Pokfulam Road Research Articles

Subspecialty nurses as an essential ingredient for modern vascular service

Surgical PracticeAccepted Articles EDUCATION Subspecialty Nurses as Essential Ingredient for Modern Vascular Service Yiu Che Chan, Corresponding Author Yiu Che Chan [email protected] orcid.org/0000-0003-3764-3782 Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, China Author Correspondence Dr. Yiu Che CHAN MB BS BSc MD FRCS(England) FRCS(General Surgery) FCSHK, Associate Professor, Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, South Wing, 14 Floor K Block, Queen Mary Hospital, Pokfulam Road, Hong Kong. Tel: +852-2255-4969, FAX: +852-2255-4967, Email: [email protected]Search for more papers by this authorPo-Ching Chan, Po-Ching Chan Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorPui-Yan Paine Kong, Pui-Yan Paine Kong Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorYee-Ming Tse, Yee-Ming Tse Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorStephen W. K. Cheng, Stephen W. K. Cheng Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this author Yiu Che Chan, Corresponding Author Yiu Che Chan [email protected] orcid.org/0000-0003-3764-3782 Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, China Author Correspondence Dr. Yiu Che CHAN MB BS BSc MD FRCS(England) FRCS(General Surgery) FCSHK, Associate Professor, Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, South Wing, 14 Floor K Block, Queen Mary Hospital, Pokfulam Road, Hong Kong. Tel: +852-2255-4969, FAX: +852-2255-4967, Email: [email protected]Search for more papers by this authorPo-Ching Chan, Po-Ching Chan Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorPui-Yan Paine Kong, Pui-Yan Paine Kong Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorYee-Ming Tse, Yee-Ming Tse Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this authorStephen W. K. Cheng, Stephen W. K. Cheng Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, SAR, ChinaSearch for more papers by this author First published: 25 April 2023 https://doi.org/10.1111/1744-1633.12625 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/1744-1633.12625. AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Accepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future. RelatedInformation

Thyroid Metastasis from Lung Adenocarcinoma.

HomeRadiology: Imaging CancerVol. 5, No. 2 PreviousNext Images in CancerThyroid Metastasis from Lung AdenocarcinomaTsz-Kit Chow Tsz-Kit Chow Author AffiliationsFrom the Nuclear Medicine Unit, Department of Radiology, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.Address correspondence to the author (email: [email protected]).Tsz-Kit Chow Published Online:Feb 10 2023https://doi.org/10.1148/rycan.220154MoreSectionsFull textPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In

CORR Insights®: No Benefit to Sensor-guided Balancing Compared with Freehand Balancing in TKA: A Randomized Controlled Trial.

1Clinical Associate Professor, Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong W. P. Yau, Department of Orthopaedics and Traumatology, The University of Hong Kong Pokfulam, General Office, Orthopaedics and Traumatology, 5/F, Professorial Block, Queen Mary Hospital, No. 102 Pokfulam Road, Hong Kong, Email: [email protected] This CORR Insights® is a commentary on the article “No Benefit to Sensor-guided Balancing Compared with Freehand Balancing in TKA: A Randomized Controlled Trial by Sarpong and colleagues available at: DOI: 10.1097/CORR.0000000000002168. The author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request. The opinions expressed are those of the writer, and do not reflect the opinion or policy of CORR® or The Association of Bone and Joint Surgeons®.

CORR Insights®: No Difference in Blood Loss and Risk of Transfusion Between Patients Treated with One or Two Doses of Intravenous Tranexamic Acid After Simultaneous Bilateral TKA.

1Clinical Associate Professor, The University of Hong Kong, Pokfulam, Department of Orthopaedics and Traumatology, Hong Kong WP Yau, The University of Hong Kong, Pokfulam, Department of Orthopaedics and Traumatology, General Office, O & T, 5/F, Professorial Block, No. 102, Pokfulam Road, Hong Kong, Email: [email protected] This CORR Insights®is a commentary on the article “No Difference in Blood Loss and Risk of Transfusion Between Patients Treated with One or Two Doses of Intravenous Tranexamic Acid After Simultaneous Bilateral TKA” by Wilde and colleagues available at: DOI: 10.1097/CORR.0000000000002037. The author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request. The opinions expressed are those of the writer, and do not reflect the opinion or policy of CORR® or The Association of Bone and Joint Surgeons®.

