Pharmacological Treatment For COVID-19 Research Articles

How important are COVID-19 vaccine responses in patients with MS on disease-modifying therapies?

How important are COVID-19 vaccine responses in patients with MS on disease-modifying therapies?

Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

COVID-19 is a lethal disease caused by the pandemic SARS-CoV-2, which continues to be a public health threat. COVID-19 is principally a respiratory disease and is often associated with sputum retention and cytokine storm, for which there are limited therapeutic options. In this regard, we evaluated the use of BromAc®, a combination of Bromelain and Acetylcysteine (NAC). Both drugs present mucolytic effect and have been studied to treat COVID-19. Therefore, we sought to examine the mucolytic and anti-inflammatory effect of BromAc® in tracheal aspirate samples from critically ill COVID-19 patients requiring mechanical ventilation. MethodTracheal aspirate samples from COVID-19 patients were collected following next of kin consent and mucolysis, rheometry and cytokine analysis using Luminex kit was performed. ResultsBromAc® displayed a robust mucolytic effect in a dose dependent manner on COVID-19 sputum ex vivo. BromAc® showed anti-inflammatory activity, reducing the action of cytokine storm, chemokines including MIP-1alpha, CXCL8, MIP-1b, MCP-1 and IP-10, and regulatory cytokines IL-5, IL-10, IL-13 IL-1Ra and total reduction for IL-9 compared to NAC alone and control. BromAc® acted on IL-6, demonstrating a reduction in G-CSF and VEGF-D at concentrations of 125 and 250 µg. ConclusionThese results indicate robust mucolytic and anti-inflammatory effect of BromAc® ex vivo in tracheal aspirates from critically ill COVID-19 patients, indicating its potential to be further assessed as pharmacological treatment for COVID-19.

Pharmacological treatment of COVID-19: an opinion paper.

The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation.

Antiviral therapy and immunotherapy of COVID-19.

The pharmacological treatment of COVID-19 has evolved in the months since the description of the disease. Published observational studies and, above all, clinical trials have highlighted drugs that are useful as well as ruled out any benefit from other drugs used at the beginning of the pandemic. The pathogenesis of the disease has suggested that patients may benefit from the administration of both antivirals, mainly in the earliest stages, and anti-inflammatory/immunomodulatory medications in more advanced stages. We present a short review of the drugs used and under investigation for the treatment of COVID-19.

Coronavirus Disease 19 (COVID-19) Pharmacologic Treatment

Since the first cases of COVID-19 were reported from China the disease became pandemic within a few months. The viral genome was sequenced soon after the outbreak of COVID-19 which enabled development of diagnostic tests and therapeutic options. As the knowledge of SARS-CoV-2 virology increased, many potential drugs appeared. At this moment (January 12th 2021), 4426 studies of COVID-19 are registered, and more than 2680 studies are investigating therapeutic options. This is a short narrative review of currently available evidence on pharmacological treatment of COVID-19.

Optimization of Analytical Procedure for In-hospital Rapid Quantification of Serum Level of Favipiravir in the Pharmacological Treatment of COVID-19.

An in-hospital rapid method for quantifying the serum level of favipiravir (FPV) in the pharmacological treatment of COVID-19 was developed by an appropriate combination of a solid-phase extraction treatment and a reversed-phase HPLC/UV detection system. The quantification method was well-validated and applied to measuring the serum FPV level in a clinical practice at a general hospital that accepts COVID-19 patients. Furthermore, an analysis of data from our preliminary interaction analysis revealed, for the first time, that FPV selectively forms complexes with ferric (Fe3+) and cupric (Cu2+) ions.

