Point Of View Research Articles

Research Progress and Prospect on Profile Roll Forming Methods and Equipment

Abstract: In recent years, with the development of aerospace, automotive, rolling stock, shipbuilding, military weapons and other industries, the demand for bent and rolled parts is increasing, and the requirements for roll forming accuracy are growing. With the rapid development of coal power, hydropower, nuclear power, wind power, and petrochemical industries, the design and research on roll bending machine and the profile roll forming methods have come into focus. The purpose of this study is to summarize the classification and characteristics of roll bending equipment, analyze the reasons that affect the accuracy of profile bending, and propose specific solutions. This paper summarizes the research status and patents on the existing roll bending equipment, introduces its structural characteristics, differences, and molding effects, and focuses on the difficulties, optimization, and improvement methods of roll bending molding. In this paper, the mechanical structures of the existing roll forming equipment have been analyzed and compared, the effects of different roll forming equipment on the profile bending results have been determined, and the reasons affecting the bending accuracy have been pointed out. By summarizing the patents and research on profile roll forming methods and equipment, the current situation and future research prospects of roll forming equipment are discussed. The roll forming equipment is divided into a roll bending machine, a CNC roll bending machine, and a flexible roll bending machine. Each design can meet different profile processing needs. From the design point of view, the optimization under the given processing profile can achieve relatively high processing accuracy. However, the processing of different profiles will still produce geometric defects, and there is some space for improvement in the structure of roll forming equipment, the materials of processing rollers, and the NC interactive system. Thus, further research on profile roll forming is needed in the future.

Camus y Sartre, ¿disputa o afinidad filosófica? Concepciones en torno a la idea de responsabilidad existencial

This essay is based on the question: how to represent the argumentative contrast of the concept of responsibility in the philosophical postulates from Jean-Paul Sartre and Albert Camus?The main objective of this study is to link the way in which bothauthors address, agree, and differ on various philosophical pointsof view about this idea (individual and social human responsibility) throughout their works, and to compare this contrast tothe disputes they have during their life, looking for establishconnections and differences between both philosophical positions (Existentialism and Absurdism), as well as to approach to the foundations of their ideas. This study is based on Sartre byhimself (1955) and The Existentialism is a Humanism (1946),by Sartre, and The Myth of Sisyphus (1942) and The Revel Man (1951) by Camus.

The Treatment of a New Entity in Advanced Non-small Cell Lung Cancer: MET Exon 14 Skipping Mutation.

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) exon 14 skipping mutation represents one of the most common MET alterations, accounting for approximately 1-3% of all mutations in advanced lung adenocarcinomas. While until 2020 no specific treatment was available for this subset of patients, as of today, three MET Tyrosine Kinase Inhibitors (TKIs) are currently approved in this setting, namely capmatinib, tepotinib and savolitinib. This article aims to provide an extensive overview of the current therapeutic standard of care for exon 14 skipped advanced Non-small Cell Lung Cancer (NSCLC) patients, alongside with mentions of the main future challenges and opportunities. FDA-approved MET-TKIs currently represent the best option for treating exon 14 skipped advanced NSCLC patients, thanks to their excellent efficacy profile, alongside their manageable safety and tolerability. However, we currently lack specific agents to treat patients progressing on capmatinib or tepotinib, due to a limited understanding of the mechanisms underlying both on- and off-target resistance. In this respect, on-target mutations presently constitute the most explored ones from a mechanistic point of view, and type II MET-TKIs are currently under investigation as the most promising agents capable of overcoming the acquired resistance.

Structure tensor-based Gaussian kernel edge-adaptive depth map refinement with triangular point view in images

<span lang="EN-US">Image reconstruction is the process of restoring the image resolution. In 3D image reconstruction, the objects in different viewpoints are processed with the triangular point view (TPV) method to estimate object geometry structure for 3D model. This work proposes a depth refinement methodology in preserving the geometric structure of objects using the structure tensor method with a Gaussian filter by transforming a series of 2D input images into a 3D model. The computation of depth map errors can be found by comparing the masked area/patch with the distribution of the original image's greyscale levels using the error pixel-based patch extraction algorithm. The presence of errors in the depth estimation could seriously deteriorate the quality of the 3D effect. The depth maps were iteratively refined based on histogram bins number to improve the accuracy of initial depth maps reconstructed from rigid objects. The existing datasets such as the dataset tanks and unit (DTU) and Middlebury datasets, were used to build the model out of the object scene structure. The results of this work have demonstrated that the proposed patch analysis outperformed the existing state of the art models depth refinement methods in terms of accuracy.</span>

