Platelet-rich Plasma Procedures Research Articles

Evaluation of Dentist Perception of Platelet Rich Plasma (PRP) for Accelerated Tooth Movement - Cross Sectional Survey.

The current survey was conducted to assess the knowledge, awareness and perception of platelet-rich plasma (PRP) on accelerated tooth movement among dentist present in the state of Tamil Nadu. Tamil Nadu dentists were the subjects of the cross-sectional questionnaire survey. 500 participants completed self-administered questionnaires about their knowledge, awareness, and perception of PRP's effect on accelerated tooth movement. The Statistical Package for the Social Sciences (SPSS) (V 22.0) was used to do the statistical analysis. It computed the frequency distribution.The result showed that 466 (93.2%) had prior knowledge of PRP, whereas 34 (6.4%) had no previous experience with it. A total of 156 (31.2%) dentists were aware that PRP procedures are used for teeth rotation and canine retraction.15.2% of participants stated that PRP facilitates accelerated tooth movement.Therefore, results of the study show that the dentists were a little aware of PRP as an additional therapeutic strategy for accelerating tooth movement.More awareness required among the dentist regarding application and its benefits of PRP in accelerated tooth movement.

Assessing the Efficacy of Laser Therapy and Autologous Platelet-Rich Plasma (PRP) Treatment for Chronic Wounds.

(1) Background: The management of persistent wounds is a topic of significant concern, particularly when they become chronic. Clinicians are focused on reducing the healing duration of chronic wounds and employing the most efficient treatments. Successful wound management requires an understanding of standard healing processes, the elements that can impede healing progress, and strategies to manage these impediments. (2) Methods: We participated in a study involving a cohort of 115 patients. Data were collected through subjective assessments via questionnaires, examining the comparative effects of laser therapy and platelet-rich plasma (PRP) on patients' conditions and monitored the progression of chronic wounds. For the study, we utilized a branded laser equipped with a 12-watt probe to stimulate chronic wounds in 65 patients, while the PRP procedure was administered to 50 patients. (3) Results: We observed a greater improvement in local symptoms among the patients who received laser therapy compared to those in the PRP group. (4) Conclusions: We consider both therapies to be of significant importance due to their positive and beneficial effects, particularly on the symptomatology and progression of chronic wounds. Nevertheless, superior results were documented in patients who underwent laser therapy.

Does Platelet-Rich Plasma Treatment Increase In Vitro Fertilization (IVF) Success in the Infertile Population?

Platelet-rich plasma (PRP) is obtained by centrifuging the platelet-rich portion of the patient's own blood. The objective of our study is to retrospectively examine the impact of intraovarian PRP injection on infertile women with diminished ovarian reserve, specifically focusing on the oocyte count, oocyte quality, and endometrial thinning. A retrospective assessment was conducted on cases who had intraovarian PRP injection at the in vitro fertilization (IVF) unit of the Obstetrics and Gynecology Department of Gazi University School of Medicine hospital. The review encompasses the period from 1 January 2015 to 30 June 2020. The endometrial thickness, follicle count of greater than 14 millimeters, estradiol levels, follicle-stimulating hormone (FSH) levels, and antral follicle count were assessed during the menstrual cycle both prior to and within a period of 1-6 months following the PRP procedure. Twenty nonpregnant patients who had IVF before and 4-6 months after PRP were admitted to the post-PRP IVF cycle. The quantification of oocytes and M2 oocytes was conducted both prior to and subsequent to PRP treatment. Among 120 cases, only 60 cases who fulfilled inclusion criteria were analyzed.The basal endometrial thickness, basal follicle number (>14 mm), estradiol value, oocyte count, and M2 oocyte count exhibited a statistically significant increase following the administration of PRP injection (p<0.001). The basal FSH value exhibited a notable drop following the administration of PRP injection, with a statistically significant difference(p=0.002). In the pregnant group, the number of oocytes obtained with oocyte pick-up (OPU) increased by 300%, and in the nonpregnant group, the increase was 125% only. The number of M2 oocytes obtained with OPU increased by 250% in the pregnant group, while it was 93% in the nonpregnant group. Ultimately, the affordability of PRP production and its considerable theoretical efficacy have the potential to substantially decrease the expenses associated with assisted reproductive technology procedures. In the present scenario, the administration of an intraovarian PRP injection may be contemplated as a therapeutic intervention for women exhibiting diminished ovarian reserve.

