Pharyngeal Test Research Articles

Comparison Of Naso Faring And Oro Pharynx Swab Samples On Positivity Rate For Covid – 19 With The Reverse Transcription Method Pcr (Rt–Pcr) In The Lab. Rsud Pcr. City Padang Sidempuan

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be a coronavirus that causes COVID-19 infection. SARS-CoV-2 is classified as an RNA infection that can cause gentle to severe respiratory diseases. Viral contaminations proceed to extend quickly, so it is critical to prevent the spread of the infection through nasopharyngeal and/or oropharyngeal swabs within the community. The point of this consider was to decide the exactness of nasopharyngeal or pharyngeal spread testing and the inspiration rate in RSUD patients. Padang Sidempuan City This think about was performed by collecting 20 nasopharyngeal swabs and 20 pharyngeal swabs from RSUD patients. City of Padang Sidempuan Infection testing was performed within the research facility by turn around transcriptase polymerase chain response (RT-PCR). Information were analyzed employing a chi-square test with p < 0.05. Judging from the nasopharynx and oropharynx positive rate comes about, the nasopharynx positive rate esteem is higher than the nasopharynx positive rate esteem, indeed in case it is the same persistent. The conclusion of this ponder is that the discovery of SARS-CoV-2 by nasopharyngeal swab will be more precise.

Incidence of sexually transmitted infections and screening models among pre-exposure prophylaxis users

IntroductionThere is discussion about the frequency of STI screening among pre-exposure prophylaxis (PrEP) users. The aim of this study was to analyse the incidence of STIs and to evaluate different screening models in order to optimise the follow-up. MethodologyA prospective study was conducted between 2017 and 2023, including 138 PrEP users in a STI clinic. Participants were tested for STIs every three months. Unscheduled visits were performed for those with STI-related symptoms or for people who were notified for an STI by a sexual partner. We performed a survival analysis of repeated events, estimating the cumulative incidence (CI) and incidence rate (IR). ResultsThe overall CI by quarterly screening was 8.3 (95% CI: 7.6–9.1) infections per person over six years, with a decreasing trend. The most frequently diagnosed pathogen was Neisseria gonorrhoeae, with a IR of 0.76 (95% CI: 0.68–0.84). If the frequency of screening is reduced to every six months, the IR of STIs is reduced by (95% CI: 0.5–0.66) infections per user per year, and at 12 months by 0.82 (95% CI: 0.73–0.89). In the case of no pharyngeal or urethral screening, IR is reduced by 0.37 (95% CI: 0.32–0.42) infections per person per year and in those over 35 years of age by 0.33 (95% CI: 0.25–0.4). Eliminating unscheduled visits, the reduction in IR is 0.33 (95% CI: 0.24–0.42). ConclusionsThe incidence of STIs among PrEP users is high, especially in the rectum, but it does not increase over time. STI screening could be optimised reducing the frequency of pharyngeal and urethral testing, particularly in those over 35 years of age. It is essential to redistribute health resources for unscheduled visits, which have been shown to be the most cost-effective screening.

Asymptomatic and Subclinical Mpox: An Association With Modified Vaccinia Ankara Vaccine.

How often mpox causes asymptomatic infections, particularly among persons who have received the Modified Vaccinia Ankara (MVA) vaccine, is unknown. We performed mpox polymerase chain reaction testing on rectal and pharyngeal specimens collected from symptomatic and asymptomatic patients at a sexual health clinic in Seattle, WA, between May 2022 and May 2023. Analyses evaluated the prevalence of asymptomatic or subclinical infection and, among persons with polymerase chain reaction-positive tests, the association of MVA vaccination status with the symptomatic infection. The study population included 1663 persons tested for mpox during 2353 clinic visits. Ninety-three percent of study participants were cisgender men and 96% were men who have sex with men. A total of 198 symptomatic patients (30%) had a first mpox-positive test during 664 visits. Eighteen patients (1.1%) tested during 1689 visits had asymptomatic or subclinical mpox based on a positive rectal or pharyngeal test done in the absence of testing done because of clinical suspicion for mpox. Fourteen (78%) of 18 persons with asymptomatic/subclinical mpox and 53 (26%) of 198 persons with symptomatic mpox had received at least 1 dose of the MVA vaccine ( P < 0.0001). Controlling for calendar month, study subjects who received 1 and 2 doses of MVA vaccine were 4.4 (95% confidence interval, 1.3-15) and 11.9 (3.6-40) times more likely to have asymptomatic versus symptomatic mpox, respectively, than persons who were unvaccinated. Asymptomatic mpox is uncommon. Modified Vaccinia Ankara vaccination is associated with an asymptomatic/subclinical infection among persons with mpox.

