Physical Restraint Research Articles

Reduction in Restraint and Critical Incidents in a Norwegian Residential Treatment Facility for Children Aged 7–13 Following the Implementation of the Neurosequential Model of Therapeutics

In child and adolescent inpatient, residential and day-treatment facilities, the use of physical restraints and the occurrence of critical incidents are a significant problem. Restraints may sometimes be necessary if a child exhibits dangerous aggressive behavior, but may also be misused or overused, and have been shown to be preventable in many cases. This study aims to investigate if the implementation of the Neurosequential Model of Therapeutics (NMT) has an effect on the annual number of physical restraint incidents in a residential treatment facility for children with complex mental health disorders. Data before and after NMT implementation were collected from the agency’s restraint records. The results showed that post-NMT implementation, there was a substantial and sustained reduction in restraint incidents, with a Cohen’s d value of 2.03, indicating a very large effect. Limiting restraint use in treating children with complex mental health disorders can foster a safer and more therapeutic environment, with potential improvements in treatment outcomes. This study demonstrated a substantial drop in restraint incidents following the implementation of the Neurosequential Model in a residential facility for children aged 7–13. This reduction is presumably pivotal for children with complex mental health disorders, making treatment less coercive and offering promise for settings in which restraint incidents are a concern.

Prehospital Restraint Use in Pediatric Patients With Mental and Behavioral Health Emergencies.

The aims of the study are to characterize children with mental and behavioral health conditions (MBH) transported by emergency medical services (EMS) and examine differences in patient, emergency department (ED), and EMS transport characteristics based on restraint interventions during EMS transport. This is a retrospective cohort study of EMS patients with MBH crises, aged 5-18, transported to 2 pediatric EDs over 9 years. Demographic and ED data were collected electronically; EMS data were extracted manually from prehospital care records. Field interventions studied included pharmacologic and mechanical restraints by EMS clinicians. Univariate analysis compared variables between patients who received EMS restraints and those who did not and multivariable logistic regression identified patient factors independently associated with EMS restraint use. Among 10,264 patients transported by EMS for MBH crises, 1400 encounters were randomly selected, with 768 records available. EMS restraint interventions were used in 73 (9.5%) patients: 5 (0.7%) received only pharmacologic restraints, 58 (7.6%) received only physical restraints, and 10 (1.3%) received both. Those who received EMS restraints were more likely to be younger (35.6% vs 19.6%, P = 0.001), male (71.2% vs 44.6%, P < 0.0001), and had longer scene times (13 vs 9 min). Restraint use was more common when patients were picked up from schools (30.1% vs 14.8%, P = 0.007). EMS-restrained patients were also more likely to receive physical (12.3% vs 2.3%, P < 0.0001), mechanical (15.1% vs 1.0%, P < 0.0001), or pharmacologic (24.7% vs 3.9%, P < 0.0001) restraints in the ED. Predictors of EMS restraint use were male sex (odds ratio, 3.00; 95% confidence interval, 1.74-5.17) and being picked up from schools (odds ratio, 2.08; 95% confidence interval, 1.13-3.81), whereas age group, race, and insurance type were not independent predictors. Nearly 1 in 10 pediatric patients experiencing mental health crises and transported by EMS required restraint interventions in the field. Male patients, younger aged children, and those picked up from school represent a distinct and vulnerable population that could benefit from specialized prehospital care to manage agitation.

