Physical Decay Research Articles

Comprehensive characterization of waterlogged archaeological wood by NMR relaxometry, diffusometry, micro-imaging and cryoporometry.

Chemical, physical, and biological decay may partially or totally hide the historical and technological information carried by waterlogged wood. Investigation of the above-mentioned decay processes is essential to assess the wood preservation state, and it is important to find new methods for the consolidation and safeguarding of wooden archaeological heritage. A conventional method for assessing the wood preservation state is light microscopy. However, the method requires sample slicing, which is destructive and challenging when dealing with fragile and spongy submerged remains of heritage wood. To this end, a promising alternative non-destructive technique is proton nuclear magnetic resonance (1H-NMR) which considers wood as a porous system. This work aimed to perform a comprehensive analysis of structures, porosity, water distribution, decay, and possible structural inclusions of three archaeological waterlogged wood fragments of the Roman age using NMR relaxometry, micro-imaging (μ-MRI), NMR diffusometry, and NMR cryoporometry. The results were compared with a similar analysis of the three contemporary wood samples of the same species. The multimodal approach presented in this study allowed us to cover all the dimensional scales of wood, from nanometers to sub-millimeters, and reconstruct the alteration of the entire archaeological wood fragment caused by degradation.

Modelling uncertainty in P-wave arrival-times retrieved from DAS data: case-studies from 15 fibre optic cables

SUMMARY Distributed acoustic sensing (DAS) technology enables the detection of waves generated by seismic events, generally as uniaxial strain/strain rate time-series observed for dense, subsequent, portions of a Fibre Optic Cable (FOC). Despite the advantages in measurement density, data quality is often affected by uniaxial signal polarization, site effects and cable coupling, beyond the physical energy decay with distance. To better understand the relative importance of these factors for data inversion, we attempt a first modelling of noise patterns affecting DAS arrival times for a set of seismic events. The focus is on assessing the impact of noise statistics, together with the geometry of the problem, on epicentral location uncertainties. For this goal, we consider 15 ‘real-world’ cases of DAS arrays with different geometry, each associated with a seismic event of known location. We compute synthetic P-wave arrival times and contaminate them with four statistical distributions of the noise. We also estimate P-wave arrival times on real waveforms using a standard seismological picker. Eventually, these five data sets are inverted using a Markov chain Monte Carlo method, which offers the evaluation of the relative event location differences in terms of posterior probability density (PPD). Results highlight how cable geometry influences the shape, extent and directionality of the PPDs. However, synthetic tests demonstrate how noise assumptions on arrival times often have important effects on location uncertainties. Moreover, for half of the analysed case studies, the observed and synthetic locations are more similar when considering noise sources that are independent of the geometrical characteristics of the arrays. Thus, the results indicate that axial polarization, site conditions and cable coupling, beyond other intrinsic features (e.g. optical noise), are likely responsible for the complex distribution of DAS arrival times. Overall, the noise sensitivity of DAS suggests caution when applying geometry-only-based approaches for the a priori evaluation of novel monitoring systems.

From desperation to best practice: Spatial decision-making in the regeneration of Gyldenrisparken

Post-war social housing estates in Europe have been undergoing wide-scale regeneration to improve the physical decay of these sites and address the concentration of vulnerable residents in these areas, which has resulted in their social segregation, marginalisation and stigmatisation. As these estates cover and affect quite large public spaces, holistic approaches have recently been adopted. Bearing in mind that each regeneration case is unique, this paper describes the collaborative approach taken in the regeneration of Gyldenrisparken in Denmark, which evolved from a desperate situation to a best practice case. The paper focuses on the spatial decision-making process — in particular, how the architectural quality of physical interventions was established and how participatory mechanisms were utilised and developed to enable liveable spaces and sustainable regeneration. Making use of a combination of qualitative documentary analysis and in-depth interviews with key actors, this study encompasses the whole regeneration process, including initiatives taken by the housing association and municipal agents, the methodology developed to collect ideas and implement them in the physical design of the public spaces, and the social effort to make the whole process sustainable and the estates liveable. It concludes that post-war estates have the potential to secure their future by embracing physical and social efforts through proactive empowerment strategies and creating new spatial identities.

