Pittsburg Sleep Quality Index Score Research Articles

Effect of holographic Guasha on sleep quality of older adults with hypertension in the community: A prospective study.

To explore the effect of holographic Guasha therapy on the Pittsburg Sleep Quality Index (PSQI) and Hamilton Anxiety Rating Scale (HAMA) in older adults with hypertension living in the community. This prospective study was conducted from July 2019 to December 2020. Older adults with hypertension (systolic pressure ≥ 140 mm Hg, diastolic pressure ≥ 90 mm Hg) were divided into the control and Guasha groups. The PSQI and HAMA were assessed before and after 4 weeks of intervention. 62 patients were enrolled, with 31/group (Guasha: 72.4 ± 6.9 years, 23.0 ± 3.1 kg/m2; control: 71.4 ± 6.3 years; 22.9 ± 2.9 kg/m2). The total PSQI score did not decrease in the control group after 4 weeks (from 14.8 ± 1.2 to 14.8 ± 1.8, P = .498) but decreased in the Guasha group (from 14.9 ± 1.1 to 6.8 ± 3.5, P < .001). All PSQI subscores decreased in the Guasha group after 4 weeks of Guasha intervention (all P < .05), except for the use of sleep medication, since the use of such drugs was an exclusion criterion. The HAMA index scores did not change in the control or Guasha group (both P > .05). Holographic Guasha appears to achieve better sleep outcomes than conventional treatment in improving the sleep quality of older adults with hypertension living in the community. The participants were not randomly assigned to the treatments, and the results should be confirmed in a formal trial.

Evaluation of isotretinoin effects on depression, sleep apnea and sleep quality

Background Isotretinoin is used to treat severe acne, treatment-resistant moderate acne, and acne that leads to scarring or psychological distress. It has many side effects and is also associated with depression, sleep apnea, and sleep disturbances. Objectives In this study, we aimed to evaluate the effects of isotretinoin on depression, sleep apnea, and sleep quality. Methods A total of 42 patients diagnosed with acne and started isotretinoin treatment were included in the study. In order to compare the effects of isotretinoin, patients were asked to fill out a questionnaire containing the Beck Depression Inventory (BDI), the Berlin Questionnaire (BQ), and the Pittsburg Sleep Quality Index (PSQI) at baseline and third months of treatment. Results There was no statistically significant difference in BDI, BQ, and PSQI scores between the 1st and 3rd months of treatment (p = .53, p = .5, p = .35). Conclusion This study showed that isotretinoin had no significant effects on depression and sleep quality.

Shared genetic mechanisms underlying association between sleep disturbances and depressive symptoms

ObjectivesPolygenic scores (PGS) for sleep disturbances and depressive symptoms in an epidemiological cohort were contrasted. The overlap between genes assigned to variants that compose the PGS predictions was tested to explore the shared genetic bases of sleep problems and depressive symptoms. MethodsPGS analysis was performed on the São Paulo Epidemiologic Sleep Study (EPISONO, N = 1042), an adult epidemiological sample. A genome wide association study (GWAS) for depression grounded the PGS calculations for Beck Depression Index (BDI), while insomnia GWAS based the PGS for Insomnia Severity Index (ISI) and Pittsburg Sleep Quality Index (PSQI). Pearson's correlation was applied to contrast PGS and clinical scores. Fisher's Exact and Benjamin-Hochberg tests were used to verify the overlaps between PGS-associated genes and the pathways enriched among their intersections. ResultsAll PGS models were significant when individuals were divided as cases or controls according to BDI (R2 = 1.2%, p = 0.00026), PSQI (R2 = 3.3%, p = 0.007) and ISI (R2 = 3.4%, p = 0.021) scales. When clinical scales were used as continuous variables, the PGS models for BDI (R2 = 1.5%, p = 0.0004) and PSQI scores (R2 = 3.3%, p = 0.0057) reached statistical significance. PSQI and BDI scores were correlated, and the same observation was applied to their PGS. Genes assigned to variants that compose the best-fit PGS predictions for sleep quality and depressive symptoms were significantly overlapped. Pathways enriched among the intersect genes are related to synapse function. ConclusionsThe genetic bases of sleep quality and depressive symptoms are correlated; their implicated genes are significantly overlapped and converge on neural pathways. This data suggests that sleep complaints accompanying depressive symptoms are not secondary issues, but part of the core mental illness.

