Combination Of Physical Activity Research Articles

Physical activity in the prevention and treatment of osteoporosis: From biomarkers to quality of life

Introduction and Objective: Osteoporosis is a common skeletal disease typified by diminished bone density and deterioration of bone structure. It represents a significant risk factor for fractures, particularly in postmenopausal women. This study evaluates the role of physical activity and bone biomarkers in the prevention and treatment of osteoporosis. Review and Methods: A review of the literature was conducted with the objective of analysing the impact of weight-bearing exercise and resistance training on bone health and the use of biomarkers in diagnosing and monitoring osteoporosis. Moreover, the potential impact of dietary interventions and supplementation was examined. Abbreviated Description of the State of Knowledge: It is of the utmost importance to engage in regular physical activity, particularly weight-bearing exercises, in order to prevent and treat osteoporosis. It has been demonstrated to enhance bone density and moderate the likelihood of fracture. Biomarkers such as osteocalcin and alkaline phosphatase are of significant value in the assessment of bone health. Summary: The combination of physical activity, a balanced diet and appropriate supplementation is fundamental to the prevention and effective management of osteoporosis. This approach confers substantial benefits with respect to bone health and quality of life. Keywords: Osteoporosis; Physical activity; Bone health; Skeletal System

Combined Exercise and Diet Induce Airway Hyperreactivity While Reducing Liver Steatosis in Mice with Diet-Induced Obesity.

Obesity is a multi-organ system disease, which is associated with, e.g., a higher prevalence of non-alcoholic fatty liver disease (NAFLD) and asthma. Little is known regarding the effect of obesity-related parameters (including liver integrity) and the respiratory phenotype after a combination of physical activity and diet. Thirty-two C57BL/6 mice were, after 27 weeks of a high fat diet (HFD), randomly assigned to two dietary interventions for three weeks: a HFD or a normal chow diet (NCD). In both dietary groups, half of the animals were subjected to a sub-maximal exercise protocol. Lung function, lung inflammation, liver histology, and metabolic profile were determined. Mice with obesity did not show airway hyperreactivity after methacholine provocation. Sub-maximal exercise with diet (NCD/E) induced a significant reduction in forced expiratory volume in 0.1 s after methacholine provocation. NCD/E had significantly more neutrophils and inflammation (IFN-γ, TNF-α, IL-4, and IL-17F) in bronchoalveolar lavage compared to non-exercising mice on a HFD (HFD/NE). However, more epithelial injury (serum surfactant protein D and IL-33) was seen in HFD/NE. Additionally, hepatic steatosis and fibrosis were reduced by combined diet and sub-maximal exercise. Combining sub-maximal exercise with diet induced airway hyperreactivity and pulmonary inflammation, while body weight, hepatic steatosis, and fibrosis improved.

The impact of social participation on the health status of the older adult: An empirical study based on CGSS 2021 data.

With the rapid pace of population aging, the health issues of the older adult have garnered widespread attention. Social participation plays a pivotal role in the health of the older adult. This study aims to explore the impact of social participation on the health status of the older adult. Using a binary logistic regression model, this study analyzes the influence of social participation methods on the health status of older adult individuals in China based on cross-sectional data from the "China Comprehensive Social Survey" in 2021. The study sample comprises individuals aged 60 to 99 years. It was found that participation in physical activities [P<0.001, OR = 1.907], social and recreational activities [P<0.001, OR = 1.387], and online activities [P<0.001, OR = 1.808] were significantly positively correlated with the health status of the older adult. The health of older adults is influenced by a combination of physical activities, social and recreational activities, and online activities. Good health is closely associated with high levels of physical activity. Engaging in physical exercise promotes physiological health, while participating in social and recreational activities has a significant impact on cognitive and depressive states. Additionally, involvement in online activities helps alleviate feelings of loneliness and enhances overall well-being. 1)Promote the development of physical activities for the older adult: Create an integrated environment for physical exercise. 2)Expand the social circle of the older adult: Construct diverse and structured communities to enhance well-being. 3)Develop online activities for the older adult: Facilitate their integration into the digital age. 4)Foster interdisciplinary collaboration for older adult health: Build partnerships across various domains to promote older adult health.