Design, Fabrication and Performance Test of an Effective Body Armor

Aims: This original research paper targets an easy but efficient design and fabrication of a safe body armor. A test bed with weapons was another key aim. Therefore, it is essential to verify the vest’s capability to withstand rigorous stab tests as prescribed by the standard. Background: The most widely used armor piece is the torso-protecting overt (worn over the uniform or clothing) one. The main concern of this work was to design and develop such a stabresistant soft body armor made from readily available materials to protect against threats such as knives, blades, and sharp-tipped objects. Objectives: From the Mechanical Engineering point of view, the present research goals for such an armor vest were: low cost, moderately lightweight, comfortable, made from easily available materials, simple forward design, easy to fabricate, and the ability to adjust the level of protection without altering the primary design structure. The effectiveness of the vest needed to be verified through rigorous testing following relevant standards. Methods: The prototype of the stab-resistant armor was fabricated with two different configurations and their performance was rigorously tested in accordance with the NIJ Standard-0115.00 to determine its level of protection. Nylon-based panel elements covered with rubber and cotton-based panels were compared in terms of their ability to stop stab threats. Taking into account the key point of strike energy levels during the stabbing, test beds were created in the laboratory to rigorously conduct the required tests. Blades of two types were made, attached with fixtures, and dropped on the armors (upon backing material) in the test bed. Results: The ‘Complete Armor’ showed excellent performance against stab attacks. The tests revealed that the nylon-based panel elements covered with rubber were more successful in stopping stab threats compared to cotton-based panels. Conclusion: The designed and fabricated prototype of the stab-resistant soft body armor achieved the desired level of protection against stab threats. The armor is also cost-effective, it can be fabricated using locally available materials, at a cost of only 10 USD compared to 300 USD for commercially available armor. Other: However, it should be noted that stab resistance does not necessarily imply ballistic resistance, and no armor can provide invincibility against all types of threats.

Conservation and Landscape Evaluation of Some Endangered Species in Türkiye

In addition to in-situ conservation activities related to endangered taxa, it has a great importance to provide ex-situ conservation activities to increase awareness and to determine their usage areas by examining reproduction methods. In the line with, the aim of the study is to prevent the extinction of some endangered endemic taxa in Ayaş, Beypazarı and Nallıhan regions of Ankara province in Türkiye, to evaluate the taxa within the framework of sustainable conservation and use principles by raising awareness, and thus to protect the biodiversity in the region. For these purposes, during their vegetation periods throughout the years 2020-2022, some observations were recorded in landscape point of view from the habitats of 9 Critically Endangered (CR) and 3 Vulnerable (VU) taxa. Moreover, all the taxa are photographed and have been archived in the Collections of National Botanical Garden of Türkiye (NBGT) as National Herbarium (TC), DNA and Tissue Banks. Also, samples have been kept in 70% EtOH for Microscobic Slide Collection of NBGT. In addition, the possibilities of using taxa in the landscape area were evaluated. The results of the habitat observations for years serve as a basis for future conservation and landscape gain efforts for the taxa.

Az intellektuális tőke mérési lehetőségei egy vállalati példán keresztül

Our research aims to examine the “invisible value” found at UPC Magyarország Kft. Since Vodafone Magyarország Nyrt. announced the acquisition of UPC Magyarország Kft. in 2020. Our research is aimed at using different methods to determine the invisible assets, intellectual capital, and added value, which cannot be determined directly from the financial statements of UPC Magyarország Kft. Since the financial statements prepared based on accounting principles follow the principle of prudence, many assets (mainly intangible assets) are not shown in the financial statements, so they only become visible after the moment of acquisition. Three different methods were used to measure intellectual capital, then the results were compared. The three methods use different points of view to measure intellectual capital and approach the concept of intellectual capital from other points of view. The CIV method shows us the lack of intellectual capital in relation to the industry or the surplus value; The EVA indicator explicitly shows us the intellectual capital size; and the VAIC method the efficiency of intellectual capital.

Is ageing undesirable? An ethical analysis

The technical possibilities of biomedicine open up the opportunity to intervene in ageing itself with the aim of mitigating, reducing or eliminating it. However, before undertaking these changes or rejecting...

Main causes of death in Italy

Understanding the major diseases processes which lead to mortality is an important aspect of healthcare planning, especially with regards to the life periods in which death is considered as “avoidable” i.e. premature (generally before the age of 70). From a methodological point of view, the identification of the major causes of death is based on the criterion of frequency. We consider the weight of deaths due to a specific cause in relation to all deaths and then define the main causes of death in relation to the highest weights. The selection criterion is thus merely quantitative.