Intake of dietary advanced glycation end products may be associated with depression and sleep quality in young adults

BackgroundThis study examined the relationship between dietary intake of advanced glycation end products (dAGEs) and depression and sleep quality in young adults. MethodsThis study, which included 420 university students (F = 80.2 %; M = 19.8 %), is observational and cross-sectional. Dietary AGEs intakes of individuals were taken with a 24-h food consumption record system. Measuring the depression status of the participants was evaluated with the Beck Depression Inventory (BDI), and the assessment of their sleep quality was evaluated with the Pittsburg Sleep Quality Index (PSQI). Individuals' dAGEs intakes were divided into three equal groups (low, medium, and high). The energy was adjusted in all analyzes of dAGEs intake. Study data were analyzed with the SPSS (27.0 version) and GraphPad program (8.0 version). ResultsThe BDI and PSQI total score averages of individuals in the high dAGEs intake group were higher than the other groups, and this difference was statistically significant (p < 0.001). There is no significant difference between individuals' dAGEs intakes and energy and macronutrient intakes. Students' dAGEs intake was affected by BDI (β = 0.722, 95 % Cl = 0.639;0.811) and PSQI (β = 0.286, 95 % Cl = 0.179;0.431) scores (p < 0.001). This effect persisted even when various confounding factors were included (age, gender, smoking, body mass index, chronic disease) (p < 0.001). LimitationsThese data are cross-sectional, which limits the generalizability of results and establishing cause-effect relationships. ConclusionThere may be an association between dAGEs intake and the development of depression and sleep quality in young adults. Clinical intervention studies using objective measurement methods should be conducted on this issue in the future.

The Relationship between Nurses’ COVID-19 Risk Perceptions, Anxiety Levels and Sleep Quality

Objective: This study was conducted to determine the relationship between COVID-19 risk perceptions, anxiety levels, and the sleep quality of nurses. Methods: The sample of the descriptive and correlational study consisted of 248 nurses. The data were collected face-to-face using a Questionnaire form, the COVID-19 Perceived Risk Scale, the Coronavirus Anxiety Scale, and the Pittsburg Sleep Quality Index between July 1, 2021, and December 29, 2021. Data were evaluated with descriptive statistics, Mann-Whitney U and Kruskal Wallis test, Spearman correlation analysis test, and linear regression analysis. Results: The mean score was 29.73±6.66 for the COVID-19 Perceived Risk Scale, 4.22±0.28 for the Coronavirus Anxiety Scale score, and 8.30±3.3 for the Pittsburg Sleep Quality Index. A moderate positive correlation was found between the participants' Pittsburg Sleep Quality Index scores and the Coronavirus Anxiety Scale total score (r=0.300, p

Sleep Quality Assessment in Correlation to Autonomic Nerve Function in Type 2 Diabetic Patients

Background and Objective Diabetes mellitus negatively impacts the quality of life of its patients. Autonomic dysfunction may disturb sleep quality by negatively affecting multiple systems, including, but not limited to, the cardiovascular, respiratory, and genitourinary tracts. The current study aims to assess sleep quality and examine the degree of correlation with autonomic nervous function in relatively well-controlled type 2 diabetic patients.Methods This study uses a cross-sectional design to assess sleep quality in 88 type 2 diabetic patients via the Pittsburg Sleep Quality Index (PSQI), accordingly dividing them into two groups: good or poor sleepers. Subsequently, the study evaluates autonomic nerves’ conductivity by measuring electrical skin conductance using Sudoscan for the hands and feet.Results Of 88 recruited patients, 53% showed poor sleep quality, with higher incidence in females. Autonomic nerve conductivity showed moderate damage in poor sleepers with 59.53 ± 13.35 μS and 59.68 ± 16.91 μS of hand and foot electrodes, respectively. Autonomic damage induces sleep disturbance mainly through increased nighttime voiding in 91.49% of the poor sleepers group compared to 41.46% in the good sleepers group. PSQI score was found to strongly and inversely correlate with autonomic nerve conductivity via hand electrodes, with a correlation coefficient of -0.62 and a determination coefficient of 0.39.Conclusion Poor sleep quality seems to be a significant problem even in relatively well-controlled type 2 diabetic patients with no diagnosed micro- or macrovascular complications. Autonomic dysfunction negatively affects the quality of sleep and leads to sleep disturbance by increasing nighttime micturition as one of its complications.

