Plane Warts Research Articles

The efficacy of 20% salicylic acid solution versus intralesional MMR vaccine combination with 20% salicylic acid solution in treatment of plane wart

Background and objectives: Plane wart treatment is challenging; modalities such as cauterization and cryotherapy having a great probability to recur, as well as the risk of scarring, discomfort, and expensive costs. The goal of this study is to compare the efficacy of salicylic acid 20% superficial chemical peel alone to topical salicylic acid solution 20% combined with intralesional measles mumps rubella vaccine. Methods: A therapeutic clinical trial conducted in outpatient department of “Shahid Nabaz Dermatology Teaching Center” a period from March to September of 2022.Fifty participants with plane wart were enrolled in this study, 27 female and 23 male. The participants were randomly divided into two groups, group­- A 25 patients, received topical 20% salicylic acid solution with intralesional measles-mumps- rubella vaccine. Group B, received topical 20% salicylic acid solution alone. The total number of therapeutic sessions was six, and the solution was applied every two weeks and the measles-mumps-rubella vaccine was injected every fortnightly. Every two weeks, the effectiveness of the treatment was assessed by counting the number of lesions. Result: Group A patients who were treated with intralesional measles mumps-rubella-vaccine combined with topical 20% salicylic acid solution showed complete clearance (24/25) with six sessions .group B patients treated with topical 20% salicylic acid solutions showed clearance (14/25) with six sessions. Lesions were significantly fewer in Group-A, which was statistically significant. Conclusion: The intralesional measles mumps-rubella-vaccine combination with 20% topical salicylic acid solution and the 20% salicylic acid solution alone were both effective in clearing plane warts, however, intralesional measles mumps-rubella-vaccine combination with 20% topical salicylic acid solution can achieve higher response with fewer sessions .

Tazarotene is as effective and well-tolerated as imiquimod in the treatment of verruca plana: a comparative randomized controlled trial.

Plane warts, when multiple and recurrent, present a therapeutic challenge acting as a source of reinfection, causing frustration and affecting a patient's quality of life. For large numbers of lesions in cosmetically significant sites, topical treatment is preferred to avoid potential sequelae. To evaluate and compare the efficacy and tolerability of tazarotene 0.1% gel vs. imiquimod 5% cream for the treatment of plane warts. In a parallel three-arm randomized controlled trial, 60 patients were randomized to imiquimod, tazarotene or placebo groups. Patients applied the corresponding treatment once daily at night for a maximum of 12 weeks. Primary outcomes were the percentage of respondents with complete clearance in the three studied groups, and the type and frequency of side-effects in each group. Both active treatments resulted in significant improvement compared with baseline and the placebo group (P = 0.001). The imiquimod 5% treated group showed complete clearance in 50% (10/20) of patients, partial response in 15% (3/20), and no response in 35% (7/20). Tazarotene 0.1% gel showed complete clearance in 40% (8/20) of patients, partial response in 40% (8/20), and no response in 20% (4/20). No significant difference was detected between the imiquimod and tazarotene groups (P = 0.19). Compared with imiquimod, tazarotene 0.1% gel for the treatment of plane warts seems to offer an equivalent treatment response, it maintained efficacy without recurrence and had a safer profile regarding dyspigmentation with an advantageous cheaper cost.

Next generation of mRNA and lncRNAs based-vaccines platforms: Highlighted for HPV in head and neck squamous cell carcinoma, cervical and colorectal cancers and oncogenic viruses HBV/HCV in hepatocellular carcinoma

More than 200 HPV genotypes and several HPV types associated with particular diseases as oral lesions (Hecks disease, oropharyngeal carcinoma, laryngeal papillomas), anogenital warts (Bowenoid papulosis, Buschike‒Lowenstein tumor), Epidermodysplasia verruciformis (plane warts, Pityriasis‒ like plaques, squamous cell carcinomas of sun‒exposed skin) have been described. Several advances in the genomics era and the development of new technological tools for next-generation sequencing have been showed that approximately 98% of RNAs are not translated into proteins. This study aims to succinctly describe long non-coding RNAs (lncRNAs) and their correlation with the hallmark of cancers since they comprise a class of RNAs that do not code for proteins. Oncogenic mutations occur with higher prevalence in non-coding regions, and the correlation of lncRNAs is extremely important for better understanding the biology of cancer cells as well as elucidating the molecular mechanisms underlying cancer. Thus, these may be promising tumor biomarkers and potential therapeutic targets exemplified in hepatocellular carcinoma, cervical and colorectal cancer induced by oncogenic viruses. Future studies are need to delve deeper into the cellular signaling pathways involved in biological processes. This theme addresses innovative issues on the ONU 2030 agenda from the perspective of global one health.