Heritable heart failure traits in mice undergoing early life stress

Abstract Introduction Adverse childhood experiences, known as early life stress (ELS), are associated with increased cardiovascular disease risk in later life, yet the underlying mechanisms remain elusive. Recent evidence indicates that parental life experiences can be transmitted to the offspring. Whether ELS exerts transgenerational effects on the heart is unknown. Purpose To investigate the effects of ELS on cardiac structure and function in exposed parents and in their offspring, across 3 generations. Methods We used a mouse model of ELS (MSUS) that mimics the exposure to traumatic experiences during childhood in humans. Mouse pups (F1) were separated from their mother (F0) unpredictably each day for 3 hours from postnatal day 1 (PND1) to PND14. During separation, dams were exposed to an additional unpredictable stressor by being subjected to either, a forced swim (18°C water for 5 minutes) or a 20-minute physical tube restraint, anytime (unpredictably) during the 3 hours. From PND15, mice are left undisturbed with their mother until PND21, are then raised normally until adulthood. Control litters were raised normally. A high-resolution Micro-Ultrasound System (Vevo 3100, Visualsonics) was used for the echocardiographic assessment at 6, 12 and 18 months both in the exposed animals (F0) as well as in their offspring (F1) and grandoffspring (F2). Both male and female mice were studied. Heart weight/tibia length and left ventricle weight/tibia length were used to assess cardiac mass while myocardial fibrosis was assessed by Masson's Trichrome and Picriosirius Red stainings. Lung congestion was assessed as lung wet/dry weight ratio. Single cell RNA sequencing (scRNAseq) was used in LV specimens from MSUS mice to unveil cell-specific transcriptional changes. Finally, MSUS mice underwent environmental enrichment (cages containing running wheels, maze) to investigate any rescuing effect on cardiac function. Results F1 mice displayed increased LV mass, impaired diastolic function, myocardial fibrosis and lung congestion. A time-dependent worsening of cardiac performance was observed from 6 to 18 months, both in males and females. ScRNAseq unveiled dysregulation of transcriptional programs underlying inflammation and lipotoxicity in the cardiomyocyte and endothelial cell clusters. The MSUS offspring did not show changes of cardiac function at 6 months, however diastolic dysfunction and lung congestion were observed at 12 and 18 months. A similar impairment of cardiac function was observed in the MSUS grandoffspring (F3). Of interest, 6-week exposure to an environmental enrichment protocol was able to improve LV mass, diastolic function and lung congestion in 12 months-old MSUS mice. Conclusions ELS induces a transgenerational transmission of cardiac phenotypic alterations which can be rescued by EE. Our results shed light on the potential role of ELS on heart failure development and potential mitigation strategies.

28 Vaccination experiences for children with special needs - An examination of the impact of behaviours on vaccine uptake

Abstract Background While vaccines have been one of the most effective medical interventions to reduce the morbidity and mortality of many communicable illnesses, many factors have led to suboptimal immunization rates amongst paediatric patients. One of which that has not been explored widely in research literature is the impact of maladaptive behaviours on annual immunization rates. Behaviours such as aggression, agitation and flight are common amongst children with a neurodevelopmental diagnosis such as autism spectrum disorder, global developmental delay, and intellectual delay. When children are young, physical restraints by parents are often the method used to aid in the administration of the vaccine. However, as they age physical restraints is often regarded as inappropriate. Objectives The purpose of this study is to determine the extent in which disruptive behaviours (aggression, agitation and flight) affect annual vaccination rates for children with a neurodevelopmental diagnosis above the age of 6 years where physical restraining for vaccinations is no longer deemed appropriate or safe. Design/Methods Families with children diagnosed with Autism Spectrum Disorder (ASD), Intellectual Disorder (ID), and/or Global Developmental Delay (GDD) aged 6-17 years, seen through outpatient clinics at the Ron Joyce Children’s Health Centre of McMaster Children’s hospital in Hamilton between November 2022 – April 2023 were invited to participate in this cross sectional survey. The study aimed to capture both quantitative data on vaccine uptake and qualitative data on how vaccination experiences could be improved for children with neurodiversity. Results A total of 109 participants completed the survey. Among them, forty-three (39%) participants had a diagnosis of ASD and sixty-six (51.2%) had a diagnosis of global developmental delay or intellectual disability. Forty-six (45.6%) and 82 (76%) did not receive the Covid-19 and the influenza vaccination respectively. Of the children that did not receive the CoVid-19 vaccine, fourteen (30%) of the families had brought their child to be vaccinated, but the health care team could not administer the vaccine due to their child’s behaviours and twenty-one (37%) of the families anticipated that the vaccination would be a difficult experience because of their child’s behaviours and did not bring their child to get vaccinated. Of the children that did not receive the influenza vaccine, fifteen (18%) families had brought their child to be vaccinated, but the health care team could not administer the vaccine due to the child’s behaviours and 42 (50%) families anticipated that the vaccination would be a difficult experience because of their child’s behaviours and did not bring their child to get vaccinated. The main themes that emerged from the studies on ways to improve the vaccination experience for families include administering the vaccine in a low sensory environment, decreasing wait time, and ensuring clinic staff have experience in caring for children with special needs. Conclusion Children with special needs are a vulnerable population warranting concerted effort to ensure equitable access to immunizations. Interventions such as clinics specifically designed for children with neurodiversity should be implemented with the hope to further improve immunization rates within this population.

