BackgroundClear discharge instructions are vital for patients and caregivers to manage post-op care at home. However, they often exceed the sixth-grade reading level recommended by national associations. We hypothesize that ChatGPT could help rewrite instructions to this level for increased accessibility and comprehension. We aim to assess readability, understandability, actionability, and safety of ChatGPT rewritten post-op instructions in four Plastic Surgery subspecialties: Breast, Craniofacial, Hand, and Aesthetic surgery. MethodsWe obtained post-op instructions from four index procedures in Plastic Surgery. We utilized ChatGPT to rewrite at the sixth- and fourth-grade reading levels. Readability was determined by seven readability indexes, understandability and actionability by the PEMAT-P questionnaire, and safety by the primary surgeons. ResultsOverall, average readability of the original post-op instructions ranged between seventh-eighth grade. Of the sixth-grade ChatGPT instructions, only one was lowered to the sixth-grade level. Of the fourth-grade ChatGPT instructions, all were reduced to sixth-grade or below, but none achieved fourth-grade level. Understandability scores increased as reading level decreased while actionability scores decreased for fourth-grade rewrites. Safety was not compromised in all rewrites. ConclusionsOur findings suggest that ChatGPT can adapt post-op instructions to a more readable sixth-grade level without compromising safety. We suggest prompting ChatGPT to write 1-2 grade levels lower than the desired reading level. While understandability increased for all ChatGPT rewrites, actionability decreased for fourth-grade level instructions. Sixth-grade remains as the optimal reading level for post-op instructions. This study demonstrates that ChatGPT can help improve patient care by improving readability of post-op instructions.