PHQ-9 For Depression Research Articles

Mindfulness-based intervention for hypertension patients with depression and/or anxiety in the community: a randomized controlled trial

ObjectiveTo evaluate mindfulness-based intervention for hypertension with depression and/or anxiety.Methods10-week mindfulness-based intervention, including health education for hypertension, exclusively for the control group, was administered to the intervention group to assist sixty hypertension patients with depression/anxiety. Among them, the intervention group comprised 8 men and 22 women, with a mean age of 60.02 years and a mean duration of hypertension of 6.29 years. The control group consisted of 14 men and 16 women with a mean age of 57.68 years and a mean duration of hypertension of 6.32 years. The severity of depressive and/or anxiety symptoms was assessed using the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7), along with blood pressure (BP) measurements taken twice daily. The study utilized a self-made self-efficacy scale and awareness of physical and mental health to evaluate mental health and state.ResultsThe depression PHQ-9 or GAD-7 scores reduced by 21.1% or 17.8% in the mindfulness-based intervention group, compared to the control (Z = -2.040, P = 0.041) post 10-week period, suggesting significant reduction in anxiety/stress. These results were consistent with a reduction in systolic BP of 12.24 mm Hg (t = 6.041, P = 0.000). The self-efficacy score of the mindfulness intervention group significantly improved compared to the control (t = 7.818, P < 0.001), while the awareness of physical and mental health in the mindfulness intervention group significantly improved compared to the control (χ2 = 5.781, P = 0.016).ConclusionMindfulness-based, short-term focused interventions provide modest relief for depression and/or anxiety and are effective in lowering blood pressure and improving self-efficacy scores.Trial registrationChinese Clinical Trial Registry, ChiCTR1900028258. Registered 16 December 2019, https://www.chictr.org.cn/showproj.html?proj=43627.

Impact of excessive interest in news related to the war on mental health in conditions of big invasion and information war: experience of Ukraine

IntroductionAn important component of the russian-Ukrainian war is information war. russia conducts psychological diversions the purpose of which is harming and disorganization the population’s mental health by reducing the ability of criticality thinking and formation of various stress-associated, anxiety-depressive, phobic, etc. disorders.ObjectivesTo study the impact of information about the war on the mental health of Ukrainian population.Methods186 Ukrainian people voluntarily completed the questionnaire in Google format. It contains tools for assessing the level of stress PTCI, anxiety response GAD-7, depression PHQ-9, the intolerance to the uncertainty (IUS-12 in G.Gromova’ adaptation) and developed by us “Test for the detection of disorders related to the obsession with news about the russian-Ukrainian war” (M.Markova et al, 2022).ResultsMost of the civilian population of Ukraine demonstrate excessive fascination with news associated with the war, with almost 50% have all the signs of clinically formed addiction.Psychopathological anxiety and depressive manifestations of varying intensity are characterized by more than 30% of the population. Almost 80% suffer from the effects of psycho-traumatic factors, of which 45% are observed by post-stress maladaptation, 25% - by signs of PTSD (23%) or PTSD (2%). The presence of anxiety-depressive response does not depend on the level of obsession of the news: among persons with signs and/or clinical psychopathological symptoms, there are persons both excessively passionate about information and with a safe level of use.Any high level of interest of news (addiction/dangerous/risky) has a close direct correlation with the intensity of pathological stressful response and the level of tolerance to uncertainty.All persons with anxiety-depressive and pathological stressful response symptoms, and 58% of people with excessive fascination with news are characterized by low tolerance to uncertainty. This can serve as a prognostic marker of development of maladaptation and testify to the leading role of a lack of tolerance to uncertainty in its development in wartime.42 % of people who have an excessive interest in news, haven’t signs of maladaptive response. They use the interest of information as a stress management’s resource, which has a positive effect on the mental state and increases the ability to successfully function in uncertainty.Conclusions The development of information and psychological stability by increasing tolerance to uncertainty is a perspective area of research in the field of mental protection of the population of Ukraine.Disclosure of InterestNone Declared

Frequency of depression among mental health patients in the POST-COVID-19 ERA.