REVIEW OF CLASSICAL AND NEW DIAGNOSTIC METHODS REFLUX-ASSOCIATED ENT PATHOLOGY: PROTON PUMP INHIBITOR TEST, OROPHARYNGEAL PH-MONITORING

To determine the advantages and effectiveness of modern methods for diagnosing extraesophageal manifestations of GERD in relation to the classical ones. Methodology. This paper presents a literature review from Pubmed, Web of Science, Willey Online Library and Google Scholar sources over the past 10 years on the diagnosis of extraesophageal manifestations of GERD. We selected 73 articles on the epidemiology and diagnosis of GERD, of which 13 were on a new oropharyngeal pH probe (Restech). Based on the literature sources studied by us, we analyzed the effectiveness and accuracy of a new method for diagnosing extraesophageal manifestations of GERD by the pharyngeal probe test (Restech) in comparison with more classical research methods – a symptom questionnaire, a scale of clinical manifestations, a test with proton pump inhibitors and 24-hour pH probe testing of the esophagus.

Overlapping Presentation of Group A Streptococcus and Upper Respiratory Infection in a Pediatric Patient: A Case Report

Group A Streptococcus (GAS) pharyngitis has increased in case presentations, higher than prepandemic data. GAS pharyngitis requires appropriate antibiotic treatment to reduce the risk of subsequent complications if not recognized and treated promptly. However, regional observations have noted an increase in overlapping symptoms of GAS pharyngitis and viral upper respiratory infection symptoms, making the decisions to test for GAS more complex. Current guidelines do not delineate testing and treatment guidelines for this presentation scenario. This case report describes a 5-year-old female with overlapping GAS and upper respiratory infection symptoms, who tested positive via rapid GAS pharyngeal test and was treated with oral antibiotics.

Research and Analysis on the Diagnosis and Treatment of COVID-19 Patients After the Full Opening of Epidemic Prevention and Control - A Population Based Study

<i>Research background</i>: Since the gradual liberalization of the epidemic in China in November 2022, economic activities have gradually resumed, the incidence of COVID-19 admitted to our hospital has gradually decreased, the symptoms and the toxicity have gradually decreased. <i>Objective</i>: By analyzing the research and analysis of the treatment of patients infected with COVID-19 infection in the Third People's Hospital of Sichuan Province from December 2022 to February 2023, can help to understand the clinical manifestations of COVID-19 virus infection after the opening of the epidemic in China, and guide patients to standardize medical treatment. The follow-up research and treatment of COVID-19 after the epidemic is released for reference. <i>Research method</i>: inclusion standard: patients with COVID-19 pharyngeal swab test positive. We used the "Case Information System and Prevention and Control System" to carry out statistical analysis and retrospectively study of theCOVID-19 infection since the opening of the epidemic. <i>Research results</i>: In this study, the total number of outpatient visits to respiratory medicine in the Third People's Hospital of Sichuan Province from December 1, 2022 to February 28, 2023 was 4,582 people/90 days. The total hospitalization rate was 7.88% (361/4582), due to the COVID-19 infection is 1.55% (71/4582); men account for 0.94%, women account for 0.61%, and the total mortality rate after hospitalization is 1.10% (4/361), and the total mortality rate of patients after the novel COVID-19 infection is 0. 55% (2/361), as shown in Figure 1, Figure 2 and Figure 3. After national vaccination, the main symptoms of patients infected with COVID-19 are fever, soreness all over the body, mainly lung invasion changes, the number of severe patients and respiratory failure is small, indicating that its toxicity is reduced. With the largest number of cases in the 50-75-year-old group, accounting for 36.61% (26/71) and a mortality rate of 2.82% (2/71). Common with respiratory failure and abnormal liver function. The more complications, the older age, the more days of hospitalization, and the higher cost of hospitalization<i>. Conclusion: </i>Since the vaccination against the COVID-19 in China, the mortality rate due to the COVID-19 in our hospital is low, and the incidence of severe clinical manifestations is low, which shows that the toxicity of COVID-19 infection has gradually decreased with COVID-19 vaccination. This study found that the older patients with multiple complications, the more hospitalization days, the higher the cost of hospitalization. For elderly patients with a variety of complications and complications, recommended to be hospitalized in time.

