Platelet Volume In Patients Research Articles

The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses.

Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admission MPV in predicting clinical outcomes in patients with CAD. PubMed, Web of Science, and Scopus were the major databases used for literature search. The risk of bias was assessed using the quality in prognostic factor studies. We used random-effects pairwise analysis with the Knapp and Hartung approach supported further with permutation tests and prediction intervals (PIs). We identified 52 studies with 47,066 patients. A meta-analysis of nine studies with 14,864 patients demonstrated that one femtoliter increase in MPV values was associated with a rise of 29% in the risk of long-term mortality (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.22-1.37) in CAD as a whole. The results were further supported with PIs, permutation tests and leave-one-out sensitivity analyses. MPV also demonstrated its stable and significant prognostic utility in predicting long-term mortality as a linear variable in patients treated with percutaneous coronary intervention (PCI) and presented with acute coronary syndrome (ACS) (HR 1.29, 95% CI 1.20-1.39, and 1.29, 95% CI 1.19-1.39, respectively). The meta-analysis found robust evidence on the link between admission MPV and the increased risk of long-term mortality in patients with CAD patients, as well as in patients who underwent PCI and patients presented with ACS.

Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume as practical markers in febrile seizure classification.

To examine the neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume in patients with febrile seizure and to determine their role in febrile seizure classification. This was a retrospective hospital-based study conducted among patients aged 5 to 72 months admitted with febrile seizure. Children who had febrile seizures due to upper respiratory tract infection were included in the study. The children were divided into two groups: simple febrile seizures and complex febrile seizures. Patients with a history of febrile status epilepticus, previous convulsions, use of antiepileptic or other chronic drugs, foci of infection other than the upper respiratory tract infection, abnormal biochemical parameters, and chronic mental or physical disease were excluded from the study. Clinical and laboratory findings of the patients were obtained from digital medical records. The records of 112 febrile seizure patients were reviewed, and 89 were grouped as simple and 23 as complex febrile seizures. Although there was no statistically significant difference between the two groups in terms of the mean red cell distribution width values (p=0.703), neutrophil-lymphocyte ratio and mean platelet volume were significantly higher in patients with complex febrile seizures (p=0.034, p=0.037; respectively). This study showed that neutrophil-lymphocyte ratio and mean platelet volume could be practical and inexpensive clinical markers for febrile seizure classification. A similar result could not be reached for red cell distribution width in this study. These findings should be supported by multicenter studies with large samples.

Evaluation of serum vitamin D level, neutrophil to lymphocyte ratio and mean platelet volume in patients with recurrent aphthous stomatitis

Evaluation of serum vitamin D level, neutrophil to lymphocyte ratio and mean platelet volume in patients with recurrent aphthous stomatitis

Relationship between Mean Platelet Volume and Disease Activity Score in Patients Presenting with Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the presence of joint inflammation, joint pain, and the progressive deterioration of synovial joints. As a consequence, individuals have physical impairment and an increased susceptibility to premature death. Objective: In order to determine the correlation between mean platelet volume and disease activity score in individuals diagnosed with rheumatoid arthritis. Study Design: Cross sectional study design. Settings: Department of Rheumatology Sheikh Zayed Hospital, Lahore Pakistan. Duration: 6th October 2021 to 5th April 2022. Methods: In this research, 140 participants of varying genders, aged between 20 and 70 years, were included, all of whom were diagnosed with rheumatoid arthritis. To evaluate disease activity, the researchers utilized the Disease Activity Score (DAS-28), and the mean platelet volume (MPV) was measured through routine complete blood examination. Results: The patient cohort spanned from 20 to 70 years old, with an average age of 45.85 ± 12.24 years. Among them, 33 (23.6%) were male, and 107 (76.4%) were female, resulting in a female-to-male ratio of 3.2:1. The duration of rheumatoid arthritis varied from 6 to 72 months, averaging 38.36 ± 16.93 months. Patients' DAS-28 scores ranged from 2.6 to 10.0, with a mean of 5.52 ± 2.10, while their mean platelet volume (MPV) ranged from 6.5 fl to 13.5 fl, with an average of 9.99 ± 1.98 fl. Conclusion: There was significantly strong negative correlation between disease activity score and mean platelet volume in patients suffering from rheumatoid arthritis across all age and gender groups.

