Background: Generally, decisions related to healthcare issues should be only made according to the clinical criteria. However, in clinical decision-making, there is mutual information sharing, in which health providers share the benefits and adverse effects of potential treatment with their patients, and patients share their values and lifestyle preference with their physicians. The clinical decision is affected by factors either related to patients or physicians; the factors related to patients include socio-economic status. Health insurance reduces the costs of medication and hospitalization of patients, and this allows patients to obtain better medical care while treating various diseases. Therefore, clinical decisions can be affected by the insurance status of patients. Aim: To describe the physicians' knowledge regarding the impact of the insurance status of patients on clinical decision-making. Methods: The study was cross-sectional that was enrolled physicians in private hospitals and clinics. The study was conducted via an online questionnaire that investigated the demographics of physicians and their knowledge. SPSS version 22 was used to analyze the collected data; a P-value≤0.05 was significant. Results: There were 401 physicians who participated in this study; 75.3% were males, 42.9% were consultants, 76.3% were non-Saudi physicians, and 72.1% were working in the private sector. The mean ±SD of the knowledge score was 18.89±4.9. The mean score of knowledge was significantly affected by nationality (P˂0.001) and type of practice (P=0.012). Conclusion: Physicians had inadequate knowledge regarding the impact of health insurance on clinical decision-making. The nationality and type of facility affected the level of physicians‘ knowledge.