Pigmented Eccrine Poroma Research Articles

Reflectance Confocal Microscopy Combined with Dermoscopy and Histology in the Diagnostic Setting of Pigmented Eccrine Poroma: A Retrospective Study.

Pigmented eccrine poroma (PEP) is a unique variant of a benign adnexal tumor known as eccrine poroma. Distinguishing PEPs from other pigmented lesions can be challenging due to overlapping clinical and dermoscopic features. To provide a comprehensive analysis of the dermoscopic, confocal (RCM), and histological features of PEPs. We undertook a retrospective study of the clinical, dermoscopic, RCM and histopathological features of PEPs that were surgically excised and histopathologically recognized. Data on epidemiological, clinical, dermoscopic, RCM and histopathological features were collected from the databases of the Skin Cancer Unit, IRCCS Policlinico di Sant' Orsola, between January 2021 and May 2023. The study population consisted of 61 patients, including 34 females (55.7%) and 27 males (44.3%). Dermoscopic examination of 61 PEPs revealed the presence of irregular borders (55.7%), milia-like cysts (50.8%), brown pseudo-network (41%), cerebriform pattern (34.4%), comedo-like openings (29.5%), atypical vessels (26.2%), glomerular vessels (18%), fingerprint-like perifollicular structures (8.2%), dots (4.9%) and dotted vessels (4.9%). RCM imaging was collected from 11 cases and showed mostly well-defined tumor nests with small cells in 100% of cases, bright structures in the upper dermis representing melanocytes and melanophages (63.6%), dark round spaces within the tumor nests (54.5%), well-demarcated borders of the nest (45.5%) and dilated and prominent vessels in upper dermis (27.3%). Histopathological pattern analysis revealed PEP sensu stricto (PEPss) as the most frequent (54.1%). The distinctive dermoscopic patterns, along with the confocal features aid in the differentiation from other pigmented lesions.

Pigmented eccrine poroma in collision with seborrheic keratosis: Dermoscopic description and histological correlation

Poromas are rare, benign neoplasms arising from the terminal ductal portion of the sweat glands. They are mainly characterized by flesh-colored or pink papules or nodules, usually located at the extremities. The pigmented variant is rare. Collisions with other benign epithelial tumors have been reported. The clinical appearance may be confused with several benign or malignant tumor pathologies, yet thanks to dermoscopy, which is a non-invasive means of exploration, some signs are highly useful in the diagnosis and in suspecting the collision of two distinct tumors before proceeding to histological confirmation. Herein, we report the original case of a collision between pigmented eccrine poroma of the leg and seborrheic keratosis. Key words: Pigmented poroma; Collision; Dermoscopy; Histology; Seborrheic keratosis

Pigmented Eccrine Poroma on the Palm: A Rare Variant in an Atypical Site.

Pigmented Eccrine Poroma on the Palm: A Rare Variant in an Atypical Site.

Pigmented Eccrine Poroma: Report of a Case with the use of Dermoscopy.

Pigmented Eccrine Poroma: Report of a Case with the use of Dermoscopy.

The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience.

article: The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience - Italian Journal of Dermatology and Venereology 2021 December;156(Suppl. 1 to No. 6):36-7 - Minerva Medica - Journals

The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience

The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience

Pigmented eccrine poroma mimicking a pigmented basal cell carcinoma

Pigmented eccrine poroma mimicking a pigmented basal cell carcinoma

Pigmented eccrine poroma: A clinical dermoscopy challenge

Pigmented eccrine poroma: A clinical dermoscopy challenge

Pigmented eccrine poroma: dermoscopic and confocal features.

Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor.Herein, we report one case of pigmented eccrine poroma (PEP) that simulated clinically a cutaneous melanoma or a basal cell carcinoma. Dermoscopy and RCM excluded the possibilities of those two diagnoses; the overall confocal findings were suggestive for a benign epithelial tumor. Histology was fundamental to diagnose this lesion as a pigmented eccrine poroma. Even if the diagnosis of eccrine poroma remains histopathological still, as in this case report, noninvasive tools such as dermoscopy and RCM examinations can be of help to rule out the diagnosis of melanoma. Larger studies on this rare pigmented variant of eccrine poroma could shed new light on the identification of specific diagnostic dermoscopic and confocal features.

Pigmented eccrine poroma: report of an atypical case with the use of dermoscopy

Poromas are uncommon benign neoplasms originating from the terminal ductal portion of the sweat glands, mainly characterized by skin-colored or pink pa pules or nodules, usually on the extremities. Due to their rarity, the pigmented form clinical hypothesis is hardly ever suggested and psychopathology is fundamental. We report a case of pigmented eccrine poroma in the right palmer area, a location considered atypical. We stress the importance of dermoscopy as a method for diagnosis of poromas, especially in the differential diagnosis with other pigmented nodular-popular lesions.

Pigmented Eccrine Poroma in abdominal region, a rare presentation

The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of epithelial cells, with an incidence of 0.001 to 0.008%1. In 2/3 of the patients it appears on the soles and lateral borders of the feet. We report the case of a patient with pigmented eccrine poroma in abdominal skin, of a rare entity presentation with a single report in the literature in that location.