Comparative evaluation of platelet-rich plasma and micro-osteoperforation effect on orthodontic tooth movement rate in class II division 1 patients: A split mouth randomized trial

The primary goal of this 2-arm split-mouth randomized clinical trial was to -see whether Platelet-rich plasma (PRP) injection could accelerate the orthodontic teeth movement compared to a micro-osteoperforation (MOP). The secondary purpose was to look at pain perception following MOP and PRP procedures at different time intervals. Of the 50 patients with Class II Division1malocclusion, 100 maxillary quadrants requiring maxillary first premolar extraction were randomly assigned to one of two groups (MOP group and PRP group, n = 50 each). Computer-assisted randomization of two maxillary quadrants of each patient was achieved. Three micro-osteoperforations were performed distal to the canines in the MOP group, and in the other group 0.6 ml of PRP was injected buccally and palatally (0.3 ml on each side) before the initiation of separate canine retractions. The primary outcome was the rate of canine retraction. Secondary outcome was the level of pain experienced by patients during the MOP and PRP procedures. In the MOP group, a small statistically significant difference in the amount of tooth movement was found when comparison was done between baseline and 4 weeks (Mean distance (Md) = â̂’.356, P = .030) and a little more significant between baseline and 8 weeks (Md = â̂’.564, P = .000). The PRP group revealed a significant increase in gingival distance from the baseline to 4 weeks (Md = â̂’.683, P = .005) and from baseline to 8 weeks (Md = â̂’1.205, P = .000); from 4 weeks to 8 weeks, it was a little less significant (Md = â̂’.52200, P = .038). The amount of tooth movement in the PRP group was greater than that in the MOP group. However, the intergroup comparison (MOP and PRP) of tooth movement with an independent t-test showed a difference in favour of PRP but only at 8 weeks ( P = .036) and not significant if we consider the Bonferroni adjustment. The pain experienced during the MOP procedure was a little greater than the pain experienced during the PRP injection ( P = .0473), but the intensity (recorded on the VAS scale) decreased the following day ( P = .2134), further decreasing over the next three days ( P = .6754). In the PRP group, it was found that there was an increased tooth movement mostly from the baseline to 4 weeks. PRP injection have short term effect and diminished through time. It is rather the opposite for the MOP a little more significant between baseline and 8 weeks.

Effectiveness of Platelet-Rich Plasma in Anterior Cruciate Ligament Reconstruction: A Systematic Review of Randomized Controlled Trials.

ObjectiveThis study aimed to identify the effectiveness of platelet‐rich plasma (PRP) for patients operated with anterior cruciate ligament reconstruction (ACLR).Databases of PubMed, Embase, and CENTRAL were independently retrieved by two authors, for identifying the eligible randomized controlled trials (RCTs) comparing the clinical and imaging outcomes of ACL reconstructed patients augmented with or without PRP. The Cochrane Collaboration tool was utilized to assess the risk of bias of the included trials. We qualitatively synthesized the outcomes include the image evaluations on the healing of bone tunnels, graft remodeling, donor site healing and tunnel widening, and clinical evaluations on knee stability and function, pain symptom by visual analogue scale (VAS), inflammatory parameters and so on.A total of 16 RCTs, including 1025 patients, were included for eligibility. Generally, the included studies were of low risk of bias, but the conducting of allocation concealment was not clearly described in many studies. Three imaging techniques, including MRI, CT and ultrasound, were selected in these trials. Significant improvement on graft remodeling, bone tunnel healing, harvest site healing and bone tunnel diameters were demonstrated in one of five (20.0%), three of five (60.0%), two of four (50.0%) and one of five (20.0%) studies respectively, for PRP group. Various clinical outcomes, such as IKDC score, Lysholm score, Tegner score, knee anteroposterior and rotational laxity, range of motion and VAS, could not be improved with PRP application.The PRP is associated with very limited role in improving knee outcomes following ACLR, and there is no indication for PRP procedures in ACLR at this stage.