Trends in Liver Transplantation for Chronic Hepatitis B in an Era of Highly Potent Antiviral Therapies.

Despite universal neonatal vaccination being implemented in 1988, the prevalence of chronic hepatitis B (CHB) infection remains high in Hong Kong. With antiviral therapy being available for over two decades now, there should be a significant decline in liver-related complications of CHB patients, especially with regards to cirrhosis and decompensated cirrhosis (1).

Molecular Clusters and Solvation in Volcanic and Hydrothermal Vapors

Research Article| November 01, 2018 Molecular Clusters and Solvation in Volcanic and Hydrothermal Vapors Kono H. Lemke; Kono H. Lemke Department of Earth Sciences, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China Search for other works by this author on: GSW Google Scholar Terry M. Seward Terry M. Seward SGEES, Victoria University of Wellington, Wellington 6140, New Zealand Search for other works by this author on: GSW Google Scholar Reviews in Mineralogy and Geochemistry (2018) 84 (1): 57–83. https://doi.org/10.2138/rmg.2018.84.02 Article history first online: 09 Nov 2018 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation Kono H. Lemke, Terry M. Seward; Molecular Clusters and Solvation in Volcanic and Hydrothermal Vapors. Reviews in Mineralogy and Geochemistry 2018;; 84 (1): 57–83. doi: https://doi.org/10.2138/rmg.2018.84.02 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyReviews in Mineralogy and Geochemistry Search Advanced Search Throughout the Earth’s crust from magmatic/volcanic to lower temperature hydrothermal environments, low density aqueous fluids play a fundamental role in its chemical evolution. These gas-like fluids contain a periodic table of elements but their molecular chemistry has been little studied. Even the gas-phase molecular chemistry of the solvent itself, steam or low density supercritical water, is poorly known. These low density, gas-like aqueous fluids are important reactive, chemical transport media (Henley and Seward 2018, this volume) throughout the crust and may exit into the Earth’s ocean–atmosphere system, contributing to ocean and atmospheric chemistry throughout geologic time. The importance... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.

Assembly, Accretion and Break‐up of the Paleo‐Mesoproterozoic Columbia (Nuna) Supercontinent: Records in the North China Craton

Acta Geologica Sinica - English EditionVolume 90, Issue s1 p. 50-50 2 The role of giant dyke swarms in reconstruction of supercontinents/ paleocontinents: progress, problems and potential Assembly, Accretion and Break-up of the Paleo-Mesoproterozoic Columbia (Nuna) Supercontinent: Records in the North China Craton Guochun ZHAO, Corresponding Author Guochun ZHAO gzhao@hkucc.hku.hk Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong KongCorresponding author. E-mail: gzhao@hkucc.hku.hkSearch for more papers by this author Guochun ZHAO, Corresponding Author Guochun ZHAO gzhao@hkucc.hku.hk Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong KongCorresponding author. E-mail: gzhao@hkucc.hku.hkSearch for more papers by this author First published: 31 October 2016 https://doi.org/10.1111/1755-6724.12881Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume90, Issues1Special Issue: The Seventh International Dyke Conference: Dyke Swarms: Keys to Paleogeographic Reconstruction IDC7, 18–20 August, BeijingOctober 2016Pages 50-50 RelatedInformation

Coordinated Control and Estimation of Multiagent Systems with Engineering Applications

1School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China 2Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong 3Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, USA 4Laboratory of Intelligent Control and Robotics, Shanghai University of Engineering Science, Shanghai 201620, China 5College of Electronics and Information Engineering, Tongji University, Shanghai 200092, China

Mid-Late Paleozoic metallogenesis and evolution of the Chinese Altai and East Junggar Orogenic Belt, NW China, Central Asia

1 Key Laboratory of Mineral Resources, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China; cm-han@mail.iggcas.ac.cn 2 Xinjiang Research Center for Mineral Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China 3 Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China 4 Department of Earth Science, University of Ghana, P.O. Box LG 58, Legon-Accra, Ghana * Corresponding author

