Physiological Responses Research Articles

Impact of neonatal noninvasive resuscitation strategies on lung mechanics, tracheal pressure, and tidal volume in preterm lambs.

This study investigated the relationship between three respiratory support approaches on lung volume recruitment during the first two hours of postnatal life in preterm lambs. We estimated changes in lung aeration, measuring respiratory resistance and reactance by oscillometry at 5 Hz. We also measured intratracheal pressure in subsets of lambs. The first main finding is that sustained inflation (SI) applied noninvasively (Mask SI; n=7) or invasively (endotracheal tube, ETT SI; n=6) led to similar rapid lung volume recruitment (~6 min). In contrast, Mask continuous positive airway pressure (CPAP) without SI (n=6) resuscitation took longer (~30-45 min) to reach similar lung volume recruitment. The second main finding is that, in the first 15 min of postnatal life, the Mask CPAP without SI group closed their larynx during custom ventilator-driven expiration, leading to intratracheal positive end-expiratory pressure of ~17 cmH2O (instead of 8 cmH2O provided by the ventilator). In contrast, the Mask SI group used the larynx to limit inspiratory pressure to ~26 cmH2O (instead of 30 cmH2O provided by the ventilator). These different responses affected tidal volume, being larger in the Mask CPAP without SI group (8.4 ml/Kg, 6.7-9.3 IQR) compared to the Mask SI (5.0 ml/Kg, 4.4-5.2 IQR), and ETT SI groups (3.3 ml/Kg 2.6-3.7 IQR). Distinct physiological responses suggest that spontaneous respiratory activity of the larynx of preterm lambs at birth can uncouple pressure applied by the ventilator to that applied to the lung, leading to unpredictable lung pressure and tidal volumes delivery independently from the ventilator settings.

A meta-analysis of photosynthetic efficiency and stress mitigation by melatonin in enhancing wheat tolerance

BackgroundOur meta-analysis examines the effects of melatonin on wheat under varying abiotic stress conditions, focusing on photosynthetic parameters, chlorophyll fluorescence, leaf water status, and photosynthetic pigments. We initially collected 177 publications addressing the impact of melatonin on wheat. After meticulous screening, 31 published studies were selected, encompassing 170 observations on photosynthetic parameters, 73 on chlorophyll fluorescence, 65 on leaf water status, 240 on photosynthetic pigments.ResultsThe analysis revealed significant heterogeneity across studies (I² > 99.90%) for the aforementioned parameters and evidence of publication bias, emphasizing the complex interaction between melatonin application and plant physiological responses. Melatonin enhanced the overall response ratio (lnRR) for photosynthetic rates, stomatal conductance, transpiration rates, and fluorescence yields by 20.49, 22.39, 30.96, and 1.09%, respectively, compared to the control (no melatonin). The most notable effects were under controlled environmental conditions. Moreover, melatonin significantly improved leaf water content and reduced water potential, particularly under hydroponic conditions and varied abiotic stresses, highlighting its role in mitigating water stress. The analysis also revealed increases in chlorophyll pigments with soil drenching and foliar spray, and these were considered the effective application methods. Furthermore, melatonin influenced chlorophyll SPAD and intercellular CO2 concentrations, suggesting its capacity to optimize photosynthetic efficiency.ConclusionsThis synthesis of meta-analysis confirms that melatonin significantly enhances wheat’s resilience to abiotic stress by improving photosynthetic parameters, chlorophyll fluorescence, leaf water status, and photosynthetic pigments. Despite observed heterogeneity and publication bias, the consistent beneficial effects of melatonin, particularly under controlled conditions with specific application methods e.g. soil drenching and foliar spray, demonstrate its utility as a plant growth regulator for stress management. These findings encourage focused research and application strategies to maximize the benefits of melatonin in wheat farming, and thus contributing to sustainable agricultural practices.