Aquatic Angiosperms of India

Some of the salient features pertaining to the taxonomy of a few interesting aquatic angiosperms and their distribution, variability of fruits and seeds, their economic importance, floral biology, anatomy, embryology and cytology are presented here. The varied and diverse pattern of distribution of some Indian aquatic taxa is described with examples. Certain unique embryological features noticed in some aquatic plants are pointed out. Though the data on the cytplogy of Indian aquatic angiosperms is raher meagre, it is evident that from the evolutionary point of view, polyploidy has played an important role in the differentiation of races, varieties and species. The nomenclature of Nymphoides Hill and Necharmndra Planch., is discussed. Finally, the ample scope present for further work for a better understanding of these plants is emphasised.

The primeness of noncommutative polynomials on prime rings

We study the primeness of noncommutative polynomials on prime rings. Let [Formula: see text] be a prime ring with extended centroid [Formula: see text], [Formula: see text] a right ideal of [Formula: see text], [Formula: see text] a noncommutative polynomial over [Formula: see text], which is not a polynomial identity (PI) for [Formula: see text], and [Formula: see text]. Then [Formula: see text] for all [Formula: see text] if and only if one of the following holds: (i) [Formula: see text]; (ii) [Formula: see text] for some idempotent [Formula: see text] and [Formula: see text] such that either [Formula: see text] is a PI for [Formula: see text] or [Formula: see text] is central-valued on [Formula: see text] and [Formula: see text]. We then apply the result to higher commutators of right ideals. Some results of the paper are also studied from the view of point of the notion of [Formula: see text]-primeness of rings.

Review on development prospect of operation scheduling strategies for flexible interconnected distribution network in renewable energy-penetrated power system

As the renewable energy integrates in the power system, the interactions between source, load, and storage equipment in the distribution network become frequent. The original distribution network could not meet the growing demand of the power grid. The use of controlled power electronic devices for flexible interconnection transformation of the distribution network could help improve the controllability, reliability, and safety of the power system and promote the consumption of distributed power sources. It is an important means of evolving towards future intelligent distribution networks. Typical devices for flexible interconnection are discussed of the operating characteristics. In addition, the core technologies of flexible interconnected distribution network system are introduced from the view of point of dispatching. Finally, to achieve a wider application of flexible interconnected distribution networks, the development trend is prospected.

Troska kardynała Karola Wojtyły o godne uczczenie jubileuszu św. Stanisława (1972-1979)

“Polish Christian tradition linked two bishops and martyrs - witnesses, so to speak, of our Christening and Confirmation. From the point of view of the history of redemption - a spiritual process progressing through the history of a nation - it is still verytelling. And it does not cease to be telling, just like in the life of each of us the dates of Christening and Confirmation do not cease to be telling, though we drift further and further apart from them with the passing away of the days of our life. We constantly realise that the dates of Christening and Confirmation were decisive for the coming of Christ into our life. That is why we come back to them. This is the reason why we will soon have to come back to the date 1079, remembering not only the day of the martyr’s death, but the whole seven years of the pastoral work of bishop Stanislaus (1072-1079) in Cracow. (...) If the meaning of St. Stanislaus in the history of redemption on our soil may be understood by analogy with developing of faith which takes place in man as well as in a given community or society, then the most adequate way of referring to the great personage after nine centuries would be working on such enrichment and deepening of faith as is required by our times.” In this way in 1970 Cracow Metropolitan, Cardinal Karol Wojtyła, justified the necessity of solemn celebrations in honour of St. Stanislaus and showed their ecclesiastical and pastoral character. In the history of the Cracow diocese there has never been a celebration more carefully prepared than the one in worship of St. Stanislaus. No other celebration has been so deeply set in the theological, historical and pastoral context. It is not easy to find other events whose general outline would be so meticulously thought over. Preparations started two years prior to the main ceremonies, thus allowing many initiatives which enabled not only experiencing the jubilee year in a proper way, but most of all, a spiritual revitalisation of the faithful. Reading the addresses and sermons of Cardinal Karol Wojtyła we come across many trains of thoughts of St. Stanislaus. The patron saint was always present in the addresses of the Metropolitan. For the future generations it is important that owing to the initiatives of the Cardinal the cult of St. Stanislaus was revitalised.