Clinical and capillaroscopy correlation of Pentraxin 3 and mean platelet volume in patients with systemic sclerosis: A case control study

Systemic sclerosis (SSc) is a systemic connective tissue disease with vasculopathy and tissue fibrosis. Mean platelet volume (MPV) indicates the platelet activation and independent risk factor for arterial diseases. Long pentraxin, or pentraxin-3 (PTX3), is a homologous pattern recognition receptor mainly presented in inflammatory diseases with some inhibitory effects on chronic inflammation. This study aimed to evaluate the relationship between clinical and capillaroscopy manifestations of patients with SSc, MPV, and PTX3 levels compared to thecontrol group. This case-control study was conducted on patients who met the SSc diagnostic criteria. Accordingly, clinical manifestations and capillaroscopy data were recorded. Thus, the MPV and PTX3 levels of the patients and the control group were checked. Then, the relationship between the clinical and capillaroscopy results was evaluated. The mean ± SD of MPV in the control group and patients was 10.11 ± 0.96 fL and 9.65 ± 1.13 fL, respectively (P-value = 0.043). In addition, the PTX3 level was 3.60 ± 8.98 and 1.79 ± 5.77 ng/ml, respectively (P-value = 0.223). The relationship of these factors with the clinical and capillaroscopy results was insignificant (P-value > 0.05). Based on the results, the MPV level was significantly lower in patients with SSc than controls, while the PTX3 level did not differ between the groups. Moreover, there was no relationship between PTX3 and MPV levels with the capillaroscopy and clinical results. However, further studies with larger sample sizes are recommended.

Platelet Count and Platelet Volume in Patients with CKD.

Platelet Count and Platelet Volume in Patients with CKD.

Mean Platelet Volume as a Prognostic Marker in Sepsis in ICU

Abstract Background Sepsis is defined as a systemic inflammatory response to confirmed or suspected infection. It is a major cause of morbidity and mortality, and the incidence is rising, probably due to the growing elderly population, antibiotic resistance, immunosuppressive medication and, invasive surgery. Pneumonia is the most common infection leading to sepsis, followed by urinary tract infections and abdominal infections. These infections are usually localized and controlled by the immune system, but they can sometimes spread and cause sepsis. Objective To correlate between the mean platelet volume in patients with sepsis with C-reactive protein as a prognostic markers. Patients and Methods This is a prospective study conducted on 80 adult critically ill patients of both sexes with sepsis and sever sepsis who admitted to the units of Critical Care Medicine Ain Shams University Hospitals. The samples were collected during the period from 1st October 2019 to 31st March 2020, MPV results were correlated to CRP, SOFA score and APACHE score. Results The results of the present study revealed: 55.8 % were male and 44.2 % were females. Sex did not affect mortality, no statistical significance found. In this study, MPV was a significant parameter in septic patients. The cut off value for MPV was 10.5 fl which was found to be significant and of a magnitude considered to be clinically useful, with sensitivity 57.1%, specificity 80.8%, p value (0.003) and accuracy 72.5% in predicting mortality. A correlation was found between high MPV, CRP, SOFA and APACHE scores. Therefore, MPV may be used as an auxiliary test in the prognosis of sepsis. Conclusion Initial values of MPV were significantly correlated with CRP, APACHE and SOFA scores and with the estimated rate of mortality.

Frequency Of Raised Mean Platelet Volume In Patients With Acute Coronary Syndrome In HIT Hospital Taxila

Frequency Of Raised Mean Platelet Volume In Patients With Acute Coronary Syndrome In HIT Hospital Taxila