0173 Improving Well-being by Changing the Shiftwork Schedules at U.S. Navy Watchfloors

Abstract Introduction Watchfloors provide around-the-clock information, intelligence, and technical support to the U.S. military. Active-duty service members (ADSMs) working on these 24/7 watchfloors stand watches to include night shifts and/or frequent shift rotations. Tailoring shiftwork schedules to optimize individual sleep patterns may reduce the negative effects of shiftwork. The purpose of this study was to test whether a new shiftwork schedule would improve ADSM well-being and sleep. Methods ADSMs (N=79; 83.5% males, 91.2% enlisted, 19 to 54 years of age) participated in a two-phase quasi-experimental longitudinal study to assess well-being and sleep before and after the implementation of a new shiftwork schedule. Both schedules involved three rotating shifts: day shift (0730-1530), evening shift (1320-2330), and night shift (2330-0730). The old schedule had 5 successive days on-shift (5-on/4-off) and the new schedule had 4 successive days on-shift (4-on/4-off). Shifts rotated after every off period. Standardized questionnaires were administered while participants were on the old schedule (study start) and ~5 months after switching to the new schedule. The questionnaires included the Pittsburg Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Profile of Mood States (POMS). Sleep was monitored using wearable devices (ŌURA rings). Results POMS total mood disturbance scores were lower (i.e., better) on the new schedule (p&amp;lt; 0.001), as were several POMS sub-scale scores including tension (p&amp;lt; 0.001), depression (p&amp;lt; 0.001), anger (p=0.014), confusion (p&amp;lt; 0.001), and vigor (p=0.029). There was a statistical trend for a decrease in ISI scores from the old schedule to the new schedule (p=0.067). Sleep duration, PSQI, and ESS scores did not differ between schedules (all p&amp;gt;0.05). Conclusion Implementation of a new shiftwork schedule that was tailored to worker sleep patterns was associated with decreased mood disturbance, improvement in negative mood states (e.g., depression and tension), and reduced insomnia symptom severity. Also, the research team received several anecdotal reports of high levels of worker satisfaction with the new schedule. This study demonstrates the positive real-world effects of using basic sleep and circadian methods to tailor shiftwork schedules to improve the well-being of military personnel. Support (if any)

0152 Natural disaster experiences and their varying impact on sleep impairment

Abstract Introduction As rates and severity of natural disasters increase due to climate change, it is crucial to consider their effects on mental health. Among Hurricane Katrina survivors, stressors experienced following the Hurricane, including financial losses, were more robustly predictive of rates of PTSD than traumatic experiences occurring during the Hurricane (Galea et al., 2008). Because sleep disturbance is intimately associated with trauma exposure and has been implicated in the etiology of PTSD, we examined relationships between experiences during and after Hurricane Harvey (a historic storm that hit Texas in 2017) and sleep disturbance in sample of college students impacted by the storm. Methods Undergraduate students (N = 191, age: M = 21.25, SD = 3.14) at the University of Houston completed online surveys 6-8 months after Hurricane Harvey. Sleep quality was measured using the Pittsburg Sleep Quality Index (PSQI) and post-traumatic stress (PTS) symptoms were measured using the PTSD Checklist for DSM-5, excluding sleep items. Participants also reported on experiences/events during, immediately after, and in the weeks/months following the Hurricane. Total traumatic experiences during the Hurricane (e.g., thinking oneself or others would get hurt or die) and stressful experiences after the storm (e.g., losing power, damage to car or property) were calculated. Financial stress was examined as a unique predictor. Analyses controlled for total traumatic life events measured with the Life Events Checklist for DSM-5. Results In a multiple linear regression model, we tested whether traumatic experiences during, stressors after, and financial stressors due to the Hurricane predicted global PSQI score, controlling for other traumatic life experiences and total PTS symptoms. The overall model was significant (R2 = 0.22, F (5,185) = 10.48, p &amp;lt; .000). Traumatic experiences during the Hurricane (B = 0.37, p = 0.04), but not stressors (B = 0.02, p = 0.87) or financial stress (B = -0.29, p = 0.67) following the Hurricane significantly predicted poor sleep quality at present. Conclusion Our findings suggest that among a sample of young adult college students impacted by Hurricane Harvey, traumatic experiences during the storm were the most robust predictor of sleep disturbance several months later even after accounting for PTS symptoms. Support (if any)