Evaluation of Topical Hydrogen Peroxide 30% versus Topical Zinc Sulphate 10% in Treatment of Plane Warts: Clinical and Dermoscopic Study

Evaluation of Topical Hydrogen Peroxide 30% versus Topical Zinc Sulphate 10% in Treatment of Plane Warts: Clinical and Dermoscopic Study

Treatment of plane warts with long pulse ND - YAGlaser 532nm.

Warts are one of the contagious viral diseases that may cause disturbing cosmetic problems. Plane warts represents a common self-limitingviralinfectionoftheskincausedby the HumanPapilloma Virus,however,those that do not disappear by themselves can be very difficult to treat with no uniformly effective treatment modality. To assess theefficacyof long pulsed 532nm ND:YAG laser in the treatment of plane warts. In thistherapeuticclinical trial study, 34 patients with plane warts were enrolled. Each patient was eligible for up to three treatment sessions administrated at 2weeks intervals with long pulsed ND:YAG laser ata spot size 3mm; wavelength 532nm; pulsed duration 20ms; and fluence 30J/cm2 . The patients were assessed before each treatment session and at 3 months after the last treatment session. Theresponseto treatment was graded using four points scale: Scale 1=poor:<25%, Scale 2=fair: 25%-50%, Scale 3=good: 51%-75%, Scale 4=excellent:>75%. Twenty-two patients only with a total of 478lesions, completed the study; their ages ranged from (6-45) years with a mean±SD 19.95±13.142 years. Thirteen patients (59.09%) were female and nine (40.90%) were male.The results from this study showing that long pulsed ND:YAG laser 532nm led toan excellentresponse in19patients (86.36%) in which 15 of 19 patients showed a complete response (78.94%); one patient showed a good response (4.545%), one showed a fair response (4.545%) and one showed a poor response (4.545%) at the end of three-months follow up. The difference was statistically significant; the P value at the three months follow-upwas 0.002.The cumulative clearance rate after the first, second, and third treatment sessions was 58.4%, 77.7%, and 89.9% respectively.Recurrencewas seen in only one patient (4.545%).Side effects were generally mild and didn't prevent normal activity. Long pulsed ND:YAG laser 532nm appears to be an effective method for treatment of plane warts.

Comparison of Topical Adapalene and Electrocautery in Treatment of Plane Warts

Background: Warts are lesions that grow on the human skin due to infection named human papilloma-virus (HPV) type 1, 2, and 4. More than 100 types of HPV virus have been identified now. Aim: To compare the efficacy of adapalene and electrocautery therapies in managing plane warts. Study design: Randomized Control Trial. Methodology: A total of 52 patients via non probability consecutive sampling technique with plane warts were enrolled and randomly divided into 2 equal groups. The patients of Group A were treated with 0.5% Adapalene gel (applied twice daily over the lesions for maximum 3 months or until resolution of warts) and patients in group B were treated with electro-cautery procedure fortnightly for maximum 3 months or until resolution of warts). Patients were assessed after every 2 weeks for initial 3 months and then these patients were followed monthly for another 3 months and final outcome was seen at 6 months. Data was evaluated by using SPSS version 23. Student-t test was applied with p-value than 0.05 taken as significant. Results: The mean duration of wart resolution was observed as 45.92±19.22 days in the adapalene group, while the electro-cautery procedure took 45 ± 17.81 days for wart clearance. There were no statistically significant differences in the complications between the two groups (p=0.60). Practical Implication: Although successful outcomes have been achieved in many studies by using Adapalene and electrocautery separately for treating warts but none of the published research compares these two treatment modalities (Adapalene vs electrocautery) for treatment of plane warts as per our knowledge. Therefore to fill this gap, this study was designed to compare the efficacy of adapalene and electrocautery therapies. Conclusion: It was concluded that Both Adapalene and electrocautery are effective in treatment of plane warts and there are no statistically significant differences in the complications/side effects of these two treatment modalities. Keywords: Adapalene Gel 0.1%, Electrocautery, Plane Warts, Clinical Outcomes and Effectiveness.

