Physiological Domains Research Articles

Bridging the divide in organismal physiology: a case for the integration of behaviour as a physiological process.

The role of behaviour in animal physiology is much debated, with researchers divided between the traditional view that separates physiology and behaviour, and a progressive perspective that sees behaviour as a physiological effector. We advocate for the latter, and in this Commentary, we argue that behaviour is inherently a physiological process. To do so, we outline the physiological basis for behaviour and draw parallels with recognised physiological processes. We also emphasise the importance of precise language that is shared across biological disciplines, as clear communication is foundational in integrating behaviour into physiology. Our goal with this Commentary is to set the stage for a debate and persuade readers of the merits of including behaviour within the domain of animal physiology. We argue that recognising behaviour as a physiological process is crucial for advancing a unified understanding of physiology, especially in the context of anthropogenic impacts.

Exercise training to preserve vitality capacity in ageing.

Ageing is an escalating global health issue, with the World Health Organization (WHO) reporting that one in six individuals will be 60years or older by the year 2030. Therefore, understanding the mechanisms of complex biological ageing processes and associated healthcare challenges has become increasingly important. Intrinsic capacity (IC), defined by WHO as the composite of all physical and mental capacities an individual possesses, can be used as a proxy for defining healthy ageing. IC has five key components: locomotion, cognition, psychological, sensory, and vitality capacity (VC). This review paper specifically focuses on exercise as an effective tool to preserve VC in ageing populations. The physiological domains of VC discussed include energy and metabolism, neuromuscular function, immune and stress response, mitochondrial function, and the methylation clock. Additionally, we highlight potential outcome measures for assessing each of these domains. This review also covers areas of focus for future research and possible interventions. We ultimately conclude that ageing is a complex, multifaceted process resulting in deficits across multiple VC components. However, regular exercise is capable of producing physiological adaptations that may be beneficial in the context of healthy ageing and improving or preserving the status of VC components.

Induced Discomfort Promotes Executive Function While Walking With(out) an Artificial Neuromuscular Impairment.

Neuromotor disorders can degrade one's ability to locomote and attend to salient stimuli in the environment. Many disorders are physiologically complex, making it difficult to tease apart interactions between motor adaptation and executive function processes. We address this challenge by giving participants a controlled artificial impairment, using electrical stimulation to produce an uncomfortable disruption in normal muscular coordination during locomotion. While adapting to this gait perturbation, participants performed an executive function task containing neutral and affectively charged stimuli. The artificial impairment was counterbalanced against control and sham (discomfort-only stimulation) walking conditions. Our twofold hypothesis that discomfort would selectively tax hot, emotionally-charged executive function and motor adaptation would challenge cold, logical executive function was not supported. However, we found that the discomfort experienced with both stimulation conditions improved participants' ability to inhibit distracting information, enhancing this aspect of executive function, and the effect did not depend on whether the task was affectively charged. Moderate discomfort during physical activity may have improved inhibitory control by increasing arousal, a known factor mediating executive function. These results show that using a sensorimotor perturbation that acts internally and bridges multiple physiological domains, including discomfort, can reveal effects not seen with purely environmental manipulations. The broader implications are that when high cognitive performance is needed during physical activity, it may be beneficial to, quite literally, operate outside one's comfort zone.

Comprehensive analysis of stress factors affecting students: a machine learning approach

BackgroundThe increasing levels of stress among students worldwide pose a significant challenge to educational institutions. This study aims to systematically identify and analyse the factors contributing to student stress using advanced machine learning techniques.ObjectiveTo explore the primary stressors affecting students and to evaluate the interrelations among psychological, physiological, environmental, academic, and social factors in influencing student stress levels.MethodsThe study utilized a comprehensive dataset, StressLevelDataset.csv, collected from a diverse group of 1100 students across various educational institutions. We employed machine learning tools, including correlation analysis and feature importance analysis using Random Forest models, to identify and rank the most significant stressors.ResultsKey findings suggest that psychological factors like self-esteem and physiological factors like sleep quality are crucial predictors of stress levels in students. A significant negative correlation was found between students’ anxiety levels and their academic performance, highlighting the adverse impacts of psychological stress on educational outcomes.ConclusionThe results underscore the importance of targeted interventions focusing on mental health and well-being within educational settings. By addressing the identified stressors, particularly in the psychological and physiological domains, educational institutions can enhance student well-being and improve academic performance.