Assessment of ecosystem health and ecotoxicology through chemical analysis and modeling

The industrialization and urbanization in China over the past 30 years have resulted in serious deterioration and contamination of the natural ecosystems in terms of air, soil, water and also the biota as evidenced by chemical and toxicological data reported widely (Ford and Cheng 2009; Ford et al. 2011; Gu and Wang 2012, 2013; Zhao et al. 2013). As chemical analysis can show the concentrations of specific contaminants at the time and locations of sampling, it serves as a direct indication on the extent of contamination, but it also has its own limitations by the entities of the sampled and the analytical methods used. Such data are only relevant to the specific compartments of the ecological niche under the specific conditions at the time of sampling and the methods used (Zhao et al. 2012a, b). Collection of environmental data that can yield historical events is hardly possible with routine chemical analysis alone except for a few cases, e.g., lead isotopic ratio for the sources of the contamination in sediment cores and nitrogen isotope ratio for the sources of pollution. As such, alternative approaches in understanding the environmental impact from pollution and toxic chemicals can be ecological based by using indicators that can stand the test of time to reflect the historical events of the past or pollution. In general, ecological investigations have not been given the importance and uniqueness as they deserve mainly due to the high variability and also the long duration of the study for collection of meaningful data to reach a more convincing conclusion (Shen et al. 2010). However, it is undeniable that ecological analysis coupling with chemical data can provide more insights to the environmental status of the ecosystems and the changes that have been taking place. In a similar but different approach, microbial community structure composition of selective biochemical process can be used as reliable environmental quality indicators, anammox bacteria as one has been proposed as selective species of this group are only detected in contaminated environments while others are only in pristine ecosystems (Cao et al. 2011, 2012, 2013; Li et al. 2011a, b). Since PCR-based amplification of specific DNA templates extracted from sediments/soils is highly specific and sensitive, this approach has been successful in confirming the anthropogenic pollution sources. All of these new advances are important in further scientific understanding of the living environment and in preventing against detrimental changes due to anthropogenic impacts. We believe that the research field of ecotoxicology can be advanced by more in-depth research and fundamental investigations of environmental chemistry, ecotoxicology and environmental/pollution toxicology, applied biology and molecular biology to provide the essential basic information and key data for a better understanding of the environmental issues and also protection of the environment. It is non-disputable that many scientists in China have actively engaged in research on pollution sources, types of the pollutants, toxic effects of chemicals on target and non-target organisms at a wide range of response levels including molecular, enzymatic, and organismic levels, especially many studies carried out in laboratory under simulated and controlled conditions (Han et al. 2011; Wu et al. 2009; Zhao et al. 2009, 2013). The information from such hypothetical studies must serve the needs for problem solving in the real world, which is community and ecosystem based. Here an integration of studies on ecosystem ecology and computer modeling with toxicology and analytical chemistry has been collected from selective papers J.-D. Gu (&) School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, People’s Republic of China e-mail: jdgu@hku.hk

The Charisma of Shangri-laThe Spread of Tibetan Buddhism in China: Charisma, Money, Enlightenment. By Dan Smyer Yü. New York: Routledge, 2012.

Previous article No AccessBook and Film ReviewsThe Charisma of Shangri-la The Spread of Tibetan Buddhism in China: Charisma, Money, Enlightenment. By Dan Smyer Yü. New York: Routledge, 2012.David A. PalmerDavid A. PalmerDepartment of Sociology, University of Hong Kong, Pokfulam Road, Hong Kong ([email protected]). Search for more articles by this author PDFPDF PLUSFull Text Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by Current Anthropology Volume 55, Number 1February 2014 Sponsored by the Wenner-Gren Foundation for Anthropological Research Article DOIhttps://doi.org/10.1086/674722 Views: 217Total views on this site HistoryAccepted April 04, 2013 For permission to reuse, contact [email protected]PDF download Crossref reports no articles citing this article.