0176 Predictors of sleep duration among university students in Japan: Cross-cultural insights for developing sleep health interventions

Abstract Introduction Inadequate sleep among university students, especially in Japan, contributes to low academic performance and mental health challenges. Sleep health, including adequate sleep duration and quality, may serve a protective role in promoting performance and full participation in daily life. We sought to identify factors explaining sleep duration in Japanese college students as potential targets for culturally sensitive sleep health promoting intervention. Methods Cross-sectional descriptive study of university students in Japan in 2021; N = 362 completed validated Japanese versions of the Pittsburg Sleep Quality Index (PSQI), Morningness and Eveningness Questionnaire, Sleep Hygiene Practice Scale, and Dysfunctional Beliefs and Attitudes about Sleep. Indicators of sleep and PSQI subscales (except sleep duration), personality, depression, anxiety, time use, and participation quality were included in multivariate logistic regression modeling to explain less healthy (6 hours or less) versus healthier (more than 6 hours) sleep duration. Results Students were 20.0 (SD = 1.3) years, 86.4% female with a mean sleep duration of 400 (SD = 67) minutes. The mean PSQI score was 4.8 (SD = 2.5) indicating good sleep quality, though 41.4% of the sample reported sleeping 6 hours or less and these persons had lower sleep quality (PSQI; d = 1.20) compared to longer sleepers. Logistic regression explained category assignment (Chi-square = 68.978, df = 8, p &amp;lt;.001; Nagelkerke R-squared = .234). Longer sleepers were more likely to report greater sleep efficiency, less frequent sleep disturbances, lesser daytime dysfunction, shorter commuting times, a morning-like chronotype, greater participation quality, and a less agreeable personality type. Interestingly, longer sleepers reported less effective sleep hygiene practices. Conclusion Short sleep was common and associated with poor sleep quality. Longer sleepers were more likely to report optimal sleep health indicators and greater participation quality (i.e. engagement in meaningful activities). Counter-intuitive sleep hygiene findings indicate potential cultural variation in sleep timing, pre-sleep arousal, and environment regulation as targets for intervention. Sleep health promotion intervention should consider personality, chronotype preference and time use (e.g. meaningful activities, commuting) as factors promoting or inhibiting sufficient sleep duration and quality in university students. Support (if any) Fulbright U.S. Scholar Award to Japan

Sleep Disturbance in Chronic Rhinitis: Evaluation of Nasal Symptoms, Sleep Disorder Questionnaires, and Sleep Architecture in Allergic and Non-allergic Rhinitis in Dr. Cipto Mangunkusumo Hospital.