Role of mean platelet volume in patients with type 2 diabetes mellitus

In type 2 diabetes mellitus, increased platelet activity is crucial for the emergence of vascular complications. Mean platelet volume (MPV), an indicator of enhanced platelet activity, may be helpful in identifying the thromboembolic events that lead to these vascular complications. This study aims to assess MPV in Type 2 Diabetes patients and investigate the relationship between MPV and glycaemic and diabetic complications. : A comparative cross-sectional study was carried out on 266 subjects (133 diabetic patients and 133 nondiabetic controls) at B.P Koirala Institute of Health Sciences for a period of one year. MPV was analyzed in both the groups and the potential association of MPV with diabetic complications and glycaemic parameters was evaluated. Statistical analysis was carried out with Student t-test and Pearson Correlation Coefficient.: The results of the study showed that diabetics' MPV was considerably higher than that of non-diabetic controls (10.07 + 1.41 vs. 7.47 + 0.60 fl, P0.001) and that diabetic patients who had complications had significantly higher MPV than those who did not (10.61 + 1.35 vs. 9.37 + 1.15 fl, P0.001). Retinopathy (p=0.004), nephropathy (p=0.001), and Peripheral artery disease (p=0.03) were diabetes complications with significantly increased MPV. With regard to HbA1C, FBS levels, and the duration of diabetes, MPV demonstrated a statistically significant positive connection (p0.001 and positive r-value).: MPV is a cost-effective tool in the early detection of vascular complications in diabetes and hence proves to be a promising indicator in preventing vascular complications.

Mean Platelet Volume in Patients With Subclinical Hypothyroidism Attending at A Tertiary Care Hospital of Bangladesh

Background: Subclinical hypothyroidism (SCH) is a common endocrine disorder affecting about 3-8% of the general population. On the other hand, mean platelet volume (MPV) is an indicator of platelet activity, and elevated MPV is associated with adverse cardio-metabolic complications. This study was conducted to observe MPV in SCH and to correlate it with thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels. Materials and Methods: This cross-sectional observational study was conducted in Medicine and Endocrinology OPD of US- Bangla Medical College & Hospital over twelve (12) months from September 2020 to August 2021. This study included forty (40) cases of newly detected SCH and twenty (20) age & body mass index (BMI) matched euthyroid control subjects as per inclusion and exclusion criteria. Results: SCH group had higher TSH and MPV than controls (P value <0.001 and <0.05 respectively) where age, BMI, and FT4 level were comparable (P value>0.05). MPV shows a positive correlation with BMI in SCH & controls (P values <0.05). MPV shows a significant positive correlation with TSH and a negative correlation with FT4 only in SCH (P<0.05) but not in controls (P value>0.05). Conclusion: Patients with SCH have elevated MPV, so they are at increased risk of developing an adverse cardiovascular outcome. J Dhaka Med Coll. 2022; 31(1) : 61-65

Evaluation of Mean Platelet Volume in Patients of Recurrent Aphthous Stomatitis

One of the most prevalent conditions affecting the oral mucosa is recurrent aphthous stomatitis (RAS), which is characterized by uncomfortable ulcerations on the movable or non-keratinized oral mucosa. Objective: To compare mean platelet volume (MPV) in patients of recurrent aphthous stomatitis (RAS) versus healthy control. Methods: This non-probability sampling case-control research included 56 RAS patients and 56 healthy controls. Patients who presented for dental treatment and have RAS in oral cavity were included. Patients with systemic inflammatory illnesses, autoimmune diseases like pemphigus, or infectious diseases like herpes who attended for dental treatment and exhibited RAS in the oral cavity were excluded. The healthy control group had no mouth ulcers or blood problems. A Student t-test compared MPV between cases and controls based on age, gender, and MPV. Results: The mean age of the participants was 29.35 ± 8.28 years, with 57 (50.89%) females and 55 (49.11%) males. The mean MPV in the RAS group (8.86 ± 0.33) was significantly higher (p < 0.001) than in the control group (6.95 ± 0.2). The univariable model coefficient of 1.91 (95% CI = 1.81-2.01, p < 0.001) indicates that the RAS group had a significantly higher MPV than the Control group. For gender, males had a lower MPV compared to females (β = -0.36), but it was not statistically significant (p = 0.056). Conclusions: RAS patients have higher platelet activity indicated by higher mean platelet volume (MPV) than healthy controls.