From desperation to best practice: Spatial decision-making in the regeneration of Gyldenrisparken

Post-war social housing estates in Europe have been undergoing wide-scale regeneration to improve the physical decay of these sites and address the concentration of vulnerable residents in these areas, which has resulted in their social segregation, marginalisation and stigmatisation. As these estates cover and affect quite large public spaces, holistic approaches have recently been adopted. Bearing in mind that each regeneration case is unique, this paper describes the collaborative approach taken in the regeneration of Gyldenrisparken in Denmark, which evolved from a desperate situation to a best practice case. The paper focuses on the spatial decision-making process — in particular, how the architectural quality of physical interventions was established and how participatory mechanisms were utilised and developed to enable liveable spaces and sustainable regeneration. Making use of a combination of qualitative documentary analysis and in-depth interviews with key actors, this study encompasses the whole regeneration process, including initiatives taken by the housing association and municipal agents, the methodology developed to collect ideas and implement them in the physical design of the public spaces, and the social effort to make the whole process sustainable and the estates liveable. It concludes that post-war estates have the potential to secure their future by embracing physical and social efforts through proactive empowerment strategies and creating new spatial identities.

Ripening and Rotting Heroes: Growth, Decay, and Narrative Abjection in Anthony Trollope's The Small House at Allington and The Last Chronicle of Barset

This essay argues that Anthony Trollope introduces a framework of character growth and decay, evinced through organic metaphors of ripening and rotting, to distinguish good and bad characters in The Small House at Allington and The Last Chronicle of Barset. By comparing a developing protagonist with a mature one who enters a phase of decline, we see how Trollope's commitment to nuanced characterisation is disrupted by his didactic aim of designating, and then torturing, patently bad figures. An analysis of the psychologies and aesthetics of character, framed around Julia Kristeva's theory of abjection, shows how Trollope figures two subtly paralleled protagonists as opposites, establishing one as a palatable figure and the other as a nauseating one. The isolation of a rotten character serves a dual purpose: Trollope teaches his moral lessons by subjecting the character to physical, psychological, and structural decay, while narrative progression, culminating in the imperative happy ending, is structured around the abjection of the bad object.

The diagnostic study of the plaster replicas of the Trajan’s Column conserved at the Museum of Roman Civilisation (Rome)

The management of indoor microclimate in museums has recently received growing attention. Museum climatology and the mechanism for the degradation process, defined as a result of progressive and cumulative decay, depends on environmental variables and their changes. In fact, temperature and relative humidity gradients are often the main causes of chemical and physical decay of artefacts. This research focuses on assessing the state of conservation of 34 gypsum-based plaster replicas of Trajan’s Column at the Museum of Roman Civilisation and on the microclimate monitoring of Room LI, where they are conserved. The decay assessment of the studied plaster casts was performed using a multidisciplinary analytical approach to characterize the constituent materials and to identify the main degradation patterns by i) on-site investigation with non-destructive methodologies; ii) chemical and petrographical characterization on collected micro samples. Microclimate variables (temperature, relative humidity and dew point) were measured along seven months to define the actual environmental conditions and the response of the materials to the microclimate.

Optimal production and purification of n.c.a.143Pr as a promising palliative agent for the treatment of metastatic bone pain

This study proposes the beta-emitting radioisotope 143Pr as a promising candidate for palliative treatment of metastatic bone pain due to its desirable physical decay characteristics. An optimized process was developed for the production and purification of non-carrier-added 143Pr using a medium flux research reactor. Calculations were performed to determine the optimal irradiation time and cooling period for irradiating 1 mg of natural cerium oxide to indirectly produce 143Pr through the decay of 143Ce. Following irradiation and cooling, extraction chromatography was employed to efficiently isolate 143Pr from the irradiated target material. A column containing Ln-resin was used along with nitric acid as the mobile phase and an optional oxidation step with NaBrO3/ascorbic acid to separate 143Pr from impurities such as 143Ce and 141Ce. Radionuclidic purity of over 99.995% was achieved as confirmed through gamma spectroscopy, demonstrating effective separation of 143Pr. Additional quality control analyses established the chemical and radiochemical purity of the purified 143Pr nitrate product. With a half-life of 13.6 days and maximum beta energy of 0.937 MeV, 143Pr exhibits favorable properties for palliative bone pain therapy. This study therefore provides a viable method for producing high-purity 143Pr through the optimized irradiation and purification processes described. Further investigation is warranted to explore potential clinical applications of 143Pr for palliation of metastatic bone cancer pain.