Visual environment in schools and student depressive symptoms: Insights from a prospective study across multiple cities in eastern China

ObjectiveTo investigate the effects of the school visual environment on depressive symptoms in children and adolescents based on cohort study in eastern China. The school visual environment-related indicators included in this study comprise personal factors (visual impairment) and school-related factors (classroom lighting, school green spaces and school air quality). MethodThe follow-up cohort comprises 15,348 students from 283 primary and secondary schools in eastern China. This represents the one-year outcomes of a school-based myopia-mental health cohort study. Data collection includes basic demographics (age, gender, region, etc.), physical examination indicators, behavioral indicators, and school visual environment-related indicators. ResultAfter a one-year follow-up, we found that compared to the more severe vision impairment group (≤4.0), healthy vision group (≥5.0) had a positive effect against the occurrence of depressive symptoms during consecutive follow-ups, with an RR value of 0.61 (95% CI: 0.57–0.66). Higher values of blackboard illumination appear to be associated with greater positive effects, with an RR (Q75%∼Q100% range) value of 0.87(95% CI: 0.81–0.93). School green spaces seem to exhibit relatively good positive effects when in the Q25%∼Q75% range. The combination of physical activity (Weekly high-intensity exercise) with school air quality(PM2.5≤50%)showed a better positive effect, with an RR value of 0.51(95%CI:0.48–0.55). ConclusionWhen addressing students' depressive symptoms, it is crucial to improve the visual environment both at the school level and in students' personal level. Paying appropriate attention to modifiable behaviors, like regular participation in high-intensity exercise sessions, can help alleviate students' depressive symptoms.

THE HEALTH IMPACT OF TOURISM ON THE PSYCHOPHYSICAL STATE OF ELDERLY INDIVIDUALS

The purpose of our research is to ascertain the impact of tourism activities on the psychophysical state of elderly individuals. Materials and methods. 221 people took part in the transformative experiment aged 60-65, who attend the University of the Third Age (152 women and 69 men). It is worth mentioning that the frequency of classes at the University of the Third Age was 3 classes per week, lasting 40-60 minutes. The program is designed for 6 months and consists of preparatory (adaptation), main (improvement) and supporting periods. Each of the periods was aimed at achieving a set of tasks. To assess the quality of life SF-36 was used. To assess the satisfaction of the participants' lives, the Life Satisfaction Index (LSIA). Physical activity was evaluated using the PWC150 test. The level of success in psychosocial adaptation was assessed using a modified Rogers and Diamond questionnaire. Mind performance was assessed using Bourdon's correction test. The Wilcoxon test was used to analyze the statistical significance of the differences between the data. In each case, the hypothesis was tested, and the p-value was calculated. Conclusions regarding the significance of testing were made at the 0.05 significance level. In the conditions of the University of the Third Age, during the implementation of the concept, positive dynamics of indicators of motor activity, quality and satisfaction with life, mental and physical working capacity, rates of aging, socio-psychological adaptation, cognitive functions, psycho-emotional state were fixed. However, we note significant changes in integral indicators of socio-psychological adaptation at the end of the study, namely, in the indicators of self-perception (women – 68.8 ± 0.7 points; men – 78.8 ± 4.1 points) and emotional comfort (women 63.3 ± 1.7 points ; men 69.2 ± 1.2 points) (p=0.05). As was anticipated, for elderly individuals who continue self-education in their later years, the tourism program had a positive impact on cognitive functioning indicators. Conclusion. Involvement in health tourism has a positive impact on the psychophysical state of elderly individuals. The combination of physical activity, social interaction and the acquisition of new experiences contributes to the improvement of emotional, physical and cognitive health.