Objective: The Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) scales were used to determine the frequency of depression and anxiety in COVID-19-positive people. Study Design: Cross Sectional study. Setting: Qateef Hospital Kingdom of Saudia Arabia. Period: 25th April, 2021 to 18th May, 2021. Material &amp; Methods: 450 participants were enrolled in this study. Both genders were included who had COVID positive but suffering from depression and anxiety were included in this study. In this study all participants were completed questionnaires describing their social and demographic status, as well as PHQ-9 for depression and GAD-7 for anxiety. To analyze the continuous and categorical data the SPSS version 20 was used. Results: Over four hundred and fifty subjects participated in this cross-sectional study with the age of 49.91±12.2 years. In addition, according to the findings when the PHQ-9 scoring is significant in old age people whereas the GAD-7 is significantly found in young age. Conclusion: The study found the evidence about the probable psychologic difficulties associated with this pandemic and underline the necessity for PHQ-9 and GAD-7 for assessing mental health. The findings of this research provide light on the emotional condition of post-COVID-19 patients and indicate the necessity for depression and anxiety treatment by a psychiatrist. This research will focus in the future on how strongly depression and anxiety in the participants predict mental disorders following COVID-19.

A Pilot Study Comparing a Community of Practice Program with and without Concurrent Ketamine-Assisted Therapy

ABSTRACT The prevalence of depression, anxiety, and post-traumatic stress disorder (PTSD) has increased among healthcare providers, while the effectiveness of conventional treatments remains limited. Ketamine-assisted therapy offers a promising alternative; however, few have integrated ketamine with a group-based therapeutic modality. We report a retrospective, secondary analysis of a 12-week pilot of a Community of Practice (CoP) oriented group therapy program with optional, adjunct ketamine for depression, anxiety, and PTSD in a sample of 57 healthcare providers. All participants moved through the treatment as one group, with 38 electing to also receive three adjunct ketamine sessions in addition to the weekly CoP. Symptoms were assessed at baseline and pilot completion with the PHQ-9 for depression, GAD-7 for anxiety, and PCL-5 for PTSD. We observed significant reductions in the mean change among all participants, suggesting that benefit was derived from the CoP component, with or without ketamine as an adjunct. PHQ-9 scores decreased by 6.79 (95% CI: 5.09–8.49, p < .001), GAD-7 scores decreased by 5.57 (CI: 4.12–7.00, p < .001), and PCL-5 scores decreased by 14.83 (CI: 10.27–19.38, p < .001). Reductions were larger, but statistically nonsignificant, among those receiving ketamine. Further research is required to assess the impact of ketamine as an adjunct in group-based therapies.

O082 A pilot study on prehabilitation for patients undergoing surgery for cancer

Abstract Introduction In 2022 Nottingham University Hospital NHS Trust (NUH) began offering structured prehabilitation sessions for patients diagnosed with cancer, to help them better prepare for surgical treatment. We have undertaken an audit of patients enrolled onto the programme and examined key outcomes. Methods Patients requiring surgery for cancer were initially assessed (April – Oct 2022) and offered 2-3 prehabilitation sessions per week. During initial and final Prehabilitation assessments, patients completed a sit-stand test, shuttle walk test and Patient Reported Outcome Measures for anxiety (GAD-7) and depression (PHQ-9). Results Two hundred and twelve patients were enrolled onto the prehabilitation programme and 87 (41%) completed the pre- and post-assessment after 3-6 weeks. Colorectal (47, 54%) and gynaecological (17, 22%) surgery represented the two major procedures for those completing the programme. Mean (±sem) physical activity score (140.1±19.4, n=78) was significantly increased (p&amp;lt;0.001) at the end of the programme (315.3±23.8). Mean shuttle walk test score (340.2±28.7, n=54) increased by approximately 15% (p&amp;lt;0.001) at the end of the programme (394±32.8), while the sit-stand test (24.9±1.3, n=64) also improved significantly (30.9±1.5; p&amp;lt;0.001). The mean (±sem) anxiety GAD-7 score (6.06±0.64 n=85) and depression PHQ-9 score (5.38±0.69, n=85) were significantly reduced (p&amp;lt;0.001) by the programme (3.29±0.46 and 2.76±0.45, respectively). Conclusion Initial results from the NUH prehabilitation programme provide evidence for a significant increase in physical activity prior to surgery, accompanied by a general improvement in the mental well-being of the patients.