The efficacy and safety study of the combined use of platelet-rich plasma and fractional radiofrequency ablation in the treatment of post-acne scars

Introduction. So far, a large number of skin scars treating methods have been proposed and tested. The use of platelet-rich plasma (PRP) is currently being considered as one of the most promising approaches to skin scar treatment.Aim. Clinical efficacy and safety evaluation of complex treatment of post-acne scars using PRP.Materials and methods. An open, randomized, prospective study was conducted in parallel groups. The study included 78 patients with post-acne scars, then randomized into 2 groups. Group 1: 36 patients receiving platelet-rich plasma (PRP); group 2: 42 patients receiving complex treatment with PRP and fractional radiofrequency ablation (PRP + FRF). PRP procedures using the micro-papular technique in group 1 were carried out 5 times with an interval of 2 weeks. The combination of PRP + FRF in group 2 was performed according to the following: the first procedure – FRF, two weeks later – PRP using the micro-papular technique. Then after 2 weeks FRF was performed again, and so on. The total number of procedures of both techniques was 10.Results and discussion. As a result of the treatment, in all patients with post-acne, the clinical indicators of the severity of skin scarring changes decreased significantly, while the most noticeable dynamics were common for patients in group 2. The scars assessment using the Vancouver scale showed that 6 and 12 months after treatment, the severity of objective components and the severity of subjective sensations decreased in most patients. The severity of their own attitude to persistent defects also decreased. Analysis of the frequency of adverse reactions during treatment and in the early period showed that there were no significant intergroup differences in individual adverse reactions. The overall frequency of adverse events in the long-term period also did not significantly differ.Conclusion. The results of the study indicate that the use of PRP in the complex treatment of scarring is a clinically effective and safe method of treatment and allows you to expand the range of therapeutic approaches for scarring skin deformities.

Assessment of Knowledge, Awareness, and Perception of Platelet-Rich Plasma among Oral Surgeons.

Aim:The current survey was conducted to assess the knowledge and awareness of platelet-rich plasma (PRP) among oral surgeons in the state of Tamil Nadu.Methodology:The cross-sectional questionnaire survey was conducted among oral surgeons in the state of Tamil Nadu. The self-administered questions related to knowledge and awareness of PRP were collected from 500 participants. The statistical analysis was done using Statistical Package for the Social Sciences SPSS (V 22.0). The frequency distribution was computed.Results:This survey exposed that 454 (90.4%) respondents had knowledge and awareness about the role of PRP. Forty (7.0%) were knowledgeable regarding the PRP treatment. Four hundred and fifty-four (90.6%) had aware about the usage of PRP procedures in oral surgery.Conclusion:The current study's findings indicate that the oral surgeons were aware of PRP as an auxiliary therapeutic technique for wound healing and maturation.

Comparison of Arthroscopic Treatment Methods in Talar Osteochondral Lesions: A Multicenter, Prospective, Randomized Clinical Trial.

The aim of the present study was to contribute new and updated information to the literature by comparing the clinical and radiologic results of arthroscopic microfracture, platelet-rich plasma (PRP) after arthroscopic microfracture, and BST-Cargel scaffold application after arthroscopic microfracture in the treatment of talar osteochondral lesions. Sixty-two talar osteochondral lesion patients (31 women and 31 men) who underwent ankle arthroscopy in two different centers were randomized into three groups. The first group consisted of patients who underwent only arthroscopic microfracture (MF) (n = 22); the second group consisted of patients who underwent the PRP procedure after arthroscopic MF (PRP; n = 19); and the third group consisted of patients who underwent the BST-Cargel procedure after arthroscopic MF was (BST-Cargel; n = 21). The talar osteochondral lesions in the three groups were classified according to magnetic resonance and arthroscopic images. American Orthopedic Foot and Ankle Society, Foot and Ankle Ability Measurement (overall pain, 15-minute walking, running function), and visual analog scale scores were evaluated preoperatively and postoperatively, and postoperative return time to sports activities was performed. Compared to the preoperative score, postoperative American Orthopedic Foot and Ankle Society score increased 48.80 ± 9.60 in the BST-Cargel group, whereas there was an increase of 46.68 ± 3.65 in the PRP group and 29.63 ± 3.69 in the MF group, which were statistically significant (P < .05).There was a statistically significant postoperative change in the visual analog scale scores of the patients in all three groups compared to the preoperative scores (P < .05). At the end of the follow-up, the Foot and Ankle Ability Measurement overall pain, 15-minute walking, and running function results of all three groups increased significantly postoperatively compared to the preoperative values (P < .005). BST-Cargel application with microfracture is a method that can be applied easily and safely with arthroscopy to lesions larger than 1.5 cm2 regardless of the size of the cartilage defect, and it has been found to be superior to the other two methods in terms of pain, functional score, radiologic recovery, and return to sports activities.