A Review Exploring the Wound-Healing Activity of Self-Healing Hydrogels: Fabrication, Characterization, Mechanism, and Biomedical Applications

AbstractThe natural physiological response to skin injury is wound healing. However, to restore skin continuity, wound healing is a complicated process that involves the collaboration of a variety of cell types and other mediators. This process ultimately results in tissue regeneration and the restoration of skin barrier function. Hydrogels are appealing dosage forms for biomedical regenerative medicine since they are composed of 3D networks with high water content and flexible rheological features. Hydrogels that can self-heal are particularly interesting for wound treatment because they can autonomously restore their original functionalities and repair structural damage. Recently, the use of self-healing hydrogels as biomedical materials has attracted increased interest. In this review, the self-healing systems used in tissue regeneration, especially wound healing, will be explored. A focus on the fabrication methods, characterization tests, and mechanism of self-healing will be introduced, along with the biomedical applications of self-healing hydrogels loaded with conventional and therapeutic biomaterials. In addition, the differences between hydrogels and self-healing hydrogels will be discussed. Graphical Abstract

Physiological responses of grapevine (Vitis vinifera var. ‘Pinot gris’) affected by different flavescence dorée genotypes: dynamics through the development of phytoplasma infection

Physiological responses of grapevine (Vitis vinifera var. ‘Pinot gris’) affected by different flavescence dorée genotypes: dynamics through the development of phytoplasma infection

Growth and physiological responses of Atlantic Forest tree seedlings to nitrogen and phosphorus addition

Growth and physiological responses of Atlantic Forest tree seedlings to nitrogen and phosphorus addition

Bone and Joint-on-Chip Platforms: Construction Strategies and Applications.

Organ-on-a-chip, also known as "tissue chip," is an advanced platform based on microfluidic systems for constructing miniature organ models in vitro. They can replicate the complex physiological and pathological responses of human organs. In recent years, the development of bone and joint-on-chip platforms aims to simulate the complex physiological and pathological processes occurring in human bones and joints, including cell-cell interactions, the interplay of various biochemical factors, the effects of mechanical stimuli, and the intricate connections between multiple organs. In the future, bone and joint-on-chip platforms will integrate the advantages of multiple disciplines, bringing more possibilities for exploring disease mechanisms, drug screening, and personalized medicine. This review explores the construction and application of Organ-on-a-chip technology in bone and joint disease research, proposes a modular construction concept, and discusses the new opportunities and future challenges in the construction and application of bone and joint-on-chip platforms.

Exploring physiological stress response evoked by passive translational acceleration in healthy adults: a pilot study utilizing electrodermal activity and heart rate variability measurements.

Passive translational acceleration (PTA) has been demonstrated to induce the stress response and regulation of autonomic balance in healthy individuals. Electrodermal activity (EDA) and heart rate variability (HRV) measurements are reliable indicators of the autonomic nervous system (ANS) and can be used to assess stress levels. The objective of this study was to investigate the potential of combining EDA and HRV measurements in assessing the physiological stress response induced by PTA. Fourteen healthy subjects were randomly assigned to two groups of equal size. The experimental group underwent five trials of elevator rides, while the control group received a sham treatment. EDA and HRV indices were obtained via ultra-short-term analysis and compared between the two groups to track changes in the ANS. In addition, the complexity of the EDA time series was compared between the 4s before and the 2-6s after the onset of PTA to assess changes in the subjects' stress levels in the experimental group. The results revealed a significant increase in the skin conductance response (SCR) frequency and a decrease in the root mean square of successive differences (RMSSD) and high frequency (HF) components of HRV. In terms of stress assessment, the results showed an increase in the complexity of the EDA time series 2-6s after the onset of PTA. These results indicate an elevation in sympathetic tone when healthy subjects were exposed to a translational transport scenario. Furthermore, evidence was provided for the ability of EDA complexity to differentiate stress states in individual trials of translational acceleration.

Adjunctive hiking bouts during 8 weeks regular sailing training improves cardiorespiratory and muscular responses during hiking emulation in highly trained sailors

AbstractTo investigate the effects of 8‐week hiking bench training on cardiorespiratory and muscular responses of highly trained sailors during hiking emulation. Twenty‐four sailors were assigned into two groups: the hiking bench training group (HTG, n = 12) and the control group (CG, n = 12). Both groups maintained their regular training with the HTG performed two additional hiking bench training sessions per week for 8 weeks, while the CG performed an equivalent duration of on‐water sailing training. Physiological responses were assessed by performing four successive 3‐min hiking bouts on a sailing emulation ergometer before and after the 8‐week training period. Comparing the pretest, both groups exhibited a significant decrease (p < 0.05) in the percentage of maximal oxygen uptake (%VO2max) and maximal heart rate (%HRmax); the HTG experienced a greater decrease in %VO2max in bouts 2 and 3. The root mean square (RMS) of rectus femoris (RF), vastus lateralis (VL), rectus abdominis (RA), and external oblique decreased significantly (p < 0.05), whereas the mean power frequency (MPF) of RF, VL, and RA exhibited an increasing trend. The RMS of RF and RA in HTG were lower than those in CG in the initial three bouts; VL and EA in HTG were lower than those in CG in bouts 1 and 2 (p < 0.05). The MPF of RA in HTG was significantly increased in bouts 2, 3, and 4 (p < 0.05). Eight‐week hiking bench training could improve hiking economy and the activation of lower limb and trunk muscles delaying the onset of fatigue in sailors.