Analysis of the nursing value of continuity care in the recovery of ureteral stone patients after Pneumatic ballistic lithotripsy: An observational study.

This study aims to assess nursing methods' effects on ureteral stone patients post-Pneumatic ballistic lithotripsy with double J-tube placement. Through comparing interventions' impact on recovery, complications, and overall quality of life, the study aims to establish a more effective nursing protocol for this patient group. This study investigates ureteral stone patients who underwent PL and subsequent double J-tube placement between January 2020 and October 2023. A total of 100 eligible subjects (n = 100), meeting the inclusion and exclusion criteria, were divided into an intervention group (n1 = 50) and a control group (n2 = 50) according to different treatments. The control group received routine in-hospital care combined with outpatient follow-up, while the intervention group underwent continuous care using the Omaha system. Nursing effects pre- and post-intervention were assessed using questionnaires, clinical indicators, and the Omaha evaluation system, evaluating aspects such as cognition, behavior, and status in terms of environment, psychosocial aspects, physiology, and health behavior. Additionally, complications during double J-tube placement and pain scores were compared among the patients. Prior to the intervention, no statistically significant differences were observed between the scores of both groups across environmental, psychosocial, physiological, and health behavioral domains. Subsequent to the nursing intervention on the first postoperative day, at discharge, and post-discharge, a statistically significant variance was evident between the groups across these domains (P < .05). Furthermore, the intervention group exhibited notably lower rates of infection, hematuria, and residual or fragmented stones, all significantly lower with a P-value of <.05, compared to the control group. While a reduction in tissue damage and acute kidney injury was observed in the intervention group compared to the control group, this difference did not reach statistical significance. Notably, 92% of patients in the intervention group reported no pain during the nursing intervention, in contrast to only 52% in the control group. Continuity care utilizing the Omaha system demonstrates favorable outcomes in managing double J stent placement post-PL among ureteral stone patients, notably leading to a significant reduction in both pain levels and the incidence of associated complications.

The Effects of Teacher's Competencies in the Application of Online Teaching and Learning on Students' Academic Stress, Learning Motivation, and Academic Achievement in Statistics Subject

Online learning may lead to several problems, causing academic stress that lowers student motivation. Thus, great instructor skills are needed to overcome challenges and automatically build a successful and efficient online learning process. The study examines how teacher competencies in four dimensions – Teacher’s technological pedagogical content knowledge (TPACK), teacher’s belief (TB), teacher’s self-efficacy (TSE), and teacher’s enthusiasm (TE) – affect students’ academic stress in the cognitive (CD), behavioral (BD), affective (AD), and physiological domains (PD), as well as learning motivation (SLM) and academic achievement (AA). The study uses multivariate regression analysis, the ordinal logistic regression, and the Structural Equation Model (SEM). Multivariate regression analysis is utilized to examine the effects partially and simultaneously of dependent and independent variables. The ordinal logistic regression is used for the same purpose but on the data with an ordinal scale; the final grade shows the AA variable. Whereas, SEM is used to investigate the relationship between complex variables. The sample retrieval technique is conducted using non-probabilistic sampling by the method of accidental sampling with 219 college students. Results show that TPACK, which is one dimension of a teacher’s competencies, negatively affects students’ academic stress, which is BD, AD, and PD. However, TPACK does not significantly affect CD. Adverse effects suggest increasing teacher’s competencies in integrating technology and pedagogies in the development of educational content, especially in online learning, and reducing or minimizing students’ academic stress. Besides that, TPACK also has a positive effect on SLM, and SLM in turn positively affects AA. On the other hand, the variable component of teachers’ competencies, such as TSE and TE, has a positive effect on CD. Likewise, CD positively affects AA, so indirectly, TSE and TE positively affect AA. Of every effect and relationship between independent and dependent variables studied, the variable to contribute most effectively to online learning is the TPACK variable. Keywords: online teaching, teacher’s competencies, student’s academic stress, student’s learning motivation, academic achievement, TPACK, SEM, multivariate regression, logistic ordinal regression

Inflammation-, immunothrombosis,- and autoimmune-feedback loops may lead to persistent neutrophil self-stimulation in long COVID.