Impact of the COVID-19 pandemic on the mental health of frontline healthcare workers in a highly affected region in Brazil

BackgroundThe COVID-19 pandemic had a major impact on the mental health of healthcare workers (HCWs), especially in low and middle-income countries, which had to face additional political, social, and economic challenges. We thus aimed to assess the prevalence of mental health outcomes and the associated factors in HCWs treating COVID-19 patients in one of the most affected regions in Brazil.MethodsWe used the Respondent-Driven Sampling method to assess the risks of COVID-19 infection and symptoms of mental disorders in nurses, nursing technicians, and physicians who worked on the frontline in the metropolitan region of Recife. 865 healthcare workers completed a survey regarding sociodemographic data, work-related risks, and symptoms of mental disorders - SRQ-20 for common mental disorders (CMD); AUDIT-C for problematic alcohol use; GAD-7 for anxiety; PHQ-9 for depression; PCL-5 for post-traumatic stress disorder (PTSD). Gile’s successive sampling estimator was used to produce the weighted estimates by professional category. A Poisson regression model with robust variance was used to analyze factors associated with a positive screening for CMD. We will present the results of a cross-sectional analysis of the mental health outcomes after the first peak of COVID-19 – from August 2020 to February 2021.ResultsThe prevalence ratios for a positive screening for CMD were 34.9% (95% CI: 27.8–41.9) in nurses, 28.6% (95% CI: 21.3–36.0) in physicians, and 26.6% (95% CI: 16.8–36.5) in nursing technicians. Nurses presented a higher prevalence of depressive symptoms (23%). Positive screening for problematic alcohol use (10.5 to14.0%), anxiety (10.4 to 13.3%), and PTSD (3.3 to 4.4%) were similar between the professional categories. The main factors associated with CMD in nurses and physicians were related to an intrinsic susceptibility to mental illness, such as previous or family history of psychiatric disorder, and female sex. Among nurse technicians, work-related factors, such as accidents with biological material, presented the strongest association with CMD.ConclusionThe mental health of HCWs fighting COVID-19 in Recife was severely affected. It is crucial that healthcare services provide adequate working conditions and psychological support, investing in programs to promote and protect HCWs mental health.

Mental Health during fatherhoood. Biopsychosocial aspects and questionnaire for depression PHQ9

IntroductionBoth women and men experience potentially stressful events during their reproductive periods and both are at risk of developing peripartum depression. Men have a reproductive period that is difficult to define, and research on their mental health has rarely considered the effects of paternity. A prevalence of postpartum depressive symptomatology of 10.4% has been described worldwide (Paulson J et al. 2010). Paternal depression is also a risk factor for peripartum maternal depression (Escribá et al, 2011; Paulson et al., 2016). Among the risk factors for developing postpartum depression in men are identified: personal history of depression, conflictive relationship, lack of family and social support, unemployment, older age, lower educational level, and the father’s ability to support his new role as a father (Morse et al., 2000).ObjectivesScreening to investigate and identify early objective biomarkers in recent fathers of early depression.MethodsAn anonymous survey is carried out through GoogleForms, to 57 men, fathers, with children born alive under 1 year of age, which includes biopsychosocial aspects and a questionnaire for depression: PHQ9.ResultsOf the total of 57 parents, the average age is 36 years. 4 of them are unemployed, 1 is a student, the rest have active work or parent´s licency. Only 10% refer to present economic problems. 36% reported that their partner had a risky pregnancy and 22% had a peripartum complication. 9% describe an unsatisfactory or very unsatisfactory relationship with the mother of their child(ren). 51% have a personal and/or family history of depression and/or anxiety. 57% are overwhelmed in their role as fathers. 33% feel they have little or no social/emotional support. 5% have increased the consumption of alcohol/psychotropic medication and 94% report that their sleep pattern has been affected. 3.5% refer self-injurious thoughts or that they would be better off dead. 14% have considered requesting/consulting with a psychiatrist/psychologist since the arrival of the baby.In relation to PHQ 9, 5% present moderate/severe depression.ConclusionsIn conclusion, it seems relevant to think about a screening to investigate and identify early objective biomarkers and rapid intervention, not only in mothers but also in fathers and thus take a first step to broaden the view from the mother-child dyad to the triad, thus understanding that mental health does not exist in isolation, it is a contextual and relational phenomenon and also reduce the negative impact of this problem, such as: dysfunction and family well-being, marital satisfaction, growth and development of your child/ren . In this context, primary care health professionals (midwives and primary care doctors) could play a fundamental role in recognizing the importance of incorporating parents as relevant figures in health .Disclosure of InterestNone Declared

Impact of COVID-19 on Rocky Vista University medical students' mental health: A cross-sectional survey.