Who is moving where? Molecular evidence reveals patterns of range shift in the acorn barnacle Hexechamaesipho pilsbryi in Asia

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 488:187-200 (2013) - DOI: https://doi.org/10.3354/meps10385 Who is moving where? Molecular evidence reveals patterns of range shift in the acorn barnacle Hexechamaesipho pilsbryi in Asia Ling Ming Tsang1, Benny K. K. Chan2, Gray A. Williams3, Ka Hou Chu1,* 1Simon F. S. Li Marine Science Laboratory, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 2Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan, ROC 3The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR *Corresponding author. Email: kahouchu@cuhk.edu.hk ABSTRACT: Global warming is predicted to cause a shift in the geographic ranges of marine organisms. Such shifts have already been observed with the polar retreat of temperate species and northern expansion of more tropical species. Hexechamaesipho pilsbryi is an intertidal acorn barnacle first identified by Hiro in 1936. Hiro reported the southern limit of H. pilsbryi as southern Kyushu Island, Japan. However, H. pilsbryi has recently been recorded in Taiwan as well as Maritime Southeast Asia—suggesting a recent southward range extension into tropical waters that would be contrary to general predictions. To test this hypothesis, we compared the mitochondrial COI gene sequences of 200 individuals sampled from two sites in the previously reported range, and nine sites in the newly reported localities. Two highly diverged lineages were found: a northern lineage, predominantly in Japan and Okinawa, and a southern lineage, primarily in Taiwan and Southeast Asia. The unimodal mismatch distribution and the star-like shaped haplotype network suggest recent demographic expansion in the southern lineage. The molecular data, therefore, rejected the southward extension hypothesis, and instead supported an alternative scenario of a northward range shift of the southern lineage from Southeast Asia to Taiwan. Our results reveal that range shifts in cryptic or poorly studied marine taxa may confound the identification of species’ distributions and consequent interpretation of possible changes in ranges and sources of invasion. The application of molecular data to identify and monitor such changes can address these problems and permits a rapid and sensitive confirmation of such events. KEY WORDS: Global warming · Intertidal · Biogeography · Cryptic species · Population genetics · Chthamalidae Full text in pdf format PreviousNextCite this article as: Tsang LM, Chan BKK, Williams GA, Chu KH (2013) Who is moving where? Molecular evidence reveals patterns of range shift in the acorn barnacle Hexechamaesipho pilsbryi in Asia. Mar Ecol Prog Ser 488:187-200. https://doi.org/10.3354/meps10385 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 488. Online publication date: August 15, 2013 Print ISSN: 0171-8630; Online ISSN: 1616-1599 Copyright © 2013 Inter-Research.

Latent effects of hypoxia on the gastropod Crepidula onyx

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 480:145-154 (2013) - DOI: https://doi.org/10.3354/meps10213 Latent effects of hypoxia on the gastropod Crepidula onyx A. Li1, J. M. Y. Chiu2,* 1School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR 2Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR *Corresponding author. Email: jillchiu@hkbu.edu.hk ABSTRACT: Despite the importance of latent effects in marine invertebrates, no study has considered how larval exposure to hypoxia may have lasting impacts on the individual in later life history stages. In this study, we exposed larvae of the gastropod Crepidula onyx to 2, 3, and 6 mg O2 l-1, measured the larval size and total lipid content, transplanted the newly settled individuals to the field, and finally, determined the growth rate, dry weight, and filtration rate of the juveniles after 2 wk in the field. The experiments were conducted separately at low and high larval food concentrations. Under the low food concentration, both hypoxic treatments increased the time needed for the larvae to be competent to metamorphose. When they did, however, they had a size and total lipid content similar to the control larvae. The latent effects of early hypoxia exposure on juvenile growth were evident. The juvenile growth rate was reduced by ca. 14 and 10% in the 2 and 3 mg O2 l-1 treatments, respectively. The mean dry weight and filtration rate were also significantly reduced in the hypoxic treatments. However, there was no discernible effect on larvae or juveniles when the food concentration during the larval stage was doubled, suggesting that the latent effects of hypoxia can be offset by larval access to high algal concentration. This study suggests that periodic hypoxic events and the resulting exposure of organisms to hypoxia during their early development may have effects that persist across the life history. KEY WORDS: Dissolved oxygen · Food concentration · Larva · Juvenile · Filtration rate · Growth rate Full text in pdf format PreviousNextCite this article as: Li A, Chiu JMY (2013) Latent effects of hypoxia on the gastropod Crepidula onyx. Mar Ecol Prog Ser 480:145-154. https://doi.org/10.3354/meps10213 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 480. Online publication date: April 22, 2013 Print ISSN: 0171-8630; Online ISSN: 1616-1599 Copyright © 2013 Inter-Research.