The Prevalence and Clinical Implications of Rectal SARS-CoV-2 Shedding in Danish COVID-19 Patients and the General Population.

Background: SARS-CoV-2 has resulted in a global pandemic since its outbreak in Wuhan, 2019. Virus transmission primarily occurs through close contact, respiratory droplets, and aerosol particles. However, since SARS-CoV-2 has been detected in fecal and rectal samples from infected individuals, the fecal-oral route has been suggested as another potential route of transmission. This study aimed to investigate the prevalence and clinical implications of rectal SARS-CoV-2 shedding in Danish COVID-19 patients.Methods: Hospitalized and non-hospitalized adults and children who were recently tested with a pharyngeal COVID-19 test, were included in the study. A rectal swab was collected from all participants. Hospitalized adults and COVID-19 positive children were followed with both pharyngeal and rectal swabs until two consecutive negative results were obtained. RT-qPCR targeting the envelope gene was used to detect SARS-CoV-2 in the samples. Demographic, medical, and biochemical information was obtained through questionnaires and medical records.Results: Twenty-eight of 52 (53.8%) COVID-19 positive adults and children were positive for SARS-CoV-2 in rectal swabs. Seven of the rectal positive participants were followed for more than 6 days. Two of these (28.6%) continued to test positive in their rectal swabs for up to 29 days after the pharyngeal swabs had turned negative. Hospitalized rectal positive and rectal negative adults were comparable regarding demographic, medical, and biochemical information. Furthermore, no difference was observed in the severity of the disease among the two groups.Conclusions: We provided evidence of rectal SARS-CoV-2 shedding in Danish COVID-19 patients. The clinical importance of rectal SARS-CoV-2 shedding appears to be minimal.

Demographic, Behavioral, and Clinical Characteristics of Persons Seeking Care at Sexually Transmitted Disease Clinics - 14 Sites, STD Surveillance Network, United States, 2010-2018.

Demographic, Behavioral, and Clinical Characteristics of Persons Seeking Care at Sexually Transmitted Disease Clinics - 14 Sites, STD Surveillance Network, United States, 2010-2018.

Out-of-hospital cardiac arrest in COVID-19 era. A single center experience

Abstract Introduction In the COVID-19 pandemic several adverse cardiovascular sequelae (myocarditis, AMI and heart failure) has been reported but it is unclear whether there is an influence of COVID-19 on incidence of out-of-hospital sudden death (OHCA) and its management by emergency medical services (EMS) Aim The aim of the study was to evaluate these items comparing OHCA during COVID-19 pandemic to that of pre-COVID era using the Progetto Vita Registry. Method We compared (OHCA) that occurred in Piacenza province during the first three months of COVID-19 outbreak (from February to April 2020, Period A) with those that occurred during the same period in 2019 (from February to April 2019, Period B) We collected data from the electronic database of the emergency medical system to identify patients affected by COVID-19, including both patient with symptoms suggestive of infection (history of fever before out-of-hospital cardiac arrest, with cough, dyspnea, or both) and patients with positive results of pharyngeal swabs test to detect SARS-CoV-2 obtained before the event or after death. Results 1. Demographic characteristics of patients were similar in both periods (Period A 70/156 Female, mean age 79.2±5 yrs, Period B 39 Female, mean age 81.5±4 years,) 2. An higher number of OHCA were observed in the Period A vs Period B (A 156 cases vs B 78 cases, p 0.005). 68 cases (43%) of OHCA were associated with a COVID-19 disease 3. The EMS response time was longer in Period A vs B (A 16.4±4 min, vs B 11.1±3 min, p 0.05) 4. Initial cardiac rhythm was shockable in 10 subjects in the Period A (6,4%) and in 15 subjects in Period B (19.2%, p 005), possibly related to longer EMS response time 5. The global survival rate was higher in Period B vs A (B 5 patients, 6.4% vs 0 patients 0% p 0.05) 6. No one received cardiopulmonary resuscitation from bystanders in Period B. Conclusion During COVID-19 pandemic in Piacenza there was an increase in OCHA compared to the pre-COVID era. The COVID 19 Pandemic influences the bystanders attitude to practice an early cardiopulmonary resuscitation intervention and the performance of EMS, worsening the outcome of patients. Funding Acknowledgement Type of funding sources: None.