Use of restrictive practices in approved mental health centres in Ireland: consideration of five years of national data.

To evaluate the rates of use of restrictive practices (RPs), such as seclusion and physical restraint, in approved mental health centres (ACs) in Ireland. Examination of data reported to the regulator of mental health in Ireland, the Mental Health Commission (MHC), and the Health Research Board (HRB). There has been a substantial reduction in RP use in Irish ACs between 2018 and 2022. The MHC welcomes this reduction in RP use and considers several possible reasons for this data.

Physical Restraint Use in Hospitalized Patients: A Study of Routinely Collected Health Records Data.

The use of restraints in hospitalized patients is associated with physical and psychological adversity for patients and staff. The minimization of restraint use is a key goal in the hospital setting. Reaching this goal requires an accurate assessment of existing patterns of use across clinical settings. This study reports the rate of physical restraints among patients hospitalized within a multi-entity healthcare network along with stratification by care context, diagnostic, and demographic factors, and examines the sensitivity and specificity of ICD-10 code Z78.1 "physical restraint status" for defining physical restraints relative to electronic health record (EHR) documentation. The EHR was used for a retrospective analysis of all adults hospitalized between 2017 and 2022. Hospitalized adults. Patient demographics, structured diagnostic information, care area, length of stay, and in-hospital mortality, Z78.1 coding for physical restraints, restraint documentation in orders and flowsheets. Among 742,607 hospitalizations, 6.3% (n=47,041) involved the use of physical restraint based on coding or EHR documentation. Treatment in the intensive care unit (ICU) included restraint in 39% of encounters whereas treatment outside the ICU included restraint use in 1.3% of encounters. Besides critical illness, demographic factors including increasing age (adjusted odds ratio (aOR)=1.21 [1.19-1.23]), male gender (aOR=1.56, [1.52-1.60]), unknown race (aOR=1.27 [1.19-1.35]), and preferred language other than English (aOR=1.24, [1.18-1.29]) were associated with higher odds of restraint utilization. As compared to EHR orders or documentation of restraint, the ICD-10 code for physical restraint had a sensitivity of 1.5% and a specificity of 99.99%. Among adults admitted to acute care hospitals, clinical, demographic, and operational factors were associated with increased odds of restraint, with care in the ICU associated with greatly increased odds of restraint. Research into restraint utilization using coded administrative claims data is likely limited by the sensitivity of physical restraint coding.

A model to increase care delivery in nursing homes: The role of Institutional Special Needs Plans.

To estimate differences in facility-level outcomes between nursing homes which reached Institutional Special Needs Plan (I-SNP) maturity and those which never cared for I-SNP enrollees. We used a difference-in-differences design to estimate the effect of I-SNP maturity, defined as having at least 33.75% of Medicare long-stayers in the nursing home enrolled in any I-SNP. Our main outcome was the hospitalization rate in each nursing home-year. Secondary outcomes included the share of residents with medication use, fall, urinary tract infection, catheter insertion, pressure ulcer, physical restraint use, increased need for help with activities of daily living (ADLs), and mortality. This repeated cross-sectional study used 100% Medicare claims, Minimum Data Set assessments, and publicly available Medicare Advantage (MA) plan characteristics data (2004-2021). We included all MA beneficiaries who resided in US nursing homes which reached I-SNP maturity and those without I-SNP enrollees. We identified 2530 nursing homes which reached I-SNP maturity (treated) and 9830 nursing homes without I-SNP enrollees (untreated). There were some differences observed between these nursing homes, including shares of residents who were White (76.42% vs. 84.84%) and on Medicaid (66.94% vs. 55.45%). These nursing homes were also larger on average (141.76 beds vs. 87.56 beds). From the difference-in-differences model, nursing homes which reached I-SNP maturity experienced declines of 4.1 percentage points (pp) for hospitalizations, 1.0 pp for pressure ulcers, 1.3 pp for urinary tract infections (p < 0.001) alongside increases in the need for help with ADLs, use of antipsychotics, falls, and physical restraints. Nursing homes which reached I-SNP maturity experienced fewer hospitalizations and pressure ulcers but a decline in function and increase in other negative outcomes. I-SNPs may be a promising model to improve care for long-stay residents, but more research is needed to understand potential adverse consequences.

