When the process of urbanization has brought economic benefits in Yangtze River Economic Belt (YREB), the environmental issues become increasingly prominent. The evolutionary coupled coordination degree (CCD) between urban social economy and ecological environments was explored in 41 cities of YREB. Results indicated that the overall CCD between urban social economy and ecological environments showed a fluctuating upward trend from 2010 to 2020 in YREB. The CCD of Shanghai was the best among these of 41 cities, while those of three provinces were lower than the average CCD of YREB. There were significant differentiated spatial clusters of high and low among these YREB cities in both the global and local spatial autocorrelation analyses during 2010–2020. The CCD estimations indicated a fitted spatial distribution of "high in the east and low in the west" in YREB. Furthermore, CCD was positively influenced by the urban density of population, economic acceleration and technical advancement (P < 0.01), while it was negatively influenced by the urban industrial structures and energy consumption (P < 0.01). Subsequently, corresponding policy implications and recommendations, including enhancing policy innovation and promoting technological progress, were proposed to facilitate the formulation of evidence-based developmental strategies and policies of sustainable cities and society in YREB.
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