Chronic rhinitis is often associated with sleep disturbance and daytime sleepiness. Disturbance in sleep impairs numerous metabolic processes and brain function. However, there is a paucity of data regarding the evaluation of nasal symptoms and sleep disturbance in chronic rhinitis, either allergic or non-allergic group. To evaluate the characteristic of sleep disturbance in allergic and non-allergic rhinitis in Dr. Cipto Mangunkusumo Hospital Jakarta, across sectional analytic descriptive study was performed. All recruited subjects were evaluated for total nasal symptom scores (TNSS) and nasal obstruction symptoms evaluation scores (NOSE). Sleep disorder was assessed using Epworth Sleepiness Scale (ESS), Pittsburg Sleep Quality Index (PSQI) questionnaires, and polysomnography (PSG). A total of 22 chronic rhinitis patients, with 11 allergic and 11 non-allergic rhinitis were evaluated. Most subjects with allergic rhinitis experienced daytime sleepiness and poor quality of sleep as well as non-allergic rhinitis, without significant differences in TNSS, NOSE, ESS, and PSQI scores. There was impairment in sleep architecture from PSG parameters in both groups, but the difference was not significant. However, RDI-REM (17.7 ± 14.5 vs. 14.7 ± 18.5) and RERA (2.2 ± 2.1 vs. 1.6 ± 1.7) parameters have a tendency to be higher in the allergic rhinitis compared to non-allergic rhinitis group. Sleep disturbance existed in chronic rhinitis, presented by excessive daytime sleepiness and impairment in sleep architecture, yet no significant difference shown in the severity of TNSS, NOSE, ESS, PSQI scores, and sleep architecture parameters between the allergic and non-allergic rhinitis.

Efficacy and Tolerability of Ich Nieu Khang Dietary Supplement for Overactive Bladder

This study aims to assess the effectiveness and safety of plant-derived food supplement Ich Nieu Khang (INK) as a dietary supplement for overactive bladder (OAB) symptoms. A total of 50 patients 18-80 years of age with the diagnosis and symptoms of the OAB were enrolled in the study and followed up for 30 days. The INK treatment efficacy, in terms of changes in nocturnal and day-time urination frequency, urination incontinence episodes, level of OAB symptoms according to Homma's OABSS scale, sleep quality according to Pittsburg Sleep Quality Index (PSQI), and possible side effects of the INK phytotherapy, was evaluated. INK significantly improved all OAB symptoms scores with a reduction of average nocturia from 4.06 ± 1.53 to 1.14 ± 0.94, the daily average urination urgency from 7.67 ± 5.00 to 5. 82 ± 3.70, the daily average frequency of urination from 9.96 ± 4.04 to 8.00 ± 3.70, weekly average incontinence of urination from 0.92 ± 1.56 to 0.60 ± 1.02, and OABSS Homma's score decreased from 9.31 ± 1.44 to 6.8 ± 2.21. INK phytotherapy also resulted in sleep quality improvement by PSQI score decreasing from 13.11 ± 1.33 to 10.54 ± 2.21. There were no adverse effects and abnormalities in paraclinical parameters with INK therapy. The results of our study suggest that INK dietary supplement is effective and safe phytotherapy for patients with primary OAB symptoms within 30 days of treatment. Larger control clinical trials are warranted to confirm our findings and promote wider use of INK for OAB and possible other age-related urination disorders.

Association of subclinical depressive symptoms and sleep with cognition in the community-dwelling older adults

/Purpose: This study aimed to explore the association of subclinical depressive symptoms and sleep with cognition in community-dwelling Taiwanese older adults. This four-year prospective cohort study (2015-2019) included 379 participants aged 65 years or older from the annual senior health checkup program at National Taiwan University Hospital who were followed up two years later. Global and domain cognitive functions were assessed using validated neuropsychological tests. Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression (CES-D) Scale. Sleep quality was evaluated using the Pittsburg Sleep Quality Index (PSQI). Excessive daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Generalized linear mixed models were used to explore the associations of subclinical depressive symptoms and sleep variables with cognition, adjusting for important covariates. Stratification analyses were performed using the sleep variables. Over time, depressive symptoms were associated with poor performance of memory (βˆ=0.24, P=0.04) and executive function (βˆ=-0.24, P=0.03). Poor sleep quality (elevated PSQI score) was associated with poor memory performance (βˆ=-0.04 to -0.03, P<0.05). Excessive daytime sleepiness (elevated ESS score) was associated with poor performance of memory (βˆ=-0.02, P<0.05) and executive function (βˆ=-0.02, P=0.001). At baseline, better sleep quality and no excessive daytime sleepiness were associated with better memory performance over time. Subclinical depressive symptoms, worse sleep quality, and excessive daytime sleepiness were differentially associated with impairment of cognitive domains (mainly memory and executive function).

