Physiological Parameters Of Patients Research Articles

The Effect of Traditional Iranian Music on Anxiety and Physiological Parameters of Patients before Coronary Artery Bypass Graft (CABG): A Randomized Controlled Trial

Background: Coronary artery bypass graft (CABG) surgery is a primary treatment for coronary artery occlusion. Anxiety is a common preoperative concern among patients undergoing this procedure. This study aimed to investigate the effect of listening to traditional Iranian music on anxiety in patients before CABG surgery. Methods: This randomized controlled trial involved 66 patients scheduled for CABG surgery. Patients were randomly assigned to either the control or intervention group, with 33 patients in each group. The intervention group listened to traditional music on an MP3 player for 20 minutes, while the control group received an MP3 player without music. Anxiety levels were measured using the Spielberger Anxiety Questionnaire before and after the intervention. Data were analyzed using the Student’s t-test, the paired t-test, and the Mann-Whitney U-test with SPSS software version 21. Results: There was no significant difference in anxiety severity between the 2 groups before the intervention (music group: 106.45±10.67 and control group: 116.36±9.78; P=0.798). However, after the intervention, there was a significant difference between the groups (music group: 65.82±7.54 vs control group: 113.72±13.04; P=0.001). There were no significant differences in physiological parameters (blood pressure, heart rate, and respiration rate) between the groups before the intervention (P<0.078). Following the intervention, systolic (P<0.013) and diastolic (P<0.003) blood pressure significantly decreased in the intervention group compared with the control group. Conclusion: Traditional Iranian music therapy can be a noninvasive, low-cost, and accessible tool to reduce anxiety in patients undergoing CABG surgery.

Systemic Effects and Absorption of Subepithelial Dexamethasone Vocal Fold Injections.

To compare the systemic changes following two office-based procedures-subepithelial vocal fold steroid injections (VFSI) and vocal fold augmentation (VFA), and to characterize the magnitude and chronicity of the effects observed. Prospective, controlled before-after comparative study. Patients prospectively underwent VFSI with 0.8-2 mg of dexamethasone or VFA. Serum cortisol, white cell count (WCC), and C-reactive protein (CRP) were measured at day 0 (pre-procedure), 1 and 7. Salivary cortisol was measured at baseline and daily for 7 days post-procedure. Fourteen patients underwent VFSI and 36 VFA. At baseline serum cortisol measured 304.6 ± 116.6 nmol/L and fell significantly to 48.1 ± 41.8 nmol/L 1 day following dexamethasone injection (p = 0.001) and recovered by day 7 to 303.7 ± 78.7 nmol/L. Salivary cortisol demonstrated a similar pattern with significant recovery demonstrated by day 3 (p = 0.001). White cell counts were affected by the systemic absorption of exogenous steroid and normalized by day 7. Patients who underwent VFA demonstrated no significant change in their serum or salivary cortisol and no significant change in their WCC. No significant changes in CRP or patient's physiological parameters were observed in either procedure. Our findings demonstrate systemic absorption of dexamethasone following VFSI, with acute hypothalamic-pituitary-adrenal (HPA) axis suppression which normalizes day 3 post-procedurally. 3 Laryngoscope, 2024.

A study of some physiological parameters in patients previously infected with COVID-19

Coronavirus disease 2019 (COVID-19), a potentially fatal illness brought on by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), had emerged posing a threat to public health throughout the world. The aim of study is evaluation the effect of Covid-19 disease on some physiological and hematological indicators of Covid-19 patients and to use as a parameter for monitoring the disease severity. This study as retrospective study was performed at the Al-Imam Hussein Teaching Hospital (January 2021 - April 2021) including 30 Covid-19 patients who were in between the ages of 18 and 84 (15 male and 15 female patients) and another 30 individuals patients who were in between the ages of 18 and 82 (15 male and 15 female individuals) as control group. The patients were previously diagnosed with Covid-19 disease using PCR. Our findings demonstrated that values of physiological and blood markers in COVID-19 varied significantly, where the random blood sugar was the highest parameter with a significant significance based on the chi-square test (P-value = 0.03) and the age group, most affected by the high concentrations of clinical parameters was 63-77 years old, while the least affected age group was 18-32 year. Our findings showed an increase in the concentrations of clinical parameters in males compared to females, where the random blood sugar was of a significant difference based on the chi-square test (P-value = 0.036). This study found that various physiological and blood indicators significantly increased in Covid-19 patients, where they suffer from an increase in blood urea nitrogen, serum creatinine, ferritin random blood sugar as a result of the virulence of the virus and its attack on pulmonary and renal cells, So, monitoring the increase in these parameters may contribute to know the severity of disease.