An Insight about Possible Role of Imiquimod in Dermatology and Possible Benefit on Plane Warts: Review Article

An Insight about Possible Role of Imiquimod in Dermatology and Possible Benefit on Plane Warts: Review Article

Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts

Immunotherapy represents a promising therapeutic option for treatment of warts. Different concentrations of Candida antigen (1/100 and 1/1000) and zinc sulfate 2% were not previously compared regarding their efficacy in treatment of cutaneous warts. The present study compared the safety and efficacy of intralesional candida antigen versus intralesional 2% zinc sulfate for treatment of cutaneous warts. This prospective controlled clinical trial included one hundred and five patients presented with common, plantar, and plane warts. Patients were divided randomly into three groups, each group included 35 patients. Group 1 were treated with intralesional candida antigen (Ag) 1/100, Group 2 were treated with intralesional candida Ag 1/1000, and Group 3 were treated with intralesional zinc sulfate 2%. This study found that target warts of group 1 displayed higher rate of complete clearance compared to group 2 and group 3 (94.3%, 77.1, 74.2%), respectively. The present study concluded that intralesional immunotherapy with Candida antigen was more effective than Intralesional 2% zinc sulfate in treatment of cutaneous warts and less painful. Clinical trial registration number is (Clinical Trials.gov Identifier: NCT03158168).

Efficacy of photodynamic therapy for warts induced by human papilloma virus infection: A systematic review and meta-analysis

BackgroundThe incidence of warts caused by human papilloma virus (HPV) infection is very high in the population. Photodynamic therapy (PDT), as an emerging method for wart treatment, has been demonstrated to be effective and safe by an increasing number of studies. This meta-analysis of previous literature aimed to investigate the potential of PDT as a first-line treatment for warts. MethodsTo acquire proper and accurate information from relevant literature, the four databases PubMed, Embase, Web of Science and the Cochrane Library were searched. The wart clearance rate and patient cure rate were analysed as the primary outcomes. The recurrence rate, patient satisfaction and adverse reactions were also recorded. ResultsA total of 19 randomized controlled trials (RCTs) were included based on our search strategy. In the hand and foot wart group, PDT showed a statistically significant improvement in the wart clearance rate compared with placebo (P = 0.02), other lasers (P < 0.0001), and cryotherapy (P < 0.009). PDT use in the condyloma acuminatum group was not superior in terms of the wart clearance rate, with a value lower than that of the carbon dioxide (CO2) laser (P = 0.003) and electrosurgical generator (P < 0.00001). However, all studies mentioned a significant decrease in the recurrence rate after PDT. In the plane wart group, PDT demonstrated its superiority over placebo (P = 0.003) and cryotherapy (P = 0.007) in terms of the cure rate. ConclusionOur study demonstrated that PDT provided several benefits, including but not limited to positive clinical outcomes, low recurrence rates and minor adverse reactions. The use of PDT as first-line therapy can be recommended.

Therapeutic outcome and safety of intralesional vitamin d3 in the treatment of cutaneous warts

Cutaneous warts are a common but vexing condition with high recurrence rate and tendency to spread inspite of various therapeutic options. Intralesional immunotherapy is an attractive modality as it has an additional role of clearing both treated and distant warts by stimulating cell-mediated immunity against human papilloma virus. To evaluate efficacy and safety profile of intralesional Vitamin D3 formulation in the treatment of cutaneous warts. Patients with multiple cutaneous warts were injected intralesionally with Vitamin D3 (0.2 ml, 15 mg/ml) at an interval of 2 weeks for maximum of 4 sessions, and patients were followed up for 6 months. : Of the 106 patients included, complete clearance was seen in 26 (76.4 %) patients of verruca vulgaris, 20 (66.6 %) of palmoplantar warts, 18 (100 %) of plane warts, 6 (50 %) of genital and filiform warts each. Moderate response was seen in 14 (13.2%) patients while mild response was seen in 6 (5.7 %) patients. No response was seen in 10 (9.4 %) patients. No serious adverse effects were reported. : Intralesional Vitamin D3 is effective, safe, cheap and long lasting modality with a short downtime for the treatment of multiple cutaneous warts.