The COVID-19 pandemic brought immense changes to medical school curriculums world-wide, such as the widespread adoption of virtual learning. We sought to better understand the impact on medical students' mental health at Rocky Vista University College of Osteopathic Medicine, Parker, CO, United States. This study assessed the impact the pandemic had on anxiety and depression levels of medical students. It also assessed the impact of several domains on student mental health during the pandemic and how various sub-groups within the studied population were affected. A cross-sectional survey was sent to students through an online anonymous google survey in May to June 2021, centered around the 7-item questionnaire used to screen for Generalized Anxiety Disorder GAD-7, 9-item questionnaire used to screen for depression PHQ-9, and self-designed questions to assess the personal impact of the pandemic. Data obtained were screened for error and analyzed with significance value of p < 0.05. A total of 152 responses were received (25.5% response rate). Of these, 64.1% identified as female, 75.8% were white, 50.3% were between ages 21-25, and 77.8% were first year medical students. During the pandemic, 79.6% of respondents felt more anxious and 65.1% felt more depressed. 67.8% of students reported feeling social isolation amidst the pandemic. Students living with friends were more likely to see a therapist for depression during the pandemic (p = 0.0169) and prescribed an antidepressant (p = 0.0394). Females and students in relationships were more likely to score higher on GAD-7 (p = 0.0194) and (p = 0.0244), respectively. This study investigated the effect of the pandemic on medical students' mental health and the need to address this issue. Results suggest that the pandemic had a negative impact on medical student's mental health and that anxiety and depression levels worsened for pre-clinical medical students at Rocky Vista University. As such, it is imperative to incorporate additional resources to protect the well-being of medical students as they progress through their medical careers.

Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study

ABSTRACT Given the potential for nosocomial outbreaks, we must understand factors associated with negative vaccine attitudes amongst healthcare professionals (HCPs) before the rollout of a newly developed vaccine in a pandemic setting. The aim of this prospective cohort study was to study the impact of preexisting and prevailing mental health on United Kingdom HCPs’ attitudes towards a newly developed COVID-19 vaccine. Two online surveys were distributed: first during vaccine development (July–September, 2020) and second during nationwide vaccine rollout (December 2020–March 2021). Mental health (PHQ-9 for depression; GAD-7 for anxiety) was assessed in both surveys. Negative attitude regarding vaccine safety and vaccine effectiveness was assessed at vaccine rollout. A series of logistic regression models were developed relating mental health (preexisting during vaccine development, ongoing and new-onset during rollout, and changes in symptom severity) to negative vaccine attitudes. In 634 HCPs, the presence of depression and/or anxiety during vaccine development was associated with elevated negative attitude towards vaccine safety (adj. OR 1.74 [95% CI 1.10–2.75], p = .02), but not vaccine effectiveness (1.13 [0.77–1.66], p = .53) at rollout. This was independent of other characteristics: age, ethnicity, professional role, and history of contracting COVID-19. Ongoing depression and/or anxiety (1.72 [1.10–2.69], p = .02) was associated with elevated negative attitude regarding vaccine effectiveness, but not vaccine safety. Worsened combined symptom scores over time were associated with elevated negative vaccine effectiveness attitudes (1.03 [1.00–1.05], p < .05), but not vaccine safety. Overall, adverse mental health can impact on HCPs’ attitudes towards a newly developed vaccine. Further work is required to understand how this translates to vaccine uptake.

