Background: Health information exchange (HIE) is the electronic exchange of data or information between healthcare institutions, despite the fact that, the format and context of the information may vary. A robust HIE, which provides the seamless networking is not currently available. The gap in research pertaining mainly to Indian scenario where this study will be proposed would provide the much-needed evidence. The proposed study aims to develop a comprehensive framework for Health information exchange and interoperability for a group of teaching hospitals. Objectives: To understand and assess the current state, barriers and challenges related to HIE and interoperability; understand the perspectives and challenges of HIE and Interoperability among healthcare providers. Methodology: A qualitative study would be carried out among healthcare stakeholders which will serve in understanding the perspective and challenges of HIE and interoperability and develop a comprehensive framework for HIE and interoperability. Results: Coordinated care among the healthcare providers can be increased and serves in reducing the lost to follow up of patients which promotes patient quality of life and lowers the rate of mortality and morbidity. This will facilitate the quick access to the patient critical information, leading to better – informed diagnosis and treatment plans. This framework will significantly elevate the quality of care, streamline operations, will contribute to a reduction in mortality and morbidity.