Factors related to the use of physical restraints and hand restraints among older adults receiving home care services.

Physical restraints and hand restraints are used in medical settings to provide protection and control. However, few studies have investigated their use among community-dwelling older adults. The study explored variables associated with the use of physical restraints and hand restraints among older adults receiving home care services and the reasons behind their use. This cross-sectional study recruited 128 older adults receiving home care services and with catheters. Data were collected regarding demographic characteristics; activities of daily living (ADLs); muscle strength; family function; the use of nasogastric tubes, urinary catheters, and tracheal tubes; and the type and duration of restraint use and the reasons behind such use. Among the participants, 76% experienced the use of physical restraints, and 34% experienced the use of hand restraints. The variables related to physical restraints were ADLs (adjusted odds ratio [AOR] = 0.95, p = .02) and the presence of a paid caregiver (AOR = 3.33, p = .02). The variables related to hand restraints were ADLs (AOR = 0.93, p = .03), use of a nasogastric tube (AOR = 13.46, p = .03) and the presence of a paid caregiver (AOR = 6.38, p = .02). The primary reasons behind restraint use were to prevent fall and extubation events. The use of physical restraints among older adults with catheters may be affected by their functioning in ADLs and the presence of paid caregivers to ensure their safety. Thus, implementing interventions that target functional capabilities and caregiving skills may help reduce the use of restraints.

Mental healthcare in South Tyrol

Mental healthcare in South Tyrol, as everywhere in Italy, is still characterized by Law 180, which came into force in 1978 under the leadership of Franco Basaglia and Bruno Orsini. The Ministry of Health subsequently set atarget number of beds of 10/100,000 inhabitants. Unlike in other parts of Italy, private clinics play aminimal role in South Tyrol. The "Psychiatric Services" are part of the state healthcare system responsible for all citizens and are also responsible for compulsory outpatient care. According to the concept of community care, also due to the small number of inpatient beds, agreat deal of care is provided on an outpatient basis. Coercive measures can only be used in the case of an illness requiring urgent treatment that the patient refuses, without recourse to endangering circumstances (self-endangerment or danger to a third party). Inpatient hospitalization is only possible if treatment also takes place and the principle of "outpatient before inpatient" also applies in this context, i.e., coercive treatment can only take place as an inpatient if it cannot be carried out as an outpatient. Forensic psychiatry has very few places and mentally ill offenders are often in prison or occupy beds in general psychiatric wards. Compared to Germany there are fewer beds available but staffing levels are better, particularly for nursing. In relation to the number of inhabitants, compulsory treatment is more frequent than in Germany, whereas involuntary hospitalization and physical restraint are much rarer (only possible in Italy by court order).

Association between patient race and emergency department physical restraint use in a statewide hospital system

ObjectiveTo measure the association between patient race and physical restraint use in the ED. MethodsAdult patients presenting to eight rural, suburban, and urban EDs in a mid-Atlantic statewide hospital system ED between January 1, 2019 and June 30, 2022 were included. Those arriving already restrained, transported from detention centers, or who left before services were provided were excluded. Multivariable logistic regression measured the association of physical restraint use with patient race, adjusting for age, sex, weight, height, mode of arrival, history of violent behavior, comorbidities, ESI acuity level, homelessness, and site. ResultsOf 896,527 patient encounters included in the analysis, 3459 (0.39 %) had a physical restraint order. The study population was 48.7 % non-Hispanic White and 43.7 % non-Hispanic Black. Black patients had higher adjusted odds of being restrained relative to White patients (OR 1.26, 95 % CI 1.15–1.37). Other key variables associated with physical restraint use were an ESI level of 1 vs 3+ (OR 13.15, 95 % CI 11.49–15.04), arrival by law enforcement (8.39, 95 % CI 7.47–9.43), and arrival by EMS (5.36, 95 % CI 4.93–5.83 Among those who were restrained, the hazard of restraint was higher among Black compared to White patients in the first hour after ED arrival (adjusted hazard ratio 1.14, 95 % CI 1.01–1.30). ConclusionBlack patients were more likely to be physically restrained compared to White patients, though the magnitude of this association was small compared to that of other clinical risk factors. Future work should evaluate if these findings are driven by differences in patient characteristics or clinician decision-making to best inform interventions to reduce this disparity.