Anxiety and Sleep Quality in Healthcare Professionals During the Covid-19 Pandemic Process

Objective: In this study it was aimed to investigate the coronavirus anxiety and sleep quality in healthcare workers during the pandemic period. Methods: This study was planned as cross-sectional and prospective type and it was carried out between February- April 2021 in a tertiary hospital. By online survey method Pittsburg Sleep Quality Index (PSQI), Coronavirus Anxiety Scale (CAS) and a questionnaire created by the researchers were used for collecting the data. Results: A total of 291 healthcare professionals, participated in the study. The mean PSQI score of patients who were detected to have coronavirus anxiety was found to be significantly higher than patients without coronavirus anxiety (p=0,005). Men's average sleep duration was found to be higher than women's (p=0,002). The mean sleep latency score was found to be higher in singles than in married people (p

Sleep quality and its associations with disease activity and quality of life in older patients with rheumatoid arthritis.

Sleep disturbance is among the most important geriatric syndromes, and its evaluation is part of the routine comprehensive geriatric assessment (CGA). Previous studies have demonstrated that older patients with rheumatoid arthritis (RA) have poorer sleep quality than younger control patients. However, there needs to be more data on the sleep quality of older patients with RA with age-matched controls. Totally 100 participants, 50 older RA patients classified according to the ACR criteria, and 50 age- and gender-matched control patients without RA were included in the study. All patients underwent CGA, including assessing their functionality, depressive, cognitive, and nutritional status. In addition, sleep quality was assessed by the Pittsburg Sleep Quality Index (PSQI), and RA disease activity by a rheumatologist using the Disease Activity Score 28 (DAS28-CRP), and quality of life with the RA QoL questionnaire (RAQoL). The median age was 70years (min-max: 65-86), and 62.5% were female. Co-morbidities and comprehensive geriatric assessment parameters were similar between the two groups. Median PSQI global score was higher in patients with RA than controls [9 (min-max: 1-20) vs. 5 (min-max: 1-13), p = 0.029). When the patients were categorized with respect to being 'poor sleepers' (PSQI score > 5), 62% of patients with RA and 38% of controls were poor sleepers (p = 0.016). The patients classified as poor sleepers were more likely to have a diagnosis of RA, higher DAS28-CRP and RAQoL scores, lower grip strength, and be a woman. PSQI global scores were significantly positively correlated with DAS28-CRP scores (r = 0.514, p < 0.001), RAQoL scores (r = 0.689, p < 0.001), number of medications used (r = 0.292, p = 0.003), and YDS scores (r = 0.407, p < 0.001), and significantly negatively correlated with handgrip strength (r = - 0.351, p = 0.001). The results suggest that older patients with RA might have poorer sleep quality compared to age- and gender-matched controls. Moreover, sleep quality correlated with RA disease activity and QoL in old age.

Sleep quality in patients of chronic obstructive pulmonary disease

Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory ailment with persistent airflow limitation associated with an enhanced chronic inflammatory response in airways and lungs to noxious particles or gases. This study aims to observe the sleep quality in these cases as it is known that most of them suffer from disturbed sleep. Aims and Objectives: The aims of this study were to assess the sleep quality in stable patients of COPD and compare with healthy controls. Material and Methods: This cross-sectional observational study was approved by ICMR and IEC and conducted in the department of Physiology and the Department of TB and Chest Medicine, Lady Hardinge Medical College, New Delhi. In this study, 33 clinically stable COPD patients and 33 normal subjects as controls were included in the study. Then, a detailed history including the demographic characteristics was recorded. Then, Pittsburg Sleep Quality Index (PSQI) Questionnaire (Hindi version was obtained from MAPI organization) was recorded by direct interview before lung functions were assessed by Spirometry. Results: In his study, COPD was found predominantly in male subjects compared to females. Poor sleep was found in majority of COPD cases. The median global PSQI scores were much higher in COPD cases compared to controls and the difference between them was statistically highly significant (P &lt; 0.001). Conclusion: This study shows that the prevalence of poor sleep quality among COPD patients of urban Delhi is very high. Limitations are small sample size and hospital-based subjects and lack of polysomnography.