Türkiye‘den İlk Yenidoğan Koronavirüs Hastalığı 2019 (COVID-19) Vakası

Newborn cases commonly have milder COVID-19 disease. However, this is not enough to define knowledge about clinical manifestation and prognosis of this disease in newborns. A 17-day-old male neonate was admitted to the emergency room with fever and refusal to breastfeed at March 12, 2020. His pharyngeal swab testing was positive with real-time reverse transcription polymerase chain reaction (rRT-PCR) assay for SARS-CoV-2. Except his father, all his close contacts were asymptomatic and screened for SARS-CoV-2 and all his close contacts have revealed as positive. During this very contagious outbreak, the COVID-19 disease should be considered in newborns with fever or refusal of feeding.

Six-Month Outcomes of Post-ARDS Pulmonary Fibrosis in Patients With H1N1 Pneumonia.

Background: Influenza virus is a common pathogen causing community-acquired pneumonia. After H1N1 infection, some patients present with rapid disease progression and various respiratory complications, especially immunocompromised patients and pregnant women. However, most patients have a favorable prognosis. Influenza viruses infect respiratory epithelial cells, leading to diffuse alveolar damage (DAD), which could induce secondary bacterial or fungal infections that could lead to serious complications, such as acute respiratory failure, severe pneumonia, pneumothorax, mediastinal emphysema, acute respiratory distress syndrome (ARDS) and post-ARDS fibrosis. Objective: The short-term mortality rate of ARDS is decreasing, and understanding survivors’ posthospitalization outcomes is very important. Our aim was to evaluate the outcomes of 69 patients who survived H1N1 pneumonia with severe respiratory complications and abnormal CT findings and developed post-ARDS pulmonary fibrosis. Materials and methods: The 280 inpatients included in this trial had been diagnosed with H1N1 infection that was confirmed by pharyngeal sputum or swab tests. The data were collected from January 2018 to January 2020 in the First Affiliated Hospital of Zhengzhou University and the Sixth People's Hospital of Zhengzhou. Of these patients, 232 had CT findings indicating pulmonary fibrosis after H1N1 infection, and 69 survived and consented to participate in this study. 6°months after diagnosis, the 69 surviving patients were interviewed and underwent physical examinations, CT scans, 6°min walk tests, and quality-of-life evaluations (SF-36). We analyzed the baseline variables and six-month outcomes of post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia. Results: Of the 69 surviving patients with post-ARDS pulmonary fibrosis, there were 24 females and 45 males, with a mean age of 53.7 ± 16.8°years; 18 patients (26%) had no underlying disease, and 14 (20%) patients had more than one underlying disease. The distance walked in 6°min increased from an average of 451.9°m at 3°months to 575.4°m at 6°months; the mean 36-Item Short Form Survey (SF-36) physical function score increased from an average of 75.3 at 3°months to 77.5 at 6°months; and the average CT score decreased from 31.3 at 3°months to 14.8 at 6°months. Treatment with systemic corticosteroids and the presence of an underlying disease were related to the CT score and the distance walked in 6°min. Conclusion: Among the survivors with pulmonary fibrosis after H1N1 influenza, the 6°min walk test and CT scores continued to be affected after 6°months. The 6°min walk distance and imaging findings improved during the first 6°months. The health-related QoL (HRQoL) scores of H1N1 pneumonia survivors were lower than those of sex- and age-matched controls.