Penetrating Barriers: Noncontact Measurement of Vital Bio Signs Using Radio Frequency Technology.

The noninvasive measurement and sensing of vital bio signs, such as respiration and cardiopulmonary parameters, has become an essential part of the evaluation of a patient's physiological condition. The demand for new technologies that facilitate remote and noninvasive techniques for such measurements continues to grow. While previous research has made strides in the continuous monitoring of vital bio signs using lasers, this paper introduces a novel technique for remote noncontact measurements based on radio frequencies. Unlike laser-based methods, this innovative approach offers the advantage of penetrating through walls and tissues, enabling the measurement of respiration and heart rate. Our method, diverging from traditional radar systems, introduces a unique sensing concept that enables the detection of micro-movements in all directions, including those parallel to the antenna surface. The main goal of this work is to present a novel, simple, and cost-effective measurement tool capable of indicating changes in a subject's condition. By leveraging the unique properties of radio frequencies, this technique allows for the noninvasive monitoring of vital bio signs without the need for physical contact or invasive procedures. Moreover, the ability to penetrate barriers such as walls and tissues opens new possibilities for remote monitoring in various settings, including home healthcare, hospital environments, and even search and rescue operations. In order to validate the effectiveness of this technique, a series of experiments were conducted using a prototype device. The results demonstrated the feasibility of accurately measuring respiration patterns and heart rate remotely, showcasing the potential for real-time monitoring of a patient's physiological parameters. Furthermore, the simplicity and low-cost nature of the proposed measurement tool make it accessible to a wide range of users, including healthcare professionals, caregivers, and individuals seeking to monitor their own health.

The Respiratory Rate, Age, and Mean Arterial Pressure (RAM) Index: A Novel Prognostic Tool to Predict Mortality among Adult Patients with Acute Heart Failure in the Emergency Department.

Background and Objectives: Acute heart failure (AHF) is a life-threatening condition frequently encountered in the emergency department (ED). Identifying reliable prognostic indicators for in-hospital mortality is crucial for risk stratification and the appropriate management of AHF patients. This study aimed to assess the most effective method for predicting in-hospital mortality among various physiological parameters in patients with AHF presenting to the ED. Additionally, the study evaluated the effectiveness of the RAM index-respiratory rate (RR), age, and mean arterial pressure (MAP)-derived from the shock index (SI) by replacing heart rate with RR, as a novel prognostic tool. This was compared with the SI and its other derivatives to predict in-hospital mortality in adult patients with AHF presenting to the ED. Materials and Methods: This is a retrospective study conducted in the ED of an urban medical center, enrolling adult patients with signs and symptoms of AHF, who met the epidemiological diagnosis criteria, between January 2017 and December 2021. Baseline physiological parameters, including the RR, heart rate, systolic blood pressure, and diastolic blood pressure, were recorded upon ED admission. The RAM index was calculated as the RR multiplied by the age divided by the MAP. Statistical analysis was performed, including univariate analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: A total of 2333 patients were included in the study. A RAM index > 18.6 (area under ROC curve (AUROC): 0.81; 95% confidence interval (CI): 0.79-0.83) had a superior mortality discrimination ability compared to an SI > 0.77 (AUROC: 0.75; 95% CI: 0.72-0.77), modified shock index > 1.11 (AUROC: 0.75; 95% CI: 0.73-0.77), age shock index > 62.7 (AUROC: 0.74; 95% CI: 0.72-0.76), and age-modified shock index > 79.9 (AUROC: 0.75; 95% CI: 0.73-0.77). A RAM index > 18.6 demonstrated a 7.36-fold higher risk of in-hospital mortality with a sensitivity of 0.80, specificity of 0.68, and negative predictive value of 0.97. Conclusions: The RAM index is an effective tool to predict mortality in AHF patients presenting to the ED. Its superior performance compared to traditional SI-based parameters suggests that the RAM index can aid in risk stratification and the early identification of high-risk patients, facilitating timely and aggressive treatment strategies.

Immune system perturbations in patients with long COVID

Klein et al. report multimodal analyses of immune cells, proteins, and physiological parameters in patients with long COVID (LC). At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to a general suppression of viral control mechanisms in LC.