Venipuncture in pediatric emergency department by using Koala Attachment Distraction method: Randomized clinical trial

ObjectiveTo assess, compare and relate the toddler’s pain and anxiety during venipuncture by using either the Koala Attachment Distraction method or the physical restraint method and to evaluate the level of anxiety perceived by the companions in both groups. MethodRandomised, single-blind, controlled clinical trial in two arms (control and intervention group) conducted in the paediatric emergency department of a tertiary university hospital. The study variables were pain and stress of the child and anxiety perceived by the accompanying persons in both groups at the time before and during the technique. The pain rating scale Face, Leg, Activity, Cry, Consolability; the Groningen stress scale and the STAI questionnaire were used. ResultsA total of 113 participants aged 3 to 4 years participated in the trial (n=113). 50% (55) were girls, mean total age 3.83±0.59 years and accompanying persons 37.17±6.96. During the technique the mean pain in control and intervention groups was 5.64±3.30 and 3.87±3.01; stress, 3.25±1.22 and 2.67±1.24, respectively. No statistically significant differences were found in the assessment of anxiety between the groups. ConclusionsPatients who underwent the Koala Attachment Distraction method venipuncture show a lower level of pain and anxiety than those who received physical restraint, and the anxiety perceived by the companion is similar in both groups.

Use of Socially Assistive Robots to Improve Outcomes Among Hospitalized Older Adults With Dementia: A Pilot Randomized Trial.

To examine the use of the PARO robotic pet seal for hospitalized older adults with dementia and compare the effects of PARO use with visits by a human on various outcomes, including physical restraint use, psychotropic medications, bedside sitters, and delirium. Complete data for 38 participants were analyzed using Mann-Whitney U and chi-square tests. Participants interacting with PARO spent less time in their interactions; however, they received fewer psychotropic medications and had fewer instances of delirium than those who interacted with human visitors only. Aspects of hospitalization may limit the time an older adult can sustain attention or be free from interruption; however, short, repeated visits with PARO may affect the development of delirium and decrease use of medications to alter behavior in the hospital setting. [Journal of Gerontological Nursing, 50(10), 11-16.].

Ireland's Mental Health Bill 2024: progress, problems and Procrustean perils.

Ireland's Mental Health Bill 2024 proposes the most significant revision of mental health legislation since the Mental Health Act 2001. To explore the 2024 Bill and provide suggestions for the subsequent Act. Review of the 2024 Bill and related literature. The 2024 Bill proposes useful new definitions (e.g., 'mental disorder', 'treatment') and provisions governing specific practices (e.g., 'physical restraint'). Revision is needed to better provide care and protect rights: (a) proposed treatment criteria for involuntary admission should be retained, but 'risk' criteria deleted; (b) treatment provisions should ensure mental health legislation provides for timely, accountable treatment for all patients; (c) detailed provisions about the content of treatment plans do not belong in primary legislation, which is ill-suited to micro-managing individual care and (d) the Mental Health Commission should be incorporated into the Health Information and Quality Authority. The 2024 Bill proposes useful changes but requires revision, especially for involuntary patients who lack decision-making capacity and decline care, for whom the Assisted Decision-Making (Capacity) Act 2015 does not (and was not designed to) provide solutions. Relying on a convoluted combination of the 2015 Act, Circuit Court and High Court would be legally impossible, clinically impracticable and de facto denial of the rights of people with serious mental illness and their families. The final Act can accord with principles of the 2015 Act without relying on its provisions and should benefit patients and support staff in delivering mental health care that is essential and often life-saving.