Improved Gonorrhea and Chlamydia Testing Among Men Who Have Sex With Men Living With HIV Through Implementation of Self-Collected Tests.

We implemented self-collected gonorrhea/chlamydia testing in 17 medical centers in California serving men who have sex with men living with HIV. From 2012 to 2018, gonorrhea/chlamydia testing increased from 45.2% to 63.4%. Among those tested, rectal testing increased from 42.0% to 77.3%; pharyngeal testing increased from 31.0% to 79.9% (all, Ptrend < 0.0001).

Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea.

Dysphagia is a common but under-recognized complication of obstructive sleep apnea (OSA). However, the mechanisms remain poorly described. Accordingly, the aim of this study was to assess swallowing symptoms and use high-resolution pharyngeal manometry to quantify swallowing biomechanics in patients with moderate-severe OSA. Nineteen adults (4 female; mean (range) age, 46 ± 26-68 years) with moderate-severe OSA underwent high-resolution pharyngeal manometry testing with 5-, 10-, and 20-mL volumes of thin and extremely thick liquids. Data were compared with 19 age- and sex-matched healthy controls (mean (range) age, 46 ± 27-68 years). Symptomatic dysphagia was assessed using the Sydney Swallow Questionnaire. Swallow metrics were analyzed using the online application swallowgateway.com. General linear mixed model analysis was performed to investigate potential differences between people with moderate-severe OSA and controls. Data presented are means [95% confidence intervals]. Twenty-six percent (5 of 19) of the OSA group but none of the controls reported symptomatic dysphagia (Sydney Swallow Questionnaire > 234). Compared with healthy controls, the OSA group had increased upper esophageal sphincter relaxation pressure (-2 [-1] vs 2 [1] mm Hg, F = 32.1, P < .0001), reduced upper esophageal sphincter opening (6 vs 5 mS, F = 23.6, P < .0001), and increased hypopharyngeal intrabolus pressure (2 [1] vs 7 [1] mm Hg, F = 19.0, P < .05). Additionally, upper pharyngeal pressures were higher, particularly at the velopharynx (88 [12] vs 144 [12] mm Hg⋅cm⋅s, F = 69.6, P < .0001). High-resolution pharyngeal manometry identified altered swallowing biomechanics in people with moderate-severe OSA, which is consistent with a subclinical presentation. Potential contributing mechanisms include upper esophageal sphincter dysfunction with associated upstream changes of increased hypopharyngeal distension pressure and velopharyngeal contractility. Schar MS, Omari TI, Woods CM, etal. Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea. J Clin Sleep Med. 2021;17(9):1793-1803.

Clinical Significance of an IgM and IgG Test for Diagnosis of Highly Suspected COVID-19.

Background: Nucleic acid detection and CT scanning have been reported in COVID-19 diagnosis. Here, we aimed to investigate the clinical significance of IgM and IgG testing for the diagnosis of highly suspected COVID-19.Methods: A total of 63 patients with suspected COVID-19 were observed, 57 of whom were enrolled (24 males and 33 females). The selection was based on the diagnosis and treatment protocol for COVID-19 (trial Sixth Edition) released by the National Health Commission of the People's Republic of China. Patients were divided into positive and negative groups according to the first nucleic acid results from pharyngeal swab tests. Routine blood tests were detected on the second day after each patient was hospitalized. The remaining serum samples were used for detection of novel coronavirus-specific IgM/IgG antibodies.Results: The rate of COVID-19 nucleic acid positivity was 42.10%. The positive detection rates with a combination of IgM and IgG testing for patients with COVID-19 negative and positive nucleic acid test results were 72.73 and 87.50%, respectively.Conclusions: We report a rapid, simple, and accurate detection method for patients with suspected COVID-19 and for on-site screening for close contacts within the population. IgM and IgG antibody detection can identify COVID-19 after a negative nucleic acid test. Diagnostic accuracy of COVID-19 might be improved by nucleic acid testing in patients with a history of epidemic disease or with clinical symptoms, as well as CT scans when necessary, and serum-specific IgM and IgG antibody testing after the window period.