Physical Activity and Engagement Coping: A Key for Stress-Recovery in Mexican University Students

Physical activity and coping styles are factors that contribute to health status and to the reduction of stress. The aim of this research was to analyze the influence of physical activity and coping styles on recovery-stress state among Regular Physical Activity University Students (n = 67) and High-Performance University Athletes (n = 67) from a Mexican university. The results show statistically significant differences in the capacity of recovery from stress in High-Performance University Athletes. Additionally, two positive correlations emerged: one of engagement coping and recovery, and one of disengagement coping and stress. The interaction between engagement coping and physical activity predicted general well-being. In females, the engagement coping style predicts recovery from stress. We concluded that physical activity in combination with an engagement coping style contributes to the development of health in university students.

Nighttime Bracing or Exercise in Moderate-Grade Adolescent Idiopathic Scoliosis

Moderate-grade adolescent idiopathic scoliosis (AIS) may be treated with full-time bracing. For patients who reject full-time bracing, the effects of alternative, conservative interventions are unknown. To determine whether self-mediated physical activity combined with either nighttime bracing (NB) or scoliosis-specific exercise (SSE) is superior to a control of physical activity alone (PA) in preventing Cobb angle progression in moderate-grade AIS. The Conservative Treatment for Adolescent Idiopathic Scoliosis (CONTRAIS) randomized clinical trial was conducted from January 10, 2013, through October 23, 2018, in 6 public hospitals across Sweden. Male and female children and adolescents aged 9 to 17 years with an AIS primary curve Cobb angle of 25° to 40°, apex T7 or caudal, and skeletal immaturity based on estimated remaining growth of at least 1 year were included in the study. Dates of analysis were from October 25, 2021, to January 28, 2023. Interventions included self-mediated physical activity in combination with either NB or SSE or PA (control). Patients with treatment failure were given the option to transition to a full-time brace until skeletal maturity. The primary outcome was curve progression of 6° or less (treatment success) or curve progression of more than 6° (treatment failure) seen on 2 consecutive posteroanterior standing radiographs compared with the inclusion radiograph before skeletal maturity. A secondary outcome of curve progression was the number of patients undergoing surgery up until 2 years after the primary outcome. The CONTRAIS study included 135 patients (45 in each of the 3 groups) with a mean (SD) age of 12.7 (1.4) years; 111 (82%) were female. Treatment success was seen in 34 of 45 patients (76%) in the NB group and in 24 of 45 patients (53%) in the PA group (odds ratio [OR], 2.7; 95% CI, 1.1-6.6). The number needed to treat to prevent curve progression with NB was 4.5 (95% CI, 2.4-33.5). Treatment success occurred in 26 of 45 patients (58%) in the SSE group (OR for SE vs PA, 1.2; 95% CI, 0.5-2.8). Up to 2 years after the primary outcome time point, 9 patients in each of the 3 groups underwent surgery. In this randomized clinical trial, treatment with NB prevented curve progression of more than 6° to a significantly higher extent than did PA, while SSE did not; in addition, allowing transition to full-time bracing after treatment failure resulted in similar surgical frequencies independent of initial treatment. These results suggest that NB may be an effective alternative intervention in patients rejecting full-time bracing. ClinicalTrials.gov Identifier: NCT01761305.

The combination of physical activity with fruit and vegetable intake associated with life satisfaction among middle-aged and older adults: a 16-year population-based cohort study