Design of a prototype of clothing for older persons with neurocognitive diseases with behavioural troubles interfering with the management of sphincter disorders

Introduction: The evolution of neurocognitive diseases is marked by increasingly disruptive behavioural disorders as well as sphincter troubles. To avoid being forced to use physical restraints or therapies that promote drowsiness to prevent older patients from removing their diapers, caregivers can use a onesie. However, this solution does not respect the dignity of these persons. Objectives: To design a prototype of onesie that will be aesthetically pleasing as daytime clothing, with features that simplify its use by professional caregivers and respect the dignity of older adults with neurocognitive diseases. Methodology: A randomized open trial was conducted comparing the prototype of onesie that was developed to a classic onesie. The degree of respect for the dignity of these older adults was rated as well acceptability and reliability of the two onesies and a satisfaction survey among caregivers was carried out using a derived questionnaire from the ITHACA project. Results: The final version of the prototype was a onesie resembling to a clothing adapted for day wear and allowing caregivers to quickly change persons with restricted participation. Forty subjects were included. No difference was found in the dignity ratings assigned by their relatives. The caregiver satisfaction survey showed that they thought the prototype respected the dignity of the subjects but that the use of the classic onesie made the work easier. Conclusion: Our prototype of onesie allowed a better usability by caregivers, was better accepted than a classic model of onesie while respecting the dignity of older adults with neurocognitive diseases.

Strategies to Avoid Physical Restraint in the Summer Treatment Program

ABSTRACT As our Summer Treatment Program (STP) grew, the rates of timeouts involving physical restraint increased. These increases necessitated significant restructuring of our approach to screening/intake, crisis response and intervention, reinforcement, staff training, and program group and leadership structure. We describe the evolution of these approaches since 2015, when the STP was first offered, through present day (2023). During STP, timeouts were documented when they occured. These data were entered for each year and analyzed. Additionally, disruptive behavior, anxiety and depression symptoms, and impairment rating scales gathered as part of the eligibility screening process were examined across years. We present data showing the decrease in physical management (restraint) during timeout associated with these changes in the STP. Since these changes were implemented, we have had zero incidents of timeout with physical management over the past 3 years. We also show that these strategies did not just eliminate the most severe children. We believe clinical decision-making for eligibility using our screening criteria and other modifications were associated with the decrease in need for physical restraint and provide guidance for future use by other Summer Treatment Programs.

Patient, Practice, and Organizational Factors Associated With Early Mobility Performance in Critically Ill Adults.

Adoption of early mobility interventions into intensive care unit (ICU) practice has been slow and varied. To examine factors associated with early mobility performance in critically ill adults and evaluate factors' effects on predicting next-day early mobility performance. A secondary analysis of 66 ICUs' data from patients admitted for at least 24 hours. Mixed-effects logistic regression modeling was done, with area under the receiver operating characteristic curve (AUC) calculated. In 12 489 patients, factors independently associated with higher odds of next-day mobility included significant pain (adjusted odds ratio [AOR], 1.16; 95% CI, 1.09-1.23), documented sedation target (AOR, 1.09; 95% CI, 1.01-1.18), performance of spontaneous awakening trials (AOR, 1.77; 95% CI, 1.59-1.96), spontaneous breathing trials (AOR, 2.35; 95% CI, 2.14-2.58), mobility safety screening (AOR, 2.26; 95% CI, 2.04-2.49), and prior-day physical/occupational therapy (AOR, 1.44; 95% CI, 1.30-1.59). Factors independently associated with lower odds of next-day mobility included deep sedation (AOR, 0.44; 95% CI, 0.39-0.49), delirium (AOR, 0.63; 95% CI, 0.59-0.69), benzodiazepine administration (AOR, 0.85; 95% CI, 0.79-0.92), physical restraints (AOR, 0.74; 95% CI, 0.68-0.80), and mechanical ventilation (AOR, 0.73; 95% CI, 0.68-0.78). Black and Hispanic patients had lower odds of next-day mobility than other patients. Models incorporating patient, practice, and between-unit variations displayed high discriminant accuracy (AUC, 0.853) in predicting next-day early mobility performance. Collectively, several modifiable and nonmodifiable factors provide excellent prediction of next-day early mobility performance.