Evaluation of chronotype and sleep quality in infertile population and comparison with fertile population: a cross-sectional study

Purpose Infertility is a stressful condition for couples and can affect patients’ circadian rhythm and sleep quality. The goal of this study is to assess differences in chronotype and sleep quality between infertile and fertile people. Methods A cross-sectional study was conducted. The infertile patient population consisted study group. Primiparous patients without any known gynecological disease who presented for routine cervical cancer screening follow-up were included in the control group. The Turkish version of the Morningness-Eveningness Questionnaire (MEQ) and Pittsburg Sleep Quality Index (PSQI) scores were evaluated between groups. Results A total of 227 patients were assessed. There were 110 patients in the study (infertile) group and 117 patients in the control (fertile) group. The evening chronotype proportion (23.6 vs. 0.9%, p < 0.001) was higher in the infertile group. The median of MEQ score was significantly higher in the fertile patients (50, IQR = 43 − 55 vs. 56, IQR = 51 − 59; p < 0.001), and the median of PSQI score was significantly higher in the infertile patients (5, IQR = 4 − 6, vs. 4, IQR = 3 − 5; p < 0.001). Conclusions In this study, we found significantly worse sleep quality, and more evening chronotype in the patients with infertility.

Altered intrinsic brain functional network dynamics in moderate-to-severe obstructive sleep apnea

ObjectivesObstructive sleep apnea (OSA) can affect temporal fluctuations in brain activity during rest. Dynamic functional connectivity (dFC) captures the fluctuations in FC during the resting state. This study aimed to investigate differences in dFC between moderate-to-severe OSA patients and healthy controls using resting-state functional magnetic resonance imaging (fMRI) and sliding-window analysis. MethodsThirty-seven consecutive patients with moderate-to-severe OSA and 16 age- and sex-matched controls underwent resting-state fMRI in the morning following overnight polysomnography. The dynamics of aberrant FC between the groups and the correlation between the dynamics and clinical variables were evaluated. ResultsdFC analysis revealed two distinct connectivity states: hypoconnected (State I) and hyperconnected (State II). In OSA patients, State I occurred 34% more often than in the controls and the occurrence of State II was proportionally reduced. The time in State I positively correlated with the Pittsburg Sleep Quality Index score in the OSA patients. ConclusionsThis study showed dFC alterations in moderate-to-severe OSA patients, which may serve as a novel physiological biomarker for OSA.

Sleep Quality in An Acute Inpatient Rehabilitation Setting: The Importance of Prior Sleep Disorders

<h3>Research Objectives</h3> To assess whether demographic and clinical factors might impact sleep quality during inpatient stay in a rehabilitation setting. <h3>Design</h3> In this prospective study, patients were assessed for their sleep quality at admission and discharge. <h3>Setting</h3> Patients admitted in the acute inpatient rehabilitation unit of Casa Colina Hospital and Centers for Healthcare (Pomona, California) were included in the study. <h3>Participants</h3> Thirty five patients participated to this study (age=61±16 years old; BMI=30±7kg/m2; 18 females, 18 Caucasians). <h3>Interventions</h3> None. <h3>Main Outcome Measures</h3> The Pittsburg Sleep Quality Index (PSQI) was administered as primary outcome. Demographic and clinical data were collected as covariates (i.e., age, BMI, gender, race, cause of hospitalization, pre-hospital setting and prior diagnosis of sleep disorders). The level of anxiety and depression were also assessed using Beck Anxiety Inventory (BAI) and Patient Health Questionnaire-9 (PHQ-9). <h3>Results</h3> The average length of hospitalization was 18±8 days. Cause of hospitalization included stroke (20%), spinal cord injury (28%), orthopedic (28%) and other diagnosis (23%). In this sample, 22% had a sleep disorder diagnosis (mostly sleep apnea) and 60% came from an acute care unit. ANOVAs with repeated measures were performed on the outcome measure (PSQI) controlling for BMI and age. Among the demographic and clinical variables considered, the presence of sleep disorders had an effect on changes in PSQI total scores. The PSQI decreased significantly in patients with prior diagnosis of sleep disorders. The pre-hospital setting trended toward statistical significance only for the group without sleep disorders. The initial level of anxiety or depression did not have an effect on the PSQI scores. However, changes in BAI and PHQ-9 total scores were related to changes in PSQI. Finally, our dataset did not reveal an effect of race or gender. <h3>Conclusions</h3> Prior sleep disorders diagnoses factors has an impact on sleep quality during hospitalization. These results identify high-risk patient characteristics that impact sleep hygiene which will be taken into consideration in developing an intervention for improving inpatient sleep hygiene. <h3>Author(s) Disclosures</h3> The authors have nothing to declare.