BackgroundLife satisfaction (LS) is part of a positive psychological feeling that protects individuals from a physical decline in old age. A healthy lifestyle, including physical activity (PA) and a healthy diet, such as the intake of fruits and vegetables (F&V), can lead to a better experience of LS in older adults. However, the association between PA and F&V intake habits when occurring together in older adults is still unclear for LS. The study aimed to investigate the combined association of PA and F&V intake on LS among a cohort of older Taiwanese adults.MethodsFive waves of population-based data gathered by the Taiwan Longitudinal Survey on Aging between 1999 and 2015 were analyzed. The year 1999 was set as the baseline, and the number of respondents was 4,440. The independent variables included the frequency, duration, and intensity of PA and the frequency of F&V intake. LS was assessed by using the Life Satisfaction Index. We performed generalized estimating equations (GEE) analysis with adjustment for covariates of health behaviors and health indicators.ResultsAfter adjusting for confounders, model 1 showed that moderate and high-PA levels significantly correlated with LS (odds ratio [OR] = 1.41, 95% CI = 1.12–1.79) and OR = 1.74, 95% CI = 1.50–2.02). Moreover, high-F&V intake significantly correlated with LS (OR = 2.07, 95% CI = 1.69–2.53). Regarding the combined association shown in model 2, compared with both the low PA and F&V intake group, there were significantly higher LS in the both-high-group (OR = 4.69, 95% CI = 3.49–6.31), only-high-F&V intake (OR = 2.87, 95% CI = 2.14–3.85), only-high-PA (OR = 2.48, 95% CI = 1.74–3.52).ConclusionsOur findings show the significant combined association of PA and F&V intake on LS among older adults. In addition, older adults who engaged in higher frequency, duration, and intensity of daily PA combined more than seven times a week of F&V intake had significantly higher LS than those who only engaged in low PA or only intake less F&V. Adopting multiple healthy behaviors in daily life is a safe and effective approach to promote LS among older adults.

The relationship between the gut microbiome and resistance training: a rapid review

The human gut microbiome is attracting increasing attention because of its overall effect on health. Several reviews have investigated the impact of physical activity on the gut microbiome; however, these predominantly concentrate on either endurance or a combination of physical activities. This study aims to describe the effect of resistance or strength training on the gut microbiome of a human population. This rapid review follows the guidelines of the Cochrane Rapid Reviews Guidance along with PRISMA. A review of the literature was carried out using articles indexed by PubMed, Scopus, and Web of Science published in the last 12 years. None of the seven studies included find significant change in the gut microbiome in terms of bacterial taxa composition or overall diversity, though the results show that resistance training might decrease the zonulin level and increase mucin production and thereby reduce inflammation in the gut. Interestingly, two studies point to a gut-muscle axis connection and this is discussed in our paper. However, due to the small number of existing studies and certain methodological disagreements, it was hard to find a consensus on the relationship between the gut microbiome and resistance training.

IMPLEMENTING OF BOXING ELEMENTS IN THE PROCESS OF PHYSICAL EDUCATION IN GENERAL SECONDARY EDUCATION INSTITUTIONS IN EUROPE AND UKRAINE

Introduction. The lack of physical activity among the youth of Ukraine is increasing every year. In recent years, there has been an increasing trend of lack of interest among students in physical education classes. This is due to the fact that the content of physical education lessons at school is not interesting and of little use, it has hardly changed since the independence of Ukraine, and there are also no sports for students to choose from. One of the ways to modernize the content of the physical education process is the inclusion in the program of the subject "Physical culture" of exercises borrowed from such a sport as boxing [7, 8, 9]. The aim of the study is to analyze and summarize the application of boxing elements in the process of physical education in educational institutions in European countries. Material and methods: analysis and synthesis of data from scientific-methodical literature sources and informative data from the Internet to clarify the key features of using boxing elements in general secondary education institutions in Europe. Results. In many European countries, boxing as a school sport is becoming more and more popular, it is often recognized as a valuable tool not only for the physical development of students, but also for improving discipline and self-confidence [7, 9]. The combination of physical activity and thinking makes boxing an exciting sport that goes far beyond the simple study of punching techniques. In this article, we will consider the prospects of using boxing tools in the process of physical education and emphasize the numerous advantages. Conclusions. Based on the analysis of the experience of implementing boxing into the physical education process in educational institutions in Switzerland, Germany, and Ukraine, it can be concluded that integrating boxing into the physical education curriculum in educational institutions can make a significant contribution to enhancing the physical education process in Ukraine.