Effects of Music Therapy on Negative Emotions and Physiological Parameters in Patients Undergoing Colonoscopic Polypectomy: A Retrospective Study.

This study aimed to determine the postoperative effects of music therapy on negative emotions, pain, and inflammatory and physiological parameters in patients undergoing colonoscopic polypectomy. Patients who underwent colonoscopic polypectomy in Funan County People's Hospital between March 2020 and June 2023 were selected as the research subjects. Patients were divided into exposure (underwent music therapy) and control (did not undergo music therapy) groups. Baseline characteristics, Self-rating Anxiety Scale (SAS) and Visual Analog Scale (VAS) scores, physiological parameters [systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)], and inflammatory marker levels [neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and erythrocyte sedimentation rate (ESR)] of patients before and after exposure to music were determined. The propensity score matching (PSM) method (1:1) was used to balance the baseline characteristics of the two groups. After PSM, the exposure group comprised 50 cases and the control group comprised 50 cases. The baseline characteristics were not significantly different between the two groups (P > 0.05). The postoperative SAS score of the exposure group was significantly lower than that of the control group (P < 0.05). Meanwhile, the postoperative VAS score of the exposure group was nonsignificantly lower than that of the control group (P > 0.05). Furthermore, the postoperative SBP, DBP, and HR levels of the exposure group were significantly lower than that of the control group (P < 0.05). The postoperative levels of NLR, PLR, and ESR were not significantly different between the exposure and control groups (P > 0.05). Music therapy exerts beneficial effects on the postoperative psychological and physiological parameters of patients undergoing colonoscopic polypectomy.

Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.

The aim of the study was to evaluate the variant (rs2910829) of the PDE4D gene in relation to its influence on biochemical, anthropometric and physiological parameters in patients with coronary artery disease and healthy subjects of the Eastern Slovak population. The male group consisted of 72 individuals and the female group consisted of 132 individuals. On the basis of clinical screening the subjects were divided into two groups - with ischaemic heart disease and control group. Genomic DNA was isolated from peripheral blood using a commercial NucleoSpin® Blood Machenery-Nagel kit. Molecular genetic analysis of the polymorphism under study was performed using the StepOne™ Real-Time PCR System instrument. The lipid profile markers TC, HDL, LDL, TG were measured by Cobas Integra 400 plus biochemical analyser, and systolic and diastolic blood pressure using a digital blood pressure monitor. Among anthropometric parameters, body height and weight, waist and hip circumference were measured and BMI and WHR indices were calculated. A statistically significant (p = 0.018) possible association between the mutant T allele and ischaemic heart disease was found in men. In women, we found a statistically significant difference in the systolic (p = 0.013) and diastolic blood parameters (p = 0.005) in the CC genotype. In the group of women, we found statistically significant differences in all observed anthropometric parameters and in LDL and TC markers. In the group of men divided on the basis of BMI, statistical significance was found in systolic blood pressure (p = 0.028). In the group of women with ischaemic heart disease, we found a negative correlation between BMI and HDL. The study contributes to new findings of the representation of genotypes and alleles of the rs2910829 PDE4D gene polymorphism in the Slovak population. This is a pilot study. Interactions between genotype and observed anthropometric, physiological and biochemical markers were confirmed.

Impact of myocardial bridge defined by computed tomographic coronary angiography on fractional flow reserve after elective percutaneous coronary intervention