A Review on COVID19: Evolution, Structure of Corona Virus and Comparison of COVID19 with Common FLU

Covid-19 is a pandemic disease that threatened the World both socially and economically. The virus originated from Wuhan – China in December 2019. Globally 18,354,342 cases were reported and total mortality cases are 6,96,147 till Aug 5 2020. The spreading of Novel Covid19 is faster than MARS and SARS Virus. The symptoms are very similar to the common cold or flu such as running nose sneezing, sore throat are the common symptoms and difficulty in breathing, severe muscle ache, dry cough GIT irregularity were the serious symptoms. The infection may leads to pneumonia, Acute Respiratory disorder (ARD) Syndrome. The incubation period varies from 7- 14 days. The transmission occurs through physical contact with infected person, infected droplets and contaminated objects. Laboratory test includes CT scan, Nasal Oral pharyngeal swab tests, RT PCR were employed for diagnosis. The disease at the end of August showed increasing mortality rate. Maintaining Physical distance is the only measure to overcome the infection.

47. Pilot Study of Self-Collected Pharyngeal Testing for Chlamydia and Gonorrhea in the Setting of COVID19 Restrictions

Given that many youth and young adults utilize multiple orifices during sexual activity, testing for STIs from multiple anatomical sites can increase rates of diagnosis. However, during the COVID19 pandemic, obtaining oral swabs by clinical staff was deemed an unacceptable COVID19 transmission risk and was discontinued in our clinic. To circumvent this obstacle to diagnosis, clinic staff developed a workaround of obtaining patient collected pharyngeal swabs for STI testing. This abstract reviews the results of this pilot intervention.

World Experience on COVID-19 Patients, Who Had Positive PCR for Nasal Swab and Underwent Surgical Interventions and Peritoneal Fluid Analysis for COVID-19

1.1. Aims: Aim of this literature review was to analyse the world experience on COVID-19 patients who underwent surgical intervention. Analyse the status of their peritoneal fluid and the surgical outcome in these COVID-19 patients. 1.2. Methods: Literature review of the published papers was performed over the last two years. The studies involving patients who had COVID -19 confirmed by PCR results of nasopharyngeal swabs and underwent a surgical procedure and had the peritoneal fluid samples examined to detect the presence of the COVID 19 virus. 1.3. Results: Ten papers assessing the COVID-19 in the peritoneal cavity were published, all of them were published in the year 2020. In all these studies total of 18 patients were confirmed COVID-19 on nasopharyngeal PCR and these were Assessed for the detection of the COVID-19 in the peritoneal cavity. Three patients (3/18, 16.6%) have no respiratory symptoms, fifteen (15/18, 83.33%) patients have respiratory symptoms. Seven patients (7/18, 38.8%) had COVID-19 detected in the peritoneum (Table 1), 2.dsa. 1.4. Conclusion: Patients with Respiratory symptoms are more likely to have peritoneal fluid positive for the disease. The overall mortality rate in patients with Pharyngeal PCR test +ve and who had surgical intervention is 9/18, 50%. Patients with Respiratory symptoms and positive Nasopharyngeal PCR had mortality rate of 8/9, 88.88% among those who died in this group. It is difficult to comment on the mortality and morbidity of patients with COVID-19 in the peritoneal fluids as number of cases is small and many other variables can influence the morbidity and mortality in this group.

Pediatric Endoscopy During the COVID-19 Pandemic: Addressing the Implications of Universal Preprocedural Testing for PPE Utilization.

Pediatric Endoscopy During the COVID-19 Pandemic: Addressing the Implications of Universal Preprocedural Testing for PPE Utilization.