Testing analytical methods to derive the cosmic-ray ionisation rate in cold regions via synthetic observations

Context. Cosmic rays (CRs) heavily impact the chemistry and physics of cold and dense star-forming regions. However, the characterisation of their ionisation rate continues to pose a challenge from the observational point of view. Aims. In the past, a few analytical formulas have been proposed to infer the cosmic-ray ionisation rate, ζ2, from molecular line observations. These have been derived from the chemical kinetics of the involved species, but they have not yet been validated using synthetic data processed with a standard observative pipeline. In this work, we aim to bridge this gap. Methods. We performed a radiative transfer on a set of three-dimensional magneto-hydrodynamical simulations of prestellar cores, exploring different initial ζ2, evolutionary stages, types of radiative transfer (for instance assuming local-thermodynamic-equilibrium conditions), and telescope responses. We then computed the column densities of the involved tracers to determine ζ2, employing a recently proposed method based on the detection of H2D+. We compared this approach with a previous method, based on more common tracers. Both approaches are commonly used. Results. Our results confirm that the equation based on the detection of H2D+ accurately retrieves the actual ζ2 within a factor of two to three in the physical conditions explored in our tests. Since we have also explored a non-local thermodynamic equilibrium (non-LTE) radiative transfer, this work indirectly offers insights into the excitation temperatures of common transitions at moderate volume densities (n ≈ 105 cm−3). We also performed a few tests using a previous methodology that is independent of H2D+, which overestimates the actual ζ2 by at least two orders of magnitude. We considered a new derivation of this method, however, we found that it still leads to high over-estimations. Conclusions. The method based on H2D+ is further validated in this work and demonstrates a reliable method for estimating ζ2 in cold and dense gas. On the contrary, the former analytical equation, as already pointed out by its authors, has no global domain of application. Thus, we find that it ought to be employed with caution.

Heterogeneity of mesenchymal cells in human amniotic membrane at term.

There is increasing interest in understanding the tissue biology of human amniotic membrane (hAM) given its applications in medicine. One cellular component is mesenchymal cells, which can be extracted, cultured and differentiated "in vitro" into various cell types. These studies show that there is heterogeneity among mesenchymal cells. The aim of this work is to study the membrane in situ to determine whether this cellular heterogeneity exists. The hAMs were obtained from caesarean deliveries at term and analyzed by histological techniques. Types I-III mesenchymal cells and Hofbauer were distinguished by light microscopy. Histochemically, mesenchymal cell types showed successively increasing positivity to: PAS, vimentin, fibronectin, and Concanavalin-A; VGEF, TGF-β2, PDGF-C, FGF-2. By the semiquantitative point of view, the percentage of Type II cells was 60%, significantly higher than the other types. With transmission electron microscopy, an intermediate cell type between II-III was observed. Strong vesiculation of the rough endoplasmic reticulum (RER) with exocytosis was observed. In addition, an accumulation of a similar material to the extracellular matrix in the RER caused its dilation especially in type IIITEM cells. Some of this material acquired a globular structure. These structures were also found free in the extracellular matrix. In conclusion, the mesenchymal cells of the fibroblastic layer of the hAMs studied are heterogeneous, with some undifferentiated and others with a probably senescent fibroblastic phenotype with accumulation in their RER of fibronectin. These results may be of interest to extract mesenchymal cells from hAMs for use in regenerative medicine and to better understand the mechanisms of fetal membrane rupture.

Important-Data-Based DoS Attack Mechanism and Resilient H∞ Filter Design for Networked T-S Fuzzy Systems.

This article is concerned with the security problems for networked Takagi-Sugeno (T-S) fuzzy systems with asynchronous premise constraints. The primary objective of this article is twofold. First, a novel important-data-based (IDB) denial-of-service (DoS) attack mechanism is proposed from the perspective of the adversary for the first time to reinforce the destructive effect of the DoS attacks. Different from most existing DoS attack models, the proposed attack mechanism can utilize the information of packets, evaluate the importance degree of packets, and only attack the most "important" ones. As such, a larger system performance degradation can be expected. Second, corresponding to the proposed IDB DoS mechanism, a resilient H∞ fuzzy filter is designed from the defender's point of view to alleviate the negative effect of the attack. Furthermore, since the defender does not know the attack parameter, an algorithm is designed to estimate it. In a word, a unified attack-defense framework is developed in this article for networked T-S fuzzy systems with asynchronous premise constraints. With the help of the Lyapunov functional method, sufficient conditions are successfully established to compute the desired filtering gains and ensure the H∞ performance of the filtering error system. Finally, two examples are exploited to demonstrate the destructiveness of the proposed IDB DoS attack and the usefulness of the developed resilient H∞ filter.