Early Childhood Role Models and Gross Motor Activities Could Assist to Build a Sense of Enterprise in Kids

This study explores the impact of gross motor activities and role-play centers on cultivating entrepreneurial spirit in early childhood. Employing both qualitative and quantitative methods, the research involved 50 children aged 4-6 years from various kindergartens. Gross motor activities such as running and jumping were integrated with role-playing games that included simulations of small business activities. The study found that a combination of physical activities and social role-playing significantly enhanced the children’s cognitive, social, and emotional skills, which are crucial components of an entrepreneurial mindset. Results showed improvements in self-confidence, creativity, and collaborative abilities in children, in addition to strengthening their understanding of basic business and economic concepts. These findings highlight the importance of incorporating entrepreneurial education in early childhood curriculums, laying the foundation for the development of entrepreneurial skills and attitudes for the future.

The effect of the physical exercise on the redox status of chil- dren with repaired congenital heart diseases

Purpose. Evaluation of the impact of the physical rehabilitation program with the inclusion of ubidecarenone on the redox status in children with repaired congenital heart diseases. Material and methods. Markers of free radical oxidation (lactate, pyruvate, lactate-to-pyruvate ratio) and antioxidant system (catalase, reduced glutathione and glutathione peroxidase) were studied in 84 children, including 48 children with repaired congenital heart diseases and 36 healthy peers. The main group consisted of 28 patients who performed a rehabilitation program using physical activity in combination with taking ubidecarenone for a year, the comparison group consisted of 20 children who received only ubidecarenone. Results. After the rehabilitation program was completed, both the main group and the comparison group had a significant (p &lt; 0.05) decrease in lactate levels, the ratio of lactate to pyruvate, and an increase in catalase and reduced RBC glutathione. The group of children who performed physical exercises had significantly lower levels of markers of free radical oxidation and higher values of markers of the antioxidant system than the patients from the comparison group. Conclusion. There are free radical oxidation and the antioxidant system impairments in children with repaired congenital heart diseases. The use of ubidecarenone reduces oxidative stress and increases antioxidant protection in children with repaired congenital heart diseases. The inclusion of physical activity in the rehabilitation program for children with repaired congenital heart diseases improves the redox status and increases the effectiveness of rehabilitation.

Physical Activity Plus Acceptance and Commitment Therapy Can Decrease Anxiety Symptoms and Insomnia Severity Among Individuals With Poor Sleep Quality

Background and Objective During the COVID-19 pandemic, there were increased reports of sleep problems. Individuals with poor sleep quality are at particular risk of reporting symptoms of anxiety, depression, and poor quality of life, along with substance abuse. The present study aimed to examine the effectiveness of combined physical activity and acceptance and commitment therapy (ACT) on anxiety and depressive symptoms and insomnia severity among individuals with poor sleep quality.Methods Participants were 60 males and females with mean age (standard deviation) of 39.29 (5.82) years. Participants were randomly divided into 4 groups of 1) physical activity, 2) ACT, 3) combination of physical activity and ACT, and 4) control. The study consisted of four stages: pre-test, interventions, post-test, and follow-up. Repeated measures analyses of variance were used to assess time by group interactions.Results The results showed that the symptoms of anxiety and depression and sleep problems were reduced for the physical activity, ACT, and combined groups, compared to the control group (p = 0.001). Superiority in all outcomes of the combined group was shown, compared to the other groups.Conclusions The present findings suggest that among individuals with poor sleep quality, combined physical activity and ACT intervention has the potential to reduce symptoms of anxiety and depression and insomnia severity. It further appears that health organizers should pay more attention to physical activity interventions in individuals with poor sleep quality.

Associations between changes in physical activity and perceived social exclusion and loneliness within middle-aged adults – longitudinal evidence from the German ageing survey

