You have accessJournal of UrologyCME1 Apr 2023MP51-09 ASSOCIATION BETWEEN LOW TESTOSTERONE AND PERIOPERATIVE OUTCOMES IN PATIENTS UNDERGOING TRANSURETHRAL PROSTATE SURGERY Jasmine Lin, Daniel Greenberg, Sai Kaushik S. R. Kumar, Xinlei Mi, Edward Schaeffer, Robert Brannigan, and Joshua Halpern Jasmine LinJasmine Lin More articles by this author , Daniel GreenbergDaniel Greenberg More articles by this author , Sai Kaushik S. R. KumarSai Kaushik S. R. Kumar More articles by this author , Xinlei MiXinlei Mi More articles by this author , Edward SchaefferEdward Schaeffer More articles by this author , Robert BranniganRobert Brannigan More articles by this author , and Joshua HalpernJoshua Halpern More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003299.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Low testosterone (T) has been associated with decreased muscle mass, increased frailty, and a higher risk of cardiovascular disease. Therefore, low T and its consequences may adversely impact perioperative outcomes for patients undergoing surgical procedures. We sought to characterize the association between low T, frailty and perioperative outcomes in patients undergoing transurethral resection of the prostate (TURP) and laser photovaporization of the prostate (PVP). METHODS: We identified men who underwent TURP or PVP with a recorded T level within 1 year prior to their procedure date. We compared the clinical characteristics, lab values, and Hospital Frailty Risk Scores (HFRS) of patients with low (<300 ng/dL) versus normal (≥300 ng/dL) T. Descriptive statistics were performed using t-test and chi-squared test, where applicable. Univariate and multivariate regression were performed to determine the association between low T and specific perioperative outcomes. RESULTS: Among 181 patients who underwent either TURP or PVP, 89 (49%) had low T. Mean preoperative T was 176.0 (±100.9) versus 471.7 (±162.4) ng/dL in the low versus normal T group (p<0.001). Patients with low T were older (68.7±9.2 vs. 64.8±11.7 years old, p=0.014) and had longer post-op stays (4.1±10.3 vs. 1.4±0.9 days, p=0.03), lower post-op hemoglobin (12.5±2.0 vs. 13.8±1.7, p<0.001) and hematocrit (37.3±6.0 vs. 41.0±4.7, p<0.001) values. Patients with low T also had higher rates of readmission within 180 days (28% vs. 13%, p=0.020). T was not independently associated with frailty (p=0.6). On multivariable analysis, both HFRS and low preoperative T were independently associated with 180-day readmission on multivariable analysis (OR 1.04, 95% CI 1.00-1.07, p=0.05 and OR 1.00, 95% CI 0.99-1.0, p=0.002, respectively). CONCLUSIONS: Almost half of men undergoing transurethral surgery had low T. While low T was not independently associated with frailty, both low T and frailty were independently associated with higher risk of 180-day readmission. While future prospective studies are needed, low T may be an independent risk factor for adverse perioperative outcomes after transurethral surgery, indicating a potential for T assessment and possibly treatment pre-operatively. Source of Funding: Urology Care Foundation Research Scholar Award SP0071384 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e696 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jasmine Lin More articles by this author Daniel Greenberg More articles by this author Sai Kaushik S. R. Kumar More articles by this author Xinlei Mi More articles by this author Edward Schaeffer More articles by this author Robert Brannigan More articles by this author Joshua Halpern More articles by this author Expand All Advertisement PDF downloadLoading ...