1545. Three Site Testing for Sexually Transmitted Infections for People Living with HIV in One Southeastern Ryan White HIV/AIDS Program Clinic: First Year of Experience

BackgroundFor comprehensive care, it is recommended that people living with HIV who are sexually active have annual multisite testing for gonorrhea and chlamydia. Appropriate testing is defined by testing at all sites of sexual exposure (urogenital, pharyngeal, rectal). In the first year of 3 site testing at our HIV clinic, we aimed to describe (1) the rate of appropriate sexually transmitted infection (STI) testing, (2) the factors associated with STI diagnosis, and (3) the percentage of extragenital STIs that would have been missed with only urogenital testing.MethodsParticipants were > 14 years old with > 1 in-person medical visit at the Ryan White HIV/AIDS Program clinic in 2019. We collected demographics, reported sexual activity, and STI test dates and results. Controlling for number of sites tested, a log-binomial model was used to estimate the association of different characteristics with an STI diagnosis.ResultsFor this cohort (n=857; Table 1), 44% reported sexual activity, 34% reported no sexual activity and 22% had no sexual activity information recorded. Of 1185 STI tests performed for 491 participants, 51 STIs were diagnosed in 33 participants. One STI was diagnosed for a female (0.7%). Overall, 68% (253/375) received appropriate urogenital testing, 63% (85/134) received appropriate pharyngeal testing and 69% (72/105) received appropriate rectal testing. For male participants with > 1 STI test (n=347), Hispanic ethnicity was associated with an STI diagnosis (Table 2). Of those with concurrent extragenital and urogenital tests, 96% of people with an STI (n=26) were positive at only an extragenital site.Table 1: Study Participants’ Characteristics Table 2: Factors Associated with Being Diagnosed With a Sexually Transmitted Infection for Men Living With HIV: Frequencies and Results of Univariable and Multivariable Log-binomial Model ConclusionNearly a quarter of participants had no sexual activity information recorded in the year, which is an area for improvement. Despite newly adopting 3 site testing, appropriate extragenital and urogenital testing rates were similar and were high compared with national averages. There was no obvious clinician/patient bias against extragenital testing. Hispanic male participants’ higher STI diagnosis rate may point to more condomless sex in this population. Based on the identification of many infections exclusively at extragenital sites, we likely missed STIs previously. This highlights the importance of 3 site testing availability and testing at all appropriate sites.DisclosuresKathleen A. McManus, MD, MSCR, Gilead Sciences, Inc (Research Grant or Support, Shareholder)

1538. Pilot Study of Self-collected Pharyngeal Testing for Chlamydia and Gonorrhea in the Setting of COVID19 Restrictions

BackgroundGiven that many youth and young adults utilize multiple orifices during sexual activity, testing for STIs from multiple anatomical sites can increase rates of diagnosis. However, during the COVID pandemic, obtaining oral swabs by clinical staff was deemed an unacceptable COVID transmission risk and was discontinued in our clinic. To circumvent this obstacle to diagnosis, clinic staff developed a workaround of obtaining patient collected pharyngeal swabs for STI testing. This abstract reviews the results of this pilot intervention.MethodsPatients presenting to an urban youth family planning/STI clinic who desired STI testing and ever engaged in oral sex were offered pharyngeal testing for chlamydia (CT) and gonorrhea (GC). Patients were instructed on how to obtain an oral sample, and subsequently sent outside of the clinic to obtain their individual sample. Chart review was conducted by clinic staff of a two month period during which this protocol was in place, and the following variables were collected: gender, sexual orientation, race/ethnicity, and STD testing results by anatomic site. Simple descriptive statistical analysis were used.Results146 patients received a GC/CT test from > 1 anatomical site, with 34 patients having > 1 positive result. All pharyngeal samples were self-collected. Four patients were positive for GC/CT from throat samples only (12% of positive tests). All were biologically female, including one transgender FTM. Sexual orientation was split evenly between bisexual and heterosexual. Reported race/ethnicity included two African-American, one white, and one “Filipino”. For comparison, of the overall subsample of patients with positive GC/CT results, patients identified as 53% female, 44% male, and 3% FTM; 74% “straight”, 15% bisexual, 9% “gay”, and 3% did not disclose; 29% white, 50% African-American, 21% unknown as other; and 11% Hispanic. Twelve patients were positive for GC/CT from the throat and either rectum and/or urine/vagina/endocervix (35% of positive tests).ConclusionOur experience demonstrates that obstacles created by the COVID crisis can be circumvented with creative strategies. We were able to pick up 12% and 35% of total infections by self-collected pharyngeal swabs in throat only and throat plus other sites, respectively.Disclosures All Authors: No reported disclosures