BackgroundPrevious research showed negative associations between physical activity and loneliness in older adults. However, information on associations among middle-aged adults is scarce. In this prognostic factor study, we investigated if starting or stopping to follow the WHO physical activity recommendations was associated with changes in perceived social exclusion and loneliness in this age bracket.MethodsWe used longitudinal representative data of participants aged 40 to 64 years from the German Ageing Survey waves in 2014 and 2017 (analytical sample = 4,264 observations, 54% women). Perceived social exclusion was investigated with the scale from Bude and Lantermann. Loneliness was quantified with the 6-items loneliness scale from De Jong Gierveld. Information from the International Physical Activity Survey items on the time spend in moderate and vigorous physical activity per week was dichotomized. Participants were coded as either following or not following the WHO´s physical activity recommendations of spending at least 150 min of moderate, 75 min of vigorous or an appropriated combination of physical activity per week. We investigated the within (individual) association between starting and stopping to follow WHO´s physical activity recommendations and perceived social exclusion as well as loneliness in asymmetric fixed effects regressions. Analyses were adjusted for age, marital status, employment status, social-network size, general self-efficacy, depressive symptoms, self-rated health, BMI, comorbidities, and physical functioning (SF-36).ResultsStopping to follow the physical activity recommendations from the WHO was associated with perceived social exclusion (ß= 0.09 p = 0.04) but not with loneliness (ß=-0.01, p = 0.71). Starting to follow the WHO physical activity recommendations was neither associated with social exclusion (ß=-0.02, p = 0.54) nor with loneliness (ß=-0.01, p = 0.74) in adjusted asymmetric fixed effects regressions.ConclusionIn middle-aged adults, longitudinal associations were found for physical activity and perceived social exclusion. Perceived social exclusion may be prevented by maintaining at least 150 min of moderate physical activities per week, which is the WHO physical activity recommendation. Future research should investigate moderators and mediators in the association between physical activity and social exclusion as well as loneliness.

The effect of different combinations of physical activity and natural environment videos on children's attention levels between class breaks

BackgroundPhysical activity intervention and watching natural environment videos have been proven to improve young children’s attention levels. However, evidence comparing the improvement effects of different combinations of the two activities has rarely been reported. By comparing the differences in the improvement effects of four combinations of physical activities and watching natural environment videos on young children’s attention levels, this study can enrich the evidence in this research field and also provide a reference for arranging effective intervention methods for children’s attention recovery between classes.MethodA total of 152 children aged 4 to 6 years were recruited and randomly divided into four intervention groups: (1) physical activity intervention first and thereafter watching a natural environment video group (activity + video group), (2) watching a natural environment video first and thereafter the physical activity intervention group (video + activity group), (3) physical activity-based group, and (4) natural environment video-based group. Physical activity involved 4 min of moderate-intensity basic physical fitness combination training. The subjects wore the Pico Neo pioneer version of the VR glasses all-in-one machine to watch a natural environment video. Thereafter, population sociological variables and daily physical activity levels were investigated. Auditory and visual sustained attention tests were performed before and after intervention in each group.ResultThe auditory attention post-test scores of the four groups showed an improvement trend compared with the pretest scores. In particular, the activity + video group (F = 10.828; ɳp2 = 0.226; p = 0.002) and natural environment video-based group (F = 9.452; ɳp2 = 0.203; p = 0.004) have the best improvement effect. For visual attention, only the activity + video group showed a significant improvement trend (F = 4.287; ɳp2 = 0.104; p = 0.045), while the other three groups showed a downward trend in scores.ConclusionsAmong the different intervention combinations, the physical activity intervention first and watching natural environment videos thereafter group has the best effect on improving children’s attention during recess. Physical activity interventions at the end of recess adversely affect young children’s visual attention levels at the beginning of the class. Therefore, this study recommends that children should not engage in physical activity interventions in the second half of the class break. Lastly, the current research recommends presenting the content of physical activity interventions first and further improving their attention thereafter by watching natural environment videos.