A multi center real world observation to evaluate the efficacy of cryotherapy versus local hyperthermia for the treatment of plane warts.

Most plane warts are recalcitrant to treatment. Both cryotherapy and local hyperthermia have been applied to treat plane warts. However, no direct comparative study on their respective efficacy and safety has ever been performed. To assess the efficacy and safety of local hyperthermia at 43 ± 1°C versus liquid nitrogen cryotherapy for plane warts. Sequential patients with plane warts entered the study, either receiving cryotherapy or local hyperthermia therapy at the discretion of the patients and the recommendations of consultants. Cryotherapy with liquid nitrogen was delivered in two sessions 2 weeks apart, while local hyperthermia was delivered on three consecutive days, plus two similar treatments 10± 3 days later. The temperature over the treated skin surface was set at 43 ± 1°C for 30 min in each session. The primary outcome was the clearance rates of the lesions 6months after treatment. Among the 194 participants enrolled, 183 were included in the analysis at 6months. Local hyperthermia and cryotherapy achieved clearance rates of 35.56% (48/135) and 31.25% (15/48), respectively (p= 0.724); recurrence rates of 16.67% (8/48) and 53.33% (8/15) (p= 0.01); and adverse events rates of 20.74% (28/135) and 83.33% (40/48), respectively (p< 0.001). Cryotherapy had a higher pain score (p< 0.001) and a longer healing time (p< 0.001). Local hyperthermia at 43°C and cryotherapy had similar efficacy for plane warts. Local hyperthermia had a safer profile than cryotherapy but it required more treatment visits during a treatment course. More patients preferred local hyperthermia due to its treatment friendly nature.

Topical hydrogen peroxide solution 40% in treatment of plane wart.

There are various available therapies for plane warts; however, no specific therapy has been established as entirely effective. The aim of work was to assess the effectiveness and safety of topically hydrogen peroxide (HP) 40% solution in treating the plane warts. The study included 30 patients diagnosed clinically as plane warts. Topical HP 40% was applied with a single-use wood end of a cotton swab soaked with the solution to minimize filtration of effective drug to the surrounding areas. Duration of the treatment was planned to be 4sessions for each lesion with 2-week interval and a 3-month follow-up period after treatment completion to detect any recurrence. Complete clearance of plane warts was observed in 27 (90%), and there was no recurrence of the lesions after a 3-month follow-up period. HP solution especially the 40% concentration may be considered a promising line of treatment for non-genital warts. It is a very effective, safe, cheap, and easy-to-use new topical treatment for non-genital warts.

Dermatologists' Impressions of Spontaneously Regressing Verruca Plana Histopathology.

Verruca plana in its regressing phase exhibits clinical and histological features distinct from classic verruca plana, but the ways in which these features should inform treatment plans are still under investigation. We conducted a retrospective single-center analysis of 25 patients with features of classic verruca plana, or plane warts, who exhibited self-remission within 4 weeks of skin biopsy. Measures included lesion sites, clinical findings preceding regression, and histological analysis. Histological analysis involved review by 2 dermatologists followed by impressions given by 4 board-certified dermatologists who were blinded to the clinical characteristics of the patients. Histopathological findings of regressing plane warts showed superficial perivascular infiltration (96%), spongiosis and exocytosis (84%), basal vacuolization (64%), parakeratosis (64%), apoptotic keratinocytes (60%), and lichenoid infiltration (44%). These findings were more compatible with the histological patterns of pityriasis lichenoides, lichen planus, and spongiotic eczema, rather than classic verruca plana. This suggests that regressing verruca plana may be included in the differential diagnosis of lesions exhibiting a lichenoid or spongiotic reaction, and observation may be a favorable treatment plan in these patients.