Understanding the pathophysiology of long COVID is one of the most intriguing challenges confronting contemporary medicine. Despite observations recently made in the relevant molecular, cellular, and physiological domains, it is still difficult to say whether the post-acute sequelae of COVID-19 directly correspond to the consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This work hypothesizes that neutrophils and neutrophil extracellular traps (NETs) production are at the interconnection of three positive feedback loops which are initiated in the acute phase of SARS-CoV-2 infection, and which involve inflammation, immunothrombosis, and autoimmunity. This phenomenon could be favored by the fact that SARS-CoV-2 may directly bind and penetrate neutrophils. The ensuing strong neutrophil stimulation leads to a progressive amplification of an exacerbated and uncontrolled NETs production, potentially persisting for months beyond the acute phase of infection. This continuous self-stimulation of neutrophils leads, in turn, to systemic inflammation, micro-thromboses, and the production of autoantibodies, whose significant consequences include the persistence of endothelial and multiorgan damage, and vascular complications.

A Preliminary Data Visualization Approach to Vestibulocochlear Diseases Based on Multiple Scalar Dimensions.

For vestibulocochlear diseases, traditional clinical history-taking, and the terminology of widely taught nosologic taxonomy, have misleading implications that can lead to errors in diagnosis and therefore in treatment. In the interest of facilitating differential diagnosis while simultaneously recognizing that many of these diseases may not be as discrete as textbooks suggest, we propose a data visualization approach focusing on several continuous scalar dimensions in the domains of anatomy, physiology, and chronology. We illustrate the application of this approach to several categories of clinical presentation.

Heart rate variability measurement and influencing factors: Towards the standardization of methodology.

Heart rate variability (HRV) is widely recognized as an effective and valuable tool for evaluating cardiac autonomic modulation. However, various factors can influence HRV before and during assessment, complicating the interpretation and comparability of results. This review outlines the different factors affecting HRV and underscores the importance of considering them to ensure consistent and reliable HRV outcomes. Key influencing factors are categorized into physiological (e.g., age, gender, genetics), lifestyle (e.g., physical activity, alcohol use, smoking, drugs, diet), environmental (e.g., time of day, temperature, noise), and methodological (e.g., body position, recording duration, and respiration) domains. Knowing these factors can help researchers and physicians gain a better understanding of HRV and improve the interpretation of their findings. Consequently, this can lead to the development of standardized methods for consistently assessing and interpreting HRV measures in clinical practice.

Exploring the potential roles of apelin, visfatin, and irisin in energy regulation in farm animals: an overview.

Adipose tissue, both intricate and fundamental to physiological functions, comprises cell types, including adipocytes, pivotal in secreting bioactive peptides known as 'adipokines.' Apelin (APLN), Visfatin (VSFTN), and Irisin (IRSN) are novel adipokines involved in regulating energy, carbohydrate, protein, and lipid metabolism. APLN acts as an endogenous ligand for G-protein-coupled receptors, VSFTN is essential in nicotinamide adenine dinucleotide (NAD) biosynthesis, and IRSN is released from skeletal muscle and adipose tissues. Their influence spans various physiological domains, including insulin resistance and sensitivity, cardiovascular functions, angiogenesis, and reproductive systems. This review focuses on the potential roles of APLN, VSFTN, and IRSN in energy regulation mechanisms related to farm animal production. Despite accumulating evidence of their significance, comprehensive understanding is still emerging, with most studies based on model organisms. Thus, there's a pressing need for targeted research on farm animals. Addressing these knowledge gaps could pave the way for improved health strategies, reproductive efficiency, and productivity in farm animals. Future research should focus on understanding the multifaceted interactions of these adipokines and their implications for promoting sustainable and effective animal production.

Setting sail for Paris 2024: Retrospective analysis of world-class ILCA 7 Olympic sailors' cardiorespiratory fitness (2015-2020).

