Agriculture is facing major challenges affected by erosion, salinity and soil degradation. Chemical pesticides and fungicides are more used the agricultural lands. Chemical pesticides and fungicides are more used environment and human diseases causes. The better approaches in agriculture, biocontrol microorganisms, and Plant Growth Promoting (PGP) have emerged as safe for the environment, and also safe alternatives to chemical pesticides. Plant associated microorganisms have helped in soil nutrients enhancement, nitrogen fixation, phosphate solubilization, siderophore production, β-1,3glucanase, cellulase, protease, and lipases. These microbes have tolerances to the biotic and abiotic stress, pH, salinity drought, extremes temperature, heavy metals, and pesticide pollution. This summarized and discussed in this review evaluated actinomycetes related research and its benefits. These bacteria are biocontrol of plant pathogens and enhance the plant growth in agriculture.