One of the important problems in the qualitative theory of real planar differential systems is limit cycles i.e., isolated periodic solutions in the set of all periodic this concept was defined at the end of the 19th century by Poincaré, and with the works of van der Pol and Liénard. The significance of these isolated solutions lies in their key role in understanding the dynamics of a certain differential system. Afterward, Hilbert specified a list of 23 problems for the advancement of mathematical science, and from then it started intensive research on these problems throughout the 20th century. Of the 23 problems, only the so-called 16th Hilbert’s problem and the Riemann conjecture remain open until now. The second part of the 16th Hilbert problem has two parts and asks for an upper bound on the number of possible limit cycles and their positions for a planar polynomial differential system of a given degree. The theory of the limit cycle operating as an indispensable mathematical tool has found broad and important applications in modern physics, chemical, biological, ,and other fields. Then the progress of these fields, in turn, promotes limit cycle research. In this paper, we prove the existence and uniqueness of the limit cycle for a family of generalized polynomial Liénard differential systems, the explicit expression of this limit cycle is given. An example illustrating our results is additionally presented.