The aim of this retrospective analysis was to provide a more comprehensive understanding of the cardiorespiratory profile of world-class ILCA-7 sailors (n=3, all males), through a longitudinal evaluation offering real-world data on physiological profile and exercise intensity domains. The cardiopulmonary exercise testing (CPET) was performed by the same researchers using the same equipment during the study. Assessments took place twice a year, aligning with major international competition preparations. Participants trained and competed at the same sailing club in Split, Croatia, under consistent supervision from the same team throughout the study, winning a total of 21 medals at major international competitions. The recorded ranged from 51.7±1.6 to 61.9±3.0mLmin-1kg-1, respectively. Similarly, peak power output varied from 352±10 to 426±34W. The changes in physiological responses at the ventilatory thresholds were proportional to the changes in peak cardiorespiratory fitness capacity. Interestingly, the oxygen pulse measured in 2015 was 25±1mLO2beat-1. Over the subsequent 6 years, the O2 pulse marginally increased and appeared to stabilize at 27±1mLO2beat-1 in 2020, when these athletes were 32±3 years old. This work offers a broader understanding of world-class Olympic sailors' cardiorespiratory fitness, going beyond the standard assessment of peak to incorporate an analysis of ventilatory thresholds. While a direct link between cardiorespiratory fitness and competitive success remains ambiguous, the importance of a well-rounded aerobic capacity for excellence in ILCA-7 sailing class is evident. HIGHLIGHTS: What is the central question of this study? What are the temporal changes in the physiological profiles of three world-class ILCA-7 sailors? What is the main finding and its importance? Data on oxygen pulse adjustments suggest the involvement of compensatory cardiovascular mechanisms, likely associated with the isometric and quasi-isometric contractions inherent in ILCA-7 sailing. This is evidenced by the absence of an age-related increase in oxygen pulse, a phenomenon often observed in endurance athletes throughout their competitive careers.

Diagnosis and management of frailty

Background: Frailty, a syndrome characterized by reduced physiological reserve and heightened susceptibility to stressors, impairs homeostasis across physical, psychological, and physiological domains in older adults. Approximately 50% of older Korean adults are frail or pre-frail, which highlights the need for targeted interventions in community healthcare and primary care settings.Current Concepts: Various methods, including use of physical and biological markers and health deficit analysis are available for frailty assessment; the Frailty Phenotype and Frailty Index are widely used screening tools. Following advances in technology, electronic health records and big data play a key role in identifying potential biomarkers. Considering the multifaceted nature of frailty, comprehensive geriatric assessments are recommended for holistic evaluation and management, based on a patient’s medical, psychological, and functional capabilities. Effective management can reverse frailty, which emphasizes the importance of early detection and multidisciplinary interventions. International and national guidelines propose a comprehensive approach focusing on modifiable risk factors, physical activity, a balanced diet, chronic disease management, social participation, and regular review of medication regimens. Personalized care plans based on comprehensive assessments are essential to enhance or maintain the residual function of frail older adults to improve their quality of life and reduce the need for long-term care.Discussion and Conclusion: Timely and effective management of potentially reversible frailty highlights the importance of prompt detection and a multidisciplinary approach to care. International and national guidelines recommend a holistic management strategy. Tailored care plans based on comprehensive geriatric assessments are pivotal in improving or maintaining the functional capabilities of frail elderly individuals to enhance their quality of life.

Assessing the quality of life in patients with drug-resistant tuberculosis: a cross-sectional study

BackgroundThis study investigated the current status of the quality of life (QOL) of drug-resistant tuberculosis (DR-TB) patients in Nanjing, China, and analyzed the influencing factors.MethodsThe survey was conducted among patients with DR-TB who were hospitalized in the tuberculosis department of the Second Hospital of Nanjing (Nanjing Public Health Medical Center) from July 2022 to May 2023. The Chinese version of the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire was used to investigate the QOL levels of patients with DR-TB, and a multiple linear regression model was used to analyze the QOL influencing factors.ResultsA total of 135 patients participated in the study; 69.6% were male, the average age was 46.30 ± 17.98 years, 13.33% had an education level of elementary school or below, and 75.56% were married. The QOL scores were 51.35 ± 17.24, 47.04 ± 20.28, 43.89 ± 17.96, and 35.00 ± 11.57 in the physiological, psychological, social, and environmental domains, respectively. The differences between the four domain scores and the Chinese normative results were statistically significant (P < 0.05). The results of multiple linear regression analysis showed that the factors related to the physiological domain included residence, family per-capita monthly income, payment method, adverse drug reactions (ADRs), and comorbidities; psychological domain correlates included educational level, family per-capita monthly income, course of the disease, and caregivers; social domain correlates included age and comorbidities; and factors related to the environmental domain included age, education level, and comorbidities.ConclusionsIn Nanjing, China, patients with younger age, higher education level, living in urban areas, high family per-capita monthly income, no adverse drug reactions, no comorbidities, and having caregivers have better quality of life. Future interventions to improve the quality of life of patients with drug-resistant tuberculosis could be tailored to a specific factor.