EFFECTS OF ISOTRETINOIN ON PLATELET COUNT AND MEAN PLATELET VOLUME DURING TREATMENT OF ACNE VULGARIS

The most effective systemic therapy for acne is Isotretinoin. However, Isotretinoin has many side effects, including known side effects like dryness, palmoplantar exfoliation, rash, teratogenicity, raised intraocular pressure, and deranged liver functions and lipid profile. Its lesser-known side effects include its effects on platelet count and mean platelet volume (M.P.V.). This Quasi-experimental case series was conducted to observe the change in platelet count and mean platelet volume in patients taking Isotretinoin for acne vulgaris, attending the dermatology outpatient department at Jinnah Hospital Lahore from May 10th 2016 to November 9th 2016. After ethical committee approval and informed consent, subjects of acne vulgaris with an indication for Isotretinoin were included in the study from O.P.D. Relevant demographic and clinical details were recorded in a standardized predesigned proforma. Citrated blood samples were taken under aseptic conditions. Baseline platelet counts and mean platelet volume were determined using an auto-analyzer in the pathology laboratory of Jinnah hospital Lahore. All the patients were advised to take daily Isotretinoin at a dose of 0.5 mg/kg for 12 weeks. Platelet counts and mean platelet volume were again measured after twelve weeks after the start of treatment. A total of 100 patients completed the study. The age of the patients ranged from 18 to 60 years with a mean + sd age of 27.26+5.88 years. Out of these 41%(n=41) were male and 59%(n=59) were females. The severity of acne was measured using Global Acne Grading System (G.A.G.S.). It was recorded that 62%(n=62) had moderate, 22%(n=22) had severe while 16%(n=16) had very severe acne vulgaris. The mean pre-treatment platelet count was 271273+9139 c/µL, while 259192+11717 c/µL was post-treatment. The mean difference was 12080+8140 c/µL, and the p-value was 0.001. The mean platelet volume was 10.63+1.01 fl as pre-treatment and 9.77+1.01 fl as post-treatment. The mean difference was 0.85+0.04 fl, and the p value was 0.001. We concluded that Isotretinoin decreases platelet count and means platelet volume in patients receiving isotretinoin treatment for acne vulgaris.

Predictive role of red blood cell distribution width to platelet ratio combined mean platelet volume in patients with microscopic polyangiitis.

We aimed to investigate the role of red blood cell distribution width (RDW)-to-platelet ratio (RPR) and mean platelet volume (MPV) in evaluating the disease activity of microscopic polyangiitis (MPA). A total of 73 newly diagnosed MPA patients and 57 healthy controls were enrolled in this study. The hematologic and biochemical indexes of two groups were assessed. The RPR was calculated as the ratio of RDW and platelet counts, and Birmingham Vasculitis Activity Score (BVAS) was used to evaluate the disease activity. Compared with the healthy controls, RPR and RDW were significantly increased, and MPV was significantly decreased in MPA patients. In the MPA group, RPR was positively correlated with BVAS (p = 0.032), but negatively correlated with lymphocyte, hemoglobin, and complement 3 (all p < 0.05). MPV was negatively correlated with white blood cell (p = 0.045). Patients with BVAS > 15 had significantly higher RPR than patients with BVAS ≤ 15 (p = 0.011). A cut-off level of 0.066 for RPR had 47.9% sensitivity and 90.4% specificity in predicting MPA, and the combination of RPR and MPV had 75.3% sensitivity and 78.9% specificity in differentiating MPA patients from healthy controls. The study suggests that RPR may be a potential marker of diagnosis and disease activity in newly diagnosed MPA patients. Additionally, a higher predictive value in monitoring and evaluation of MPA was found when RPR and MPV were combined.

Evaluation of Mean Platelet Volume in Patients with Pulmonary Embolism

Amaç: Pulmoner emboli acil servislerde sık karşılaşılan ve yüksek mortaliteye sahip bir pulmoner vasküler hastalıktır. Pulmoner emboli tanısı için geliştirilmiş spesik bir biyobelirteç henüz dünyada bulunmamaktadır. Çalışmamızda acil servise başvuran akut pulmoner emboli tanısı alan hastaların başvuru anındaki ortalama trombosit hacmi (mean platelet volume, MPV) değerlerini incelemeyi, MPV değerlerinin pulmoner emboli hastalığından kuşku duymada kullanılıp kullanılamayacağını araştırmayı amaçladık.&#x0D; &#x0D; Gereç ve Yöntemler: Çalışmamıza dahil etme kriterlerine uyan 51 pulmoner emboli tanısı konulan hasta ve aynı demografik özelliklere sahip, 18 yaş üzeri aktif bir şikâyeti / kronik hastalığı olmayan ve genel kontrol amaçlı hastanemize başvurmuş 25 sağlıklı gönüllü kişi dahil edilmiştir. Hastaların verileri, hastanenin sisteminden ve hastaların takip dosyalarından elde edilmiştir. Çalışmamızda hastaların yaş, cinsiyet ve başvuru anındaki MPV değerleri incelenmiş ve kontrol grubu ile karşılaştırılmıştır.&#x0D; &#x0D; Bulgular: MPV değeri hasta grubunda 7.87±1.85 fL, kontrol grubunda 7.94±1.24 fL olarak bulundu. Hasta grubunda kontrol grubuna göre daha yüksek değerler saptanmasına rağmen istatistiksel olarak anlamlı değerlendirilmedi (p=0.176, p

Expression of p53, bax and bcl-2 and Predictive Value of Fibrinogen, D-Dimer, and Mean Platelet Volume in Patients with Acute Cerebral Infarction after Intravenous Thrombolysis.