Analysis of Sound Propagation Behaviors for Supersonic Jet on Far Field Region by Computational Aero-Acoustics (CAA) Simulation

Noise emission is an essential issue for the aviation industry, as it harms health and induces various physiological responses. The noise generated by supersonic jets is very intense. It will cause fatigue and even damage the human hearing system in the surrounding area of jet operation. Besides, the experimental and prototyping cost for the jet model is prohibitive, and it is a vast project and process that takes a lot of time to run. The purpose of this study is to determine the sound propagation behaviours of a supersonic jet in the far-field region and to analyse the consequences of the velocity of a supersonic jet on sound propagation of supersonic jet by using computational fluid dynamics (CFD) and computational aeroacoustics (CAA) simulations. This study focused on the perspective of observing the distance of the receiver when receiving the sound propagation of a supersonic jet, the observed angle of the receiver when receiving the sound propagation of a supersonic jet, and the velocity of the supersonic jet. The CFD and CAA analyses were performed in transient state simulation and the 2-inch Acoustics Reference Nozzle (ARN2). The result shows that the overall SPL throughout the frequency is proportional to the jet velocity of the supersonic jet. However, the distance and angle of the receiver gave different results in sound propagation behaviour. The results also conclude that as the distance between the receiver and jet nozzle exit increases, the overall SPL trend will decrease throughout the frequency increase. As the vertical distance between the receiver and the axisymmetric line of the jet nozzle increases, the frequency of the receiver starts to observe will decrease.

Hepatic Expression of Genes Related to Fatty Acid Biosynthesis during Tropical Summer in Broilers: Effect of Organic Selenium Supplementation

Background: The physiological responses during adaptation to summer in poultry could be related to modulation of energy metabolism. Enhanced deposition of fat in spite of reduced feed intake seems to have an advantage under hot conditions. Thus, the present study was conducted to investigate the seasonal status of de novo synthesis of fatty acids in broiler chicken (Gallus gallus) and its response to organic selenium supplementation. Methods: The study was conducted in two phases, one during autumn and the other during summer, with a total of 300 birds as autumn control, summer control, group-I (0.3 ppm SeMet), group-II (0.6 ppm SeMet) and group-III (0.9 ppm SeMet) groups. Blood samples and hepatic tissues were collected at 21 and 42 d for further analysis. Result: An elevation in serum lipid profile, glucose, cortisol and T4 levels was observed during the summer while the T3 concentration decreased compared to the autumn. The hepatic expression of Acetyl Co. A carboxylase α (ACCα) and Fatty acid synthase (FASN) was increased at 21 d, while it was decreased at 42 d during summer in broilers. Serum total cholesterol levels and LDL levels decreased with SeMet at 0.6 and 0.9 ppm levels. The expression of hepatic ACCá and FASN genes was decreased with selenium supplementation at higher levels. Increased serum total cholesterol levels were associated with lower de novo fatty acid synthesis at 42d during summer in broilers.

Low frequency oscillations reflect neurovascular coupling and disappear after cerebral death

Spectrum power analysis in the low frequency oscillations (LFO) region of functional near infrared spectroscopy (fNIRS) is a promising method to deliver information about brain activation and therefore might be used for prognostication in patients with disorders of consciousness in the neurocritical care unit alongside with established methods. In this study, we measure the cortical hemodynamic response measured by fNIRS in the LFO region following auditory and somatosensory stimulation in healthy subjects. The significant hemodynamic reaction in the contralateral hemisphere correlation with the physiologic electric response suggests neurovascular coupling. In addition, we investigate power spectrum changes in steady state measurements of cerebral death patients and healthy subjects in the LFO region, the frequency of the heartbeat and respiration. The spectral power within the LFO region was lower in the patients with cerebral death compared to the healthy subjects, whereas there were no differences in spectral power for physiological activities such as heartbeat and respiration rate. This finding indicates the cerebral origin of our low frequency measurements. Therefore, LFO measurements are a potential method to detect brain activation in patients with disorders of consciousness and cerebral death. However, further studies in patients are needed to investigate its potential clinical use.