Use of Placebo in Urologic Oncology Randomized Controlled Trials.

Use of placebo in oncology randomized controlled trials (RCT) is ethically controversial. Placebo may introduce bias, as toxicity profiles of treatment arms can inadvertently unblind subjects and investigators. We investigated the use of placebo in urologic oncology RCTs, hypothesizing that most placebo-controlled trials are effectively unblinded, either explicitly with open-label design or implicitly due to large differences in adverse events (AE) or oncologic outcomes. Urologic oncology RCTs utilizing placebo were identified via ClinicalTrials.gov. Interventional prostate, bladder/urothelial, and renal cancer trials from 2014 to 2024 were included. Subject incompletion, all-cause mortality, AE rates, and serious AE (SAE) rates were identified and compared between placebo and active arms using χ2 and Fisher's exact tests. Sixty studies met inclusion criteria and included 66 placebo arms with 12,918 subjects and 81 active arms with 16,098 subjects. There was no significant difference in incompletion rates between placebo and active arms. Subjects enrolled in active arms reported statistically significant higher SAE and AE rates compared to those in placebo arms across the majority of physiological domains, including 18/24 domains for SAEs and 13/24 for AEs. This relationship persisted in sensitivity analyses where unblinded trials were excluded. In urologic oncology placebo-controlled RCTs, active arms are associated with significantly higher rates of AEs and SAEs compared with placebo arms. These findings indicate a strong possibility that true blinding is not possible in oncology RCTs, even with optimal study design, and serve to better inform future clinical trial design and implementation challenges in employing placebo control.

Fear of the COVID-19 vaccine in a public healthcare system and university setting.

Despite the known benefits, some individuals remain apprehensive about receiving the COVID-19 vaccine, which hampers vaccination efforts and the achievement of herd immunity. Therefore, this cross-sectional study aimed to assess vaccination rates and identify factors influencing fear of the COVID-19 vaccine among individuals served by the public healthcare system (Family Health Strategy - FHS) and in a university community in Minas Gerais, Brazil. Surveys were conducted face-to-face with FHS participants and online with university members, employing a free sharing approach on social media. A total of 1896 and 312 responses were collected, respectively. The survey covered sociodemographic information, COVID-19 fear levels, and vaccination status for both individuals and their children Vaccination coverage was 83% among FHS participants and 99.1% in the university setting. Female respondents in both groups exhibited higher levels of COVID-19 fear (p<0.05), with FHS-assisted women reporting greater apprehension towards vaccination (p<0.05). Educated parents demonstrated better understanding of the importance of child vaccination, while younger parents expressed heightened concerns about vaccine side effects. Among FHS participants, women exhibited a 1.6 times higher fear of vaccination compared to men. Additionally, fear of vaccination increased by 1.10 times for each additional point on the COVID-19 Fear Scale (physiological domain). Effective communication strategies and dispelling misconceptions surrounding immunization could alleviate fear and promote vaccination acceptance.

A Scoping Review on the Influence of Contextual Factors on Training Load in Adolescent Soccer Players: What Do We Know?