An ontology of 3D environment where a simulated manipulation task takes place (ENVON)

Thanks to the advent of robotics in shopfloor and warehouse environments, control rooms need to seamlessly exchange information regarding the dynamically changing 3D environment to facilitate tasks and path planning for the robots. Adding to the complexity, this type of environment is heterogeneous as it includes both free space and various types of rigid bodies (equipment, materials, humans etc.). At the same time, 3D environment-related information is also required by the virtual applications (e.g., VR techniques) for the behavioral study of CAD-based product models or simulation of CNC operations. In past research, information models for such heterogeneous 3D environments are often built without ensuring connection among different levels of abstractions required for different applications. For addressing such multiple points of view and modelling requirements for 3D objects and environments, this paper proposes an ontology model that integrates the contextual, topologic, and geometric information of both the rigid bodies and the free space. The ontology provides an evolvable knowledge model that can support simulated task-related information in general. This ontology aims to greatly improve interoperability as a path planning system (e.g., robot) and will be able to deal with different applications by simply updating the contextual semantics related to some targeted application while keeping the geometric and topological models intact by leveraging the semantic link among the models.

Improving Clinical Trials of Antioxidants in Alzheimer's Disease.

Maintaining diversity in drug development in research into Alzheimer's disease (AD) is necessary to avoid over-reliance on targeting AD neuropathology. Treatments that reduce or prevent the generation of oxidative stress, frequently cited for its causal role in the aging process and AD, could be useful in at-risk populations or diagnosed AD patients. However, in this review, it is argued that clinical research into antioxidants in AD could provide more useful feedback as to the therapeutic value of the oxidative stress theory of AD. Improving comparability between randomized controlled trials (RCTs) is vital from a waste-reduction and priority-setting point of view for AD clinical research. For as well as attempting to improve meaningful outcomes for patients, RCTs of antioxidants in AD should strive to maximize the extraction of clinically useful information and actionable feedback from trial outcomes. Solutions to maximize information flow from RCTs of antioxidants in AD are offered here in the form of checklist questions to improve ongoing and future trials centered around the following dimensions: adhesion to reporting guidelines like CONSORT, biomarker enrichment, simple tests of treatment, and innovative trial design.

Improved ant colony optimization algorithms for multi-objective investment decision model based on intelligent fuzzy clustering algorithm

With the continuous changes and development of financial markets, it has brought many difficulties to investment decision-making. For the multi-objective investment decision-making problem, the improved Ant colony optimization algorithms was used to improve the effectiveness and efficiency of the multi-objective investment decision-making. Therefore, based on intelligent Fuzzy clustering algorithm and Ant colony optimization algorithms, this paper studied a new multi-objective investment decision model, and proved the advantages of this method through comparative analysis of experiments. The experimental results showed that the improved Ant colony optimization algorithms has significantly reduced the system’s construction costs, operating costs and financial costs, all of which were controlled below 41%. Compared with the traditional Ant colony optimization algorithms, this method had lower values in policy risk, technical risk and market risk, and can effectively control risks. Meanwhile, the environmental, economic, and social benefits of this method were all above 58%, and the average absolute return rate and success rate in this experiment were 21.5450% and 69.4083%, respectively. Therefore, from the above point of view, the multi-objective investment decision model based on intelligent Fuzzy clustering algorithm and the improved Ant colony optimization algorithms can effectively help decision-makers to find the best investment decision-making scheme, and can improve the accuracy and stability of decision-making. This research can provide reference significance for other matters in the field of investment decision-making.

The multiple trajectories of the allergic march.

The allergic march comprises the sequential appearance of a series of allergic comorbidities. However, variability in the onset and progression of allergic diseases generates a heterogeneous scenario that does not follow a linear and single trajectory. Almost half of the pediatric population presents at least 1 allergy symptom. However, only 4%-6% present multimorbidity, with several allergic diseases co-occurring. It has recently been shown that although they share etiological mechanisms and risk factors, allergic diseases arise independently. In most cases, progression is not consecutive, or at least not the same in all patients. TH2- mediated inflammation, epithelial barrier dysfunction, and genetic predisposition play a fundamental role in the etiology of allergic diseases, on which the interaction with the exposome acts decisively. Therefore, studying diseases from an omics point of view is essential when attempting to describe the various trajectories of allergic progression and to propose effective interventions to prevent multimorbidity. In this narrative review, we provide an overview of the current perception of the allergic march, including clinical observations, omics data, risk factors, and measures aimed at modifying its course or even preventing its onset.