This was to study the application value of fibrinogen (FIB), D-dimer (D-D), and mean platelet volume (MPV) in the prediction of vascular re-occlusion (VRO) after intravenous thrombolysis (IVT) in patients with acute cerebral infarction (ACI). 114 patients with ACI were retrospectively included as the research objects and then were divided into the improvement group (66 cases) and the progressive group (48 cases). A multivariate Logistic regression model was applied to analyze the independent risk factors of VRO after IVT. The receiver operator characteristic (ROC) curve was also adopted to assess the predictive value of relevant factors for VRO after IVT. In addition, the expression of p53, bax and bcl-2 genes was investigated in patients with acute cerebral infarction and healthy people by real-time PCR. As a result, MPV, FIB, and D-D levels of venous blood in the improvement group were remarkably lower than those in the progressive group (P<0.05). The regression coefficients between MPV, FIB, D-D at admission and VRO after IVT were 0.411, 0.362, and 0.391, respectively, so there was a significant positive correlation (P<0.05). The combined prediction model of MPV, FIB, and D-D had greater sensitivity, specificity, and area under the curve (AUC) in predicting the risk of VRO after IVT than single MPV, FIB, or D-D, showing differences of statistical significance (P<0.05). In conclusion, MPV, FIB, and D-D in venous blood at admission were independent risk factors for the VRO after IVT. The combined model of MPV, FIB, and D-D had an excellent predictive performance on the risk of VRO after IVT. The expression level of genes p53 and bax was 4.5 and 3 times higher in patients than in controls, respectively. The expression of gene bcl-2 decreased (0.75 times) in patients (P<0.001).

Evaluating the clinical role of fibrinogen, D-dimer, mean platelet volume in patients with acute exacerbation of COPD

BackgroundThere is limited research on clinical indicators for clinicians to judge the hypercoagulability of COPD patients. ObjectiveThe aim in this study was to evaluate the level changes of fibrinogen (FIB), d-dimer (D-D), and mean platelet volume (MPV) in plasma during the stable phase of chronic obstructive pulmonary disease (COPD), as compared with acute exacerbation of COPD (AECOPD). MethodsA total of 240 patients admitted with COPD in our hospital and 60 healthy people were enrolled in this prospective study using data from August 2016 to August 2017. Patients were allocated to AECOPD or stable COPD group. The levels of white blood cell (WBC) count, absolute neutrophil counts (NEU%), activated partial thromboplastin time (APTT), prothrombin time (PT), and hypoxia inducible factor-1(HIF-1) were detected. The MPV, D-D, and the FIB level were also determined and compared between groups. ResultsThe WBC count, NEU%, FIB, and D-D were significantly higher in the AECOPD group than in the stable COPD group and the healthy group (P < 0.05), while the MPV, APTT and PT was significantly lower in the AECOPD group than in the stable COPD group and the healthy group (P < 0.05). Additionally, MPV was significantly negatively correlated with WBC count (r=-0.798) and NEU% (r=-0.749) in the AECOPD group (P < 0.05); and the percentage of forced expiratory volume in one second (FEV1) in the predicted value was significantly negatively correlated with D-D (r=-0.891) and FIB (r=-0.656) (P <0.05). ConclusionWe demonstrated that, for patients hospitalized for exacerbation of COPD, MPV may indeed be a valid indicator of inflammation and a marker of thrombosis.

Comparison of the Effects of Second Generation Antihistamines and Omalizumab Treatment on Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Mean Platelet Volume in Patients with Chronic Spontaneous Urticaria with Each Other and with the Control Group

Comparison of the Effects of Second Generation Antihistamines and Omalizumab Treatment on Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Mean Platelet Volume in Patients with Chronic Spontaneous Urticaria with Each Other and with the Control Group

Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis.