Abstracts from the 3rd World Congress of Dermoscopy, May 17 to 19, 2012, Brisbane Australia

Background:Non pigmented eccrine poroma is a benign tumor that can have dermoscopic features mimicking malign neoplasias. The characteristic vascular pattern of this tumor hasn’t been established. We found a scarcely reported vascular pattern, which can be useful to distinguish this tumor from malignant ones and propose a new nomenclature to these vessels due their similarity with the common calla flower and cherry blossoms tree.Observations:We study 10 proven Mexican cases of eccrine poroma and nearly half of them presented irregular linear and branched vessels with semi-elliptical, circular or semicircular endings, we called them “chalice-form” and “cherry-blossoms” vessels. The structureless pink-white areas were the most common finding and some vascular patterns reported in other studies were barely found.Conclusions:Due to the variability in the dermoscopic patterns found in non pigmented eccrine poroma, further studies are required to establish the specificity of these vessels, however they hasn’t been reported in other benign or malign neoplasias so, if seen, they can be an useful key leading to the diagnostic of eccrine poroma.

A pigmented lesion on the foot

Conflict of interest: none declared. A 58‐year‐old white man presented with an 8‐year history of an enlarging pedunculated, soft, fleshy, pigmented lesion on the outer surface of his right foot, which would bleed on trauma. On physical examination, a nontender, variably pigmented nodule, 25 mm in size, was seen on his foot (Fig. 1). The patient had no relevant medical or drug history. ... On histological examination of the pedunculated lesion, it was found to be composed of a sharply demarcated proliferation of uniform basaloid cells with foci of melanin pigmentation (Fig. 2a). Superficial ulceration and foci of squamous differentiation were noted, consistent with the history of trauma. Rare mitoses and focal evidence of ductal differentiation (Fig. 2b) were seen. ... What is your diagnosis? Pigmented eccrine poroma (EP). EPs are benign adnexal tumours derived from cells of the outer layer of acrosyringium and the upper dermal eccrine duct.1 EPs were first described by Pinkus in 1956,2 and most commonly present as soft, slow‐growing, well‐circumscribed solitary lesions, often on acral sites, but also on the face or scalp of middle‐aged or elderly patients.3 Uncommonly, they may present on the neck or chest. Generally, poromas are skin‐coloured, and lack pigmentation clinically and microscopically. Pigmented EPs are uncommon, with < 20 cases having been documented in the literature, most of which have been described on non‐acral sites in patients of ethnicity other than white.4

Eccrine Porocarcinoma of Scalp: An Uncommon Tumor at an Unusual Site

Eccrine porocarcinoma (EPC) is a very rare malignant sweat gland tumor and those arising in the scalp, are still rarer. Very few cases are reported in literature [1]. Malignant eccrine poroma was first described in 1963 by Pinkus and Mehregan using the term epidermotropic eccrine carcinoma. It is regarded as the rare malignant counterpart of eccrine poroma, a benign tumor of the intraepidermal eccrine sweat gland duct [2]. Porocarcinoma is commonly found in older age group and usually located in the lower extremities (more than 50%), rarely may occur on scalp, face, ear, upper extremities, trunk and abdomen [1, 3]. In the scalp, it is commonly seen in occipital region [4, 5]. The tumor presents as nodular, infiltrative, ulcerated or polypoid growth [6]. Surgical resection is the treatment of choice. There is 17% incidence of local recurrence and an 11% incidence of distant metastasis [3]. We report a case of EPC of scalp arising from a pigmented eccrine poroma in a 35 yr old.

Dermoscopic Features of Eccrine Poroma

Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma. The dermoscopic features of pigmented and nonpigmented eccrine poroma have recently been described. We present 2 cases of eccrine poroma, with their dermoscopic features. The lesions were characterized by multiple red lacunes and a polymorphous vascular pattern in both cases. Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.

A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma

Poroid hidradenoma (PH) is a variant of poroma. This entity was defined by Abenoza and Ackerman in 1990. This neoplasm shows architectural characteristics of hidradenoma (tumor cells confined entirely within the dermis in both solid and cystic components) and cytologic characteristics of poroid neoplasm (poroid and cuticular cells, the latter showing ductal differentiation). We herein document a case of single poroid lesion with the features of both eccrine poroma and PH. The patient was a 55-year-old woman with a pigmented nodular lesion on her upper back for 7 years. The histopathologic features of the lesion were consistent with those of eccrine poroma and PH. Unlike most eccrine poromas, this case was pigmented, clinically and microscopically.

Pigmented Eccrine Poroma Occurring on the Scalp

We describe a man with a pigmented poroma on the scalp mimicking a pigmented melanocytic nevus. Histopathological examination showed that melanocytes were mostly distributed at the periphery of the tumor masses. It is suggested that melanocytes in the tumor masses may have migrated from the adjacent epidermis.

Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation

Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation

Pigmented Eccrine Poroma

Pigmented Eccrine Poroma

Pedunculated Pigmented Eccrine Poroma of the Scalp with Increased Urinary Excretion of 5‐S‐Cysteinyldopa

We describe a 52-year-old man with a pedunculated pigmented eccrine poroma mimicking a nodular malignant melanoma in the occipital region. The tumor was once resected but soon recurred. Histologically, the tumor mass extended from the epidermis downwards into the dermis and contained melanin granules in some areas. The tumor cells were uniformly cuboidal in appearance and had round, deeply basophilic nuclei. Initially, the urinary excretion level of 5-S-cysteinyldopa (5-S-CD) was high, but, after resection of the tumor, the level of 5-S-CD returned to normal.