Effect of platelet-rich plasma on the outcome of mini-punch grafting procedure in localized stable vitiligo: Clinical evaluation and relation to lesional basic fibroblast growth factor.

Surgical methods are favorably used for treatment of stable vitiligo, and platelet-rich plasma (PRP) can be added to augment the effect. The additive value of PRP, however, remains elusive. Basic fibroblast growth factor (bFGF) is released from activated platelets with a capacity for stimulating melanocyte proliferation and migration. The treatment outcomes for the mini-punch grafting (MPG)/phototherapy treatment with and without PRP were assessed and the relation between bFGF and the obtained results were evaluated. Thirty-four vitiliginous patches, two per each patient with stable vitiligo, were enrolled in this intrapatient-controlled study and treated with autologous MPG and subsequent exposure to phototherapy with and without enhancement via PRP procedure at the time of the procedure, and monthly for the subsequent 3 months. Re-pigmentation assessment via vitiligo scores as well as measurement of lesional bFGF were done. PRP assistance to MPG/phototherapy treatment resulted in earlier re-pigmentation at week 8. However, this enhancement effect vanished at the study end (week 20) as ideal re-pigmentation (>75% re-pigmentation) was encountered in 10 patches (58.8%) treated with MPG/phototherapy modality, and in 12 patches (70.6%) treated with PRP-assisted method without significant difference between them. Lesional bFGF increased after both treatments with a higher expression with PRP assistance but without clinical reflection on the final outcome. PRP can speed the re-pigmentation response for MPG/phototherapy procedure without any significant effect on the final outcome.

Acne: modern approaches to solving an old problem

Background. Acne is one of the most common chronic dermatoses, which occurs in almost 8590% of the population. The disease manifests itself as polymorphic eruptions and is characterized by a recurrent and torpid course. Acne treatment is constantly improving, requires an integrated approach and long courses of therapy.&#x0D; Aims. To increase the effectiveness of acne therapy using new opportunities and promising methodological approaches using a combination of the therapeutic effects of platelet-rich plasma (PRP) and topical bacteriophage therapy.&#x0D; Materials and methods. The study included 30 patients with papulopustular acne of mild and moderate severity. Patients with mild acne were treated with PRP procedures as monotherapy. For moderate acne, PRP therapy was combined with regular applications of a staphylococcal bacteriophage (NPO Microgen, Nizhny Novgorod, Russia). The treatment was carried out on an outpatient basis: at least 3 procedures with an interval of 12 weeks (up to a maximum of 6 procedures within one year). The results were analyzed using descriptive statistics and the parametric Student's t-test. Data processing was carried out using the Biostat software. The value of the level of statistical significance of differences was taken as p 0.05.&#x0D; Results. Evaluation of the effectiveness of treatment was carried out on the basis of an analysis of the immediate outcomes of the disease, the dynamics of clinical symptoms and the severity of acne: regression of inflammatory elements of acne, a decrease in the phenomenon of seborrhea, improvement of the skin relief. As a result of the therapy, a transition to remission was noted in 16.6% of patients, an improvement in their condition 36.7%, a significant improvement 46.7%.&#x0D; Conclusions. An integrated approach combining PRP procedures and bacteriophage therapy can serve as a pathogenetically substantiated strategy for treating acne. A promising direction for further research is the development of new regimens and combinations of alternative therapeutic strategies using bacteriophages.