Abstract Background Myocardial bridge (MB) is a common anomaly of epicardial coronary artery that courses through myocardium. MB can be identified by computed tomographic coronary angiography (CTCA) or invasive coronary angiography (ICA). However, its relevance to coronary physiological parameters remains unknown. Purpose This observational study aimed to explore how MBs affect physiological parameters in patients with chronic coronary syndrome before and after revascularization. Methods We investigated 172 consecutive patients who underwent preprocedural CTCA and elective fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in left anterior descending artery (LAD). We compared patient characteristics, angiographic, and pre- and post-PCI physiological parameters in patients with versus without MB. Results We identified MB in 70 (40.7%) and 23 (13.3%) patients by CTCA and ICA, respectively. CTCA detected the presence of MB with a sensitivity of 100% and a specificity of 33% when ICA-defined MB was regarded as a reference standard. Longer MB (adjusted odds ratio 1.18 [95% confidence interval 1.05-1.33], P &amp;lt; 0.01) and smaller left ventricular myocardial mass volume in whole LAD territory (adjusted odds ratio 0.93 [95% confidence interval 0.89-0.98], P&amp;lt;0.01) were associated with ICA detectability of MB. Older age and higher frequency of diabetes mellitus were observed in patients with MB compared with those without MB. Pre-PCI FFR values were not associated with a presence of MB regardless of either CTCA- or ICA-defined MB. On the other hand, post-PCI FFR values were significantly lower in patients with versus without MB by CTCA (0.82 [0.80-0.86] vs. 0.86 [0.82-0.89], P&amp;lt;0.01), while no significant difference was observed in post-PCI FFR between patients with and without ICA-defined MB (0.82 [0.81-0.84 vs. 0.84 [0.80-0.88], P=0.08). Multivariable linear regression analysis revealed that a presence of CTCA-defined long MB (≥25mm) (adjusted β coefficient = -0.040, P&amp;lt;0.01) and greater myocardial mass volume in whole LAD territory (adjusted β coefficient = -0.0004, P&amp;lt;0.01) were independently associated with lower post-PCI FFR. Conclusion A presence of MB was an independent predictor of lower post-PCI FFR after successful and elective PCI for LAD.

Association of severity and prognosis with elevated blood pressure and heart rate levels in patients with intracerebral hemorrhage

BackgroundIntracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. Elevated blood pressure (BP) and heart rate (HR) have been identified as independent risk factors, with potential to predict prognosis and recurrence of cardiovascular diseases. Our study aimed to elucidate the association between BP and HR levels and the severity, as well as prognosis, of patients diagnosed with ICH.MethodsThe basic characteristics of patients and laboratory examination results, inclusive of BP and HR levels upon admission, were recorded as baseline data. The modified Rankin Scale and living status were taken into account for all patients at a 1-year follow-up. The relationship between various BP and HR levels and clinical outcome was analyzed using logistic regression and the Kaplan-Meier survival method.ResultsA total of 1,416 patients with acute ICH from 13 hospitals in Beijing were enrolled in our study. Logistic regression analysis indicated that patients with higher HR and BP (group 4), along with those with higher HR but lower BP (group 2), exhibited a poorer prognosis compared to those with lower BP and HR (group 1). This result was particularly pronounced in younger, male subgroups (OR (95% CI) = 4.379(2.946–6.508), P < 0.0001 for group 4; OR (95% CI) = 1.819 (1.219–2.714), P = 0.0034 for group 2). At the 1-year follow-up, group 4 patients demonstrated a significantly higher rate of fatal incidence compared to other groups (P < 0.01).ConclusionsHigher HR and BP levels, suggestive of an autonomic dysfunction, were independently associated with a poorer 1-year prognosis and reduced survival rate in ICH patients. Our findings underscore the need for early intervention to modulate these physiological parameters in patients with ICH.

Relationship between Triage Patients Related Factors and 48 Hours Outcomes at the Accident and Emergency Department, Kenyatta National Hospital

Context: The goal of triage is to prioritize patients who require the most urgent care and increase efficiency when resources are insufficient to treat all patients as per their degree or grade of injury. An effective and efficient emergency center triage system should be able to sort both trauma and non-trauma patients according to the level of acuity and involves treatment as per the physiological parameters, either coded as red, orange, yellow, green, or black. Kenyatta National Hospital has adopted the South African Triage Score (SATS), which has proven effective in monitoring the patient's physiological parameters. It involves using a score form called triage early warning scores (TEWS). Emergency triage is an effective way to speed up the triage process, decrease waiting times, and boost patient outcomes in first-world nations. Low-income or limited-resource situations present unique obstacles that substantially affect the selection and application of the most suitable triage scale and the success of its implementation.&#x0D; Aim: The objective of the study was to determine the relationship between triage patients related factors and 48 hours outcomes at the Accident and Emergency Department, Kenyatta National Hospital&#x0D; Methods: The study was a cross-sectional study involving the triaged and coded patients flagged by scores using the Triage Early Warning Score (TEWS). A sample of 385 patients was from the accident and emergency department at Kenyatta National Hospital,&#x0D; whereby a structured interview questionnaire and patient outcomes observation checklist were used.&#x0D; Results: The study indicated that patient-related factors significantly influenced the management outcome of triaged patients' (t-statistic=0.210, p-value = 0.039 &lt; 0.05).&#x0D; Conclusion: It is, therefore, important to note that patient-related factors impact the outcome of triaged and coded patients in the accident and emergency department at Kenyatta national hospital. The hospital management reviews the triage process and policy to ensure that the patients can be followed up easily, using an online queue system guide, monitoring of the patient system, and subsequent follow-up that reduces waiting time.