Science unites a troubled world: Lessons from the pandemic

European Journal of Pharmacology has published a special issue entitled Therapeutic targets and pharmacological treatment of COVID-19 that contains more than 30 manuscripts. Scientists from around the world contributed both review articles and original manuscripts that are remarkable in their diversity. Each contribution offers a unique perspective on the current approaches of the discipline called pharmacology. Yet the contributions share an enthusiasm to put forward a fresh viewpoint and make a positive difference by the exchange of ideas during the troubled times of this pandemic. What other enterprise but science can unite so many diverse cultures and nationalities in global uncertainty and discord, and mobilize an effective response against a common enemy. The efforts of science are in stark contrast to those of populism that has introduced division and a self-serving attitude that are not simply ill-matched to tackle the pandemic, but foster its spread and severity. We trust that the readers of European Journal of Pharmacology will discover new ideas and concepts in our special COVID-19 series as members of the scientific community and shared world.

Pharmacological Treatment of COVID-19 and Cluster Headache

Pharmacological Treatment of COVID-19 and Cluster Headache

Pharmacological Treatment of COVID-19 and Treatment of Migraine Crisis

Pharmacological Treatment of COVID-19 and Treatment of Migraine Crisis

A review on pathophysiology and pharmacological treatment of COVID-19

A cluster of patients with unidentified pneumonia cause emerged among people in a city of China named Wuhan, at the end of 2019, which then by laboratory analysis, was considered to be caused by a novel coronavirus (CoV) called 2019-nCoV. It has been declared a pandemic by the World Health Organization on March 11, 2020. By the spread of pandemic novel coronavirus, it is revealed that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is genetically related to SARS-CoV of the 2003 outbreak. However, the latest study showed that angiotensin-converting enzyme-2 is the receptor used by SARS-CoV-2 to enter into the human cells, alike its predecessor (SARS-CoV). Both excessive immune reactions and lytic effects of the virus on host cells play a central role in the pathogenesis of COVID-19. Commonly, the antivirals, corticosteroids, antibiotics, Immunoglobulin, and some other drugs are used as a pharmacological treatment in COVID-19 patients. Recently, the food and drug administration (FDA) has authorized the emergency use of remdesivir for the treatment of COVID-19 under an emergency use authorization (EUA). The majority of the current drugs are recommended based on the treatment of previous epidemic viruses. Due to its pandemic prevalence, and the insufficient of specifically approved drugs and vaccines, COVID-19 is becoming an emergency public health concern. Furthermore, there is a lack of comprehensive knowledge about pathogenesis and treatment of COVID-19. Thus, this review answers to the questions about pathogenesis and pharmacological treatment of COVID-19 and provide the newest information in term of the pathogenesis and pharmacological treatment of COVID-19, inclusively, and simultaneously.

Pharmacological treatment of COVID-19: lights and shadows

At the end of December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China and then the entire world, forcing the World Health Organization to make the assessment that the coronavirus disease (COVID-19) can be characterized as a pandemic, the first ever caused by a coronavirus. To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking. In the absence of definitive management protocols, many treatments for COVID-19 are currently being evaluated and tested worldwide. Some of these options were soon abandoned due to ineffectiveness, while others showed promising results. The basic treatments are mainly represented by antiviral drugs, even if the evidence is not satisfactory. Among the antivirals, the most promising appears to be remdesivir. Corticosteroids and tocilizumab seem to guarantee positive results in selected patients so far, although the timing of starting therapy and the most appropriate therapeutic schemes remain to be clarified. Efficacy of the other drugs is still uncertain, and they are currently used as a cocktail of treatments in the absence of definitive guidelines. What will represent the real solution to the enormous problem taking place worldwide is the identification of a safe and effective vaccine, for which enormous efforts and investments are underway.

A review on pharmacological treatment for covid-19 (coronavirus disease-2019)

COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), is a highly contagious disease. The WHO (World Health Organization) has declared the ongoing outbreak to be pandemic on March 12, 2020. Currently, effective therapies for this virus are not available. The fast-growing knowledge regarding SARS-CoV-2 virology provides a substantial number of potential drug targets. The most promising therapy appears to be Remdesivir. This drug has potent in vitro activity against SARS-CoV-2 and is now approved by US Food and Drug Administration for its emergency use for treating COVID-19 patients. Based on current published evidence, this review systematically summarizes the pharmacological targeted treatment for COVID-19 which are on ongoing clinical trial.