ABSTRACT Public spaces have many tangible health benefits for children. This paper draws on the work developed by the authors working closely with UNICEF, UN-Habitat, and WHO to conceptualize, research, and write the principles and guidance of public spaces for children and a compendium of 50 case studies. For this paper, the authors selected eight case studies that directly or indirectly address children’s physical and mental health as a rationale for urban transformations and the development of public spaces within neighbourhoods and local areas using evidence-based health-promoting strategies. The analysis within and across cases understands some of these strategies, and the degree of urban transformation achieved as measured through changes in the physical and social environments and institutional arrangements. The case studies demonstrate it is possible to develop safe and vibrant public spaces within neighbourhoods through equity-focused planning to reduce health disparities for children and adolescents. Lessons are drawn for scaling up niche ideas to create healthy cities and neighbourhoods for children while also addressing the gaps, most notably that of insufficient efforts devoted to moving beyond assumptions of health benefits to actually making visible the health impacts of the interventions.