Introduction: In Mali, sexuality is a subject considered taboo and parents often find it difficult to communicate with their children on this subject. The general objective of this study is: to study the knowledge, attitudes and practices of adolescents attending El Moctar high school in Banconi Farada in commune I of the district of Bamako. Patients and Method: This was a descriptive cross-sectional study carried out with students from El Moctar high school in Banconi Farada in commune I of the district of Bamako. It was conducted during the period from April 26 to May 25, 2021, i.e. a duration of one month. All the pupils who gave their consent answered the questions mentioned on the survey sheets. We used SPSS version 20.0 software. Results: The analyzes showed that boys were more likely to participate in our study with 62%. During the survey 43.2% had started sexual intercourse, only 22% of these only active students knew about condoms during their first sexual intercourse and 70.6% had never used condoms. Half of the students questioned do not know about STIs with 52%, the majority knew about HIV/AIDS, ie 91%, more than half did not know about cancer of the cervix, ie 59% of the students surveyed. Among sexually active girls at least 8.8% have a pregnancy and 85.8% of these pregnancies were unwanted. Among the students surveyed, 73% had heard of Family Planning (FP), among them only a few used FP methods and the frequently used methods are condoms, injectables and jadelle. Conclusion: In conclusion, this study, which took place in a private high school in commune I of the district of Bamako, gave us the opportunity to study in general the level of knowledge, attitudes and practices of adolescents in terms of sexual health and reproduction, specifically to describe their socio-demographic characteristics, determine the level of knowledge, their attitude and practice in matters of sexual and reproductive health. The majority of adolescents, about 52% do not .....
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