High temperature seamless pipes of dimensions O.D. × T × L = 457 × 15 × 5500 mm 3 made from 15 NiCuMoNb 5 material were loaded by internal pressure and a superimposed external bending moment. 27 tests with different geometries and positions of circumferential flaws in the base metal or in circumferential welds were performed at room temperature. Depending on the geometric conditions, the load bearing and failure behaviour of the investigated pipes could clearly be represented in a common failure diagram. Significant differences in maximum loads due to the position of the flaws in the structure, or whether inside or outside, could not be detected. Maximum loads were compared with calculations using applied engineering failure approaches, based on concepts of local flow stress and plastic limit load. Elastic-plastic fracture mechanics was applied to some of the component tests and the initiation and instability criteria verified.