Prioritizing Environmental Attributes to Enhance Residents’ Satisfaction in Post-Industrial Neighborhoods: An Application of Machine Learning-Augmented Asymmetric Impact-Performance Analysis

Post-industrial neighborhoods are valued for their historical and cultural significance but often contend with challenges such as physical deterioration, social instability, and cultural decay, which diminish residents’ satisfaction. Leveraging urban renewal as a catalyst, it is essential to boost residents’ satisfaction by enhancing the environmental quality of these areas. This study, drawing on data from Shenyang, China, utilizes the combined strengths of gradient boosting decision trees (GBDTs) and asymmetric impact-performance analysis (AIPA) to systematically identify and prioritize the built-environment attributes that significantly enhance residents’ satisfaction. Our analysis identifies twelve key attributes, strategically prioritized based on their asymmetric impacts on satisfaction and current performance levels. Heritage maintenance, property management, activities, and heritage publicity are marked as requiring immediate improvement, with heritage maintenance identified as the most urgent. Other attributes are categorized based on their potential to enhance satisfaction or their lack of immediate improvement needs, enabling targeted and effective urban revitalization strategies. This research equips urban planners and policymakers with critical insights, supporting informed decisions that markedly improve the quality of life in these distinctive urban settings.

CURRENT STATE OF THE 137CS MILK POLLUTION IN SETTLEMENTS OF RIVNE REGION AND VILLAGE NARODYCHI ZHYTOMYR REGION

The article analyses the results of selective monitoring of 137Cs content in milk from private households in the village of Narodychi, Zhytomyr region, and 14 settlements of Rivne region. A total of 213 milk samples were collected and analysed in 2023 in the Rivne region and about 30 in Narodychi. The analysis of the milk samples for 137Cs content showed that the contamination of this livestock product with 137Cs has complex dynamics. In most settlements of the monitoring network, the average values of 137Cs contamination in whole milk exceed the hygienic standards (PL-2006 - 100 Bq/l). 70% of milk samples recorded an exceedance of the permissible level. The highest activity concentration of this radionuclide (350 Bq/l) was observed in Stare Selo. Seasonal changes in the activity concentration of the radionuclide in milk were also observed. During the stall period, the activity concentration of milk with 137Cs ranged from less than 2 to 88 Bq/l. However, during the grazing period, the level of milk contamination with 137Cs increased to 100-350 Bq/l. Recent studies have shown a steady decrease in milk radioactivity. Nevertheless, without countermeasures, the reduction of 137Cs accumulation and transfer to milk will be mainly due to the physical decay of the radionuclide. The mineral part has likely exhausted its absorption capabilities for the natural processes, and therefore, it will not affect the reduction of milk contamination.

Temporal variation in environmental radioactivity and radiation exposure doses in the restricted areas around the Fukushima Daiichi Nuclear Power Plant

Temporal variation and fluctuation in environmental contamination in Futaba town and Okuma town, the location of the Fukushima Daiichi Nuclear Power Plant (FDNPP), were evaluated based on a car-borne survey conducted from October 2021 to November 2022. Although the environmental radioactivity in the interim storage facility area (ISF) was higher than that in open areas (i.e., the evacuation order lifted areas in Futaba town and the Specific Reconstruction and Regeneration Base area [SRRB] in Okuma town), only minor temporal changes were seen in the ambient dose and detection rate of radiocesium (the proportion of radiocesium detected points per all measuring points) in those areas, respectively. These findings suggest that the observed variations may result from physical decay and environmental remediation. Resuspension caused by human activities and weather could also affect the detection rate of radiocesium. The annual external effective doses in Futaba town and Okuma town were estimated to be at a limited level (< 1 mSv/year). Nevertheless, to help ensure the safety and future prosperity of residents and communities in the affected areas around the FDNPP, long-term follow-up monitoring of temporal exposure dose levels during the recovery and reconstruction phases is extremely important.

