I will present our efforts for investigating flexible electronic sensors for potential health monitoring applications and bioinspired sutureless anastomosis devices for easier, faster, and safer surgery.Highly sensitive flexible tactile sensors are of continuing interest for various applications including human–machine interface systems, internet of things, and wearable health monitoring devices. Current technologies for high sensitivity piezoresistive sensors tend to rely on costly materials and/or fabrication methods, limiting accessibility and scalability. Here, we report a facile sacrificial casting–etching method to synthesize nanoporous carbon nanotube/polymer composites for ultra-sensitive and low-cost piezoresistive pressure sensors. Our synthesis method overcomes the limitations of the traditional solution-dip-coating method for adhering nanoscale conductive materials to the nanoscale porous surface. Importantly, we show ultra-high sensitivity with a strain gauge factor over 300, which is ∼50 times higher than that of traditional CNT-based piezoresistive sensors. For practical tactile sensing applications, we demonstrate that the sensors can detect both gentle pressures (1 Pa–1 kPa) and low pressures (1 kPa–25 kPa) with a fraction of the cost. Our nanoporous polymer composite could contribute to expanding the scope of using nanocomposite sensors for medical applications from its easy tunability for sensing diverse range of tactile signals.Anastomosis, the surgical connection of adjacent tubular organs is a foundational surgical skill for many surgical procedures. The current standard of anastomosis is manually suturing two tubular structures together around an opening with fine sutures. However, it requires several years of surgical training, a long time (60 to 90 minutes per anastomosis) for procedure, and, at times, specialized equipment, facility and staffs. Thus, it is an expensive (up to $35,000 per procedure).Moreover, even in the hands of skilled surgeons, the anastomosis can be complicated by leakage or thrombosis. To address current challenges, we investigated a sutureless anastomosis device inspired by rose prickles. I will present our approach to design, fabricate, and test devices. Our device showed the failure force comparable to that of the handsewn suture (4.9 N) and no leakage up to 45 mL/min flow rate, well above the physiologic blood flow rate. Compared with handsewn anastomosis, the device resulted in minimum deformation of the anastomotic site. From in-vivo non-survival porcine studies, the device showed successful anastomosis (< 5 min per anastomosis) with no leaking for both arterial and venous anastomoses. We envision our findings can contribute to enabling easier, faster, and safer anastomosis, and making anastomotic techniques more accessible to a broad range of clinicians, researchers, and patients across the world.