The Utility of High-Intensity, Intermittent Exercise Protocols to Induce Fatigue for Screening Purposes in Jump-Landing Sports

Short-term fatigue protocols simulating sports participation are scarce and not well-documented in jump-landing sports. Therefore, this study investigated physiological and physical responses following high-intensity, intermittent exercise protocols (HIIPs) with a standardized level of subjective exhaustion (Borg ≥18/20) and a modified fixed version of five circuits (HIIP-5) for future inclusion in biomechanical screening protocols. Twenty male volleyball and basketball players participated in this study to complete the HIIP and the HIIP-5. Physiological and physical variables were assessed before and up to 30 min after cessation of both protocols. Regarding physiological variables, heart rate values increased (+104 bpm, p < 0.001) and remained elevated up to 30 min (+34 bpm, p < 0.001), and blood lactate levels increased (+17 mmol/l, p < 0.001) compared to baseline. Regarding physical variables, decreased jump height (−4 cm, p = 0.001–0.009) and quadriceps muscle strength (p = 0.001−0.050) were observed up to 30 min compared to baseline. The type of the fatigue protocol did not have an effect on the investigated variables (p > 0.05). To conclude, both the HIIP and the HIIP-5 seem valuable tools to induce acute and long-lasting responses, providing a sufficiently large time window of 30 min within which biomechanical markers of injury can be assessed under fatigued conditions in future risk factor screenings. In practice, the fatigue protocol can be terminated after only five circuits if athletes had not yet been stopped at that point due to exhaustion (Borg ≥18/20).

The Relationship of Hot Work Climate on Physiological Response in Traditional Clover Leaf Oil Refining Workers

In the clove leaf oil refining process which uses steam, it produces a hot temperature residue which affects clove leaf oil refinery workers. Exposure to a hot working climate can have an impact on human physiological responses such as an increase in body temperature, pulse rate, blood pressure and weight loss. as a result of producing quite a lot of sweat fluid. This research aims to investigate the physiological responses of clove leaf oil refinery workers to exposure to a hot working climate. In the clove leaf oil refining process, which utilizes steam, the production of hot temperature residue affects the workers. Exposure to such conditions can lead to various physiological responses, including increased body temperature, pulse rate, blood pressure, and weight loss due to significant sweating. Employing a quantitative research design with a cross-sectional analytical approach, data were collected from all 22 workers using a total sampling technique. The primary data collected were subjected to analysis using paired simple t-tests and the Pearson correlation test to explore relationships between variables. The findings reveal significant increases in physiological responses post-work, including elevated body temperature, pulse rate, systolic and diastolic blood pressure, and a reduction in body weight. The obtained p-values for all variables were <0.05, indicating statistically significant differences between pre-work and post-work conditions. Furthermore, the Pearson correlation test analysis between heat stress data and post-work physiological responses, including body temperature, pulse rate, systolic and diastolic blood pressure, as well as body weight, revealed moderate to strong correlations (r). These results underscore the detrimental impact of hot working climates on the physiological well-being of clove leaf oil refinery workers. Such findings highlight the urgent need for implementing appropriate measures to mitigate heat-related health risks in occupational settings, safeguarding the health and safety of workers.

Bacterial Endophytes and Their Contributions to Alleviating Drought and Salinity Stresses in Wheat: A Systematic Review of Physiological Mechanisms

Drought and salinity stresses significantly threaten global wheat productivity, limiting growth and reducing yields, thus endangering food security worldwide. These stresses disrupt physiological processes, impair photosynthesis, and hinder optimal growth and yield by diminishing water uptake, causing osmotic stress, ion toxicity, and oxidative stress. In response, various mitigation strategies have been explored, including breeding for stress-tolerant cultivars, improved irrigation techniques, and the application of exogenous osmoprotectants and soil amendments. Among these strategies, the emergence of rhizospheric and endophytic growth-promoting microorganisms has attracted significant attention. Therefore, a systematic review was undertaken to illustrate the role of endophytic bacteria in enhancing wheat tolerance to drought and salinity stresses. This review analyzes physiological mechanisms and research trends, identifies gaps, and discusses implications for sustainable agriculture. An analysis of the literature related to endophytic bacteria in wheat was conducted using databases of major publishers from 2004 to 2023. The review explores their mechanisms, such as phytohormone production and stress-responsive gene induction, emphasizing their contribution to plant growth and stress resilience. The current research trends indicate a growing interest in utilizing endophytic bacteria to mitigate these stresses in wheat cultivation, with studies focusing on understanding their physiological responses and interactions with wheat plants. Future research should concentrate on elucidating the role of endophytic bacteria in enhancing host plant tolerance to multiple stressors, as well as aspects like endophytic mechanism of action , endophytic lifestyle, and transmission pathways. Overall, endophytic bacteria offer promising avenues for sustainable agricultural practices, aiding in crop resilience and food security amid environmental challenges.

