Polylactic acid (PLA) has become desirable for biomedical applications, particularly implantable devices. However, the degradation of PLA in biological environments under mechanical stress remains incompletely understood and requires further investigation. This study compared the plain fatigue (PF) and the biodegraded fatigue (BDF) behavior of 3D-printed PLA. For this purpose, two sets of standard fatigue specimens were additively manufactured by the fused filament fabrication (FFF) method. One set was used for plain fatigue testing, and the other was immersed for 330 days in simulated body fluid (SBF). After immersion, the samples were dried and weighed before fatigue testing. The fully reversed rotary bending fatigue tests were conducted on both sets of specimens, and the stress-lifetime (S-N) curves were obtained. Additionally, the fatigue properties of PF and BDF specimens were evaluated. Moreover, the fracture behaviors of the materials were studied using field emission scanning electron microscopy (FESEM). The outcomes implied that the weight of the samples extended during the immersion period, primarily due to water absorption by the PLA. However, after drying, the final weights did not change compared to the weights before immersion. The SBF immersion significantly reduced the fatigue performance of the biodegraded samples comparing the PF result.
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