Resistant Plane Warts Treated by 40% Salicylic Acid and 16% Lactic Acid Combination on the Face

Human papillomaviruses (HPV) cause warts, which are the benign epithelial proliferation of the mucous membrane and skin. HPV-3 and HPV-10 commonly cause plane warts. Multiple treatment options must be used as no specific treatment option is available. We have a lot of limitations for the face as treatment can cause permanent scarring on the face. We report a case of 41 years immunocompetent male presenting with many plane warts on the face who was successfully treated with topical application of 40% Salicylic acid cream and 16% lactic acid cream made up of 44% of bees wax on lesions after a failure of many other treatment options, a) Topical zinc oxide twice per day for 3 months, b) Topical 5% salicylic acid dispensing cream made in 95% bees wax, c) Topical 5% fluorouracil cream, d) Topical imiquimod cream, e) Topical retinoids cream only at night for one month, f) Oral Isotretinoin 20mg twice per day for 2 months, and 3 sessions of cryotherapy. The patient's last treatment was oral isotretinoin 20 mg twice per day for the last 2 months. In general, doctors avoid using more than 5% salicylic acid, but after a detailed discussion with the patient, we decided to try this combination and succeeded.

Primary Localized Cutaneous Amyloidosis Presenting as Pigmented Papules Over Pinna.

Dear editor, Amyloidosis of the auricular concha is a rare type of primary cutaneous amyloidosis that affects the outer ear, generally not associated with other types of cutaneous amyloidosis or systemic diseases. Hereby, we report the first Indian case of pigmented papules over pinna due to cutaneous amyloidosis with no systemic disease. A 38-year-old female complained of pigmented papules on bilateral ear pinna for 6 months. Lesions were asymptomatic and she denied history of any topical application, photosensitivity, oral ulcers, or hair loss. Examination revealed multiple pigmented papules of 1–2 mm in diameter in the bilateral auricular concha [Figure 1]. The differential diagnosis of plane warts, seborrheic keratosis, comedones and discoid lupus erythematosus was considered.Figure 1: Multiple pigmented papules of 1–2 mm in diameter over left ear pinnaDermoscopy showed a white central hub pattern surrounded by brown pigmentation and white scar-like morphology [Figure 2a and b]. A punch biopsy from the papule showed a deposit of amorphous, homogeneous eosinophilic, PAS-positive material in the papillary dermis, widening of dermal papillae with hyperkeratosis and acanthosis of epidermis corroborating with diagnosis of cutaneous amyloidosis of the auricular concha. A Congo red stain showed an orange-red deposit [Figure 3a and b]. Complete hemogram, renal function test and liver function test were normal. Urine examination for Bence Jones proteins, immunoglobulin profile for multiple myeloma and antinuclear antibody test were negative. Lesions resolved in 5 months with topical tretinoin 0.1%.Figure 2: (a) Dermoscopy (Dinolite Dermoscope polarized mode, ×50 magnification) showing white central hub pattern surrounded by brown pigmentation (black arrow). (b) Dermoscopy (Dinolite Dermoscope polarized mode, ×50 magnification) showing white scar-like morphology (black circle)Figure 3: (a) Hyperkeratosis and acanthosis of the epidermis with amorphous, homogeneous eosinophilic material in papillary dermis with the widening of dermal papillae (Hematoxylin and eosin stain 10×). (b) Orange-red deposit of amyloid in the papillary dermis (Congo red stain 10×)In 1988, Hicks et al.,[1] first reported amyloidosis of ear pinna in four adult patients that were not associated with other cutaneous amyloidosis lesions and proposed that the disorder was a new type of primary cutaneous amyloidosis. Bakos et al.,[2] considered it to be a topographic variant of lichen amyloidosis. It mainly affects women between 40-70 years of age, appears asymptomatic to pruritic small papules that can be normochromic, yellowish, erythematous, or pigmented and located anywhere on the outer ear, mainly in the auricular concha. Kelmens et al.,[3] reported a case of multiple myeloma with heaped lesions in the external auditory meatus. In our case, there were no abnormal laboratory findings suggestive of systemic disease. According to the filamentous degeneration theory, degenerated keratinocytes are discharged into the dermis, and cytokeratins are converted into amyloid-K.[4] Few similar reported cases suggest the collagenous nature of the material, as they were stained with Verhoeff-van Gieson and Periodic acid-Schiff and not with Congo red, and the lesions were called collagen papules of the auricular concha.[5] The most characteristic dermoscopic finding of primary cutaneous amyloidosis is a central hub, which could be either white or brown, surrounded by various configurations of pigmentation, including fine radiating streaks, leaf-like projections, and bulbous projections. Dermoscopic and histological correlation of amyloidosis is tabulated in Table 1. Dermoscopy helped us to rule out our clinical differentials such as discoid lupus erythematosus, milia, seborrheic keratosis, and plane warts.Table 1: Dermoscopic features of amyloidosis and their histological counterpartPrimary cutaneous amyloidosis of ear pinna is a rare entity but should be considered in the differential diagnosis of pigmented papules of the pinna. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Efficacy and safety of oral isotretinoin in treatment of plane warts