American Society of Laboratory Animal Practitioners Position Statement: Handling and Physical Restraint of Research Animals.

American Society of Laboratory Animal Practitioners Position Statement: Handling and Physical Restraint of Research Animals.

B-mode, Doppler, and Elastography abdominal ultrasound in Tamandua tetradactyla.

The aim of this study was to describe the normal B-mode, Doppler, and 2D Shear Wave Elastography ultrasonographic findings of some abdominal structures in a six-month-old male Southern Tamandua (Tamandua tetradactyla). The animal was found and rescued by the environmental police after being discovered in the wild near its mother, who had died in a car accident. For the ultrasonographic exams, the animal's abdominal region was shaved, and only physical restraint was used. In the B-mode exam, the urinary bladder, small intestine, kidneys, left adrenal gland, stomach, liver, and gallbladder were located and evaluated. Doppler examination obtained spectral tracings of the arcuate and renal arteries of both kidneys. Elastography assessed the stiffness of the renal cortex, liver, and spleen. The ultrasound examination provided an adequate evaluation and novel findings of the Southern Tamandua abdominal structures without invasiveness.

Information-Motivation-Behavioral Skill model-based physical restraint education program for nursing care providers in long-term care hospitals: A quasi-experimental repeated measures non-equivalent control group design

Information-Motivation-Behavioral Skill model-based physical restraint education program for nursing care providers in long-term care hospitals: A quasi-experimental repeated measures non-equivalent control group design

Ketamine Analgo-sedation for Mechanically Ventilated Critically Ill Adults: A Rapid Practice Guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine.

This Rapid Practice Guideline (RPG) aimed to provide evidence‑based recommendations for ketamine analgo-sedation (monotherapy and adjunct) versus non-ketamine sedatives or usual care in adult intensive care unit (ICU) patients on invasive mechanical ventilation (iMV) and to identify knowledge gaps for future research. The RPG panel comprised 23 multinational multidisciplinary panelists, including a patient representative. An up-to-date systematic review and meta-analysis constituted the evidence base. The Grading Recommendations, Assessment, Development, and Evaluation approach, and the evidence-to-decision framework were used to assess the certainty of evidence and to move from evidence to decision/recommendation. The panel provided input on the balance of the desirable and undesirable effects, certainty of evidence, patients' values and preferences, costs, resources, equity, feasibility, acceptability, and research priorities. Data from 17 randomized clinical trials (n=898) and 9 observational studies (n=1934) were included. There was considerable uncertainty about the desirable and undesirable effects of ketamine monotherapy for analgo-sedation. The evidence was very low certainty and downgraded for risk of bias, indirectness, and inconsistency. Uncertainty or variability in values and preferences were identified. Costs, resources, equity, and acceptability were considered varied. Adjunctive ketamine therapy had no effect on mortality (within 28 days) (relative risk [RR] 0.99; 95% confidence interval [CI] 0.76 to 1.27; low certainty), and may slightly reduce iMV duration (days) (mean difference [MD] -0.05 days; 95% CI -0.07 to -0.03; low certainty), and uncertain effect on the cumulative dose of opioids (mcg/kg/h morphine equivalent) (MD -11.6; 95% CI -20.4 to -2.7; very low certainty). Uncertain desirable effects (cumulative dose of sedatives and vasopressors) and undesirable effects (adverse event rate, delirium, arrhythmia, hepatotoxicity, hypersalivation, use of physical restraints) were also identified. A possibility of important uncertainty or variability in patient-important outcomes led to a balanced effect that favored neither the intervention nor the comparison. Cost, resources, and equity were considered varied. The RPG panel provided two conditional recommendations and suggested (1) against using ketamine as monotherapy analgo-sedation in critically ill adults on iMV when other analgo-sedatives are available; and (2) using ketamine as an adjunct to non-ketamine usual care sedatives (e.g., opioids, propofol, dexmedetomidine) or continuing with non-ketamine usual care sedatives alone. Large-scale trials should provide additional evidence.