Humanist Cities and Post-Feminist Urban Social Geographies: Public Spaces and Plural Cultural Urbanism of Just Renewal

This conceptual and exploratory research paper brings multiple yet interconnected ideas about the contemporary discussions on the form and content our cities should take, especially on the public spaces as the critical spatial and social nodes. One is the idea of plural urbanisms where by incorporating the City's plural elements — 'those many elements imagined for more than a single design or by a single designer, which is more powerful and wide-ranging, more influential and beneficial, even as it becomes more democratic, participatory, open-ended, and infinite.' This is coupled with cultural Urbanism, which promotes and celebrates the everyday, temporal, occasional, and timeless. From a methodological point of view, the article is based on the multilayered desk research method. Secondary analysis of relevant documents allowed us to examine previous research findings on the issue at hand and the successful way to reduce it through sampling a coding of relevant material. The approach is a qualitative one, focused on a light motive case study. Last not but not least, the paper draws attention and leitmotif focus to the feminist approach in looking at cities, especially places undergoing new (urban) renewal that was preceded by decades of physical and social decay, such as Detroit in the US. Such an approach works towards ethnographies of belonging and increases diversity in city renewal, where we improve our fundamentally heterogeneous, intersectional, and constantly evolving urban environments for the better. Using a critical approach without conclusive arguments, this exploratory paper analyzes the aforementioned positions further and explores its application to various urban phenomena; as a focus on a policy-oriented paper, it ends with some crucial policy recommendations regarding feminist urban planning.

Specific Absorbed Fractions for Reference Paediatric Individuals.

The calculation of doses to organs and tissues of interest due to internally emitting radionuclides requires knowledge of the time-dependent distribution of the radionuclide, its physical decay properties, and the fraction of emitted energy absorbed per mass of the target. The latter property is quantified as the specific absorbed fraction (SAF). This publication provides photon, electron, alpha particle, and neutron (for nuclides undergoing spontaneous fission) SAF values for the suite of reference individuals. The reference individuals are defined largely by information provided in ICRP Publication 89. Some improvements and additional data are provided in this publication which define the reference individual's source and target region masses used in the Occupational Intake of Radionuclides (OIR) and Dose Coefficients for Intakes of Radionuclides by Members of the Public series of publications. The set of reference individuals includes males and females at 0 (newborn), 1, 5, 10, 15, and 20 (adult) years of age. The reference adult masses and SAFs provided in this publication are identical to those in ICRP Publication 133 and those used in the OIR series of publications. Computation of SAF values involves simulating radiation transport in computational models which represent the geometry of the reference individuals. The reference voxel phantoms of ICRP Publication 143 are used for photon and neutron transport, and most electron transport. Alpha particle transport is not necessary for large tissue regions as the short range allows for an assumption of full energy absorption (absorbed fraction of unity) for self-irradiation geometries. Additional computational models are needed for charged particles in small, overlapping, or interlaced geometries. Stylised models are described and used for electrons and alpha particles in the alimentary and respiratory tract regions. Image-based models are used to compute SAFs for charged particles within the skeleton. This publication is accompanied by an electronic supplement which includes files containing SAFs for each radiation type in each reference individual. The supplement also includes source and target region masses for each reference individual, as well as skeletal dose-response functions for photons incident upon the skeleton.© 2024 ICRP. Published by SAGE.