Acne: modern approaches to solving an old problem

Background. Acne is one of the most common chronic dermatoses, which occurs in almost 8590% of the population. The disease manifests itself as polymorphic eruptions and is characterized by a recurrent and torpid course. Acne treatment is constantly improving, requires an integrated approach and long courses of therapy. Aims. To increase the effectiveness of acne therapy using new opportunities and promising methodological approaches using a combination of the therapeutic effects of platelet-rich plasma (PRP) and topical bacteriophage therapy. Materials and methods. The study included 30 patients with papulopustular acne of mild and moderate severity. Patients with mild acne were treated with PRP procedures as monotherapy. For moderate acne, PRP therapy was combined with regular applications of a staphylococcal bacteriophage (NPO Microgen, Nizhny Novgorod, Russia). The treatment was carried out on an outpatient basis: at least 3 procedures with an interval of 12 weeks (up to a maximum of 6 procedures within one year). The results were analyzed using descriptive statistics and the parametric Student's t-test. Data processing was carried out using the Biostat software. The value of the level of statistical significance of differences was taken as p 0.05. Results. Evaluation of the effectiveness of treatment was carried out on the basis of an analysis of the immediate outcomes of the disease, the dynamics of clinical symptoms and the severity of acne: regression of inflammatory elements of acne, a decrease in the phenomenon of seborrhea, improvement of the skin relief. As a result of the therapy, a transition to remission was noted in 16.6% of patients, an improvement in their condition 36.7%, a significant improvement 46.7%. Conclusions. An integrated approach combining PRP procedures and bacteriophage therapy can serve as a pathogenetically substantiated strategy for treating acne. A promising direction for further research is the development of new regimens and combinations of alternative therapeutic strategies using bacteriophages.

Platelet-rich plasma for genital lichen sclerosus: analysis and results of 94 patients. Are there gender-related differences in symptoms and therapeutic response to PRP?

Background Lichen sclerosus is a chronic relapsing inflammatory dermatosis with a predilection for anogenital skin in 85%–98% of cases and is more prevalent in women (3%) than in men (> 0.07%). Objectives The purpose of this study was to investigate gender differences in clinical presentation and therapeutic response to treatment with platelet-rich plasma (PRP), an emerging innovative strategy for LS. Methods Forty-three male and 51 female patients affected by LS were evaluated. Each patient was subjected to PRP treatment (1 infiltration every 15 days, for 3 times). Results The PRP procedure was well tolerated by all patients and an overall significant decrease in symptoms was reported 6 months after PRP infiltration. Reduction in pain and burning sensation was significant in both gender but more accentuated in women than in men, whereas reduction of itching was similar. On the contrary, dyspareunia evidenced sex-related difference since a significant diminution was observed only in male. Conclusions This study demonstrates that PRP based therapy may exert a relevant role in LS patient management due to its effect on Quality of Life (QoL) and sexual function in both gender. In addition, the study underlined gender-related differences in severity of symptoms and disease age onset.

Implementation and Evaluation of a Platelet-Rich Plasma Multimedia Patient Education Tool for Patients With Androgenetic Alopecia

ABSTRACT Androgenetic alopecia (AGA) is a chronic, progressive hair loss disorder affecting both men and women. It is the most common form of alopecia. Platelet-rich plasma (PRP) is an alternative treatment modality that provides individuals with AGA with a safe and effective treatment option. A practice improvement needs assessment was conducted within a private dermatology practice in South Florida to evaluate the need for a patient education tool for patients with AGA. Upon the completion of this needs assessment, dermatology providers discovered that there is a need for a PRP education tool to aid in patient comprehension of the PRP procedure. This clinical practice improvement study examined the impact of a brief multimedia educational intervention on patient comprehension of PRP for the treatment of AGA. A commercially produced PRP patient education video was viewed by 10 patients with AGA within this practice. Postintervention, the teach-back method was utilized to measure patient comprehension of the PRP procedure. On the basis of the study results, it can be concluded that the utilization of a PRP multimedia patient education tool may provide dermatology providers with a standardized patient education method for patients with AGA and improve patient comprehension of PRP for the treatment of AGA.

Effect of Physiotherapy Intervention after Platelet Rich Plasma Procedure in Subjects with Grade 3 Osteoarthritis Knee

Effect of Physiotherapy Intervention after Platelet Rich Plasma Procedure in Subjects with Grade 3 Osteoarthritis Knee

Intra-articular Platelet-Rich Plasma Injections for Treating Knee Pain Associated with Articular Cartilage and Degenerative Meniscal Lesions.