This scoping review aimed to systematically explore the breadth and extent of the literature regarding the relationship between contextual factors (CFs) and training load (TL) in adolescent soccer players. Further aims included comprehending potential underlying mechanisms and identifying knowledge gaps. CFs were defined as factors not part of the main training process, such as the coach-athlete relationship and educational responsibilities. PubMed, EBSCO APA PsycINFO, Web of Science, ProQuest Dissertations & Theses A&I, and SportRxiv were searched. Studies involving adolescent soccer players that investigated the CF-TL relationship and measured TL indicators were deemed eligible. Seventeen studies were included, reflecting the limited number of articles published regarding the CF-TL relationship. CFs were mostly related to match-play (N = 13) and phase of the season (N = 7). Moreover, these factors appeared to affect TL. CF related to players' personal environment (N = 3) were underrepresented in the reviewed studies. Overall, the CF-TL relationship appears to be rarely scrutinized. A likely cause for this lack of research is the segregation of the physiological and psychological research domains, where the CF-TL relationship is often speculated upon but not measured. Therefore, a holistic approach is warranted which also investigates the effect of personal environment, such as stressful life stress events, on TL.

Radiation-induced Chronic Pain Plagues Head and Neck Cancer Survivors: A Cross-sectional Analysis From the Cohort in Radiotherapy-related Nervous System Complications

The epidemiology and prognosis of radiation-induced chronic pain, especially chronic neuropathic pain (CNP), are the understudied domain among head and neck cancer (HNC) survivors after radiotherapy (RT). This study aimed to estimate the prevalence of such chronic pain, and explore its correlations with mental health, sleep disorders, cognitive function, and quality of life (QOL) within these patients. This research encompassed HNC survivors post RT. The determination of radiation-induced chronic pain and CNP adhered to the guidelines outlined by the International Association for the Study of Pain. Multivariable regression analyses were employed to explore the relationship between pain and anxiety, depression, sleep disturbances, cognitive function, and QOL. A total of 1,071 HNC survivors post RT were included in this study. The prevalence of radiation-induced chronic pain was 67.1%, and the prevalence of RT-associated CNP was 38.3%. Compared with those reporting no pain, patients with radiation-induced chronic pain had a significantly increased risk of anxiety, depression, and sleep disorders (all P < .001). And there was a significantly negative association between chronic pain and QOL across physiological (P < .001), psychological (P < .001), social relationships (P = .001), and environmental (P = .009) domains. Compared with non-CNP, patients with RT-related CNP had a higher risk of anxiety (P = .027) and sleep disorders (P = .013). The significantly negative associations were found between CNP and the physiological (P = .001), psychological (P = .012), and social score (P = .035) in World Health Organisation Quality of Life Assessment-Bref. This study underscores the substantial prevalence of chronic pain, particularly CNP, and its potential impact on the mental health, sleep, and QOL among HNC survivors post RT. PerspectiveThis study highlights the high prevalence of radiation-induced chronic pain and CNP, and their potential impacts on anxiety, depression, sleep, and QOL among the HNC survivors. Clinically, these findings have important implications for improving the care and outcomes of HNC survivors.

Development and Validation of a Scoring System (SAGA Score) to Predict Weight Loss in Community-Dwelling, Self-Supported Older Adults.

This retrospective cohort study explored the prevalence of substantial weight loss (≥10% per year) in independent older individuals in order to develop and validate a scoring system for high-risk group identification and targeted intervention against malnutrition. We used insurance claims and the Kokuho Database (KDB), a nationwide repository of Japanese-specific health checkups and health assessments for the older people. The study included 12,882 community-dwelling individuals aged 75 years and older who were self-supported in their activities of daily living in Saga Prefecture, Japan. Health evaluations and questionnaires categorized weight-loss factors into organic, physiological, psychological, and non-medical domains. The resulting scoring system (SAGA score), incorporating logistic regression models, predicted ≥ 10% annual weight-loss risk. The results revealed a 1.7% rate of annual substantial weight loss, with the SAGA score effectively stratifying the participants into low-, intermediate-, and high-risk categories. The high-risk category exhibited a weight-loss rate of 17.6%, highlighting the utility of this scoring system for targeted prevention. In conclusion, the validated SAGA score is a crucial tool for identifying individuals at high risk of significant weight loss, enabling tailored interventions and social support benefiting both older individuals and their relatives.

Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study.