A Translation and Analysis of ʾAbd al-Jabbār Ibn Ḥamdīs’ Poem No. 110: “Qaḍat al-Nafs”

In this paper, I undertake a complete translation of Ibn Ḥamdīs’ poem No.110 “Qaḍat al-Nafs” and provide a structural analysis in order to demonstrate that the poem in its entirety is structured through a succession of related metaphors that lends unity and organization to the speaker’s experience. Though Ibn Ḥamdīs is committed to the canon of classical Arabic poetry in the division of the poem into three canonical segments of the classical qasīda (physical decay and the loss of youth, the wine song and the nostalgic feelings for a lost homeland), I argue that these segments are not loosely structured but built upon a succession of related and resonating metaphors that lends unity and coherence to the speaker’s experience. The poem can also be read as an autobiographical document in which Ibn Ḥamdīs records his own tragedy as an exile and the tragedy of Muslim Sicily and Arabic culture. Having led a very active life in his youth, the persona is now old, frequenting taverns and indulging himself in merry making in an attempt to recapture youth. However, the speaker’s attempt is overwhelmed by the tragic awareness that his action is futile; youth cannot be regained. This realization is intensified by the feeling that Sicily, the speaker’s birthplace and the setting of his youth, is also lost forever. Regaining his “paradise” is as impossible as regaining his youth. Old age and the great sense of loss make him turn to God with a penitent attitude.

MEDIA LIBRARIES: CATALYSTS FOR CULTURAL HERITAGE PRESERVATION AND DISSEMINATION

Cultural heritage, the rich tapestry of a societys history, traditions, and identity, has evolved and adapted to the changing needs of society. It is instrumental in fostering a sense of identity and belonging, connecting people to their roots, and preserving the collective memory of communities. However, cultural heritage faces formidable challenges, including physical decay, loss, and the imperative need for wide-reaching dissemination. In this research article, we explore the multifaceted role of media libraries as catalysts for cultural heritage preservation and dissemination. These digital repositories serve as custodians of tangible and intangible cultural assets, preserving them through digitization and providing a global stage for their accessibility. Media libraries play pivotal functions in digitization and preservation, accessibility, metadata and cataloging, cross-cultural exchange, and education and research. While they offer numerous advantages, they also encounter challenges, including copyright issues, data security, cultural sensitivity, accessibility, resource constraints, and technological obsolescence. Case studies from renowned institutions, including the British Library, UNESCOs World Heritage Center, the American Folklife Center, and the Smithsonian Institution, serve as exemplars of best practices in cultural heritage preservation and dissemination. As we navigate the digital age, media libraries stand as transformative agents in preserving and sharing cultural heritage, promising to enrich contemporary identities and safeguard the legacy of the past for future generations.

Radiation Protection Considerations for Cancer Patients with End-stage Renal Disease Receiving 131 I Treatment.

Differentiated thyroid cancer (DTC) is commonly treated first with a partial or complete thyroidectomy, followed by radioiodine (RAI) ablative therapy to eliminate remaining cancer cells. In such treatments, physical decay and urinary excretion are the primary means of 131 I. As such, patients with impaired urinary ability clearance, such as patients with end-stage renal disease (ESRD) whose urinary ability is impaired by dysfunction, can retain abnormally high activities of RAI, posing a concern to both the patient and those with whom the patient interacts. Additionally, ESRD patients are commonly administered dialysis therapy, wherein their blood is externally cycled through a dialyzer (hemodialysis) or filtered by instilling a dialysate fluid into the peritoneum (peritoneal dialysis) to filter uremic toxins from their blood that accumulate due to kidney dysfunction. These factors make determining release and dosing for ESRD patients receiving RAI therapy dependent on a plurality of variables. An evaluation of the current patient release guidelines, as given in US Nuclear Regulatory Commission (US NRC) Regulatory Guide 8.39 Rev. 1 for ESRD patients receiving RAI, has yet to be addressed. In this study, a biokinetic model for 131 I in ESRD patients receiving dialysis has been developed, improving on traditional two-compartment models, reflective of kinetics from multi-compartment models with updated transfer coefficients modified to reflect the different physiological functions of compartments. This updated biokinetic model was integrated with Monte Carlo radiation transport calculations using stylized computational hermaphroditic phantoms to calculate dose rate coefficients in exposure scenarios and compared with those of the point source models of NRC Reg Guide 8.39 Rev. 1 (and the proposed verbiage in Rev. 2). Results demonstrated that the baseline models of Rev. 1 and Rev. 2 overestimated the effective dose rate to an exposed individual for the majority of time post-administration, where both models overestimated the total dose to the maximally exposed individual. However, the application of several patient-specific modifying factors to the Rev. 2 model resulted in an overestimation by only a factor of 1.25, and in general, the results produced with the patient-specific modifications provide improved convergence with the dose rate coefficients computed in this study for ESRD patients.