Introduction: Plane warts is one of the commonest viral infections which may be resistant to many treatment modalities, isotretinoin has been shown effectiveness in many HPV (human papilloma virus) infections. This study aimed to assess the efficacy and safety of oral isotretinoin in the treatment of plane warts. Methods: A prospective clinical trial study was conducted in Erbil Dermatology Center in Erbil city, Kurdistan region through the period from 1st of July 2019 to 5th of January 2020. Forty patients with plane warts included. All patients received isotretinoin in a dose of 0.5 mg/kg/day in two divided doses for three months and patients were assessed monthly clinically and by investigations. After last dose patients were followed up for three months to see any recurrence.Results: After three months of therapy 15 patients (37.5%) showed complete response while only 2 patients (5%) showed partial response and the remaining had significant reduction in number of their plane warts during this period. During the 3 months therapy, comparing the results after 1st, 2nd and 3rd month, there was significant increase in number of patients who achieved complete response at the end of three months with (p=0.003). At the end of three months follow up, only 2 patients out of 15 who achieved complete response revealed recurrence while remainder 13 were still free of disease. All the adverse effects of isotretinoin during treatment period were mild and reversible with no recorded serious adverse effects.Conclusion: Oral isotretinoin is effective and safe in treatment of plane warts.

A comparative Study Between Needling and Homologous Autoimplantation Techniques in Treatment of Multiple Plantar Warts

Abstract Background Warts are a common dermatologic complaint resulting from infection with HPV which spread by direct skin-to-skin contact or by autoinoculation. The clinical appearance of warts is variable depends on the type of HPV involved and the site of infection. There are various types of viral warts including common warts, plantar warts, plane warts and genital warts, usually diagnosis of warts is made through clinical examination of the lesions and no laboratory investigations are required. Objective To compare between the therapeutic efficacy and safety of needling versus homologous autoimplantation techniques in treatment of multiple plantar warts and assess their recurrence rate. Patients and Methods Our study included 40 patients with multiple de novo planter warts(3 -10 warts) of (&amp;gt;1 and &amp;lt;3 years duration) divided into 2 groups, 20 patients per group, one group subjected to autoimplantation of wart tissue and the other subjected to needling procedure. Follow up of studied patients was assessed by physician after 2,8 and 12 weeks of procedure through clinical and dermoscopic examination to assess treatment response and after 16 weeks to assess recurrence Results Results of our study reported that there was high statistically significant difference between the 2 studied groups as regard response to treatment after 12 weeks being higher among autoimplantation group (p = 0.001). Moreover, there were no significant relations between treatment response of both patient groups and each of gender, age of patients, number of warts and duration of lesions. Conclusion Autoimplantation technique is more effective and less painful than needling procedure in treatment of multiple plantar warts (both manipulated and remote warts). No significant relations were found between treatment response of either techniques and demographic or clinical characteristics of studied patients.