Lifestyle factors associated with poor sleep quality among undergraduate dental students at a Malaysian private university.

The purpose of this study was to look into the associations between lifestyle factors, gender, clinical level, and sleep quality among undergraduate dental students at a private university in Malaysia. A self-administered Pittsburg sleep quality index (PSQI) scale and the lifestyle and habits questionnaire-brief (LHQ-B) were used in this cross-sectional study. A global PSQI score of greater than 5 indicates poor sleep quality. All university dental students were invited to take part. Descriptive statistics and logistic regression analyses were used to analyze the data. A total of 338 students took part in the study, with a response rate of 90.4%. The proportion of females was higher (68.3 %) and more than half of the respondents (56.7 %) were in their clinical years. The prevalence of poor sleep quality was 36.7%. At multivariable level, poor sleep quality was associated with being male (OR=1.72 [95% confidence interval (1.05, 2.83)] and engaging in an unhealthy lifestyle for psychological health (OR=2.64 [95% confidence interval (1.34, 5.21)] and nutrition (OR=2.48 [95% confidence interval (1.028, 4.82)]. The prevalence of poor sleep quality among undergraduate dental students in our study was comparable to that found in other studies. Male students were more likely to have poor sleep quality than female students. Our findings indicate that poor sleep quality (PSQI score >5) may be linked to unhealthy lifestyle habits related to psychological health and nutrition. Health education that emphasizes these domains is essential for improving their lifestyle habits and sleep quality.

The Effects of Food Intake and Eating Behavior on Sleep Quality in Adolescents

Background: Food and eating behaviors can be related to nutrition as well as sleep for healthy society. Objectives: The aim of the study is to examine the eating behaviors of adolescents and the effect of some foods on sleep quality in adolescence. MethodS: The study was carried out as a survey model of 580 adolescents in Konya, Turkey. The questionnaire consists of demographic features and anthropometric measurements, Pittsburg Sleep Quality Index (PSQI), Eating Behavior Scale (EBS), and 24-hour recalled food consumption record used for evaluation of daily nutrient intakes. The SPSS (ver. 22) software was used to analyze the data. Results: PSQI score was 5.79±0.17 in girls and 5.27±0.15 in boys, with a significant difference (p=0.022) and sleep quality was found to be good in 42.4% and poor in 57.6%. Sleep duration (p=0.011), sleep disturbances (p=0.002), daytime dysfunction (p=0.000) were differed by gender. The mean of EBS score was found to be 211.04±61.32, differed between girls and boys (p&lt;0.05). Also, the EBS score differed by night eating (p=0.000). Total energy (p=0.001), protein (p=0.001), carbohydrate (p=0.003), B1 (p=0.028), B6 (p=0.006), niacin (p=0.000), folic acid (p=0.001), B12 (, Zn, and Fe daily intake changed between girls and boys (p&lt;0.05). Conclusion: Adolescents with poor sleep quality, poor eating behavior should consider night eating is to determine if it may be associated with their sleep.