Automatic Controlled Pressure Sensor to Prevent Pressure Ulcer Obtained For Prolonged Hospitalization

The prototype model presented in this paper proposes a solution for evaluating and preventing pressure ulcers in long-lasting bedridden patients. The system integrates various sensors capable of monitoring critical factors such as pressure, temperature, and moisture. These sensors are embedded within the prototype bed, allowing for the collection of real-time data concerning the patient's condition and identification of potential risk factors associated with pressure ulcer development. The bed is equipped with switches that facilitate the monitoring of the patient's mobility and activities. These switches can detect movements, providing valuable information on changes in posture, frequency of turning, and overall activity level. Through data analysis, the system can assess the probability of pressure ulcer occurrence, taking into account factors such as prolonged pressure on specific areas, excessive moisture levels, or extreme temperatures. This prototype model shows significant promise in preventing pressure ulcers among long-lasting bedridden patients. Continuous monitoring of the patient's physiological parameters and activity levels enables healthcare providers to receive timely alerts and intervene appropriately to mitigate the risk of pressure ulcers. Additionally, the system can generate informative reports and offer valuable insights into the patient's condition, assisting healthcare professionals in making informed decisions regarding patient care and preventive measures. Overall, this prototype model provides a comprehensive approach to evaluating and preventing pressure ulcers in long-lasting bedridden patients. By leveraging sensor technology and real-time data analysis, it has the potential to improve patient outcomes, enhance the quality of care, and reduce the incidence of pressure ulcers in this vulnerable population.

Effect of Nature-Based Sound Therapy on Stress and Physiological Parameters in Patients with Myocardial Infarction.

Non-pharmacological interventions in clinical practice, such as Nature-Based Sounds (N-BS), can be an efficient way to reduce stress in patients with Myocardial Infarction (MI). This study was an attempt to investigate the effect of N-BS on stress and physiological parameters in patients with MI. This double-blind, randomized clinical trial was conducted on 80 patients with MI from two selected hospitals. Using headphones, the subjects in the intervention group listened to 30 minutes of N-BS twice a day for 3 days. The control group, on the other hand, wore headphones playing no sound. The data were collected using the Persian version of the Depression, Anxiety, and Stress Scale. The significance level was set at 0.05. The repeated measure analysis showed that the within group effect is statistically significant for Systolic Blood Pressure (SBP) (F = 113.32, p < 0.001), Diastolic Blood Pressure (DBP) (F = 67.22, p < 0.001), Heart Rate (HR) (F = 28.52, p < 0.001), respiration rate (F = 36.41, p < 0.001), and stress (F = 102.82, p < 0.001). The reciprocal effect was statistically significant for SBP (F = 11.76, p < 0.001) and stress (F = 5.31, p < 0.001). N-BS can provide an effective, inexpensive, and non-invasive method of reducing stress in patients with MI. Nurses can incorporate N-BS intervention into the daily care of patients with MI in order to reduce their stress and lower their SBP and HR.

Evaluation of treatment results in patients after surgical hemostasis using CT-angiography

Objective: to evaluate the results of treatment of patients after undergoing surgical hemostasis in obstetric hypotonic bleeding. Materials and methods: the 31 patients were examined, whose delivery was complicated by hypotonic uterine bleeding, and as a result, surgical hemostasis was performed in the amount of ligation of the ovarian and internal iliac artery. Anthropometric data were analyzed, as well as the dynamics of the results of laboratory and instrumental research methods before and after surgery. In the late postoperative period, the results of helical computed tomography (CT) under angiography conditions were evaluated in the period from 6 months to 5 years. Statistical processing was carried out using the IBM SPSS Statistics 25 program. Results: the age, anamnestic data, anatomical and physiological parameters of patients, terms of delivery and their outcome did not become predictors of developed hypotonic bleeding. Early postpartum bleeding was determined in 93,5% of cases. Extirpation of the uterus was performed in 9,7% of cases. The median blood loss was 1200,0 ml, blood loss of 45-50% of the BCC was determined in 19,4%, 35–45% of the BCC was also in 19,4%. The reduced level of erythrocytes persisted until the moment of discharge, and the reduced hemoglobin after the operation tended to increase. In the course of CT, in 100% of cases, defects in the contrasting of the internal iliac artery on both sides were determined. Collateral circulation was also developed in 100,0% of cases, despite the type of defect in the internal iliac artery. Conclusions: ligation of the ovarian and internal iliac artery is a reliable method of surgical hemostasis, which allows saving the uterus in 90,3% of cases. In the late postoperative period, all patients developed various degrees of arterial patency in the ligation zone, and collateral circulation developed on both sides.

