The adoption of drone technology in agriculture is transforming farming practices across Africa by enhancing resource efficiency, reducing operational costs, and promoting environmental sustainability. This paper explores the various applications of drones in African agriculture, including precision farming, crop monitoring, pest control, and livestock management. Drones enable farmers to optimize the use of water, fertilizers, and pesticides, leading to increased yields and improved profitability. Despite the potential benefits, the deployment of drones faces challenges such as high costs, lack of technical expertise, and regulatory barriers. This study highlights the importance of addressing these obstacles to facilitate the widespread adoption of drone technology among both small and large-scale farmers. By leveraging drones, African agriculture can improve food security, scale up operations, and contribute to the continent’s sustainable development goals. The findings of the review include case studies from Ghana, Kenya, and Nigeria which show that government intervention and private-sector partnerships are crucial for overcoming these barriers. This paper highlights the need for targeted training programs and policy reforms to enhance accessibility for smallholder farmers. By leveraging drones, African agriculture can improve food security, scale up operations, and contribute to the continent’s sustainable development goals.