Molecular priming with H2O2 and proline triggers antioxidant enzyme signals in maize seedlings during drought stress

BackgroundDrought and water stress impose major limitations to crops including Maize as they affect the plant biology at multiple levels. Drought activates the cellular signalling machinery to maintain the osmotic and ROS homeostasis for controlling plant response and adaptation to stress. Molecular priming of seeds plays a significant role in imparting stress tolerance by helping plants to remember the stress, which improves their response when they encounter stress again. MethodsIn this study, we examined the effect of priming maize seeds with H2O2 and proline, individually or in combination, on response to drought stress. We investigated the role of molecular priming on the physiological, biochemical and molecular response of maize seedlings during drought stress. ResultsWe observed that seed-priming played a significant role in mediating stress tolerance of seedlings under drought stress as indicated by changes in growth, biochemical properties, pigment and osmolyte accumulation, antioxidant enzyme activities, gas exchange parameters and gene expression. Seed-priming resulted in reduced expression of specific miRNAs to increase target transcripts associated with synthesis of osmolytes and maintenance of ROS homeostasis for reducing potential damage to the cellular components. ConclusionsSeed-priming induced changes in the growth, biochemical properties, pigment and osmolyte accumulation, antioxidant enzyme activities, gas exchange parameters and gene expression, though the response was dependent on the genotype, as well as concentration and combination of the priming agents.

Expression of octopamine/tyramine receptors and immune regulation in Litopenaeus vannamei under acute and chronic thermal stress.

This study investigated the impact of hyperthermal (34 °C) and hypothermal (14 °C) stress on the expression of the octopamine/tyramine receptor (LvOA/TA-R) and immune parameters in Litopenaeus vannamei, which is a species critical to the aquaculture industry. Given the sensitivity of aquatic organisms to climate change, understanding the physiological and immune responses of L. vannamei to temperature variations is essential for developing strategies to mitigate adverse effects. This research focuses on the immune response and expression changes of LvOA/TA-R under acute (0.5, 1, and 2 hours) and chronic (24, 72, and 168 hours) thermal stress conditions. Our findings reveal that thermal stress induces changes in LvOA/TA-R expression and impacts immune responses. Immune parameters such as total haemocyte count, differential haemocyte count, phenoloxidase activity, respiratory bursts, lysozyme activity, clearance efficiency, and phagocytosis exhibited a general trend of significant decline under the stress conditions. LvOA/TA-R had a higher expression in haemocyte under hyperthermal stress. The study elucidated that thermal stress modifies the expression of the LvOA/TA-R and diminishes immune functionality in L. vannamei, underscoring the potential influence of climate change on industry.

Physiological response of Metarhizium rileyi with linoleic acid supplementation

Metarhizium rileyi has a broad biocontrol spectrum but is highly sensitive to abiotic factors. A Colombian isolate M. rileyi Nm017 has shown notorious potential against Helicoverpa zea. However, it has a loss of up to 22% of its conidial germination after drying, which limits its potential as a biocontrol agent and further commercialization. Conidial desiccation resistance can be enhanced by nutritional supplements, which promotes field adaptability and facilitates technological development as a biopesticide. In this study, the effect of culture medium supplemented with linoleic acid on desiccation tolerance in Nm017 conidia was evaluated. Results showed that using a 2% linoleic acid-supplemented medium increased the relative germination after drying by 41% compared to the control treatment, without affecting insecticidal activity on H. zea. Also, the fungus increased the synthesis of trehalose, glucose, and erythritol during drying, independently of linoleic acid use. Ultrastructural analyses of the cell wall-membrane showed a loss of thickness by 22% and 25%, in samples obtained from 2% linoleic acid supplementation and the control, respectively. Regarding its morphological characteristics, conidia inner area from both treatments did not change after drying. However, conidia from the control had a 24% decrease in length/width ratio, whereas there was no alteration in conidia from acid linoleic. The average value of dry conidia elasticity coefficient from linoleic acid treatment was 200% above the control. Medium supplementation with linoleic acid is a promising fermentation strategy for obtaining more tolerant conidia without affecting production and biocontrol parameters, compatible solutes synthesis, or modifying its cell configuration.