A Review Article: The Combination of Physical Activity and Healthy Diet in Adolescents to Prevent Diabetes Mellitus

Diabetes Mellitus is a metabolic disorder marked by hyperglycemia and caused by insulin deficiency or insulin resistance. Teenagers can be affected by diabetes mellitus as well as adults and the elderly. Disease prevention efforts are one method of reducing the risk factor. A combination of physical activity and healthy diet can help control risk factors, especially in teenagers. Purpose: for the investigation and identification of various research findings relating to the influence of physical activity and healthy diet on the prevention of diabetes mellitus in adolescents Method: a method study which we use in the form of analytical content to build a review article by identifying, reviewing, and evaluating all related research with an influence on the combination of physical activity and healthy diet in adolescents. The source of data in review articles is Google scholar, PubMed, and Science Direct with the key words "Diabetes mellitus", "Physical activity", and "healthy diet. We found 5.000 related articles using search engines as our article data source. Out of 100 articles, only 10 articles were eligible for literature review. People who don't do physical activity have a higher risk of having diabetes mellitus by 3,198 times, compared to people who do physical activity heavily every day. People who consume food processed from flour like a biscuit have a 1.198 times greater risk of having diabetes mellitus compared with people who never consume food processed from flour. Activity physically is greatly influenced by its intensity, so it will have an effect on the rate of glucose in the blood. Based on the literature review, we do show that in the age group of adolescents, prevention of diabetes mellitus can be conducted with combining physical activity with dietary pattern. This thing is related to insulin secretion, so glucose homeostasis can be more awake. Nonetheless, more research is needed to account for other diabetes risk factors, such as overweight and obesity, genetics, and a healthy lifestyle pattern.

Abstract P010: Molecular mediators of the energy balance-colorectal cancer link: evaluating the gut microbiome and pro-inflammatory biomarkers

Abstract Background: Physical activity and BMI are convincingly associated with colorectal cancer risk, yet the underlying molecular mediators and their interplay in the energy balance-cancer link remain unclear. Possible counteracting effects of physical activity on obesity-induced metabolic changes, including systemic inflammation and changes in the gut microbiome, have yet to be studied. Here, we investigated associations of several combinations of physical activity and BMI with pro-inflammatory biomarkers and the gut microbiome and relationships between these two mediators among patients with colorectal cancer. Methods: N=579 patients with newly diagnosed colorectal cancer (stages I-IV) were included. Physical activity at baseline was assessed using an adapted International Physical Activity Questionnaire (IPAQ) and participants were classified as being ‘active’ or ‘inactive’ based on physical activity guidelines. BMI at baseline was abstracted from medical records and categorized into ‘normal weight’ and ‘overweight/obese’. Pro-inflammatory biomarkers (CRP, SAA, IL-6, IL-8, and TNF-α) were measured in pre-surgery serum samples. In a subset of patients (n=179), 16S rRNA gene sequencing was additionally performed in pre-surgery stool samples. Relative abundances were determined for each taxonomic level and used to calculate diversity metrics. Analyses were adjusted for sex, stage at diagnosis, neoadjuvant treatment, and study site. Results: ‘Obese’ patients had 88% and 17% higher CRP and TNF-α levels compared to ‘normal weight’ patients (p=0.03 and 0.02, respectively). Highest CRP levels were observed among ‘overweight or obese/inactive’ compared to ‘normal weight/active’ patients (p=0.03). Lower gut microbial diversity was observed among ‘inactive’ vs. ‘active’ patients (Shannon index: p=0.01, Simpson: p=0.03), ‘obese’ vs. ‘normal weight’ patients (Shannon index, Simpson, and Observed species: p=0.02, respectively), and ‘overweight or obese/inactive’ vs. ‘normal weight/active’ patients (Shannon index: p=0.02, Observed species: p=0.04). Two phyla and 12 genera (e.g., Actinobacteria and Fusobacteria, and Ruminococcus, Succinivibrio, Succiniclasticum) were differentially abundant across physical activity and BMI groups. High CRP and TNF-α levels were statistically significantly associated with lower alpha diversity metrics (p=0.02-0.05). Conclusions: This is the first evidence indicating that the gut microbiome may be a molecular mediator of the energy balance-colorectal cancer link. We further provide evidence of associations between physical activity and BMI groups with pro-inflammatory biomarkers. While BMI was identified as the key driver of inflammation, biomarker levels were higher among ‘inactive’ patients across BMI groups. Physical activity may offset obesity-induced inflammation and gut microbiome dysbiosis. Our results further provide new insights into the host-microbiome interactions with respect to systemic inflammation. Citation Format: Caroline Himbert, W. Zac Stephens, Biljana Gigic, Tengda Lin, Jennifer Ose, Anjelica Ashworth, Christy Warby, David Nix, Jolanta Jedrzkiewicz, Anita R Peoples, Mary Bronner, Bartley Pickron, Courtney Scaife, Jessica N. Cohan, William M. Grady, Stacey A. Cohen, Mukta Krane, Petra Schrotz-King, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, Christopher I. Li, Alexis Ulrich, David Shibata, June L. Round, Lyen C. Huang, Martin Schneider, Sheetal Hardikar, Cornelia M Ulrich. Molecular mediators of the energy balance-colorectal cancer link: evaluating the gut microbiome and pro-inflammatory biomarkers. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P010.