Detection of sepsis using biomarkers based on machine learning

Sepsis is the second most common cause of death in patients with non-cardiovascular diseases admitted to the ICU. It is one of the top ten reasons for death among all hospitalized patients. This study aimed to compare the value of some blood parameters in diagnosing sepsis and investigate their relationship to select a more practical diagnostic method. In this descriptive-analytical study, 208 patients with sepsis admitted to the ICU were selected. Then the physiological parameters of patients and normal individuals were measured. Data analysis was performed using the p value and effect size methods and MATLAB software. To classify the disease, the MLP, RBF, and KNN methods were used. The values of the HR, O2Sat, and SBP in patients with sepsis have changed significantly compared to NORMAL conditions. The classification results using different classifications showed that the values of specificity, sensitivity, and accuracy values in the classifier are more than MLP and RBF and equal to 98 %, 100 %, and 99 %, respectively. Clinically, accurate detection of sepsis and predicting the patients at risk of developing sepsis is useful for improving treatment. Given the significant differences between HR, O2Sat, and SBP between normal and sepsis patients in this study, it may be possible to use these tests as simple tests instead of the complement protein 3 (C3) and Procalcitonin (PCT) tests to diagnose sepsis in the ICU (Tab. 8, Fig. 10, Ref. 39). Text in PDF www.elis.sk Keywords: sepsis, physiological parameters, detection; feature extraction, statistical analysis.

The effect of preoperative fasting time on physiological parameters in patients undergoing thyroid surgery

The research was conducted between January 2022 and June 2022 in the Department of Surgery, Inonu University, Turkey. The sample of the study consisted of 40 consecutive patients who underwent thyroidectomy surgery. After obtaining the necessary permissions from the ethics committee, patients, and the chief physician of the medical faculty hospital, the research was conducted. Research data were collected using the patient diagnosis form, the form for assessing patients; vital signs, the form in which the laboratory values of the patients are determined, and the wound site evaluation form of patients three days after surgery. As a result of the research, it was determined that heart rate, body temperature, and HbA1c value may be affected as the fasting period gets longer. In surgeries performed in other patient groups and in patients with a higher population of thyroid surgery, it was suggested that new research should be done to examine the effect of fasting duration on vital signs, wound site, and blood laboratory values.

The effect of music therapy on anxiety and pain in patients undergoing prostate biopsy: A systematic review and meta-analysis

ObjectivesThis study aims to explore the effect of music therapy on pain, anxiety and physiologic parameters in patients undergoing prostate biopsy. Design and settingA systematic review and meta-analysis of randomized controlled trials. InterventionsFive databases were systematically searched. The included studies reported randomized controlled trials comparing the effects of music therapy and non-music therapy on pain, anxiety, and physiologic parameters in patients undergoing prostate biopsy. The random-effects meta-analyses were performed for data synthesis. Main outcome measuresThe primary outcome was pain; secondary outcomes included anxiety and physiologic parameters. ResultsWe analyzed seven eligible studies involving 662 males undergoing prostate biopsy. We synthesized the mean difference between music and control groups in different outcomes. Compared with control groups, music therapy reduced pain (visual analog scale score, mean difference [95% CI]: −0.92 [−1.68 to −0.17], P = 0.017, low quality) and anxiety (State-Trait Anxiety Inventory equivalent scale score, mean difference [95% CI]: −4.37 [−7.72 to −1.03], P = 0.010, low quality) after the prostate biopsy. In terms of the physiological parameters, music therapy only slightly reduced heart rate, but not blood pressure and respiratory rate after the prostate biopsy. ConclusionsLow quality of evidence showed that music therapy during prostate biopsy might reduce pain and anxiety. However, a good standard of music intervention was lacking. Cost-effective analyses are warranted to better delineate the value of music therapies for prostate biopsy.