Recent reports have shown increased cannabis use among women, leading to growing concerns about cannabis use disorder (CUD). While there is preclinical evidence suggesting biological sex influences cannabinoid effects, human research remains scant. We investigated sex differences in the acute response to oral tetrahydrocannabinol (THC) in humans. 56 healthy men and women with prior exposure to cannabis but no history of CUD participated in a randomized, placebo-controlled, human laboratory study where they received a single 10mg dose of oral THC (dronabinol). Subjective psychoactive effects were assessed by the visual analog scale of "high", psychotomimetic effects by the Clinician-Administered Dissociative Symptoms Scale and Psychotomimetic States Inventory, verbal learning and memory by Rey Auditory Verbal Learning Test (RAVLT), and physiological effects by heart rate. Outcomes were regularly measured on the test day, except for the RAVLT, which was assessed once. Peak differences from baseline were analyzed using a nonparametric method for repeated measures. Oral THC (10mg) demonstrated significant dose-related effects in psychotomimetic and physiological domains, but not in RAVLT outcomes. A notable interaction between THC dose and sex emerged concerning the subjective "high" scores, with women reporting heightened sensations (p = 0.05). No other significant effects of sex and THC dose interaction were observed. Oral THC (10mg) yields similar acute psychotomimetic and physiological effects across sexes, but women may experience a pronounced subjective psychoactive effect. Further research is needed to identify individual vulnerabilities and facilitate tailored interventions addressing CUD. GOV REGISTRATION: https://clinicaltrials.gov/study/NCT02781519?term=Ranganathan&intr=THC&rank=3 .

Multi-dimensional measurements of long-term quality of life and recovery patterns of patients with cervical cancer after treatment.

e17533 Background: Cervical cancer is a prevalent malignancy affecting the female reproductive system globally, and its incidence among younger individuals is on the rise. This study employed the CC-PRO137 scale to evaluate the long-term quality of life and recovery patterns of cervical cancer patients post- treatment. Clinicians are guided to provide individualized treatment and psychological support. Methods: This study recruited patients with primary cervical cancer who underwent primary surgical treatment at the Obstetrics and Gynecology Hospital of Fudan University from October 2018 to June 2021. The CC-PRO137 (Cervical Cancer Patient Reported Clinical Outcome Assessment Scale) was used for follow-up to assess changes in the patients' physical, psychological, and social life states. The data was analyzed to examine variations in the recovery status of the patients across 13 modules: urinary function (URI), bowel function (BOW), pelvic organ prolapse (POP), ovarian function (OVA), lymphatic function (LYM), nervous function (NEU), sexual function (SEX), anxiety (ANX), depression (DEP), shame (SHA), belief (BEL), social support (SUP), and daily life (LIF). Subgroup analysis was conducted based on different stages, surgical methods, and adjuvant treatment plans. Results: A total of 304 participants were tested both 6 months and 12 months after the completion of treatment. The scores for URI, NEU, and SEX were significantly higher after one year compared to within 6 months (URI: t=-3.519, p=0.001; NEU: t=-2.138, p=0.033; SEX: t=-2.338, p=0.021). This suggests a notable improvement in urinary function, nervous function, and sexual function after 12 months. In terms of the psychological domain, DEP scores were significantly higher after 12 months compared to within 6 months ( t=-2.517, p=0.012). The LIF index showed a significant improvement after 12 months ( t=-5.224, p&lt;0.001). Subgroup analysis revealed that Stage II had worse outcomes compared to Stages I and III, particularly in terms of URI ( F(2,297) = 10.619, p &lt; 0.001) and POP ( F(2,299) = 8.559, p&lt; 0.001) indexes. The laparoscopy had a greater impact on the urinary system ( t = 2.157, p = 0.046). The adverse effects of concurrent chemoradiotherapy on URI ( F(2,297) = 11.497, p &lt; 0.001) and DEP ( F(2,299) = 4.149, p = 0.017) functions were more significant than those of chemotherapy. Conclusions: The recovery of patients following cervical cancer treatment is primarily observed in improvements in urinary, bowel, and nervous functions in the physiological domain. In the psychological domain, there is a noticeable improvement in depressive state, while the social life domain also shows signs of improvement over time. By focusing on the disease impact within a limited time frame, the scale helps clinicians provide targeted guidance and advice based on the main issues.