LettersMay 2021Nonpharmacologic and Pharmacologic Management of Acute Pain From Non–Low Back, Musculoskeletal Injuries in AdultsStephanie Mathieson, PhD, Matthew K. Bagg, BPhysio(Hons), BExSpSci, Mark Schoene, BS, Christopher G. Maher, PhD, DMedScStephanie Mathieson, PhDInstitute for Musculoskeletal Health, University of Sydney, Camperdown, New South Wales, AustraliaSearch for more papers by this author, Matthew K. Bagg, BPhysio(Hons), BExSpSciNeuroscience Research Australia, University of New South Wales, Sydney, New South Wales, AustraliaSearch for more papers by this author, Mark Schoene, BS The BackLetter, Lippincott Williams & Wilkins, Philadelphia, PennsylvaniaSearch for more papers by this author, Christopher G. Maher, PhD, DMedScInstitute for Musculoskeletal Health, University of Sydney, Camperdown, New South Wales, AustraliaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L21-0060 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We noted that the American College of Physicians' guideline on nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries (1) was informed by a network meta-analysis (NMA) (2). This NMA questioned what the best treatment was for patients with this condition and concluded that nonopioid drugs showed the “most convincing and attractive benefit–harm ratio for patients with acute pain from non–low back, musculoskeletal injuries.”The NMA review systematically identified 207 trials. It combined a range of musculoskeletal conditions and interventions that would never feature in the same clinical decision. The choice to combine all ...