JAK2 V617F mutation positive primary myelofibrosis with concomitant t(9;11;22)(q34;p15;q11.2) but no BCR/ABL fusion

Dear Sir, A 50-year-old woman with a strong family history of cancer (ca: father ca lung age 52, mother ca lung age 50, brother ca colon age 42) and hepatitis B virus carriage on tenofovir presented with anemia [hemoglobin (Hb), 5.6 g/ dL; white blood cell (WCC), 19.4 9 10/L; platelet (Plat), 150 9 10/L with a leukoerythroblastic peripheral blood picture (Fig. 1a). Gross splenomegaly was also observed (Fig. 1b). Serum lactate dehydrogenase (LDH) was raised at 1985 IU/L, reference range 143–280]. A marrow biopsy showed osteosclerosis with markedly thickened bony trabeculae, narrowed intertrabecular spaces (Fig. 1c), and dilated sinusoids. Focal areas showed prominent blasts and clusters of megakaryocytes abutting on vascular sinuses (Fig. 1d). Reticulin fibres are markedly coarsened. The overall features were consistent with the fibrotic stage of primary myelofibrosis (PMF). A polymerase chain reaction (PCR) test showed the presence of JAK2 V6517F mutation. Cytogenetic studies, however, showed a sub-clone with a three-way translocation generating a Ph chromosome: 47,XX, ? 8[1]/47,idem,t(9;11;22)(q34;p15;q11.2)[5]/46,XX[1] (Fig. 1e). Reverse transcription PCR and fluorescent in situ hybridization (FISH) studies showed no BCR/ABL fusion (Fig. 1e). There was no clinical response to a trial of imatinib mesylate. She was treated with oral hydroxyurea, and a splenectomy (1.5 kg) specimen showed extramedullary haemopoiesis only. One year later, she remained stable (Hb, 7.9 g/dL; WCC, 22.7 9 10/L; Plat, 226 9 10/L; LDH, 655 IU/L) on regular transfusion and chelation. She refused work up for stem-cell transplantation and remained well at 2 years post-diagnosis. In myeloproliferative disorders (MPD) JAK2 mutations and BCR/ABL fusion are regarded as hallmark events. They occur in polycythemia vera/essential thrombocytosis/PMF and chronic myelogenous leukemia (CML), respectively. Although there may be preceding genetic events, both are definitive clonal markers and are mutually exclusive. There are many reports of patients possessing both the JAK2 V617F mutation and BCR/ABL transcripts. These two lesions can occur in either sequence, resulting in a transition in disease phenotype [1, 2]. Rarely, they may occur concomitantly at diagnosis, resulting in a mixed disease phenotype [3, 4]. A review of nine cases showed a median age of 48 years (range 32–66), male predominance (8/9), and a median lapse of 48 months (0–144) between the two disorders [3]. The two clones are always distinct [1–3, 5, 6]. The response of the CML element to tyrosine kinase inhibitor (TKI) is good and overall prognosis is favorable. The emergence of the second MPD should not be mistaken for TKI failure [5]. In our patient, the three-way translocation generates a morphological Ph chromosome-looking der(22). This was a subclonal evolution from a stem trisomy 8 clone. There was no BCR/ABL fusion or any clinical response to TKI. The presentation and disease course is also typical for PMF. Hence the ‘‘Philadelphia’’ chromosome in our case appeared to be an incidental cytogenetic anomaly. On the metaphase FISH analysis, the entire ABL gene was translocated onto 11p, no residue ABL signal was found in 9q. W.-Y. Au (&) Department of Medicine, Queen Mary Hospital, UMU, 4/F, Professorial Block, Pokfulam Road, Hong Kong, China e-mail: auwing@hotmail.com