Abstract 12722: The Impact of Covid-19 on Patients in Cardiac Rehabilitation Phase II

Introduction: COVID-19 significantly affected outpatient cardiac rehabilitation which is a central resource for patients recovering from cardiovascular disease. The aim of the study was to examine the impact of COVID-19 on Cardiac Rehabilitation (CR) Phase II clinical outcomes. Methods: A single-site retrospective chart review of CR Phase II patients who completed 12 or more visits during 2019 (pre-COVID) and 2020 (COVID) was performed. Depression was measured using the PHQ-9, functional capacity was measured by the 6-minute walk in distance (ft) and metabolic equivalents (METs), and quality of life (QOL) was measured by the Ferrans and Powers Index. Descriptive and linear mixed methods were used to analyze the data. Results: A total of 212 patients who were predominately male 67% and 66.5 (SD=10.8) years old were included. PHQ-9 results showed a significant interaction COVID*pre-post scores F(1, 119.66) = 4.66, p = 0.03. For the remaining scores, all results showed significant improvements in pre-post: distance F(1, 151.90) = 226.92, p &lt;.001; METs F(1, 180.13) = 138.7, p &lt;.001; and QOL F(1, 145.32) = 5.89, p =0.02. Interactions were not significant for the three variables. QOL results showed significant differences in the COVID group with F(1, 239.12) = 6.13, p = 0.01. Conclusions: All four outcomes improved significantly in the pre-COVID and COVID sample. COVID significantly impacted depression PHQ-9 score change, with a pre-post improvement of 0.62 points in the pre-COVID group and 2.08 points during COVID. Finally, the mean overall QOL score was significantly lower in the COVID group than the pre-COVID group.

Screening Utility of the PHQ-2 and PHQ-9 for Depression in College Students: Relationships with Substantive Scales of the MMPI-3

We investigated the validity and screening effectiveness of the PHQ-2 and PHQ-9 scores in 229 college students in a cross-sectional design. PHQ associations with Minnesota Multiphasic Personality Inventory-3 internalizing scales suggest PHQ scores are effective screening tools for college students and may aid in effective triage and service needs.

Effects of Promove – Saúde da Mulher on anxiety, depression, social skills, and satisfaction: A single-subject design

Terapia Analítico-Comportamental (TAC) (in English, behavioral-analytic therapy, behavior therapy, or clinical behavior analysis) is a possible intervention for cases of anxiety and depression, but it still has much to advance in terms of efficacy and clinical utility evidence. This article aims to describe the effects of a semi-structured intervention in the model of TAC regarding anxiety and depression, behavior, complaints, and satisfaction indicators. Participants included three women with children, marital relationships, and work, aged between 34 and 41 with complaints compatible with anxiety and depression disorders. The intervention used Promove – Saúde da Mulher (PSM) (in English, Promote Women’s Health), which included 17 topics, most of them related to social skills. Instruments included the GAD-7 for anxiety, PHQ-9 for depression, IHS-2 Del Prette for social skills, a Complaints Checklist for monitoring clinical demands, and an Evaluation of the Therapeutic Process to describe clients’ satisfaction rates. The results from the standardized instruments were statistically analyzed via the JT method. All three participants showed reliable improvements in anxiety and/or depression, improvement in most complaints, and satisfaction with the intervention and its outcomes. Acquisition of social skills occurred in two cases. One participant dropped out and another one relapsed at follow-up. The efficacy criteria were used to evaluate the internal validity of the present study. The study collected the first evidences of outcome and satisfaction for PSM, thus enabling future investigations on the efficacy and clinical utility of this intervention program.

Аналіз феноменів тривоги та депресії у перші тижні війни: гендерно-вікові аспекти