BACKGROUND:Platelet-rich plasma (PRP) is an autologous concentration of platelets that contain a large number of growth factors. These growth factors play a role in the regeneration, repair, and acceleration of the biochemical process, thereby reducing the pain associated with injuries of the articular cartilage and meniscusAIM:The purpose of this study is to evaluate the effect of the PRP method in the treatment of knee joint cartilage injuries and degenerative meniscus lesions as well as pain relief.MATERIAL AND METHODS:The process of obtaining PRP begins by taking 15 ml of blood from the patient with a special system called Arthrex Double Syringe system. The test tube is centrifuged at 4000 rpm for 5 minutes. From the separated plasma, 5-6 ml PRP is taken and prepared for application. PRP is administered intra-articularly.RESULTS:At the Jan Mitrev Clinic in Skopje in 2018, PRP procedures were performed on 126 patients, 56 (44.4%) of whom were male, and 70 (55.6%) were female. The patients were evaluated by the Tegner Lysholm Knee Scoring Scale (TLKSS) before applying 3 doses of PRP for 7 days as well as 3 and 6 months after the application of PRP. The results showed considerable improvement 3 months after the PRP application, and 6 months after the application the results remained approximately identical.CONCLUSION:The application of PRP in the field of medicine is widely applied, and it will continue to be because the understanding of PRP therapy is increasingly refined. This therapy represents a potential and latest method in short-term pain reduction, but additional studies are needed to prove its long-term effectiveness.

Review for good platelet-rich plasma procedure in cosmetic dermatology and surgery

Review for good platelet-rich plasma procedure in cosmetic dermatology and surgery

Platelet rich plasma in androgenetic alopecia: A systematic review.

In recent years, dozens of manufacturers and clinics have been promoting the use of platelet rich plasma (PRP) procedures for skin and hair regeneration. Well-designed randomized controlled studies for these procedures are lacking. In this communication, we review the efficacy and safety of PRP procedures for androgenetic alopecia from multiple published peer-reviewed studies. The conclusion of our analysis is that until the present moment there is not enough evidence for the use of PRP procedures in the treatment of androgenetic alopecia. We hope that this review will help practitioners and patients to make better-informed treatment decisions.

Platelet-Rich Plasma Procedures and the Responsible Discontinuation of Antithrombotic Therapy

Platelet-Rich Plasma Procedures and the Responsible Discontinuation of Antithrombotic Therapy

Response to “Platelet-Rich Plasma Procedures and the Responsible Discontinuation of Antithrombotic Therapy” and “Platelet-Rich Plasma Protocols Can Potentiate Vascular Emboli

Response to “Platelet-Rich Plasma Procedures and the Responsible Discontinuation of Antithrombotic Therapy” and “Platelet-Rich Plasma Protocols Can Potentiate Vascular Emboli

Platelet-rich plasma versus Tenex in the treatment of medial and lateral epicondylitis

Medial epicondylitis and lateral epicondylitis are among the most common elbow pathologies affecting people aged between 40 and 50 years. Although epicondylitis is often a self-limiting condition that improves with conservative treatment, the condition can be difficult to eradicate. The purpose of this study was to compare the effectiveness of platelet-rich plasma (PRP) injections and ultrasound-guided percutaneous tenotomy (Tenex) for the treatment of medial or lateral epicondylitis. Our hypothesis was that the Tenex procedure would not be inferior to PRP injections in the treatment of medial or lateral epicondylitis. In this retrospective review, 62 of 75 patients were available for contact via phone and e-mail to complete post-procedure patient-reported outcome surveys. Subjective assessment of pain and function included a visual analog scale for pain; the Quick Disabilities of the Arm, Shoulder and Hand questionnaire; and the EuroQol-5D questionnaire. The inclusion criteria included age of 18 years or older and previous failure of nonoperative treatment. The average ages in the PRP and Tenex groups were 47 years and 51 years, respectively. The PRP cohort (n = 32) included 10 female and 22 male patients, whereas the Tenex cohort (n = 30) included 12 female and 18 male patients. The PRP and Tenex groups both demonstrated clinical and statistical improvement in visual analog scale pain scores; Quick Disabilities of the Arm, Shoulder and Hand scores; and EuroQol-5D scores. No statistically significant difference was found between the 2 treatment modalities. The PRP and Tenex procedures were both successful in producing clinically and statistically significant improvements in pain, function, and quality of life.