Writing facilitates learning to read in Chinese through reduction of holistic processing: A developmental study

Writing facilitates learning to read in Chinese through reduction of holistic processing: A developmental study

Heat Transfer in Nanofluids 2012

1 School of Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854-8058, USA 2Dipartimento di Ingegneria Aerospaziale e Meccanica, Seconda Universita degli Studi di Napoli, Viale Beneduce 10, Via Roma 29, 81031 Aversa, Italy 3 Laboratory of Thermodynamics in Emerging Technologies, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland 4Department of Mechanical Engineering, University of California, Riverside, A363 Bourns Hall, Riverside, CA 92521-0425, USA 5Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong

Multi-focal EBV-mucocutaneous ulcer heralding late-onset T-cell immunodeficiency in a woman with lupus erythematosus

Epstein Barr virus (EBV)-positive mucocutaneous ulcer (MCU) is a new clinicopathologic entity with a self-limited indolent course, and responds well to conservative management [1]. These are invariably localized (60% in oropharyngeal area) and may occur in patients with senile or iatrogenic immunosuppression. Lesions typically regress with reduction in immunosuppression, but may recur. Prognosis is always favorable. We report a unique case of multifocal EBV-related MCU as the first manifestation of an unsuspected T-cell immunodeficiency. A 45-year-old woman had been treated with azathioprine and steroids for lupus nephritis and encephalitis from age 20. Her medications were stopped for 10 years. She presented with mycobacterium avium intracellulare (MAI) lymphadenopathy of groin and was treated with ethambutol, clarithromycin and rifampicin. Six months later, she suffered from left facial palsy, molluscum contagiosum (Fig. 1a) and a gum lesion (Fig. 1b). Positron emission tomography (PET) scanning showed uptake in left ear, lung, and gum (SUVmax 1.5–5.0) (Fig. 1c). A biopsy (Fig. 1d, e) showed a dense lymphoid infiltrate positive for CD20 (L26), CD30 (BerH2), and EBER. This was compatible with EBV-related mucocutaneous lymphoproliferation [1]. Antibodies to human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV-1) and autoimmune markers were negative, but her CD4 (76 L/lL, normal 354–1,526) and CD8 counts (71 L/lL, normal 318–1,458) were severely depressed, with normal B and NK cell numbers. Cytogenetic study showed mosiac 46, XX, delXq27 [5]/46, XX [59]. In view of likely persistent low T-cell counts, disseminated lesions, and functional deficit, she was treated with rituximab (375 mg/ m 9 8) [2] with a complete metabolic response and partial facial nerve recovery. The CD4 and CD8 counts remained depressed at 2 years and she refused further genetic tests or family studies. We report the first case of multifocal EBV-related MCU in an adult patient with multiple opportunistic infections due to cellular immune defect. In HIV patients, molluscum contagiosum and MAI infections occur when the CD4 count falls near 50 L/lL [3], and both are rare in acquired T-cell immunodeficiency cases. Late-onset T-cell immunodeficiency (10% of cases and up to age 64) is increasingly recognized [4]. Over 20% of late-onset immunodeficiencies had lymphoma and autoimmune manifestations [4]. Patients with genetic T-cell defects are genetically heterogeneous ([150 disorders described). Intriguingly, our case carries a mosaic chromosome X cytogenetic defect. Iatrogenic immunodeficiency is also possible, but her therapy had been stopped many years ago, and her SLE is likely secondary to her T-cell dysregulation [5]. Irrespective of the underlying predisposition, in patients with unexplained sequential opportunistic infections and malignancies, a full work-up for immunodeficiency is needed. W. Y. Au (&) Department of Medicine, UMU, 4/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong e-mail: auwing@hotmail.com

Comment on ‘Paleokarst on the top of the Maokou Formation: Further evidence for domal crustal uplift prior to the Emeishan flood volcanism’

a Department of Geoscience, 121 Trowbridge Hall, University of Iowa, Iowa City IA 52242, USA b Biogeoscience, Queensland University of Technology, Brisbane, Queensland 4001, Australia c Department of Earth and Environment, University of Leeds, Leeds LS2 9JT, UK d DougalEARTH Ltd., 12 Nevilles Cross Villas, Durham DH1 4JR, UK e Department of Earth Sciences, University of Hong Kong, Pokfulam Road, Hong Kong, China