Cellular lethal damage of 64Cu incorporated in mammalian genome evaluated with Monte Carlo methods.

Targeted Radionuclide Therapy (TRT) with Auger Emitters (AE) is a technique that allows targeting specific sites on tumor cells using radionuclides. The toxicity of AE is critically dependent on its proximity to the DNA. The aim of this study is to quantify the DNA damage and radiotherapeutic potential of the promising AE radionuclide copper-64 (64Cu) incorporated into the DNA of mammalian cells using Monte Carlo track-structure simulations. A mammalian cell nucleus model with a diameter of 9.3 μm available in TOPAS-nBio was used. The cellular nucleus consisted of double-helix DNA geometrical model of 2.3 nm diameter surrounded by a hydration shell with a thickness of 0.16 nm, organized in 46 chromosomes giving a total of 6.08 giga base-pairs (DNA density of 14.4 Mbp/μm3). The cellular nucleus was irradiated with monoenergetic electrons and radiation emissions from several radionuclides including 111In, 125I, 123I, and 99mTc in addition to 64Cu. For monoenergetic electrons, isotropic point sources randomly distributed within the nucleus were modeled. The radionuclides were incorporated in randomly chosen DNA base pairs at two positions near to the central axis of the double-helix DNA model at (1) 0.25 nm off the central axis and (2) at the periphery of the DNA (1.15 nm off the central axis). For all the radionuclides except for 99mTc, the complete physical decay process was explicitly simulated. For 99mTc only total electron spectrum from published data was used. The DNA Double Strand Breaks (DSB) yield per decay from direct and indirect actions were quantified. Results obtained for monoenergetic electrons and radionuclides 111In, 125I, 123I, and 99mTc were compared with measured and calculated data from the literature for verification purposes. The DSB yields per decay incorporated in DNA for 64Cu are first reported in this work. The therapeutic effect of 64Cu (activity that led 37% cell survival after two cell divisions) was determined in terms of the number of atoms incorporated into the nucleus that would lead to the same DSBs that 100 decays of 125I. Simulations were run until a 2% statistical uncertainty (1 standard deviation) was achieved. The behavior of DSBs as a function of the energy for monoenergetic electrons was consistent with published data, the DSBs increased with the energy until it reached a maximum value near 500 eV followed by a continuous decrement. For 64Cu, when incorporated in the genome at evaluated positions (1) and (2), the DSB were 0.171 ± 0.003 and 0.190 ± 0.003 DSB/decay, respectively. The number of initial atoms incorporated into the genome (per cell) for 64Cu that would cause a therapeutic effect was estimated as 3,107 ± 28, that corresponds to an initial activity of 47.1 ± 0.4 × 10-3 Bq. Our results showed that TRT with 64Cu has comparable therapeutic effects in cells as that of TRT with radionuclides currently used in clinical practice.

Examining the effects of cumulative environmental stressors on Gulf Coast child and adolescent health.

This study examines how community-level cumulative environmental stress affects child and adolescent emotional distress and chronic health conditions both directly and indirectly through stressors at the household, family, and individual levels. Data comes from the Women and their Children's Health (WaTCH) Study, which sought to understand the health implications of exposure to the 2010 Deepwater Horizon oil spill (DHOS) among a cohort of 596 mothers with children ages 10 to 17 in southeastern Louisiana. Community-level environmental stress was measured using a newly developed geospatial index. Household-level stressors included previous hurricane impacts, impacts of DHOS, degree of financial difficulty, and degree of housing physical decay. Family stressors included maternal depression, self-rated physical health, and degree of parenting stress. Child stress was based on perceived stress; child mental health was based on serious emotional disturbance; and child physical health was based on diagnosis of chronic illness. Structural equation modeling used weighted least squares means and variance and theta parameterization. Results showed a significant negative direct path between community-level cumulative environmental stress and child/adolescent serious emotional disturbance and chronic illness. However, the indirect relationship through household, family, and individual-level stressors was significant and positive for both child/adolescent serious emotional disturbance and chronic illness. These findings point to the centrality of the household and family in determining child and adolescent physical and mental health outcomes in communities exposed to frequent disasters and ongoing environmental stressors.