ObjectiveThe mean platelet volume (MPV) is a measure of platelet size, and it is considered a surrogate marker of platelet activation. Because the correlation between platelet count/size and lung cancer prognosis remains unclear, this meta-analysis comprehensively evaluated the prognostic significance of MPV among patients with lung cancer.MethodsA systematic search of PubMed, Embase, Google Scholar, and additional sources of relevant studies were conducted with no language restrictions from inception to 7 May 2021. Overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS), as well as their hazard ratios (HR) and 95% confidence intervals (CIs), were pooled to evaluate the relationship between MPV and survival. The study protocol was registered on PROSPERO.ResultsEleven studies involving 2421 patients with lung cancer were included in our analysis. Nine studies including only patients with non-small cell lung cancer were included in the meta-analysis. Our analysis revealed no significant associations of MPV with OS (HR = 1.09, 95% CI = 0.84–1.41) and DFS/PFS (HR = 1.13, 95% CI = 0.58–2.20).ConclusionPretreatment MPV levels did not display prognostic significance in patients with NSCLC. Large-scale prospective studies and a validation study considering ethnicity and lung cancer staging are warranted.

The Prognostic Utility of Mean Platelet Volume in Patients With Acute Coronary Syndrome: A Systematic Review With Meta-Analyses.

Mean platelet volume (MPV) is a hematological index that is routinely measured in clinical settings. Although many studies have been conducted to investigate the prognostic significance of MPV in acute coronary syndromes (ACS), the findings have been inconsistent. The goal of this study was to systematically review all current evidence on the association between admission MPV and clinical outcomes after ACS. PubMed, Scopus, Web of Science, and other databases were searched. The primary endpoints were major adverse cardiovascular events (MACE) and mortality. We applied a Knapp and Hartung adjustment, prediction interval calculations and permutation tests during pairwise meta-analyses. A one-stage dose-response meta-analysis was also conducted. The meta-analysis consisted of 41 studies with 33443 participants. Mean platelet volume, as a continuous variable, was associated with the risk of long-term mortality (hazard ratio 1.33, 95% CI 1.19-1.48). After conducting permutation tests and calculation of prediction intervals, this association remained significant. The results for MACE were nonsignificant. Linear models were the best fitted models during dose-response meta-analyses, trends for nonlinearity were significant for long-term endpoints. Admission MPV was associated with long-term mortality in ACS patients, with nonlinear associations between MPV levels and long-term clinical outcomes.

Effectiveness of statin treatment in reducing red cell distribution width and mean platelet volume in patients with stable coronary artery disease: A retrospective study

Objectives: Mean platelet volume (MPV) has been shown to be a predictor of platelet activation and plays a crucial role in the pathogenesis of atherosclerosis. Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes and might reflect underlying chronic inflammation. Both MPV and RDW are related to increased risk for cardiovascular disease. Since statins have pleiotropic effects, we aim to investigate the effect of statins on this possible hematologic markers of atherosclerotic risk in stable coronary artery disease (CAD). Materials and Methods: One hundred and twenty-one statin-naive patients who had undergone coronary angiography for stable CAD between June 2012 and June 2013 were retrospectively enrolled in this study. Patients were treated with atorvastatin or rosuvastatin. The lipid profile and hematological parameters were measured at baseline and after statin treatment. Results: One hundred and twenty-one patients were included in the study. The mean age was 60.5 ± 9 years and 38% of patients were women. Out of 121 patients, 106 (87.6%) patients received atorvastatin therapy and 15 (12.4%) patients received rosuvastatin therapy. After a median follow-up period of 36 days, statin treatment markedly reduced low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels (P = 0.0001, for all). For hematological parameters, only RDW significantly decreased after statin treatment (P = 0.0001). The Δ RDW were not associated with Δ LDL-C (r = 0.03; P = 0.72), ΔTG (r = 0.06; P = 0.49) and Δ TC levels (r = 0.05; P = 0.55). Statins had no effect on MPV levels (P = 0.32). Conclusions: Statin therapy significantly reduces the RDW levels in stable CAD irrespective of cholesterol levels, which might confirm the anti-inflammatory effect of statins. However, the association between decreased RDW levels and prognosis in stable CAD has to be established by multi-center, prospective studies in large populations.