Errata for “Suction-Monitored Direct Shear Testing of Residual Soils from Landslide-Prone Areas” by Apiniti Jotisankasa and Warakorn Mairaing

December 2009, Vol. 135, No. 12, pp. 1932–1940. DOI: 10.1061/ ASCE GT.1943-5606.0000157 W. M. Yan, M.ASCE Assistant Professor, Dept. of Civil Engineering, Univ. of Hong Kong, Pokfulam Road, Hong Kong, China corresponding author . E-mail: ryanyan@hku.hk Ka-Veng Yuen Associate Professor, Dept. of Civil and Environmental Engineering, Univ. of Macau, Macau, China. Gil Lim Yoon, A.M.ASCE Principal Researcher, Dept. of Coastal Development and Energy, Korea Ocean Research and Development Institute, Ansan, South Korea 425-600.

Methods to Derive the Differential Equation of the Free Surface Boundary

GroundwaterVolume 48, Issue 4 p. 486-493 Methods to Derive the Differential Equation of the Free Surface Boundary Jacob Bear, Jacob Bear Department of Civil and Environmental Engineering, Technion-Israel Institute of Technology, Haifa, Israel. School of Engineering, Kinneret College on Sea of Galilee, Zemach, Israel; cvrbear@tx.technion.ac.ilSearch for more papers by this authorAlexander H.-D. Cheng, Corresponding Author Alexander H.-D. Cheng Department of Civil Engineering, University of Mississippi, MS 38677; acheng@olemiss.eduSearch for more papers by this authorVedat Batu, Vedat Batu URS Corporation, 100 South Wacker Drive, Chicago, IL 60606; vedat_batu@urscorpSearch for more papers by this authorChongxi Chen, Chongxi Chen Institute of Environmental Geology, China University of Geosciences, Wuhan, 430074, China.Search for more papers by this authorXingxing Kuang, Xingxing Kuang Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China; (852)28578246; fax: (852) 25176912; jjiao@hku.hk, May–June issue 2010, v. 48, no. 3: 329–332.Search for more papers by this authorJiu Jimmy Jiao, Jiu Jimmy Jiao Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China; (852)28578246; fax: (852) 25176912; jjiao@hku.hk, May–June issue 2010, v. 48, no. 3: 329–332.Search for more papers by this author Jacob Bear, Jacob Bear Department of Civil and Environmental Engineering, Technion-Israel Institute of Technology, Haifa, Israel. School of Engineering, Kinneret College on Sea of Galilee, Zemach, Israel; cvrbear@tx.technion.ac.ilSearch for more papers by this authorAlexander H.-D. Cheng, Corresponding Author Alexander H.-D. Cheng Department of Civil Engineering, University of Mississippi, MS 38677; acheng@olemiss.eduSearch for more papers by this authorVedat Batu, Vedat Batu URS Corporation, 100 South Wacker Drive, Chicago, IL 60606; vedat_batu@urscorpSearch for more papers by this authorChongxi Chen, Chongxi Chen Institute of Environmental Geology, China University of Geosciences, Wuhan, 430074, China.Search for more papers by this authorXingxing Kuang, Xingxing Kuang Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China; (852)28578246; fax: (852) 25176912; jjiao@hku.hk, May–June issue 2010, v. 48, no. 3: 329–332.Search for more papers by this authorJiu Jimmy Jiao, Jiu Jimmy Jiao Department of Earth Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China; (852)28578246; fax: (852) 25176912; jjiao@hku.hk, May–June issue 2010, v. 48, no. 3: 329–332.Search for more papers by this author First published: 22 June 2010 https://doi.org/10.1111/j.1745-6584.2010.00711.xCitations: 5 All equation numbers below 100 refer to equations in Chen et al. (2010). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume48, Issue4July/August 2010Pages 486-493 RelatedInformation