic growth, fossil energy use, technological innovation, and globalisation boost CO2Es, whereas renewable energy consumption reduces CO2Es. The output of the canonical cointegrating regression and fully modified least squares estimators also supports the output of the DOLS estimator. We concluded that, in South Africa, a rise in economic growth, fossil energy use, technological innovation, and globalisation results in an upsurge in CO2Es. In contrast, an increase in renewable energy consumption leads to a reduction in CO2Es. This research work contributes to the discourse on CO2Es in the South African context. The study recommends that policymakers in South Africa should design policies that foster the formation of a low-carbon country, the consumption of renewable energy, and the implementation of environment-friendly technological innovations that reduce the use of fossil energy.Graphical