Background. There is a high prevalence of psychogenic disorders, in particular depressive and anxiety, in people who have been exposed to extreme intensity of traumatic influences. However, there is no data on depression and / or anxiety in the first weeks of the war. The aim of the study was to assess the prevalence of anxiety and depression, as well as to identify risk factors for the development of these conditions in individuals during the first weeks of the war. Methods. A cross-sectional epidemiological study involving 140 respondents who voluntarily and anonymously have completed a questionnaire with complaints, anamnestic data, and a self-assessment scale for depression PHQ-9 and anxiety GAD-7 was performed. Results. The mean severity of anxiety was 8.0 (4.5; 12.5) points. The prevalence of anxiety on the GAD-7 test with an accuracy cut-off of 4 points was 75% (105/140) of respondents, with an accuracy cut-off of 10 points - 37.86% (53/140) of respondents. The mean severity of depression was 8.5 (5.0; 12.5) points. The prevalence of depression on the test PHQ-9 with an accuracy cut-off of 4 points was 76.4% (107/140) of respondents, with an accuracy cut-off of 10 points - 42.5% (60/140) respondents. The study found no statistically significant differences in gender, age, employment, complaints, chronic diseases, COVID-19 and its vaccination. Conclusions. The prevalence of anxiety and depression in the first weeks of the war was high. The most significant risk factors for anxiety and depression are the number of complaints, the presence of depression / anxiety respectively, and subjectively reduced work capacity. Past COVID-19 and / or vaccination against it have not affected the occurrence of depression and anxiety.

0325 A Comprehensive Evaluation of Sleep Disorders in Male and Female U.S. Military Personnel

Abstract Introduction Sleep disorders are increasingly recognized in military personnel. However, no study has comprehensively evaluated male and female service members with clinically significant sleep disturbances. While, insomnia and obstructive sleep apnea (OSA) are the two most recognized sleep disorders, some studies have suggested that comorbid insomnia and OSA, also known as COMISA, potentially is the most frequent sleep disorder. Further little is known regarding the co-occurrence of nightmares, shift work disorder, depression, anxiety, and posttraumatic stress disorder (PTSD) in this population. Methods Participants were 309 active duty service members (females n = 113, male n = 196) in all branches of the military who underwent a clinically indicated sleep evaluation in a military sleep disorders center. All underwent an attended in-lab polysomnogram, were diagnosed with insomnia, OSA, or COMISA and completed self-report measures. Participants completed the Nightmare Disorder Index and Shift Work Disorder Index, and non-sleep questionnaires using the PCL-5 for post-traumatic stress disorder (PTSD), the PHQ-9 for depression, the GAD-7 for anxiety, and History of Head Injuries for traumatic brain injury (TBI). Results COMISA was diagnosed in 36.8% of the sample, insomnia in 32.7%, and OSA in 30.4%. Males were significantly more likely to have COMISA or OSA and females were more likely to have insomnia. Polysomnographic variables were consistent with the respective sleep diagnoses. Forty service members (12.9%) met criteria for nightmare disorder; those with OSA were significantly less likely to have nightmares. Shift work disorder was present in 49 (15.9%) and did not differ between sleep diagnoses. PTSD was present in 57 (18%) and those with COMISA were significantly more likely to have PTSD. A history of head injuries was reported by 38.2% and there was no difference in rates between the sleep disorder groups. Conclusion The most frequent sleep disorder profile in service members with sleep disturbances was COMISA, which was associated with significantly higher rates of PTSD and anxiety. Conversely, OSA alone was not associated with higher rates of any comorbid disorders. Nightmare disorder and shift work are relatively prevalent in military personnel with sleep disorders. Support (If Any) This work was supported by the Defense Health Agency, Defense Medical Research and Development Program, Clinical Research Intramural Initiative for Military Women’s Health (DM170708; Mysliwiec), and the Air Force Research Laboratory, Wright Patterson Air Force Base, Ohio (FA8650-18-2-6953; Peterson). The views expressed herein are solely those of the authors and do not represent an endorsement by or the official policy or position of the U.S. Air Force, the U.S. Army, the Defense Health Agency, the Department of Defense, the Department of Veterans Affairs, or the U.S. Government.

Alternative scoring of the Patient Health Questionnaire-9 in neurological populations: an approach based on a predictive algorithm deriving from individual item scores

ObjectiveThe study objective was to assess whether machine learning methods could improve predictive performance of the PHQ-9 for depression in patients with neurological disease. Specifically, we assessed whether a predictive algorithm deriving from all nine items could outperform the tradition of summing the items and applying a cut-point. MethodData from the NEEDS Study was used (n = 825). Demographic data, PHQ-9 scores, and MDD diagnoses (via the SCID) were obtained. Logistic LASSO, logistic regression, and non-parametric ROC analyses were performed. The ROC curve was used to identify the optimal cut-point for regression-derived predictive algorithms using the Youden method. ResultsThe traditional approach to PHQ-9 scoring had a classification accuracy of 85.1% (sensitivity: 84.5%; specificity: 85.2%). The logistic LASSO regression model had a classification accuracy of 85.6% (sensitivity: 83.3%; specificity: 86.1%). The logistic regression model had a classification accuracy of 85.8% (sensitivity: 91.4%; specificity: 84.8%). Both models had similar areas under the curve values (logistic LASSO: 0.9097; logistic regression: 0.9026). ConclusionsThe current cut-off threshold approach to PHQ-9 scoring and interpretation remains clinically appropriate.