Can Weather Be a Factor in Liver Transplant Waitlist and Posttransplant Outcomes? Analysis of United Network for Organ Sharing Registry

Cold climate is known to affect the frequency and attributable mortality of various illnesses. This study aims to evaluate the effect of climate among regions on liver transplant (LT) outcomes. We analyzed data from the United Network for Organ Sharing registry for 98,517 adult patients (aged ≥ 18 years) who were listed for LT between 2010 and 2019. During this period, 51,571 patients underwent single-organ, deceased LT. States were categorized based on their mean winter temperature: warm states (45°F-70°F), intermediate states (30°F-45°F), and cold states (0°F-30°F). Post-LT outcomes at 1 month, 1 year, and 3 years were compared using Cox proportional hazard models. Ninety-day and 1-year waitlist outcomes were compared among climate regions using Fine-Gray hazard regression model. After adjusting risks for recipient and donor characteristics, LT candidates in cold states had a significantly higher waitlist (90-day: subdistribution hazard ratio (HR) 1.46; 1-year: subdistribution HR 1.41; P < .001) and posttransplant mortality (30-day: subdistribution HR 1.23; P=.009, 1-year: subdistribution HR 1.16; P=.001; 3-year: subdistribution HR 1.08; P=.007). LT recipients in cold states had a higher proportion of deaths due to infections than warm states (cold states: 2.3%; intermediate states: 2.1%; and warm states: 1.7%; P < .001). Potential reasons include weather-related changes in the behavioral and physiological parameters of patients.

The effect of light on sleep quality and physiological parameters in patients in the intensive care unit

BackgroundIf patients in the intensive care unit are constantly exposed to artificial light, various problems related to sleep, and circadian rhythm may develop. ObjectivesThe aim of this study was to determine the effect of light in the ICU on sleep quality and physiological parameters of patients. DesignExperimental and randomized-controlled trial. MethodsThe study was conducted in the ICU of a training and research hospital between May 2019‐March 2021. The patients hospitalized in the ICU constituted the population of the study, and 148 patients constituted the sample calculated by power analysis. In individuals allocated into the experimental and control groups according to randomization, a cyclic lighting system was organized in isolation rooms for the experimental group, and a standard ICU lighting system was used in the control group. ResultsThe durations of deep sleep, light sleep and total sleep in the experimental group were statistically significantly higher compared to the control group (P < .05). No statistically significant difference was found in terms of systolic and diastolic blood pressure, peak heart rate and body temperature values in the experimental and control groups according to 48-hour sleep duration (P > .05). The 48-hour respiratory rate values in the ICU were statistically significantly higher in the control group compared to the experimental group (P < .05). ConclusionIt was determined that the light in the ICU affected the sleep quality and physiological parameters of individuals. It is recommended to make environmental arrangements for light according to human biorhythm and to reduce exposure to artificial light in order to increase sleep quality and sleep duration in the ICU. Trial registration numberNCT0466142.

Impact of intradialytic exercise on fatigue, biochemical and physiological parameters in patients on maintenance hemodialysis - A pilot study - Part 1

IntroductionPhysical inactivity is most prevalent in hemodialysis population and is associated with a variety of unfavourable clinical outcomes. Fatigue and elevated biochemical markers are directly linked to decreased physical activity. Intradialytic exercise is one of the non-pharmacological interventions for end-stage renal disease (ESRD) patients receiving hemodialysis which is seldom implemented at most of the hemodialysis centers. This pilot study aims to evaluate the effect of intradialytic exercise program (IDEP) on fatigue and biochemical markers in endstage renal disease patients receiving hemodialysis. MethodsUsing quasi experimental design, forty patients from two dialysis centers were recruited and assigned randomly to intervention (n = 20) and control groups (n = 20). Patients in intervention group were taught IDEP for 25 min, two times a week along with routine care whereas control group patients received only routine care. Fatigue, biochemical and physiological parameters were assessed at baseline and at various time points after IDEP. In intervention group there was a gradual decrease in fatigue but the physiological and biochemical parameters such as haemoglobin, urea, creatinine, potassium, systolic blood pressure and diastolic blood pressure remained without much change. In control group, the level of fatigue did not change in most of the patients. In some patients there was an increase in fatigue level. ConclusionIDEP is a cost-effective, safe, complementary, non - pharmacological intervention for fatigue which can be performed under medical supervision during hemodialysis. IDEP incorporation in the routine care shall lead to improvement in the fatigue level but will not cost extra time for the patient.