Melatonin administration during the first half of pregnancy improves physiological response and reproductive performance of rabbits under heat stress conditions.

Context Melatonin may have a heat-stress-alleviating role during pregnancy. Aims To investigate the effects of melatonin administration during the first half of pregnancy on heat-tolerance capacity and pregnancy outputs of naturally heat-stressed rabbits. Methods Forty female rabbits were stratified equally into two experimental groups and daily received 1mg melatonin/kg body weight or not (control) for 15 consecutive days post-insemination. Heat tolerance indices, hormone profile, ovarian structures, and fetal loss were determined. Key results Treatment with melatonin significantly decreased respiration rate and rectal temperature, improved concentrations of nitric oxide, and tended to decrease malondialdehyde concentrations (P =0.064) compared to control. Melatonin treatment significantly increased concentrations of high-density lipoprotein, oestradiol, and progesterone compared to control. No significant differences in the numbers of visible ovarian follicles, corpora lutea, and total implantation sites on day 18 of pregnancy were observed between experimental groups. However, melatonin treatment significantly reduced the number of absorbed implantation sites and significantly improved amniotic fluid volume and conception rate compared to control. Conclusions Melatonin administration during the first half of pregnancy can improve reproductive performance of heat-stressed female rabbits. Implications Melatonin can improve fetal survivability via improving heat-tolerance capacity of does and steroidogenesis.

Thymol Deploys Multiple Antioxidative Systems to Suppress ROS Accumulation in Chinese Cabbage Seedlings under Saline Stress

Developing biostimulants is a promising approach for sustainable agriculture under a saline environment. Thymol is a plant-derived compound with a potential antioxidative capacity. However, little is known about whether and how the antioxidative property of thymol plays a role in inducing plant tolerance against abiotic stresses. Here, we find that thymol induces saline tolerance in Chinese cabbage seedlings via enhancing the antioxidative capacity. Treatment with NaCl (100 mM) decreased the seedling fresh weight by 59.9% as compared to a control. Thymol at 20 μM showed the greatest effect on promoting seedling growth under saline stress, with the seedling fresh weight being increased by 71.0% as compared to NaCl treatment. Thymol remarkably decreased the overaccumulation of ROS (hydrogen peroxide and a superoxide radical); cell membrane damage (evaluated by lipid oxidation, membrane integrity, and relative conductivity); and cell death in seedlings under saline stress. Thymol induced three antioxidative systems to lower the ROS level in salt-treated seedlings. First, thymol remarkably activated a set of antioxidative enzymes, such as SOD (superoxide dismutase), APX (ascorbate peroxidase), CAT (catalase), and POD (peroxidase). Second, thymol balanced the cellular redox status by increasing the ratio of AsA/DHA (ascorbic acid/dehydroascorbic acid) and GSH/GSSG (glutathione/oxidized glutathione). Third, thymol significantly enhanced the level-two kinds of antioxidants (total phenol and flavonoid). All of these physiological responses were observed in both the shoots and the roots. In sum, thymol deploys multiple antioxidative systems to help Chinese cabbage seedlings against saline stress. Such findings suggest that thymol has great potential to be developed as a novel biostimulant enhancing crop tolerance against saline stress.

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status.

Genetic factors are important in terms of athletic performance. Recent studies to determine the relationship between the genes that lead to physiological responses have attracted attention. In this respect, this meta-analysis study was designed to examine the relationship between genetic polymorphism (BDKRB2 rs5810761, GNB3 rs5443, HIF1A rs11549565, MCT1 rs1049434, NOS3 rs2070744) and endurance athlete's status. The search included studies published from 2009 to 2022. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned. Only case-control studies were included in the meta-analysis. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned, and a total of 31 studies met the criteria for inclusion in the meta-analysis. Relevant data from the included studies were collected and analyzed using a random effects or fixed effects model. The effect size was calculated as the odds ratio or a risk ratio the corresponding 95% confidence intervals. According to the results of the analysis, BDKRB2 rs5810761 + 9 allele, and NOS3 rs2070744 T allele were significantly more prevalent in endurance athletes (p < 0.05). Genotype distributions of BDKRB2 rs5810761, MCT1 rs1049434, and NOS3 rs2070744 showed significant differences in the dominant model (p < 0.05). However, no significant association was found between endurance athlete status and GNB3 rs5443 and HIF1A rs11549465 polymorphisms. These results show that some gene polymorphisms play an important role in endurance athlete status and suggest that having a specific genetic basis may also confer a physiological advantage for performance.