Psychosocial Impact of COVID-19 on Healthcare Workers: A cross-sectional survey from Pakistan.

ObjectivesThis study aimed to assess the anxiety and depression symptoms in healthcare professionals in Pakistan as a result of the coronavirus pandemic.MethodsThis cross-sectional study was conducted from May to June 2020 and included six different hospitals in Pakistan. An English-language demographics questionnaire, a validated COVID-19 fear scale, depression scale PHQ-9 and anxiety scale GAD-7 were sent to doctors, nurses and paramedical staff via WhatsApp. Data were analysed using descriptive statistics, Chi-square test and Student’s t-test.ResultsA total of 400 participants were included in this study (response rate: 80.0%); 263 (65.8%) were doctors and 137 (34.3%) were nurses and paramedical staff. Of the participants, 57.0% were less than 40 years old and 18.3% were aged above 50. Most of the participants (n = 262; 65.5 %) experienced moderate levels of fear and 16.5% (n = 66) experienced a high level of fear. Moreover, 19.5% feared death and 56.5% reported social media to be responsible for increasing their fears. On the depression PHQ-9 and anxiety GAD-7 scales, 21.8% (n = 87) reported moderate to severe depression and anxiety symptoms. A significant relationship was demonstrated between the depression level and age, education and profession (P <0.001 each). Similarly, anxiety and depression scores were strongly related to the availability of personal protective equipment (P <0.001).ConclusionIt was found that 21.8% of healthcare professionals are suffering from moderate to severe depression symptoms, 15.5% had moderate to severe anxiety, whereas 65.5% had moderate symptoms of fear. The predictors are age, education level and co-morbidities. These moderate to high levels of fear and anxiety and depression raise concerns about the psychological well-being of healthcare staff and should be addressed through different programmes.

Zastupljenost simptoma depresije kod zaposlenih u hitnoj medicinskoj pomoći Beograd

Introduction: According to the WHO, depression is a common mental disorder where workplace conditions play a significant contributing factor. Objective: To examine the prevalence of depression symptoms and the relationship with sociodemographic characteristics in staff at the Institute for Emergency Medical Services (EMS) Belgrade, i.e., physicians, medical technicians, drivers and administrative workers. Methodology: The research was conducted at the City Institute for EMS in Belgrade in the period from December 1 to December 6, 2007. The questionnaire consisted of questions about the sociodemographic characteristics of participants, a self-assessment questionnaire for depression PHQ-9 and a question about the use of antidepressants. The data that was collected was statistically processed with the software package SPSS 20.0 Results: The study included 118 participants, 58,47% were male and the average age was 40,77 ± 8,86. The result of the PHQ-9 test showed that 30% of the participants had symptoms of subsyndromal depression, 11% had symptoms of mild depressive episode, most often in female participants (p = 0,023) and in administrative workers (p = 0,003). Depressive symptoms was present in 16.95% of respondents. Out of the 9 listed symptoms of depression, fatigue/extreme exhaustion were most commonly present (47,46%) as well as feelings of emptiness and hopelessness (43,22%). Only 11,86% of participants used antidepressants and there was no statistically significant difference in relation to the observed parameters. Conclusion: Symptoms of subsyndromal depression is significantly present among the EMS staff in Belgrade, more often among female participants and those working in administration.