Mask associated dermatosis: unmasking the challenges- a cross sectional study

&lt;p class="abstract"&gt;&lt;strong&gt;Background: &lt;/strong&gt;The novel coronavirus, referred to as SARS-COV 2 causing COVID 19, has become a great health challenge to the mankind. After its origin from Wuhan, China, it spread all over the globe within a short period of time. World Health Organization (WHO) officially declared COVID 19 as pandemic on 11th March, 2020. Aerosoles or droplets are the commonest mode of infection through respiratory tract making it mandatory to wear masks as a preventive measure.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods: &lt;/strong&gt;It is a cross-sectional study conducted over patients attending the out patients department of Dermatology. They were observed for presence of dermatosis over the face and categorized according to nature of dermatoses.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; We observed 385 patients, 200 (52%) patients had new dermatoses and 185 (48%) patients noticed flare of existing dermatoses. The predominant new dermatoses were dermatophytosis, indentations, sweat induced dermatitis, urticaria, pressure urticaria developing with indentations, contact dermatitis to metal and other materials in 49 (24.5%%), 42 (21%), 42 (21%) ,38(19%), 19 (9.5%) and 10 (5%) cases respectively. The flared dermatoses were acne, rosacea , plane warts and molluscum contagiosum in 120 (64.8%), 24 (12.9%), 22 (11.9%) and 17 (9.2%) cases respectively. Koebnerisation of vitiligo and lichen planus was also seen in few subjects.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; The prolonged use of face mask may cause various infective and non infective facial dermatoses. In the current scenario, it is mandatory to wear face mask as a preventive measure hence it is important to wear the mask properly. However, care of the mask as well as breaks from the mask are important factors to avoid the development of mask associated dermatosis.&lt;/p&gt;

Efficacy of Topical 5% 5-Fluorouracil and 0.05% Tretinoin and Electrosurgery in the Treatment of Plane Warts: A Randomized Controlled Comparative Trial

Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence. Plane wart is one of the morphological varients accounting for approximately one fifth of HPV lesions. Treatment of plane warts is difficult and recurrence quite common .The objective of our study is to compare the efficacy and safety of 5% 5 –fluorouracil (5 FU),0.5% tretinoin and electrosurgery in the treatment of plane wart. Seventy five patients 38 males and 37 females were included in this randomized controlled comparative trial .Patients were age and sex matched and divided into three groups, GROUP A : Patients treated with 5% 5-Fluorouracil ,GROUP B:Patients treated with 0.5% tretinoin and GROUP C : Patients treated with electrodessication .While topical treatments were applied once nightly for 4 weeks(5% 5-fluorouracil for four hours and tretinoin overnight), radiodessication was done at first visit only.Result and conclusion:While radiofrequency showed faster results , results were more consistent with least recurrence in 5-FU and fair recurrence with .05% tretinoin.

Possible clinical efficacy and tolerability of platelet-rich plasma in the treatment of patients with recalcitrant plane warts: The first clinical study.

Plane warts are prevalent cutaneous diseases, caused by different serotypes of human papillomavirus. This study aimed to assess the possible clinical efficacy and tolerability of platelet-rich plasma (PRP) in the treatment of patients with multiple recalcitrant plane warts. This prospective cohort clinical study was carried out on 25 patients with clinical and dermoscopic evident multiple recalcitrant plane warts. The patients were treated with autologous intralesional PRP injections every month until a complete clearance or for a maximum of two sessions. Then, patients were clinically evaluated one month after every session and after a six-month follow-up from the last injection. Of the included patients, 20 (80%) patients had facial plane warts, 3 (12%) patients had plane warts in the dorsum of hands, and 2 (8%) patients had plane warts in the dorsal aspect of feet. 60% of the patients have more than 100 plane warts, and all the patients had plane warts than 1cm in size. The complete improvement was observed in 20% and 100% of the patients after the first and second sessions, respectively. No recurrence was detected after a six-month follow-up. No side effects were recorded after the treatment sessions. Intralesional injection of PRP could be potentially effective and well-tolerated immunotherapy for the treatment of multiple recalcitrant plane warts. Whatever, more studies are needed with a larger sample size and a longer period of follow-up. Also, randomized and controlled studies are required to evaluate its efficacy in treating different clinical types of warts.