Running and Reading Remnant Danwei Walls in China's Postsocialist City

Built on visual and running/walking ethnography, this article analyzes visual traces left on remnant danwei walls in postsocialist China. The article considers danwei walls as yiji (remnant traces) that serve as loci of political memory and as a medium to host other visual traces by a variety of different actors. Drawing on a range of concepts from cultural studies and visual ethnography, the article provides a close reading of these traces, treating them as important historical documents and examples of how human actors interact with the built environment during China's postsocialist transformation. The article is built around three case studies, each of which captures different stages of the physical decay of the danwei as represented in the materiality of the walls in varying states of (dis)repair and the different nature of the visual traces local actors have left on them. The analysis of traces—understood as signs on the walls as well as the walls themselves—reveals a story of the ways in which humans interact with a very specific part of China's built environment at a moment of transition and of how relationships between these human actors change in the process. The article provides a reading of visual social phenomena, contributing to the understanding of signifying practices in postsocialist urban China.

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody.

Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we examine the dosimetry in beagle dogs and cross-reactivity with human tissues of a novel human antibody, IF3, that targets the insulin growth factor receptor type 2 (IGF2R), which is overexpressed on OS cells, making it a candidate for radioimmunotherapy of OS. [89Zr]Zr-DFO-IF3 was injected into three healthy beagle dogs. PET/CT was conducted at 4, 24, 48, and 72 h. RAPID analysis was used to determine the dosimetry of [177Lu]Lu-CHXA"-IF3 for a clinical trial in companion dogs with OS. IF3 antibody was biotinylated, and a multitude of human tissues were assessed with immunohistochemistry. PET/CT revealed that only the liver, bone marrow, and adrenal glands had high uptake. Clearance was initially through renal and hepatobiliary excretion in the first 72 h followed by primarily physical decay. RAPID analysis showed bone marrow to be the dose-limiting organ with a therapeutic range for 177Lu calculated to be 0.487-0.583 GBq. Immunohistochemistry demonstrated the absence of IGF2R expression on the surface of healthy human cells, thus suggesting that radioimmunotherapy with [177Lu]Lu-CHXA"-IF3 will be well tolerated. Image-based dosimetry has defined a safe therapeutic range for canine clinical trials, while immunohistochemistry has suggested that the antibody will not cross-react with healthy human tissues.

Psychological distance and physical distance induced residents' heterogeneous willingness to pay for transboundary watershed ecosystem services in the Wei River Basin, China.

Under the framework of payment for transboundary watershed ecosystem services (ESs), identifying midstream and downstream residents' preference and willingness to pay (WTP) for ESs provided by the upstream is crucial for sustainable watershed management. The residents' preferences and WTP are not evenly distributed within the watershed. This study uses a choice experiment assessing the spatial impact of physical distance (including residents' watershed location and distance to waterbody) and psychological distance on residents' preference and WTP for the Wei River Basin ESs. The results showed that midstream and downstream residents' preference and WTP for the ecological attributes have a significant distance-decay effect, either the physical distance to the upstream exit or physical and psychological distance to the waterbody. However, compared with the residents in the midstream, the residents downstream have a stronger preference and WTP for upstream ecological governance. Besides, the distance-decay effect differs between urban and rural residents. There is a psychological distance-decay effect in rural residents' preference for water quality and a physical distance-decay effect in their preference for water quantity, entertainment area, and cost; there is a physical distance decay effect in urban residents' preference for entertainment areas. The above differences lead to heterogeneity in WTP and total economic value (TEV) for ESs. When calculating the TEV of the transboundary watershed ES and charging the public, policymakers should consider the location of the residents, the physical and psychological distance to the water body, and the difference between urban and rural areas.