Multi-level health indicators as predictors of students’ subjective well-being experience

The subjective well-being as an integral experience of health state is a multidimensional phenomenon. The intrapersonal, social and environmental levels of subjective well-being were distinguished. The aim of the study was to determine predictors of subjective well-being of students. 850 students of different courses of St Petersburg and Novosibirsk universities took part in the study. The screening techniques MHC-SF (C.Keyes) and test of resilience (D.Leont’ev and E.Rasskazova), Scale of subjective well-being (C.Ryff), Measuring of prosocial tendencies (G.Carlo and B.A.Randall, adaptation of N.Kukhtova), Measuring of attitude to significant life situations (E.Korjova, A.Berdnikova), Scale of depression PHQ-9 and Scale of anxiety GAD-7 (Patient Health Questionnaire) were used. The results showed that students with a high level of subjective well-being rated all levels of health significantly higher than students with a low level of subjective well-being. The greatest influence on the subjective wellbeing is exerted by intrapersonal (endopsychic) predictors — resilience (β=0.322; p=0.000) and the presence of a goal in life (β=0.176; p=0.000). To a lesser extent, exopsychic predictors have an impact — attitude to a significant life situation and prosocial orientation, as well as self-assessment of mental health and presence of depression. The greatest contribution to the subjective well-being of intrapersonal characteristics confirms the leading role of personality in regulating the relationship between human and world. The data obtained make it possible to build a hierarchy of significant health resources for working out different health-saving programs.

Prevalence of depression, anxiety and Quality of life among North Indian Polycystic ovary syndrome Women: Evidence from a prospective observational study

Background: Polycystic ovary syndrome (PCOS) is a common heterogeneous gynaecological endocrine disorder characterized by clinical features including oligo-amenorrhea/ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. PCOS increases the risk of depression and anxiety which leads to poor quality of life. Aim of the study were to determine the prevalence of anxiety and depression among women suffering from PCOS and to determine the quality of life (QOL) in PCOS women.Methods: The study was prospective, observational, non-interventional and questionnaire-based. 192 women with PCOS voluntarily helped in filling the questionnaires consisting of questions using PHQ-9 for depression, GAD-7 for anxiety, SF-12 for general health and PCOSQ-50 for disease-specific domains. All data were recorded in pre-designed case record forms and analysis of data was done using different statistical methods.Results: Majority of PCOS women were either overweight or obese. Based on PHQ-9 20% of women was suffering with major depression and based on GAD-7, 25% with major anxiety. It is found that psychosocial and emotional domain and coping domain of PCOSQ-50 is significant in patients with major depression and major anxiety. Significant effects were seen on their general health as per SF-12 domain. Lack of physical exercise was found in 83% of women.Conclusions: PCOS is a complex disease which decreases the overall quality of life. Therefore, treatment of PCOS women should include psychological counselling along-with with medication, especially in obese PCOS women. Women should be educated with the benefits of lifestyle modification in PCOS.

Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods.

PurposeDepression is a symptom commonly encountered in primary care; however, it is often not detected by doctors. Recently, disease diagnosis and treatment approaches have been attempted using smart devices. In this study, instrumental effectiveness was confirmed with the diagnostic meta-analysis of studies that demonstrated the diagnostic effectiveness of PHQ-9 for depression using mobile devices.Patients and MethodsWe found all published and unpublished studies through EMBASE, MEDLINE, MEDLINE In-Process, and PsychINFO up to March 26, 2021. We performed a meta-analysis by including 1099 subjects in four studies. We performed a diagnostic meta-analysis according to the PHQ-9 cut-off score and machine learning algorithm techniques. Quality assessment was conducted using the QUADAS-2 tool. Data on the sensitivity and specificity of the studies included in the meta-analysis were extracted in a standardized format. Bivariate and summary receiver operating characteristic (SROC) curve were constructed using the metandi, midas, metabias, and metareg functions of the Stata algorithm meta-analysis words.ResultsUsing four studies out of the 5476 papers searched, a diagnostic meta-analysis of the PHQ-9 scores of 1099 people diagnosed with depression was performed. The pooled sensitivity and specificity were 0.797 (95% CI = 0.642–0.895) and 0.85 (95% CI = 0.780–0.900), respectively. The diagnostic odds ratio was 22.16 (95% CI = 7.273–67.499). Overall, a good balance was maintained, and no heterogeneity or publication bias was presented.ConclusionThrough various machine learning algorithm techniques, it was possible to confirm that PHQ-9 depression screening in mobiles is an effective diagnostic tool when integrated into a diagnostic meta-analysis.