THE EFFECT OF PHYSICAL ACTIVITY ON THE PREVENTION AND NUMBER OF FALLS IN ELDERLY PEOPLE

Regular physical activity can bring significant health benefits to people of all ages, and the need for physical activity does not decrease with age, but it has been proven that it can prolong a healthier and more independent life, prevent disability and significantly contribute to improving the lives of the elderly. In addition to the fact that each type of physical activity to a certain extent improves motor skills (strength, coordination, balance, agility, ...), mental health (self-esteem, quality of life) and reduces the risk of cardiovascular and all other causes of death, regular participation in exercise promotes mobility and functional independence in adults. A fall is an event in which a participant without their own intention comes to a lying position on the ground or at a lower level. Regardless of the health status of the individual, falls are associated with insufficient movement, reduced opportunities to perform daily activities (dressing, bathing, housework, ...) and the risk of being admitted to institutions where the care of dependent persons is taken. Arthritis, depression, cognitive impairment, vision, problems with balance and unbalanced gait, decreased muscle mass, as well as excessive use of medication increase the risk of falling. The total volume and type of physical activity needed by the elderly is not very well defined. However, it can be concluded that the combination of physical activity (strength training, endurance training, exercises for the development of balance and mobility, ...) and adequate nutrition (sufficient intake of essential amino acids/protein sources) is of crucial importance for preserving physical condition, motor skills and the health status of persons of the third age, and thus also in the prevention of falls. The aim of this study is to describe and find the best training programs for the prevention of falls in the elderly.

PCR161 Being Active Is Not Enough – Combination of Physical Activity, Sedentary Behaviour and Sleep Characteristic Shows More Positive Effect on Infertility Related Quality of Life in Women Undergoing Art

The relationship between the adherence to 24-hour movement behaviour (24-HMB) and mental-health-related outcomes are well known in general adult population. The current study investigates, whether physical activity (PA), sedentary behaviour (SB) and sleep characteristics (SC) prior to the assisted reproductive treatments associated with infertility related quality of life in women undergoing assisted reproductive technology (ART) treatments.

Interactive Associations between Physical Activity and Sleep Duration in Relation to Adolescent Academic Achievement

The present study aimed to examine independent and interactive associations between physical activity and sleep duration with adolescent academic achievement. This cross-sectional study used data from the 2019 cycle of the US-based Youth Risk Behavior Surveillance System. A total of 13,677 American adolescents in grades 9 through 12 (MAGE = 16.06 ± 1.24 years; 50.9% female) self-reported their sleep and physical activity behavior as well as their grades. Linear regression models fit with cubic splines were computed to capture potential non-linear associations. Findings for the independent effect models revealed significant curvilinear relationships between physical activity and sleep with academic achievement wherein optimal grades were associated with 7-9 h/night of sleep and 5-7 days/week of physical activity. A significant physical activity by sleep interaction was also observed for academic achievement, which demonstrated that the association between sleep duration and academic achievement is not uniform across levels of physical activity engagement, and tradeoffs may exist. Overall, the results help to identify different combinations of physical activity and sleep behavior associated with optimal academic achievement and suggest that a one-size-fits-all approach to physical activity and sleep recommendations may not be adequate for promoting academic achievement during adolescence.